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| 1 | 肿瘤相关巨噬细胞在肿瘤微环境中的作用新进展显示文摘众所周知,在肿瘤发生发展的各个阶段都有单核细胞通过血管壁进入肿瘤组织,这些单核细胞可分化形成具有独特表型的巨噬细胞,即肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)。TAMs是肿瘤微环境的重要组成部分,参与了肿瘤的发生、生长、侵袭及转移过程,其中,向肿瘤组织的转移是肿瘤恶性发展的关键步骤。本文将TAMs在肿瘤微环境形成中发挥作用的最新进展进行了总结,特别值得注意的是,细胞及动物实验研究表明,TAMs可为肿瘤的发生发展进程提供一个有利的微环境;同时,临床病理实验表明,TAMs在肿瘤内的累积与较差的临床疗效相关。最后,本文讨论了靶向TAMs的治疗手段作为一种间接癌症治疗新方法的可行性。 | 李海涛 谭超 田书梅 张晓磷 赵云云 | 2015 | 肿瘤防治研究2015，42，11： | 8 |
| 2 | Correlation between TAMs and proliferation and invasion of type endometrial carcinoma显示文摘Objective: To explore the correlation between tumor-associated macrophages and the proliferation and invasion of type endometrial carcinoma. Methods: Immunohistochemistry was used to investigate the infiltration of macrophages in normal and different types of hyperplastic endometrial lesions. The proliferation and invasion ability of type endometrial carcinoma cell line RL95-2 influenced by mononuclear macrophage cell line THP-1(constructed M2 type macrophages) was detected by CCK8 and transwell technologies respectively. Transwell was used to evaluate the recruiting ability of RL95-2 on THP-1 cells. Otherwise, the western blot was also used to detect the expression of Cyclin D1 and MMP-2 in RL95-2 with the influence of THP-1. Results: Immunohistochemistry result showed a positive correlation between the number of infiltrating macrophages and the progression of endometrial hyperplasia.THP-1 recruited by RL95-2 could promote its proliferation and invasion and enhance the expression of the Cyclin D1 and MMP-2 protein in a time dependent manner(P<0.05). Conclusions: Increase of the number of infiltrating macrophages and its contribution to the tumor inflammatory microenvironment may result in the development of the type endometrial carcinoma. | Hong-Lin Hu Han-Song Bai Hai-Xia Pan | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，8： | 2 |
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