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| 1 | HDV感染的流行病学、发病机制及诊疗进展显示文摘HBV/HDV合并感染可导致肝病进展加速,但由于HDVRNA等检测方法学尚存在一定局限,HDV的流行病学尚不十分清楚;HDV导致HBV/HDV共感染者的发病机制及其治疗措施也需要进一步探讨。通过回顾我国以及其他国家HDV流行病学特征、HDV特异性免疫与基因型发病机制,并总结HDV的检测方法及治疗方法,分析表明现有HDV感染的检测方法敏感度、特异度低,也无标准化检测方法;探究新的HDV感染检测方法,将有助于研发新型有效抗的HDV药物,对提高HDV感染的疗效具有重要意义。 | 王宇 陈小华 赵志敏 黄恺 刘成海 | 2019 | 临床肝胆病杂志2019，35，3： | 1 |
| 2 | Treatment of chronic hepatitis delta virus with peg-interferon and factors that predict sustained viral response显示文摘AIM:To observe the efficacy of peg-interferon in the treatment of hepatitis delta virus(HDV) and to identify the factors that would be predictive of the sustained viral response(SVR).METHODS:This prospective study was conducted in Medical Unit Ⅳ of the Liaquat University of Medical and Health Sciences Hospital Jamshoro from June 2008 to September 2011.This study cohort included all patients of either sex who presented during this time with hepatitis B surface antigen positivity,hepatitis B virus DNA > 20 000 IU/mL,serum glutamic pyruvic transaminase(SGPT) > 2(upper limit of normal),HDV-RNA positivity with fibrosis stage ≥ 2.Informed consent was obtained from each of these individuals.Patients were diagnosed with hepatitis D on the basis of detectable viral antibodies and the presence of HDV-RNA in their serum.A liver biopsy was performed in all cases and fibrosis staging was performed in accordance with the METAVIR scoring system.All eligible patients were administered peg-interferon at a weekly dosage of 1.5 g/kg body weight for 48 wk.HDV-RNA was assayed at the end of this treatment period and again at 24 wk later.A biochemical response was determined by a normalization of SGPT at the end of the treatment or during follow up.The end of treatment response was defined by a HDV-RNA negative status.A sustained virological response was defined by undetectable serum HDV-RNA at six months after the end of treatment.RESULTS:Among the 277 patients enrolled in our present study,238 completed a course of peg-interferon therapy of which 180(75.6%) were male and 58(24.4%) female.Biochemical responses were achieved in 122/238(51.3%) patients.End of treatment responses were achieved in 71/238(29.8%) cases.A SVR was achieved in 70 of these patients(29.4%).A strong association was found between the SVR and the end of treatment responses(P = 0.001),biochemical responses(P = 0.001) and the degree of fibrosis(P = 0.002).CONCLUSION:Peg-interferon therapy can induce remission in nearly one third of patients harboring HDV. | Shaikh Samiullah Devrajani Bikharam Nasreen | 2012 | World Journal of Gastroenterology2012，18，40： | 1 |
| 3 | Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus显示文摘Viral hepatitis remains a worldwide public health problem.The hepatitis D virus(HDV)must either coinfect or superinfect with the hepatitis B virus(HBV).HDV contains a small RNA genome(approximately 1.7 kb)with a single open reading frame(ORF)and requires HBV supplying surface antigens(HBsAgs)to assemble a new HDV virion.During HDV replication,two isoforms of a delta antigen,a small delta antigen(SDAg)and a large delta antigen(LDAg),are produced from the same ORF of the HDV genome.The SDAg is required for HDV replication,whereas the interaction of LDAg with HBsAgs is crucial for packaging of HDV RNA.Various clinical outcomes of HBV/HDV dual infection have been reported,but the molecular interaction between HBV and HDV is poorly understood,especially regarding howHBV and HDV compete with HBsAgs for assembling virions.In this paper,we review the role of endoplasmic reticulum stress induced by HBsAgs and the molecular pathway involved in their promotion of LDAg nuclear export.Because the nuclear sublocalization and export of LDAg is regulated by posttranslational modifications(PTMs),including acetylation,phosphorylation,and isoprenylation,we also summarize the relationship among HBsAg-induced endoplasmic reticulum stress signaling,LDAg PTMs,and nuclear export mechanisms in this review. | Chi-Ruei Huang Szecheng John Lo | 2014 | World Journal of Gastroenterology2014，20，40： | 1 |
| 4 | 拉米夫定治疗活动性乙型、丁型重叠感染肝炎肝硬化失代偿期临床观察显示文摘【目的】研究核苷类药物治疗失代偿期乙型、丁型重叠感染肝炎肝硬化48周的临床疗效。【方法】24例失代偿期乙型、丁型重叠感染肝炎肝硬化患者在内科综合治疗基础上口服拉米夫定100mg每日1次。疗程中监测患者生化学指标(ALT、AST、TBil、ALB)、凝血功能(凝血酶原时间PT)、HBsAg定量、child—push评分,B超门静脉宽度、门静脉峰值流速均有不同程度的改善。并观察有无不良反应的发生。【结果】24例患者各项指标得到明显改善,疗程中无明显不良反应发生。【结论】拉米夫定治疗失代偿期乙型、丁型重叠感染肝炎肝硬化患者有较好生化学指标改善、HBsAg下降及抗HBV病毒学应答,部分患者抗HDV病毒学应答。 | 明芳 赵云 张沛枫 姚煜 | 2013 | 医学临床研究2013，30，11： | 0 |
| 5 | 丁型肝炎流行病学显示文摘1977年,Rizzetto等[1]在乙型肝炎患者肝脏中首次发现了一种新抗原,将其命名为delta抗原。3年后,他与Gerin研究发现一个小RNA与delta抗原有关,正式将其命名为丁型肝炎病毒(HDV)[2]。HDV依赖HBV传播,使用乙型肝炎表面抗原(HBsAg)作为病毒包膜,并通过相同的受体进入肝细胞。HDV是引起人类疾病的最小病毒之一。 | 王丽丽 郑可心 谢雯 | 2020 | 肝脏2020，25，11： | 0 |
| 6 | Seroprevalence of HDV among non-hospitalized HBs Ag positive patients from KPK-region of Pakistan显示文摘Objective: To study the seroprevalence of hepatitis B virus(HBV) and hepatitis delta virus(HDV) infections in patients visiting outpatient department of a major tertiary care hospital in Khyber Pakhtunkhwa region of Pakistan.Methods: Blood samples were collected from non-hospitalized patients. Serological analysis was done by ELISA and viral DNA was amplified by PCR. The amplified DNA was analyzed by agarose gel electrophoresis.Results: Altogether, 946 blood samples were screened, overall percentage of HBs Agpositive patients remained 22.41%(prevalence: 224.10/1 000; CI: 0.197 5 ± 0.250 7) with the highest incidence rates among relatively younger age groups(20–29 years). The prevalence of HBV–HDV co-infection was found to be 46.75/1 000; CI: 0.031 8 ± 0.061 7.In HBs Ag-positive patients, anti-HBc-total was detected in 86.79% while 25.00% were positive for anti-HBc-immunoglobulin M. Similarly, among these patients, HBV DNA was detected in 64.13% and 10.85% were co-infected with HDV. Different symptoms were associated with the prevailing infection, including malaise(62%), anorexia(66%) and fatigue(73%). The most commonly associated symptom was abdominal discomfort. Among these patients, certain risk factors, including surgery, visit to dentist and intravenus infusions were frequently associated with the infection(x^2= 95.23; df = 11; P < 0.000 1).Conclusions: Overall, this study confirmed higher prevalence of active HBV/HDV infection, among young patients from Khyber Pakhtunkhwa region having no prior history of viral hepatitis. | Ismail Jalil Muhammad Arshad Zara Rafaque Fazle Raziq Robina Wazir Sajid Malik Javid Iqbal Dasti | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，7： | 0 |
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