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| 1 | 冠心病患者冠状动脉评分变化与他汀类药物的依从性及血脂达标率关系研究显示文摘为了探讨冠心病患者冠状动脉评分变化和他汀类药物的依从性及血脂达标率的关系,对冠状动脉评分降低的冠心病患者208例和评分未下降的冠心病患者192例进行研究,比较他汀类药物的依从性和低密度脂蛋白胆固醇达标率。结果显示:冠状动脉评分降低组患者他汀类药物的依从性好占57.7%,评分未降低组患者他汀类药物的依从性好占42.2%,差异有统计学意义(P<0.05);冠状动脉评分降低组患者低密度脂蛋白胆固醇的达标率占61.5%,评分未降低组患者低密度脂蛋白胆固醇的达标率占45.3%,差异有统计学意义(P<0.05)。因此,冠状动脉评分降低的冠心病患者他汀类药物依从性高且低密度脂蛋白胆固醇的达标率高。 | 沈德良 刘闯 | 2018 | 医学与哲学(B)2018，39，5： | 5 |
| 2 | Lipoprotein abnormalities in South Asians and its association with cardiovascular disease:Current state and future directions显示文摘South Asians have a high prevalence of coronary heart disease(CHD) and suffer from early-onset CHD compared to other ethnic groups. Conventional risk factors may not fully explain this increased CHD risk in this population. Indeed, South Asians have a unique lipid profile which may predispose them to premature CHD. Dyslipidemia in this patient population seems to be an important contributor to the high incidence of coronary atherosclerosis. The dyslipidemia in South Asians is characterized by elevated levels of triglycerides, low levels of high-density lipoprotein(HDL) cholesterol, elevated lipoprotein(a) levels, and a higher atherogenic particle burden despite comparable low-density lipoprotein cholesterol levels compared with other ethnic subgroups. HDL particles also appear to be smaller, dysfunctional, and proatherogenic in South Asians. Despite the rapid expansion of the current literature with better understanding of the specific lipid abnormalities in this patient population, studies with adequate sample sizes are needed to assess the significance and contribution of a given lipid parameter on overall cardiovascular risk in this population. Specific management goals and treatment thresholds do not exist for South Asians because of paucity of data. Current treatment recommendations are mostly extrapolated from Western guidelines. Lastly, large, prospective studies with outcomes data are needed to assess cardiovascular benefit associated with various lipid-lowering therapies(including combination therapy) in this patient population. | Ozlem Bilen Ayeesha Kamal Salim S Virani | 2016 | World Journal of Cardiology2016，8，3： | 3 |
| 3 | 冠心病与血清总胆汁酸及胆碱酯酶关系的中西医研究概况显示文摘近年来伴随我国经济飞速发展,生活水平不断改善,我国冠心病的患病率和死亡人数较前出现明显增长,严重危害人们的健康及生活质量,流行病学研究已经确认了一系列冠心病的危险因素,主要包括高血脂、吸烟、糖尿病、高血压、缺乏体力活动等。很多研究结果显示,即使能有效控制以上危险因素,也不能较好的控制心血管疾病的进展,因此考虑可能存在新的心血管疾病危险因素,血脂有关成分、炎性相关因子、代谢相关因子等被列入其中,胆汁酸及胆碱酯酶与血脂代谢联系密切,如能结合中西医对冠心病的认识,进一步探讨胆汁酸及胆碱酯酶与冠心病中医证型的关系,以期可为中医辨证客观化提供参考。 | 刘文香 辛效毅 | 2019 | 新疆中医药2019，37，3： | 2 |
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