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| 1 | Telaprevir/boceprevir era: From bench to bed and back显示文摘Hepatitis C virus (HCV) infects approximately 200 million people worldwide. Interferon-based therapies have dominated over the past two decades. However, the overall response rates remain suboptimal. Thanks to the tremendous effort from both academia and industry, two serine protease inhibitors telaprevir and boceprevir for treating chronic hepatitis C have finally reached the clinic. Although these compounds are only approved for combination use with interferon and ribavirin in genotype 1 HCV infected chronic patients, the management of HCV patients however is now evolving incredibly. Here, we overviewed a series of landmark studies, regarding the clinical development of telaprevir and boceprevir. We discussed the mechanism-of-action of telaprevir/boceprevir and their potential application in HCV-positive liver transplantation patients. We further emphasized some emerging concerns with perspective of further development in this field. | Maikel P Peppelenbosch Harry LA Janssen Robert J de Knegt | 2012 | World Journal of Gastroenterology2012，18，43： | 3 |
| 2 | The response to TLR ligation of human CD16 + CD14 ? monocytes is weakly modulated as a consequence of persistent infection with the hepatitis C virus显示文摘 | Cheng Peng Bi-Sheng Liu Robert J. de Knegt Harry L.A. Janssen André Boonstra | 2011 | Molecular Immunology2011，，12： | 2 |
| 3 | Effect of thrombocytopenia on treatment tolerability and outcome in patients with chronic HCV infection and advanced hepatic fibrosis显示文摘 | Raoel Maan Adriaan J. van der Meer Bettina E. Hansen Jordan J. Feld Heiner Wedemeyer Jean-Fran?ois Dufour Hooman F. Zangneh Frank Lammert Michael P. Manns Stefan Zeuzem Harry L.A. Janssen Robert J. de Knegt Bart J. Veldt | 2014 | Journal of Hepatology2014，，： | 2 |
| 4 | Crigler‐Najjar syndrome in The Netherlands: Identification of four novel UGT1A1 alleles, genotype–phenotype correlation, and functional analysis of 10 missense mutants显示文摘 | NinaSneitz Conny T.Bakker Robert J.de Knegt Dicky J.J.Halley MosheFinel Piter J.Bosma | 2009 | Hum Mutat2009，，1： | 1 |
| 5 | Crigler-Najjar syndrome in The Netherlands:identification of four novel UGT1A1 alleles,genotype-phenotype correlation,and functional analysis of 10 missense mutants显示文摘 | Sneitz N Bakker CT de Knegt RJ | | 0，，01： | 1 |
| 6 | Identification of Endogenous Gibberellins in Petunia Flowers(Induction of Anthocyanin Biosynthetic Gene Expression and the Antagonistic Effect of Abscisic Acid)显示文摘 | Weiss D van der Luit A Knegt E | 1995 | Plant Physiol1995，，3： | 1 |
| 7 | Identification of endogenous gibberellin in petunia flowers (Induction of anthocyanin biosynthetic gene expression and the antagonistic effect of abscisic acid)显示文摘 | Weiss D Van Der Luit A Knegt E | | 0，，： | 1 |
| 8 | Living donor liver transplantation in HCV-infected patients: improvement of the donor risk-recipient benefit ratio is around the corner显示文摘 | Koning L de Knegt RJ Metselaar HJ | 2014 | Transpl Int2014，27，8： | 1 |
| 9 | Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage 显示文摘 | Goddijn M Joosten JH Knegt AC | 2004 | Hum Reprod2004，19，4： | 1 |
| 10 | Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis显示文摘 | Claassen MA de Knegt R J Tilanus HW | 2010 | J Hepatol2010，52，： | 1 |
| 11 | Abundant numbers of regulatory T cells localize to the liver of chro nic hepatitis C infected patients and limit the extent of fi- brosis显示文摘 | Claassen MA De Knegt RJ Tilanus HW | 2010 | J Hepatol2010，52，3： | 1 |
| 12 | Applicability of the tri- modal distribution of trauma deaths in a Level I trauma centre in the Netherlands with a population of mainly blunt trauma显示文摘 | Knegt CD Meylaerts SAG Leenen LPH | 2008 | In- jury2008，39，： | 1 |
| 13 | Acoustic radiation force impulse imaging for non-invasive assessment of liver fibrosis in chronic hepatitis B显示文摘 | Friedrich-Rust M Buggisch P de Knegt R J | 2013 | J Viral Hepat2013，20，4： | 1 |
| 14 | Telaprevir for chronic HCV infec- tion显示文摘 | Van der Meer AJ de Knegt RJ | 2009 | N Engl J Med2009，361，5： | 1 |
| 15 | Telaprevir for chronic HCV infection显示文摘 | van der Meet AJ de Knegt RJ | | New England Journal of Medicine0，，： | 1 |
| 16 | Insulin-like growth factor I (IGF-I)replacement therapy increases albumin concentration in liver cirrhosis:results of a pilot randomized controlled clinical trial显示文摘 | Conchillo M de Knegt R J Payeras M Castilla-Cortazar I, Frystyk J, Flyvbjerg A, Yoshizawa C, Jansen PL, Scharschmidt B, Prieto J | | 0，，： | 1 |
| 17 | Serum Markers andIntestinal Mucosal Injury in Chronic Gastrointestinal Ischemia显示文摘 | van Noord D Mensink PB de Knegt RJ | 2011 | Dig Dis Sci2011，56，2： | 1 |
| 18 | Crigler - Najjar syndrome in the Netherlands : Identification of four novel UGT1 A1 alleles, genotype - phenotype correlation, and functional analysis of 10 missense mutants 显示文摘 | Sneitz N Bakker CT de Knegt RJ | 2009 | Hum Mutat2009，31，1： | 1 |
| 19 | Ad- of the ethmoidal sinus complex : surgical debulk- ing and topical Xuorouracil may be the optimal treatment显示文摘 | KNEGT P P AH-SEE K W Van D E VELDEN L A | 2001 | Arch Otolaryngol Head Neck Surg2001，127，： | 1 |
| 20 | Identification of endogenous gibberellins in petunia flower, induction of anthocyanin biosynthetic gene expression, and the antagonistic effect of abscisic acid 显示文摘 | Weiss D Van der Luit A Knegt E | 1995 | Plant Physiol1995，107，： | 1 |
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