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| 1 | Prognostic significance of red blood cell distribution width in gastrointestinal disorders显示文摘The red blood cell distribution width(RDW) is a routinely measured and automatically reported blood parameter,which reflects the degree of anisocytosis. Recently,the baseline RDW was found to have clinical significance for assessing clinical outcome and severity of various pathological conditions including cardiovascular diseases,sepsis,cancers,leukemia,renal dysfunction and respiratory diseases. A myriad of factors,most of which ill-defined,have an impact on the red cell population dynamics(i.e.,production,maturation and turnover). A delay in the red blood cell clearance in pathological conditions represents one of the leading determinants of increased anisocytosis. Further study of RDW may reveal new insight into inflammation mechanisms. In this review,we specifically discuss the current literature about the association of RDW in various disease conditions involving the gastrointestinal and hepatobiliary systems. We also present some of the related measurements for their value in predicting clinical outcomes in such conditions. According to our data,RDW was found to be a valuable prognostic index in gastrointestinal disorders along with additional inflammatory biomarkers(i.e.,C reactive protein,erythrocyte sedimentation rate,and platelet count) and current disease severity indices used in clinical practice. | Hemant Goyal Giuseppe Lippi Altin Gjymishka Bijo John Rajiv Chhabra Elizabeth May | 2017 | World Journal of Gastroenterology2017，23，27： | 20 |
| 2 | 红细胞分布宽度与消化系统疾病关系的研究进展显示文摘红细胞分布宽度(red blood cell distribution width,RDW)是外周血细胞常规检测项目之一,它是反映外周血红细胞异质性的参数。近年来研究表明,RDW与炎症指标有显著相关性,它可作为慢性心血管疾病、急性心肌梗死的独立危险因素,成为其患病率及病死率的预测指标。RDW除了在心血管系统有独特的优势之外,还在慢性胃炎、炎症性肠病(inflammatory bowel disease,IBD)、肝炎、胰腺炎、消化系肿瘤等相关疾病中有一定的作用。本文就近年来RDW在常见消化系统疾病中的应用及进展作一概述。 | 向旭 戴跃青 | 2017 | 胃肠病学和肝病学杂志2017，26，7： | 13 |
| 3 | 慢性HBV感染相关性肝病患者RDW、RPR与肝损伤严重程度的关系显示文摘目的分析慢性乙型肝炎病毒(HBV)感染相关性肝病患者外周血红细胞分布宽度(RDW)及RDW/血小板计数比值(RPR)与肝损伤严重程度的关系。方法纳入慢性HBV感染相关性肝病患者142例,其中慢性乙型肝炎(CHB)患者82例(CHB组)和乙型肝炎肝硬化(HBV-LC)患者60例(HBV-LC组)。采用全自动血液细胞分析仪检测血常规,并计算RPR。结果各组之间RDW、RPR水平比较差异有统计学意义(均P=0. 000),HBV-LC组RDW、RPR水平明显高于CHB组(均P<0. 01),HBVLC组、CHB组RDW、RPR水平明显高于NC组(P<0. 01或0. 05)。Spearman相关性分析显示,RPR与丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)水平均呈正相关(均P=0. 000);RDW与ALT、AST水平均呈正相关(P=0. 000);受试者工作特征(ROC)曲线分析结果显示,RPR诊断乙肝肝硬化的AUC值为0. 810(95%CI:0. 741~0. 879,P=0. 000),当RPR的截断值为0. 087时,其灵敏度为91. 7%,特异性为57. 3%;AST/ALT比值(AAR)诊断乙肝肝硬化的AUC值为0. 714(95%CI:0. 627~0. 801,P=0. 000),当AAR的截断值为0. 724时,其灵敏度为75. 0%,特异性为45. 1%。结论 RDW和RPR可能是评估慢性HBV感染相关性肝病病情严重程度的一种新的无创性指标。 | 牛广林 程昌盛 黄献球 潘卫珍 韦建良 | 2018 | 中国老年学杂志2018，38，24： | 9 |
| 4 | Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease显示文摘BACKGROUND Looking for undiscovered blood markers of liver fibrosis and steatosis still remains an issue worth exploring.There are still plenty of unresolved issues related to the actual role of hematological indices as potential markers of liver function.AIM To study red blood cell distribution width(RDW),RDW-to-platelet ratio(RPR)and RDW-to-lymphocyte ratio(RLR) in alcohol-related liver cirrhosis(ALC) and metabolic-associated fatty liver disease(MAFLD).METHODS The study group was composed of 302 people:142 patients with ALC and 92 with MAFLD;68 persons were included as controls.RDW,RPR and RLR were measured in each person.Indirect and direct parameters of liver fibrosis were also assessed [aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index(APRI),fibrosis-4(FIB-4),gamma-glutamyl transpeptidase to platelet ratio(GPR),procollagen I carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,plateletderived growth factor AB,laminin].MELD score in ALC patients and nonalcoholic fatty liver disease(NAFLD) fibrosis score together with BARD score were obtained in the MAFLD group.The achieved results were compared to controls.Then a correlation between assessed markers was done.Diagnostic value of each investigated parameter and its suggested cut-off in the research group RESULTS RDW,RPR and RLR values turned out to be significantly higher in ALC and MAFLD groups compared to controls(ALC:P<0.0001;NAFLD:P<0.05,P<0.0001 and P<0.0001,respectively).RPR correlated positively with MELD score(P<0.01) and indirect indices of liver fibrosis(FIB-4 and GPR;P<0.0001) in ALC patients;negative correlations were found between PDGF-AB and both:RDW and RPR(P<0.01 and P<0.0001,respectively).RPR correlated positively with NAFLD fibrosis score and APRI(P<0.0001) in the MAFLD group;a positive relationship was observed between RDW and FIB-4,too(P<0.05).AUC values and suggested cut-offs for RDW,RPR and RLR in ALC patients were:0.912(>14.2%),0.965(>0.075) and 0.914(>8.684),respectively.AUC values and suggested cut-offs for RDW,RPR and RLR in MAFLD patients were:0.606(>12.8%),0.724(>0.047) and 0.691(>6.25),respectively.CONCLUSION RDW with its derivatives appear to be valuable diagnostic markers in patients with ALC.They can also be associated with a deterioration of liver function in this group. | Agata Michalak Małgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Tomasz Lach Halina Cichoż-Lach | 2022 | World Journal of Gastroenterology2022，28，38： | 4 |
| 5 | 血常规相关参数在慢性乙型肝炎病毒感染性肝病患者预后中的应用显示文摘目的:探讨血常规相关参数红细胞体积分布宽度(RDW)、单核细胞/淋巴细胞比值(MLR)及血小板(PLT)在慢性乙型肝炎病毒(HBV)感染相关性肝病患者预后中的应用。方法:纳入慢性HBV感染相关性肝病患者126例,其中慢性乙型肝炎(CHB)患者79例(CHB组)和乙型肝炎肝硬化(HBV-LC)患者47例(HBV-LC组)。应用全自动血液细胞分析仪检测血常规,记录RDW、MLR及PLT参数,评估RDW、MLR及PLT参数与慢性HBV感染相关性肝病预后的相关性。结果:HBV-LC组、CHB组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、乙型肝炎e抗原(HBeAg)、RDW、MLR、血小板分布宽度(PDW)、平均血小板体积(MPV)水平均高于对照组(P<0.05),血清蛋白(ALB)、PLT、血小板比容(PCT)水平均低于对照组(P<0.05);且HBV-LC组各指标优于CHB组(P<0.05)。RDW、MLR、MPV与ALT、AST水平呈正相关,与ALB水平呈负相关,MLR与TBIL水平呈正相关,PLT、PCT与ALT、AST、TBIL水平呈正相关,与ALB水平呈负相关。肝脏硬度值(LSM)与RDW、MLR、MPV呈正相关,与PLT、PCT呈负相关。预后不良组患者RDW、MLR、PDW、MPV水平高于预后良好组(P<0.05),PLT、PCT水平低于预后良好组。结论:RDW、MLR及PLT参数可能是评估慢性HBV感染相关性肝病病情程度及预后的有效指标,值得推广和应用。 | 王亚鹏 王明良 侯晓禹 汪洋 | 2021 | 临床血液学杂志2021，34，6： | 4 |
| 6 | Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?显示文摘Red cell distribution width(RDW)may play an important role in predicting steatohepatitis and liver fibrosis.In the original study,it was aimed to determine whether RDW could be used for this purpose or not.There are studies indicating that higher RDW is correlated well with components of metabolic syndrome.Because nonalcoholic fatty liver disease is now recognized as the hepatic manifestation of metabolic syndrome,possible impact of the accompanying confounders on the study findings should have been detailed.There may be a patient selection bias due to use of improper cutoff values for alcohol consumption and inclusion of only subjects with normal aminotransferase levels and normal abdominal ultrasonography.Patients without hepatosteatosis on ultrasonography and with any restriction of aminotransferase levels should have been included in the control group,because isolated aminotransferase elevation is not decisive in the diagnosis of hepatosteatosis.Although iron,vitamin B12 and folic acid deficiencies were included in exclusion criteria,functional forms of these molecules like methylmalonic acid,homocysteine,ferritin levels and total iron binding capacity,which are more sensitive and specific parameters for vitamin B12 and folic acid deficiencies,were not mentioned.Consequently,RDW,an inexpensive,non-invasive,but powerful indicator overlooked on whole blood analysis,itself without other inflammatory markers may not accurately provide information about progression of nonalcoholic steatohepatitis and fibrosis. | Huseyin Kayadibi Erdim Sertoglu Metin Uyanik Serkan Tapan | 2014 | World Journal of Gastroenterology2014，20，35： | 3 |
| 7 | Red cell distribution width and nonalcoholic steatohepatitis显示文摘Red cell distribution width is a measure of deviation of the volume of red blood cells.It is a marker of anisocytosis and often used to evaluate the possible causes of anemia.Elevated red cell distribution width levels are also associated with acute and chronic inflammatory responses.In nonalcoholic steatohepatitis,inflammation is accompanied with steatosis.For assuming red cell distribution width as a marker of nonalcoholic steatohepatitis,intervening factors such as levels of inflammatory markers should also be evaluated. | Yasemin Gulcan Kurt Tuncer Cayci Fevzi Nuri Aydin Mehmet Agilli | 2014 | World Journal of Gastroenterology2014，20，43： | 2 |
| 8 | 红细胞分布宽度与肝脏疾病的关系显示文摘红细胞分布宽度(RDW)是红细胞异质性的客观指标,反映了红细胞大小不均一性。RDW升高与许多疾病相关,特别是心血管疾病,而与肝脏疾病的关系研究主要集中于与慢性HBV感染相关的疾病和非酒精性脂肪性肝病纤维化程度以及疾病严重程度的相关性上。此文就RDW与上述肝脏疾病相关性研究的进展进行综述。 | 林青 石建凤 王莉 | 2015 | 国际流行病学传染病学杂志2015，42，2： | 2 |
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