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| 1 | 血红素氧合酶-1与冠心病炎性反应的相关性研究显示文摘血红素氧合酶(heme oxygenase,HO)有HO-1、HO-2、HO-3三种同工酶,其中HO-1又称热休克蛋白32,是HO的诱导型,广泛分布于各种组织和细胞中,在心、肺、肾、肝脏、脾脏、骨髓和网状内皮细胞中表达较多.HO-1具有抗损伤、对抗炎性反应、组织修复等功能.现就HO-1在冠心病中抗炎作用及其代谢产物的抗炎作用的研究进展作一综述. 一、血红素氧合酶一氧化碳(HO-CO)系统的抗炎作用 1.直接抑制致炎因子:HO-1能分解血红素生成等摩尔的CO、胆绿素和自由铁,参加细胞自动调节,在组织修复中起着重要的作用,衰减炎性反应应答,抑制编程性细胞死亡,调节细胞增殖[1].近年研究表明HO-1对心血管的自我保护和机体稳态的维持起着重要作用,尤其是在抗炎方面的作用. | 刘洁 阚志超 | 2014 | 中国医师进修杂志2014，37，10： | 4 |
| 2 | 肝硬化门脉高压患者血红素氧合酶—一氧化碳系统与血浆内皮素关系的初步研究显示文摘目的探讨肝硬化门静脉高压时HO-CO系统及ET变化,以及这两种血管活性物质之间是否存在相关性。方法试验对象分为3组:健康对照组20人,中、重度慢性肝炎患者组20人及肝硬化门脉高压组26人。运用双波长紫外分光光度法测定全血COHb百分比浓度以间接反映HO-CO系统水平,同时用放射免疫学方法检测血浆ET-1水平,了解二者与肝硬化门脉高压的关系及二者之间的关系。结果肝硬化门脉高压组的HO-CO水平显著高于对照组及慢性肝炎组(P<0.05),而慢性肝炎组与对照组之间的HO-CO水平无显著差异(P>0.05)。肝硬化门静脉高压组的血浆ET-1水平明显高于对照组及慢性肝炎组(P<0.05),且慢性肝炎组的血浆ET-1水平较对照组亦显著升高(P<0.05)。肝硬化门静脉高压组的HO-CO系统水平和血浆ET水平呈正相关(P<0.05)。慢性肝炎组的HO-CO系统水平和血浆ET水平无明显相关性(P>0.05)。结论HO-CO系统在肝硬化门静脉高压中发挥重要作用,但与慢性肝纤维化的程度无明显关系。血浆ET在肝硬化门静脉高压中发挥重要的生物学效应,并且与肝脏纤维化程度有关系。肝硬化门静脉高压患者的HO-CO系统水平与血浆ET水平呈正相关关系,两者共同参与维持肝硬化门静脉高压的高动力循环状态。 | 刘洁 段志军 朱丽萍 杨冬 王丽霞 邵海燕 | 2008 | 胃肠病学和肝病学杂志2008，17，9： | 4 |
| 3 | 血红素氧合酶-1与心血管炎症的相关性研究显示文摘血红素氧合酶-1(HO-1)在氧化应激状态下表达明显增加、与心血管炎症相关。其具有①直接抑制致炎因子;②抗氧化应激;③衰减炎症应答,保护心肌细胞。其代谢产物胆绿素、胆红素以及一氧化碳、铁和铁蛋白均有抗炎作用。HO-1很有可能成为治疗心血管疾病的新靶点。 | 张宏伟 李元红 | 2009 | 中国心脏起搏与心电生理杂志2009，23，4： | 3 |
| 4 | Glutamine prevents oxidative stress in a model of portal hypertension显示文摘AIM To evaluate the protective effects of glutamine in a model of portal hypertension(PH) induced by partial portal vein ligation(PPVL).METHODS Male Wistar rats were housed in a controlled environment and were allowed access to food and water ad libitum. Twenty-four male Wistar rats were divided into four experimental groups:(1) control group(SO)-rats underwent exploratory laparotomy;(2) control + glutamine group(SO + G)-rats were subjected to laparotomy and were treated intraperitoneally with glutamine;(3) portal hypertension group(PPVL)-rats were subjected to PPVL; and(4) PPVL + glutamine group(PPVL + G)-rats were treated intraperitoneally with glutamine for seven days. Local injuries were determined by evaluating intestinal segments for oxidative stress using lipid peroxidation and the activities of glutathione peroxidase(GPx), endothelial nitric oxide synthase(e NOS) and inducible nitric oxide synthase(i NOS) after PPVL.RESULTS Lipid peroxidation of the membrane was increased in the animals subjected to PH(P < 0.01). However, the group that received glutamine for seven days after the PPVL procedure showed levels of lipid peroxidation similar to those of the control groups(P > 0.05). The activity of the antioxidant enzyme GTx was decreased in the gut of animals subjected to PH compared with that in the control group of animals not subjected to PH(P < 0.01). However, the group that received glutamine for seven days after the PPVL showed similar GTx activity to both the control groups not subjected to PH(P > 0.05). At least 10 random, non-overlapping images of each histological slide with 200 × magnification(44 pixel = 1 μm) were captured. The sum means of all áreas, of each group were calculated. The mean areas of e NOS staining for both of the control groups were similar. The PPVL group showed the largest area of staining for e NOS. The PPVL + G group had the second highest amount of staining, but the mean value was much lower than that of the PPVL group(P < 0.01). For i NOS, the control(SO) and control + G(SO + G) groups showed similar areas of staining. The PPVL group contained the largest area of i NOS staining, followed by the PPVL + G group; however, this area was significantly smaller than that of the group that underwent PH without glutamine(P < 0.01).CONCLUSION Treatment with glutamine prevents gut mucosal injury after PH in rats. | Gilmara Pandolfo Zabot Gustavo Franco Carvalhal Norma Possa Marroni Francielli Licks Renata Minuzzo Hartmann Vinícius Duval da Silva Henrique Sarubbi Fillmann | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 5 | 内源性一氧化氮/一氧化氮合酶体系及一氧化碳/血红素合酶体系对大鼠肝硬化门静脉压力的影响显示文摘目的:研究内源性一氧化氮(nitric oxide,NO)/一氧化氮合酶(nitricoxide synthase,NOS)体系及一氧化碳(carbonic oxide,CO)/血红素合酶(heme oxygenase,HO-1)体系对肝硬化大鼠门静脉压力的影响,探讨NO/NOS体系及CO/HO-1体系在大鼠肝硬化门静脉高压中的作用.方法:将SD大鼠随机分为4组:正常对照组(N C组)、正常对照+左旋硝基精氨酸甲酯(L-NAME)+锌原卟啉-Ⅸ(Znpp-Ⅸ)组(NC+LNAME+ZnPP-Ⅸ组)、肝硬化模型组(CIRM组)、肝硬化模型+左旋硝基精氨酸甲酯(L-NAME)+锌原卟啉-Ⅸ(Znpp-Ⅸ)组(CIRM+LNAME+ZnPP-Ⅸ组).均用插管法测定门静脉压力,用硝酸还原酶法测定血浆中NO含量,联二亚硫酸盐还原法测定血浆CO含量,运用蛋白免疫印迹技术(Western blot)测定肝组织中内皮细胞一氧化氮合酶(endothelial nitricoxide synthase,e N O S)、诱导型一氧化氮合酶(i n duc i b l e nitricoxide synthase,iNOS)及HO-1蛋白的表达情况.结果:与NC组相比,CIRM组血浆NO、CO含量明显升高(160.12μmol/L±4.18μmol/L,111.12μmol/L±2.26μmol/L vs 81.11μmol/L±2.91μmol/L,70.51μmol/L±3.10μmol/L,均P<0.01),门静脉压力明显升高(16.08 mmHg±1.16 mmHg vs 9.85 mmHg±1.10 mmHg,P<0.01),肝组织中iNOS及HO-1蛋白含量明显升高(165.69±1.17,155.79±1.29 vs 135.22±0.54,125.44±0.94,均P<0.01),但eNOS在肝组织的表达却明显降低(118.65±1.29 vs 160.77±2.12,P<0.01),而NC+L-NAME+ZnPP-Ⅸ组NO、CO含量则明显降低(52.06μmol/L±3.17μmol/L,52.51μmol/L±2.63μmol/L,均P<0.01),门静脉压力无统计学意义,肝组织中eNOS、iNOS及HO-1蛋白含量亦明显降低(130.83±1.57,120.81±1.47,111.03±1.45,均P<0.01);与CIRM组相比,CIRM+L-NAME+ZnPP-Ⅸ组血浆NO、CO含量明显降低(100.24μmol/L±3.80μmol/L,83.73μmol/L±1.78μmol/L,均P<0.01),门静脉压力明显降低(14.13 mmHg±0.56 mmHg,P<0.01),肝组织中eNOS、iNOS及HO-1蛋白含量明显降低(87.50±1.07,150.66±1.42,139.88±1.73,均P<0.01).结论:NO、CO作为新型气体信号分子,与肝硬化门静脉压力的变化密切相关,而NO、CO抑制剂的干预研究则进一步证明了内源性NO/NOS体系及CO/HO-1体系对肝硬化门静脉高压的形成具有重要的调节作用. | 宋丽秀 陈卫刚 郑勇 张宁 齐翠花 | 2014 | 世界华人消化杂志2014，22，19： | 2 |
| 6 | HO-CO系统与肝硬化门脉高压血液动力学改变的研究进展显示文摘肝硬化门脉高压患者多存在高动力循环状态,有报道血红素氧合酶(hemeoxygenase,HO)与内源性一氧化碳(carbon monoxide,CO)作为HO-CO系统在血管调节中发挥重要的生物学效应,与肝硬化门静脉高压(portal hypertension,PH)的持续存在、肝微循环变化以及高动力循环状态有着密切的关系.本文将从肝硬化PH的血液动力学改变、HO-CO系统的生物学活性和HO-CO系统与PH的血液动力学改变等三部分的研究进展作一综述. | 段志军 刘洁 赵钢 杨冬 李蕾蕾 | 2008 | 世界华人消化杂志2008，16，8： | 2 |
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