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| 1 | Programmed cell death and its role in inflammation显示文摘Cell death plays an important role in the regulation of inflammation and may be the result of inflammation. The maintenance of tissue homeostasis necessitates both the recognition and removal of invading microbial pathogens as well as the clearance of dying cells. In the past few decades, emerging knowledge on cell death and inflammation has enriched our molecular understanding of the signaling pathways that mediate various programs of cell death and multiple types of inflammatory responses. This review provides an overview of the major types of cell death related to inflammation. Modification of cell death pathways is likely to be a logical therapeutic target for inflammatory diseases. | Yong Yang Ge-Ning Jiang Peng Zhang Jie Fan | 2015 | Journal of Medical Colleges of PLA(China)2015，30，2： | 17 |
| 2 | Probiotics against neoplastic transformation of gastric mucosa:Effects on cell proliferation and polyamine metabolism显示文摘Gastric cancer is still the second leading cause of cancer death worldwide, accounting for about 10% of newly diagnosed neoplasms. In the last decades, an emerging role has been attributed to the relations between the intestinal microbiota and the onset of both gastrointestinal and non-gastrointestinal neoplasms. Thus, exogenous microbial administration of peculiar bacterial strains(probiotics) has been suggested as having a profound influence on multiple processes associated with a change in cancer risk. The internationally accepted definition of probiotics is live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. The possible effects on the gastrointestinal tract following probiotic administration have been investigated in vitro and in animal models, as well as in healthy volunteers and in patients suffering from different human gastrointestinal diseases. Although several evidences are available on the use of probiotics against the carcinogen Helicobacter pylori,little is still known about the potential cross-interactions among probiotics, the composition and quality of intestinal flora and the neoplastic transformation of gastric mucosa. In this connection, a significant role in cell proliferation is played by polyamines(putrescine, spermidine, and spermine). These small amines are required in both pre-neoplastic and neoplastic tissue to sustain the cell growth and the evidences here provided suggest that probiotics may act as antineoplastic agents in the stomach by affecting also the polyamine content and functions. This review will summarize data on the most widely recognized effects of probiotics against neoplastic transformation of gastric mucosa and in particular on their ability in modulating cell proliferation, paying attention to the polyamine metabolism. | Francesco Russo Michele Linsalata Antonella Orlando | 2014 | World Journal of Gastroenterology2014，20，37： | 3 |
| 3 | 细胞凋亡在激素性股骨头坏死中的研究进展显示文摘概述糖皮质激素诱导的股骨头坏死(Steroid-inducedfemoralhead necrosis,SIFHN)又称糖皮质激素诱导的股骨头缺血性坏死或股骨头无菌性坏死,激素导致股骨头坏死早在20世纪50年代就已经确立。据推测[1],目前中国股骨头坏死患者有500~750万,每年新增病例约7.5~15万,激素成为我国股骨头坏死发病的首要原因。激素诱导的股骨头坏死严重影响患者的生活质量和劳动能力,给社会带来了巨大的负担。 | 刘玉 赵建民 王雪梅 刘瑞 李强 | 2014 | 生物骨科材料与临床研究2014，11，4： | 1 |
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