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| 1 | 砷的表观遗传学作用及其机制研究进展显示文摘砷是重要的环境污染物和生产性毒物,饮水型砷中毒和燃煤污染型砷中毒是危害较严重的公共卫生问题,而职业性砷接触可引起接触者急性和慢性砷中毒,甚至导致职业性肿瘤。砷及其化合物的致癌作用机制包括氧化应激、基因突变和染色体畸变等。但最近的研究表明,表观遗传学作用也是砷致癌作用的重要机制[1]。表观遗传学是指研究不涉及遗传物质核苷酸序列的改变,但可以通过有丝分裂和减数分裂实现代间传递(遗传)的生物现象的遗传学分支领域[2]。 | 黄丹妮 廖维瑶 黎静 余日安 | 2015 | 中国职业医学2015，42，4： | 7 |
| 2 | Complex interactomes and post-translational modifications of the regulatory proteins HABP4 and SERBP1 suggest pleiotropic cellular functions显示文摘The 57 kDa antigen recognized by the Ki-1 antibody,is also known as intracellular hyaluronic acid binding protein 4 and shares 40.7%identity and 67.4%similarity with serpin mRNA binding protein 1,which is also named CGI-55,or plasminogen activator inhibitor type-1-RNA binding protein-1,indicating that they might be paralog proteins,possibly with similar or redundant functions in human cells.Through the identification of their protein interactomes,both regulatory proteins have been functionally implicated in transcriptional regulation,mRNA metabolism,specifically RNA splicing,the regulation of mRNA stability,especially,in the context of the progesterone hormone response,and the DNA damage response.Both proteins also show a complex pattern of post-translational modifications,involving Ser/Thr phosphorylation,mainly through protein kinase C,arginine methylation and SUMOylation,suggesting that their functions and locations are highly regulated.Furthermore,they show a highly dynamic cellular localization pattern with localizations in both the cytoplasm and nucleus as well as punctuated localizations in both granular cytoplasmic protein bodies,upon stress,and nuclear splicing speckles.Several reports in the literature show altered expressions of both regulatory proteins in a series of cancers as well as mutations in their genes that may contribute to tumorigenesis.This review highlights important aspects of the structure,interactome,post-translational modifications,sub-cellular localization and function of both regulatory proteins and further discusses their possible functions and their potential as tumor markers in different cancer settings. | Carolina Colleti Talita Diniz Melo-Hanchuk Flavia Regina Moraes da Silva Angela Saito Jorg Kobarg | 2019 | World Journal of Biological Chemistry2019，10，3： | 4 |
| 3 | APC基因3′-非编码区rs1804197多态性与结直肠癌易感性的关系显示文摘目的探讨结肠腺瘤性息肉病(APC)基因3′-非编码区rs1804197多态性与结直肠癌易感性的关系。方法收集573例结直肠癌病例及588例对照外周静脉血标本,提取外周血DNA,使用实时荧光定量PCR进行基因分型,通过病例对照研究方法分析rs1804197多态性位点不同基因型与结直肠癌易感性的关系。结果结直肠癌病例组中rs1804197位点CC型387例(67.5%),AC型153例(26.7%),AA型33例(5.8%);对照组中CC型427例(72.6%),AC型144例(24.5%),AA型17例(2.9%);病例组与对照组中AA基因型比例差异有统计学意义(OR=2.14,95%CI为1.17~3.91,P=0.011),A等位基因频率差异有统计学意义(P=0.011)。进一步亚组分析显示,男性人群和不饮酒的人群中,病例组和对照组之间rs18041797位点基因型的频率分布差异具有统计学意义(P男性=0.048,P不饮酒=0.020);在男性人群中,携带A等位基因的个体罹患结直肠癌的风险增加了0.41倍(OR=1.41,95%CI为1.01~1.98);在不饮酒的人群中,携带A等位基因的个体罹患结直肠癌的风险增加了0.22倍,但该结果并无统计学意义(OR=1.22,95%CI为0.91~1.64)。结论APC基因3′-非编码区的rs1804197多态性与结直肠癌易感性相关,AA基因型可能增加部分人群中结直肠癌的易感性。 | 陈志鹏 卢玮冬 左云 朱陵君 宋宇 周芳 张永芹 | 2017 | 国际肿瘤学杂志2017，44，6： | 2 |
| 4 | GROβ在基础及肿瘤研究领域的新进展显示文摘GROβ是CXC蛋白趋化因子家族成员之一,在炎症反应及损伤修复过程中起着非常重要的作用。研究逐渐发现gro是一种原癌基因,其表达的产物GROβ在血管新生、肿瘤形成转移和肿瘤与免疫细胞的相互作用中起着不可忽视的作用。 | 孙思进 彭小忠 高红军 | 2015 | 基础医学与临床2015，35，10： | 2 |
| 5 | 微小RNA与多发性骨髓瘤耐药机制的研究进展显示文摘多发性骨髓瘤(MM)为起病隐匿、治疗难度较大的血液系统恶性疾病,目前其治疗主要以药物化疗为主,但是治疗药物的耐药是影响MM患者疗效的重要原因.微小RNA(miRNA)为核苷酸长度短的非编码RNA,其在多种人类基因,包括致癌基因与抑癌基因的转录后负向调控中发挥重要作用.因此,miRNA成为癌症发病机制相关研究的热点.miRNA的发现亦为进一步阐明肿瘤的耐药机制提供新思路.然而,尽管miRNA在MM发病与进展过程中的作用机制已经得到充分证实,但是其参与MM耐药机制的研究仍处于初步阶段.笔者拟就miRNA在MM耐药机制中作用的最新研究结果,以及如何将miRNA应用于临床治疗MM耐药患者进行综述. | 亢倩玉 方美云 | 2018 | 国际输血及血液学杂志2018，41，4： | 1 |
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