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| 1 | 肠道菌群与肥胖发生显示文摘肠道菌群是人体不可或缺的'微生物器官',对维持人体健康至关重要,这早已被人们所认识。肠道菌群与肥胖发生之间的关系在近10年才被发现,随后大量的研究显示肠道菌群失调在肥胖发生中起着重要作用,其机制涉及促进能量吸收、影响肠粘膜通透性和食欲调控因子分泌、引发内毒素血症和慢性炎症反应状态等多个方面。深入对与肥胖发生有关的具体关键菌及其作用机制的研究,将有助于从肠道菌群的调控和益生菌应用环节寻找新的肥胖治疗和预防'靶点'。 | 齐可民 | 2015 | 中国儿童保健杂志2015，23，4： | 6 |
| 2 | Pathogenesis of Crohn's disease: Bug or no bug显示文摘The possibility of an infectious origin in inflammatory bowel disease(IBD)has been postulated since the first description of Crohn’s disease(CD).Many observations implicate bacteria as a trigger for the development of CD:lesions occur in regions with higher bacterial concentrations;aphthous ulcers occur in Peyer’s patches;inflammation resolves when the fecal stream is diverted and is reactivated following reinfusion ofbowel contents;severity of the disease is correlated with bacterial density in the mucosa;granulomas can contain bacteria;and susceptible mice raised in germfree conditions develop inflammation when bacteria are introduced in the 1990’s,several studies sought to establish a relationship with viral infections and the onset of IBD,finally concluding that no direct link had been demonstrated.In the past fifteen years,evidence relating IBD pathogenesis to Mycobacterium avium paratuberculosis,salmonella,campylobacter,etc.,has been found.The tendency now under discussion to regard microbiota as the primary catalyst has led to the latest studies on microbiota as pathogens,focusing on Escherichia coli,mainly in ileal CD.The present review discusses the literature available on these'bugs'. | Marta Maia Bosca-Watts Joan Tosca Rosario Anton Maria Mora Miguel Minguez Francisco Mora | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，1： | 1 |
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