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| 1 | Optimizing aerobic biodegradation of dichloromethane using response surface methodology显示文摘Response surface methodology(RSM) was employed to evaluate the optimum aerobic biodegradation of dichloromethane(DCM) in pure culture.The parameters investigated include the initial DCM concentration,glucose as an inducer and hydrogen peroxide as terminal electron acceptor(TEA) .Maximum aerobic biodegradation effciency was predicted to occur when the initial DCM concentration was 380 mg/L,glucose 13.72 mg/L,and H2O2 115 mg/L.Under these conditions the aerobic biodegradation rate reached up to 93.18%,which was significantly higher than that obtained under original conditions.Without addition of glucose,degradation effciencies were 80%at DCM concentrations<326 mg/L.When concentrations of DCM were more than 480 mg/L,the addition of hydrogen peroxide did not help to significantly increase DCM degradation effciency.When DCM concentrations increased from 240 to 480 mg/L,the overall DCM degradation effciency decreased from 91%to 60%in the presence of H2O2 for 120 mg/L. | WU Shijin,YU Xiang,HU Zhihang,ZHANG Lili,CHEN Jianmeng College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou 310032,China | 2009 | Journal of Environmental Sciences2009，21，9： | 13 |
| 2 | Weighted Markov chains for forecasting and analysis in Incidence of infectious diseases in jiangsu Province,China显示文摘This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence course.Then the paper presents a weighted Markov chain,a method which is used to predict the future incidence state.This method assumes the standardized self-coefficients as weights based on the special characteristics of infectious disease incidence being a dependent stochastic variable.It also analyzes the characteristics of infectious diseases incidence via the Markov chain Monte Carlo method to make the long-term benefit of decision optimal.Our method is successfully validated using existing incidents data of infectious diseases in Jiangsu Province.In summation,this paper proposes ways to improve the accuracy of the weighted Markov chain,specifically in the field of infection epidemiology. | Zhihang Peng Changjun Bao Yang Zhao Honggang Yi Letian Xia Hao Yu Hongbing Shen Feng Chen | 2010 | The Journal of Biomedical Research2010，24，3： | 10 |
| 3 | Prevalence and risk factors of HIV and syphilis,and knowledge and risk behaviors related to HIV/AIDS among men who have sex with men in Chongqing,China显示文摘High HIV prevalence and incidence burdens have been reported in men who have sex with men(MSM)in Chongqing,China.We aimed to estimate the prevalence of HIV and other sexually transmitted infections(STIs),to appraise the knowledge and risk behaviors related to HIV/AIDS among MSM,and to analyze the possible causes of deviation between behavior and knowledge to make better strategies.We recruited 617 MSM from February to July in 2008 by using a respondent-driven sampling(RDS) method in Chongqing,China.Through the collection of questionnaire-based data and biological testing results from all objects,we launched a crosssectional survey.STATA/SE was used for data analysis by frequency,ANOVA,rank sum test and logistic regression models.MSM with syphilis(OR=4.16,95%CI:2.35-7.33,P<0.0001) were more likely to be HIV infected.Being a company employee(OR=3.64,95%CI:1.22-10.08,P<0.0001) and having bought male for sex(OR=3.52,95%CI:1.10-11.32,P<0.034) were associated with a higher probability of syphilis.MSM with younger age,higher education and greater monthly income had a higher mean knowledge score.MSM who had HIV testing had a higher mean knowledge score than those who never had.Students,venues for finding sex partners by Internet and homosexuals in MSM had a higher mean knowledge score compared to other occupations,venues for finding sex partners and sexual orientation.There is an urgent need for delivery of barrier and biomedical interventions with coordinated behavioral and structural strategies to improve the effect of HIV interventions among MSM. | Wenzhe Ma Guohui Wu Hui Zheng Wenjuan Zhang Zhihang Peng Rongbin Yu NingWang | 2016 | The Journal of Biomedical Research2016，30，2： | 9 |
| 4 | Estimation and Projection of the HIV Epidemic Trend among the Migrant Population in China显示文摘Objective The migrant population is a vulnerable group for HIV infection in China.Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.Methods The Estimation and Projection Package (EPP) model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in China.Results The prevalence of HIV among migrants in 2009 was estimated at 0.075% (95% CI:0.042%,0.108%) in China.The HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% (95% CI:0.070%,0.150%) by 2015.Conclusion Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 years.Migrants will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population. | MENGXiaoJun WANG Lu Susan CHAN Kathleen Heather REILLY PENG ZhiHang GUO Wei DING GuoWei DING ZhengWei QIN QianQian | 2011 | Biomedical and Environmental Sciences2011，24，4： | 8 |
| 5 | A unified algorithm for mobility load balancing in 3GPP LTE multi-cell networks显示文摘3GPP long term evolution (LTE) is a promising candidate for the next-generation wireless network, which is expected to achieve high spectrum efficiency by using advanced physical layer techniques and flat network structures. However, the LTE network still faces the problem of load imbalance as in GSM/WCDMA networks, and this may cause significant deterioration of system performance. To deal with this problem, mobility load balancing (MLB) has been proposed as an important use case in 3GPP self-organizing network (SON), in which the serving cell of a user can be selected to achieve load balancing rather than act as the cell with the maximum received power. Furthermore, the LTE network aims to serve users with different quality-of-service (QoS) requirements, and the network-wide objective function for load balancing is distinct for different kinds of users. Thus, in this paper, a unified algorithm is proposed for MLB in the LTE network. The load balancing problem is first formulated as an optimization problem with the optimizing variables being cell-user connections. Then the complexity and overhead of the optimal solution is analyzed and a practical and distributed algorithm is given. After that, the proposed algorithm is evaluated for users with different kinds of QoS requirements, i.e., guaranteed bit rate (GBR) users with the objective function of load balance index and non-GBR (nGBR) users with the objective function of total utility, respectively. Simulation results show that the proposed algorithm leads to significantly balanced load distribution for GBR users to decrease the new call blocking rate, and for nGBR users to improve the cell-edge throughput at the cost of only slight deterioration of total throughput. | WANG Hao LIU Nan LI ZhiHang WU Ping PAN ZhiWen YOU XiaoHu | 2013 | Science China(Information Sciences)2013，56，2： | 7 |
| 6 | Assembling of a novel 3D Ag(Ⅰ)-MOFs with mixed ligands tactics:Syntheses, crystal structure and catalytic degradation of nitrophenol显示文摘A silver-based metal-organic framework(Ag-MOFs), [Ag2(H3 ddcba)(dpp)2](1)(H5 ddcba = 3,5-(di(2',5'-dicarboxylphenyl)benozoic acid, dpp = 1,3-di(4-pyridyl)propane), was successfully constructed via hydrothermal assembly of a pentacaboxylate ligand, a N-donor ligand and Ag(I) ions, which possesses a pcu topology and exhibits excellent catalytic properties in aqueous solution for the degradation of onitrophenol(2-NP), m-nitrophenol(3-NP) and p-nitrophenol(4-NP). Related kinetics of such catalytic reactions, photoluminescent and thermal stability of compound 1 were also investigated. | Dandan Huang Xueqian Wua Junwu Tian Xiaokun Wang Zhihang Zhou Dongsheng Li | 2018 | Chinese Chemical Letters2018，29，6： | 7 |
| 7 | QoS and channel state aware load balancing in 3GPP LTE multi-cell networks显示文摘In this paper,we investigate the load balancing problem with the consideration of different qualityof-service(QoS) and channel state in 3GPP long term evolution(LTE) multi-cell networks.Load imbalance among nearby cells often causes inefficient utilization of the system resources.Then in overloaded cells,users cannot get satisfied services for short resources,while in idle cells,there is plenty of unoccupied resources.However,switching users only for load balancing with no consideration of channel state often results in aggressive handover of users,which may occupy too many resources in their target cells and deteriorate the network efficiency.Thus,how to efficiently perform load balancing with the consideration of channel state becomes an important issue.Meanwhile,LTE network aims to serve users with different QoS requirements,which should be taken into account when performing load balancing.Thus we propose a multi-objective optimization problem,whose objectives are load balancing index and network average load for users with QoS requirements and a unified utility function for users without QoS requirements.The constraints are physical resource limits and users' QoS demands.Then we analyze its complexity and propose a practical algorithm,load balancing,with the consideration of different QoS requirements and channel state services(LBQC).Extensive simulations are conducted.The results show that the proposed algorithm can approximate the optimal algorithm efficiently,and leads to significantly better performances than load balancing with no consideration of channel state,e.g.a lower new call blocking rate with a fewer system resources occupation for users with QoS requirements,a higher cell edge throughput and total throughput for users without QoS requirements. | LI ZhiHang WANG Hao PAN ZhiWen LIU Nan YOU XiaoHu | 2013 | Science China(Information Sciences)2013，56，4： | 6 |
| 8 | Parameter Optimization of Nose Landing Gear Considering Both Take-off and Landing Performance of Catapult Take-off Carrier-Based Aircraft显示文摘Optimization of the parameters of landing gear systems with double-stage air springs of catapult take-off carrier-based aircraft is here studied based on the mathematical equations of the classic dual mass spring-damper dynamic model.Certain standards for both take-off and landing performance are put forward.The contradictory factors between take-off and landing processes are analyzed.The optimization of oil in the pin area and the area near the rear oil hole is performed.Then these optimized parameters are used to assess the influence of the initial pressure of the low chamber,the ratio of the high chamber to the low chamber,and the tire inflation pressure on the performance of arresting landing and catapult take-off.The influences of these parameters on carrier-based aircraft and the aircraft-carrier on aircraft catapult take-off is also assessed.Based on the results of the simulation,respective take-off criteria must be drafted considering different types of aircraft and different take-off load cases,all of which must be matched to parameters relevant to catapult take-off. | Zhang Ming Nie Hong He Zhihang | 2016 | Transactions of Nanjing University of Aeronautics and Astronautics2016，33，2： | 5 |
| 9 | Radiofrequency ablation versus partial nephrectomy for the treatment of clinical stage 1 renal masses: a systematic review and meta-analysis显示文摘 | Wang Shangqian Qin Chao Peng Zhihang Cao Qiang Li Pu Shao Pengfei Ju Xiaobing Meng Xiaoxin Lu Qiang Li Jie Wang Meilin Zhang Zhengdong Gu Min Zhang Wei Yin Changjun | 2014 | Chinese Medical Journal2014，，13： | 5 |
| 10 | Effect of Ultraviolet Aging on the Bonding and Tensile Properties of Polymer-Cement Composite显示文摘In this paper,the specimens of polymer-cement composites after 1 d,7 d,15 d,and 30 d aging without aging and UV aging are subjected to fixed extension test and tensile test.By observing the mode of the composite in the fixed-elongation test,and measuring the elastic recovery rate,tensile strength,elongation at break,peak tensile strain,tensile toughness and pre-peak tensile toughness of the composite,the effects of UV aging on the bonding and the tensile properties of the composite were studied.And combining with scanning electron microscopy experiments,the micro-mechanism of the effect of ultraviolet aging on the properties of composite was analyzed.The results showed that the composite had a good bonding property,and no damage was observed after UV aging for 30 days.The UV aging increased the elastic recovery rate and peak tensile within a certain range.The elastic recovery rate and peak tensile strain of the composite increased by 6.60%and 23.55%respectively after UV aging for 15 days.Therefore,the UV aging could enhance the tensile property and the tensile energy consumption performance of the composite.The tensile strength of the composite increased by 65.36%after UV aging for 30 days.The tensile toughness and pre-peak tensile toughness of the composite were increased by 43.29%and 101.83%respectively after UV aging for 15 days.The elongation at break of composite decreased continuously after UV aging due to the photo-oxygen reaction,as well as secondary hydration reaction and cross-linking curing reaction of cement. | Zhihang Wang Jinyu Xu Xin Meng Congjin Zhu | 2021 | Journal of Renewable Materials2021，9，6： | 5 |
| 11 | A nanocleaner specifically penetrates the blood-brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease显示文摘Insurmountable blood-brain barrier(BBB) and complex pathological features are the key factors affecting the treatment of Alzheimer's disease(AD).Poor accumulation of drugs in lesion sites and undesired effectiveness of simply reducing Aβ deposition or TAU protein need to be resolved urgently.Herein,a nanocleaner is designed with a rapamycin-loaded ROS-responsive PLGA core and surface modification with KLVFF peptide and acid-cleavable DAG peptide [R@(ox-PLGA)-KcD].DAG can enhance the targeting and internalization effect of nanocleaner towards neurovascular unit endothelial cells in AD lesions,and subsequently detach from nanocleaner in response to acidic microenvironment of endosomes to promote the transcytosis of nanocleaner from endothelial cells into brain parenchyma.Then exposed KLVFF can capture and carry Aβ to microglia,attenuating Aβ-induced neurotoxicity.Strikingly,rapamycin,an autophagy promoter,is rapidly liberated from nanocleaner in the high ROS level of lesions to improve Aβ degradation and normalize inflammatory condition.This design altogether accelerates Aβ degradation and alleviates oxidative stress and excessive inflammatory response.Collectively,our finding offers a strategy to target the AD lesions precisely and multi-pronged therapies for clearing the toxic proteins and modulating lesion microenvironment,to achieve efficient AD therapy. | Ting Lei Zhihang Yang Xue Xia Yuxiu Chen Xiaotong Yang Rou Xie Fan Tong Xiaolin Wang Huile Gao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 4 |
| 12 | Effects of CO_(2)atmosphere on slow pyrolysis of high-ash lignite显示文摘Slow pyrolysis of a typical high-ash lignite in China was carried out in atmospheres of N_(2),20%CO_(2)/N_(2),40%CO_(2)/N_(2),and 60%CO_(2)/N_(2)in a fixed bed reactor.The evolution of char,tar,and gases in yield and characteristics,and the physico-chemical characteristics of chars in different atmospheres were compared.Results revealed that CO_(2)almost behaves as an inert gas in the evolution of char and CO before 600℃.The decrease in char and CO_(2)yields and the increase in CO yield at temperatures higher than 600℃are ascribed to the occurrence of char-CO_(2)gasification.The higher the CO_(2)level present in the atmosphere,the higher the severity of the gasification becomes.Introducing CO_(2)into the atmosphere raises tar and water yields but cuts down H_(2),CH_(4),and C_(2)H_(6)yields.The promotion of tar yield results from the higher phenols and aliphatics yields in the presence of CO_(2).The reduction of H_(2)yield is associated with the increase in water yield,while the decline of light hydrocarbon gases is connected with the suppression effects of CO_(2)on methyl decomposition.The role of inherent minerals was also investigated by comparing product yields from raw coal and demineralized coal.The comparison indicated that the char-CO_(2)gasification rate is sharply reduced to nearly zero without the catalytic effects of calcium,iron,and magnesium minerals.The evolution of tar and light hydrocarbon gases in the CO_(2)-containing atmosphere greatly depends on inherent minerals.Without minerals,tar yield is inhibited in the presence of CO_(2).In the absence of minerals,CO_(2)hardly has influences on CH_(4)and C_(2)H_(6)yields. | Qinhui Wang Kaikun Li Zhihang Guo Mengxiang Fang Zhongyang Luo Kefa Cen | 2018 | Carbon Resources Conversion2018，1，1： | 4 |
| 13 | Gecko-inspired composite micro-pillars with both robust adhesion and enhanced dry self-cleaning property显示文摘Self-cleaning surfaces are desirable in many engineering applications where low energy consumption,reusability and sustainability are of the biggest concerns.Inspired by the gecko’s unique ’dry selfcleaning’ hierarchical structures.Here we fabricated artificial Fe304/PDMS composites that show robust self-cleaning capabilities.The enhanced adhesion performance is attributable to the decrease of PDMS polymerization degree and the load transfer between PDMS matrix and Fe304 magnetic particles.The self-cleaning surfaces showed up to 24.3% self-cleaning rate with as few as 4 steps.Simulation result indicated that the changing of cross linking between Fe304 and PDMS is the main reason for the enhanced self-cleaning surfaces.This work reveals an alternative route of making high-performance self-cleaning smart surfaces that are applicable in the textile industry,robotic locomotion/gripping technology,outerspace explorations and tissue engineering. | Xiaoxiao Dong Hong Zhao Zhihang Wang Miray Ouzounian Travis Shihao Hu Yongjian Guo Lipeng Zhang Quan Xu | 2019 | Chinese Chemical Letters2019，30，12： | 3 |
| 14 | Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection显示文摘The treatment of Alzheimer's disease(AD)is one of the most difficult challenges in neurodegenerative diseases due to the insufficient blood‒brain barrier(BBB)permeability and unsatisfactory intra-brain distribution of drugs.Therefore,we established an ibuprofen and FK506 encapsulated drug co-delivery system(Ibu&FK@RNPs),which can target the receptor of advanced glycation endproducts(RAGE)and response to the high level of reactive oxygen species(ROS)in AD.RAGE is highly and specifically expressed on the lesion neurovascular unit of AD,this property helps to improve targeting specificity of the system and reduce unselective distribution in normal brain.Meanwhile,these two drugs can be specifically released in astrocytes of AD lesion in response to high levels of ROS.As a result,the cognition of AD mice was significantly improved and the quantity of Aβplaques was decreased.Neurotoxicity was also alleviated with structural regeneration and functional recovery of neurons.Besides,the neuroinflammation dominated by NF-κB pathway was significantly inhibited with decreased NF-κB and IL-1βin the brain.Overall,Ibu&FK@RNPs can efficiently and successively target diseased BBB and astrocytes in AD lesion.Thus it significantly enhances intracephalic accumulation of drugs and efficiently treats AD by anti-neuroinflammation and neuroprotection. | Xueqin He Xiaorong Wang Lianyi Yang Zhihang Yang Wenqi Yu Yazhen Wang Rui Liu Meiwan Chen Huile Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 15 | A power adjustment based e ICIC algorithm for hyper-dense Het Nets considering the alteration of user association显示文摘This paper evaluates power adjustment based enhanced inter-cell interference coordination(e ICIC)problem in the hyper-dense Het Net under the practical serving cell selection rule where each user selects the base station with the strongest received signal power as its serving cell while the alteration of the serving cell happens during the power adjusting process. In this paper, the e ICIC problem is solved by cooperatively adjusting the transmission power of all small cells. A power adjustment method based on modified particle swarm optimization(MPSO) is proposed to tackle the NP-hard e ICIC problem caused by the alteration of the serving cell, and considering the drawbacks of MPSO, an improved MPSO is proposed for effective algorithm.Local search and multi-restart process are introduced in the improved MPSO based e ICIC algorithm to guarantee the local and then global optimality, and the convergence conditions and the global optimality are proved by mathematical deduction to guide the selection of the parameters. Simulations show that, while considering the fifty-picocell case as an example, the proposed improved MPSO based e ICIC algorithm can increase the system throughput by 66.0% compared with the full power transmission, and compared with the existing schemes which do not alter the serving cells, the proposed algorithm can improve the system throughput by 32.2%. By improving MPSO, the consequent algorithm costs less iteration time to achieve higher system throughput, and it is effective and feasible to solve the e ICIC problem in the hyper-dense Het Net. | JIANG HuiLin TONG En LI ZhiHang PHAN NhuQuan PAN ZhiWen LIU Nan | 2015 | Science China(Information Sciences)2015，58，8： | 3 |
| 16 | Modeling the Epidemic Trend of the 2019 Novel Coronavirus Outbreak in China显示文摘A new coronavirus disease(COVID-19)with infection by a novel coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread globally since December 2019.By 22th September 2020,more than 200 countries worldwide have reported about 30 million confirmed cases and more than 950,000 deaths.1 China has reported a total of 85,307(including 2,758 imported)cases and 4,634 deaths. | Mingwang Shen Zhihang Peng Yanni Xiao Lei Zhang | 2020 | The Innovation2020，1，3： | 3 |
| 17 | An Optimal Over-frequency Generator Tripping Strategy for Regional Power Grid with High Penetration Level of Renewable Energy显示文摘This paper proposes an optimal over-frequency generator tripping strategy aiming at implementing the least amount of generator tripping for the regional power grid with high penetration level of wind/photovoltaic(PV),to handle the over-frequency problem in the sending-end power grid under large disturbances.A steady-state frequency abnormal index is defined to measure the degrees of generator over-tripping and under-tripping,and a transient frequency abnormal index is presented to assess the system abnormal frequency effect during the transient process,which reflects the frequency security margin during the generator tripping process.The scenariobased analysis method combined with the non-parametric kernel density estimation method is applied to model the uncertainty of the outgoing power caused by the stochastic fluctuations of wind/PV power and loads.Furthermore,an improved fireworks algorithm is utilized for the solution of the proposed optimization model.Finally,the simulations are performed on a real-sized regional power grid in Southern China to verify the effectiveness and adaptability of the proposed model and method. | Zhihang Zhou Libao Shi Yixuan Chen | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，5： | 2 |
| 18 | A survey of HIV infection and related high-risk factors among men who have sex with men in Suzhou,Jiangsu,China显示文摘A cross-sectional study using the snowball sampling method was conducted in May 2008 to investigate human immunodeficiency virus (HIV) infection status and related high risk factors among men who have sex with men (MSM) in Suzhou city of Jiangsu province. The researchers carried out a face-to-face questionnaire interview among MSM, and collected their blood samples to test for HIV and other sexually transmitted diseases (STDs). Among the 280 respondents, 91.1% had homosexual acts in the past 6 months and 87.5% had multiple homosexual partners; 46.4% had heterosexual sex in the past 6 months and 33.1% had multiple heterosexual partners. The rate of continued condom use was 44.3% in homosexual sex in the past 6 months, while the rate in heterosexual sex was 33.9%. Laboratory test results showed that the prevalences of HIV and syphilis were 7.1% (20/280) and 15.0% (42/280), respectively, but no HCV-positive person was found. In the multivariate logistic regression model, subjects with a monthly income of more than RMB $ 1,000 (OR=4.83,95% CI=1.44-16.22), subjects who often went to bars for sexual partners (OR=2.25, 95%CI=1.21-4.20), and subjects who had more than one sexual partner in the past 6 months (OR=0.49, 95%CI=0.25-0.97) and had sex with fixed sexual partners in the past 6 months (OR=0.42, 95%CI=0.25-0.75) were significantly associated with the rate of continued condom use in homosexual sex in the past 6 months. Unprotected sex and multiple sexual partners were more common among MSM in Suzhou city; furthermore, the prevalences of HIV infection and syphilis were relatively high. HIV preventive measures should be designed to address these risk factors and control the spread of HIV among MSM. | Hongling Bai Xiping Huan Weiming Tang Xin Chen Hongjing Yan Xiaoyan Liu Haitao Yang Zhihang Peng Xiuping Zhao Rongbin Yu Hao Yu Feng Chen | 2011 | The Journal of Biomedical Research2011，25，1： | 2 |
| 19 | Linking key intervention timings to rapid declining effective reproduction number to quantify lessons against COVID-19显示文摘Coronavirus disease 2019(COVID-19)is currently under a global pandemic trend.The efficiency of containment measures and epidemic tendency of typical countries should be assessed.In this study,the efficiency of prevention and control measures in China,Italy,Iran,South Korea,and Japan was assessed,and the COVID-19 epidemic tendency among these countries was compared.Results showed that the effective reproduction number(Re)in Wuhan,China increased almost exponentially,reaching a maximum of 3.98 before a lockdown and rapidly decreased to below 1 due to containment and mitigation strategies of the Chinese government.The Re in Italy declined at a slower pace than that in China after the implementation of prevention and control measures.The Re in Iran showed a certain decline after the establishment of a national epidemic control command,and an evident stationary phase occurred because the best window period for the prevention and control of the epidemic was missed.The epidemic in Japan and South Korea reoccurred several times with the Re fluctuating greatly.The epidemic has hardly rebounded in China due to the implementation of prevention and control strategies and the effective enforcement of policies.Other countries suffering from the epidemic could learn from the Chinese experience in containing COVID-19. | Zhihang Peng Wenyu Song Zhongxing Ding Quanquan Guan Xu Yang Qiaoqiao Xu Xu Wang Yankai Xia | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 20 | Associations of IFN-γ rs2430561 T/A,IL28B rs12979860 C/T and ERα rs2077647 T/C polymorphisms with outcomes of hepatitis B virus infection:a meta-analysis显示文摘Several studies investigated associations of IFN-γ rs2430561 T/A,IL28 B rs12979860 C/T and ERα rs2077647 T/C gene polymorphisms with outcomes of hepatitis B virus(HBV) infection,but the results were controversial.Therefore,we performed a meta-analysis of all published observational studies to address this inconsistency.Literature was searched in online database and a systematic review was conducted based on the search results.A total of 24 studies were included and dichotomous data were presented as odds ratio(OR) with a 95%confidence interval(CI).The rs2430561 T allele was associated with reduced persistent HBV infection risk(T vs.A:OR,0.690;95%CI,[0.490,0.971]),while the rs2077647 T allele significantly increased the risk of persistent HBV infection(T vs.C:OR.1.678;95%CI,[1.212,2.3231).Rs 2077647 CC might play a role in protecting individuals against HBV persistence(TT vs.CC:OR,4.109;95%CI,[2.609,6.473]).Furthermore,carriers of the rs2430561 TT genotype were more likely to clear HBV spontaneously compared with those of the AA genotype(TT vs.AA:OR,0.555;95%CI,[0.359,0.856]).For rs12979860 C/T polymorphism,no significant correlation with HBV infection outcomes was found.In subgroup analyses,the results were similar to those of overall analysis.However,for rs2077647 TT vs.TC+CC,significantly increased risks were observed in the Asian and hospital-based population,but not in the overall analysis.IFN-γrs2430561 T/A and ERα rs2077647 T/C genetic polymorphisms were associated with outcomes of HBV infection,but no association was found between IL28 B rs12979860 C/T and HBV infection. | Shaidi Tang Ming Yue Jiajia Wang Yun Zhang Rongbin Yu Jing Su Zhihang Peng Jie Wang | 2014 | The Journal of Biomedical Research2014，28，6： | 2 |
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