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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Purified human bone marrow multipotent mesenchymal stem cells regenerate infarcted myocardium in experimental rats显示文摘 | Zhang S Jia Z Ge J Gong L Ma Y Li T Guo J Chen P Hu Q Zhang P Liu Y Li Z Ma K Li L Zhou C | 2006 | 中国生物学文摘2006，20，5： | 5 |
| 4 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 5 | Assay of serum arylesterase activity by fitting reaction curve with an integrated rate equation显示文摘 | Liao F Liu W L Zhou Q X | 2001 | Clin Chim Acta2001，314，12： | 2 |
| 6 | Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods显示文摘 | Zhou Q Li L Xiang J | 2009 | Biochimie2009，91，2： | 1 |
| 7 | Comparison of the survival of human biopsied embryos after eryopreservation with four different methods using non - transferable embryos 显示文摘 | ZHENG W T ZHUANG G L ZHOU C Q | 2005 | Hum Reprod2005，20，6： | 1 |
| 8 | NUMBL interacts with TRAF6 and pro- motes the degradation of TRAF6 显示文摘 | Zhou L Ma Q Shi H | 2010 | Biochem Biophys Res Commun2010，3，： | 1 |
| 9 | Inflammatory Mediators in Chinese Patients With Congestive Heart Failure显示文摘 | WANG Y Q ZHOU Y L MENG L | 2009 | J Clin Pharmacol2009，49，： | 1 |
| 10 | Study on properties of CaO-SiO2-B2O3 system glass-ceramic显示文摘 | Zhu H K Min L Zhou H Q | 2007 | Materials Research Bulletin2007，42，： | 1 |
| 11 | Comprehensive understanding on the formation of highly ordered mesoporous tungsten oxides by X-ray diffraction and Raman spectroscopy显示文摘 | Zhou L Ren Q J Zhou X F | 2008 | Microporous and MesoporousMaterials2008，109，13： | 1 |
| 12 | Effect of temperature and strain rate on mechanical properties of 63Sn/37Pb solder alloy显示文摘 | Shi X Q Zhou W Pang H L J | 1999 | ASME:Journal of Electronic Packaging1999，121，： | 1 |
| 13 | Dendritic cells loaded with XAGE-1b protein induce specific antitumor response against lung cancer显示文摘 | Zhou Q Wu Y L Guo A L | 2007 | ASCO Meeting Abstracts2007，25，18： | 1 |
| 14 | Intestinal absorption of forsythoside A in different compositions of Shuang- Huang-Lian 显示文摘 | ZHOU W DI L Q SHAN J J | 2011 | Fitoterapia2011，82，3： | 1 |
| 15 | Effect of high magnetic field on intermetallic phase growth in Ni-AI diffusion couples 显示文摘 | REN X CHEN G Q ZHOU W L WU C W ZHANG J S | 2009 | Journal of Alloys and Compounds2009，472，12： | 1 |
| 16 | Quantitative evaluation of precipitates in an A1-Zn-Mg-Cu alloy after isothermal aging 显示文摘 | DU Z W SUN Z M SHAO B L ZHOU T T CHEN C Q | 2006 | Materials Characterization2006，56，： | 1 |
| 17 | Inhibition of browning onthe surface of peach slices by short-term exposure to nitric oxide andascorbic acid显示文摘 | ZHU L Q ZHOU J ZHU S H GUO L H | 2009 | Food Chemistry2009，114，1： | 1 |
| 18 | Preparation and properties of high purity Mg-Y biomaterials显示文摘 | Peng Q M Huang Y D Zhou L Hort N Kainer K U | | 0，，： | 1 |
| 19 | IrrE, a global regulator of extreme radiation resistance inDeinococcus radiodurans, enhances salt tolerance in Escherichia coli and Brassica napus显示文摘 | Pan J Wang J Zhou Z Yan Y Zhang W Lu W Ping S Dai Q Yuan M Feng B Hou X Zhang Y Ma R Liu T Feng L Wang L Chen M Lin M | 2009 | PloS One2009，4，2： | 1 |
| 20 | Microstructure difference between core and skin of T700 carbon fibers in heat-treated carbon/carbon composites显示文摘 | Zhou G S Liu Y Q He L L | 2011 | Carbon2011，49，9： | 1 |
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