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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The epidemi- ology of sepsis in Colombia: a prospective muhicenter co- hort study in ten university hospitals显示文摘 | Rodriguez F Barrera L De La Rosa G | 2011 | Crit Care Med2011，39，7： | 1 |
| 3 | A new mesophase of isotactic polypropylene in copolymers of propylene with long branched comonomers 显示文摘 | De Rosa C Auriemma F Di Girolamo R | 2010 | Macromolecules2010，43，20： | 1 |
| 4 | Perianal Paget's disease associated with rectal carcinoma:a rare report显示文摘 | de la Portilla F de la Rosa A Bejarano D | 2005 | Int J Colorectal Dis2005，20，2： | 1 |
| 5 | 查看详情显示文摘 | De Rosa C Auriemma F Di Capua A Resconi L. Guidotti S. Camurati I. Nifant'ev I.E.and Laishevtsev I.P | | 0，，： | 1 |
| 6 | 查看详情显示文摘 | De Rosa C Auriemma F De Lucia G Resconi L | | 0，，： | 1 |
| 7 | On the inter-harmonics components generated by adjustable speed drives显示文摘 | De Rosa F Langella R Sollazzo A | 2005 | IEEE Trans on Power Delivery2005，20，4： | 1 |
| 8 | Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure显示文摘 | Galasso G De Rosa R Piscione F | 2010 | Eur J Heart Fail2010，12，12： | 1 |
| 9 | Subacute combined de-generation of the spinal cord in a vegan显示文摘 | De Rosa A Rossi F Lieto M | | 0，，7： | 1 |
| 10 | Subacute combined degeneration of the spinal cord in a ve- gan显示文摘 | De Rosa A Rossi F Lieto M | 2012 | Clinical Neurol Neurosurg2012，114，： | 1 |
| 11 | A land evaluation decision support system(MicroLEIS DSS)for agricultural soil protection显示文摘 | De la Rosa D Mayol F Diaz-Pereira E | 2004 | Environmental Modelling & Software2004，，19： | 1 |
| 12 | 3D spiral computerized tomography in the reconstructive treatment of malignant maxillofacial tumors显示文摘 | De Rosa V Ionna F Mozzillo N | 2000 | Radiol Med(Torino)2000，100，6： | 1 |
| 13 | Structural study of silica sonogels 显示文摘 | de la Rosa F N Esquivias L Craievich A F | 1990 | J Non-Cryst Solids1990，121，： | 1 |
| 14 | Infective endocarditis in patients with human immunodeficiency virus infection 显示文摘 | CICALINI S FORCINA G DE ROSA F G | 2001 | J Infect2001，42，4： | 1 |
| 15 | A chemical speciation of trace metals for fine urbanparticles 显示文摘 | Espinosa A J F Rodriguez M T De La Rosa F J B | 2002 | Atmospheric Environment2002，36，5： | 1 |
| 16 | The epidemiology of sepsis in Colombia: a prospective multicenter cohort study in ten university hospitals 显示文摘 | Rodrfguez F Barrera L De La Rosa G | 2011 | Crit Care Med2011，39，7： | 1 |
| 17 | Identification,isolation,characterization,and banking of human dental pulp stem cells显示文摘 | Tirino V Paino F De Rosa A | | 0，，： | 1 |
| 18 | Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed显示文摘 | Silva-Sa'nchez C de la Rosa A P León-Galván M F | 2008 | J Agric Food Chem2008，56，4： | 1 |
| 19 | Haematological safety of long-term therapy with linezolid 显示文摘 | Garazzino S De Rosa F G Bargiacchi O | 2007 | Int J Antimicrob Agents2007，29，： | 1 |
| 20 | A land evaluation decision support system (MicroLEIS DSS) for agricultural soil protection显示文摘 | De la Rosa D Mayol F Diaz-Pereira E | 2004 | Environmental Modelling and Software2004，19，4： | 1 |
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