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| 1 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 2 | CA19-9对胰腺癌诊断价值探讨显示文摘目的分析各种因素特别是CA19—9对胰腺新生物性质的诊断意义。方法回顾性分析昆明医学院附属昆华医院118例因胰腺占位接受胰腺根治性部分切除术的病人(包括恶性59例和良性59例)的术前CA19—9水平及年龄和有无黄疸等因素,使用Logistic回归分析以上变量。结果重要的恶性预测指标包括CA19—9升高、年龄大于50岁及术前黄疸单独的CA19—9升高的敏感性和特异性分别为71%和83%,而年龄联合黄疸因素的预测准确率(敏感性和特异性分别为76%和92%)高于CA19—9。老年黄疸病人CA19—9升高或单独的CA19—9〉150kU/L对胰腺癌有很高的特异性。结论年龄联合黄疸因素比单独的CA19—9升高对胰腺癌的预测价值要高CA19—9升高必须综合考虑其他临床因素才能有效判断胰腺占位的性质。CA19—9〉150kU/L预测价值较高。 | 胡平海 乔鸥 孙志为 | 2009 | 中国实用外科杂志2009，29，S1： | 0 |
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