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| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | Micronuclei in Nasal Mucosa, Oral Mucosa and Lymphocytes in Students Exposed to Formaldehyde Vapor in Anatomy Class显示文摘The frequency of micronuclei (MN) in cells of the nasal mucosa, oral mucosa and in lym-phocytes was evaluated for 25 students in anatomy classes exposed to formaldehyde (FA) overan 8-week period. Each student served as his or her own control. The time-weighted averageconcentration (TWA) of fOrmaldehyde in anatomical laboratories and in students’ dormitorieswas 0. 508 ± 0. 299 mg/m3 and 0. 012 ± 0. 0025mg/m3, respectively. A higher frequency ofmicronuclei was observed in nasal and oral exfoliative cells after formaldehyde exposure (3. 85± 1. 48 vs 1 .20± 0. 676 and 0. 857 ± 0. 558 vs 0. 568 ± 0. 317, paired-t test: P< 0. 001and P < 0. 01, respectively). No significant increase in the frequency of lymphocyte micronu-clei was found after formaldehyde exposure (P >0. 05 ). The present study shows that nasalmucosa cel1s exposed through respiration are the chief target of FA-induced genotoxic | YING CHEN -JlANG YAN WEN-SHENG ZHAO MEI-YING YE XIAO-LEI XIE HONG YIN SHU-YI ZHU XIAN-SHU(Department of Environmental Health, n Dgurtment of Anatomy,Tongji the ical University, Wuhan, China)(Department of Public Health, Wengzhou theical Chllege, Ch | 1997 | Biomedical and Environmental Sciences1997，10，4： | 7 |
| 3 | Sonochemical effect of a bifrequency irradiation显示文摘The sonochemical effect of a bifrequency orthogonal ultrasonic irradiation has been studied by using two different detecting methods. It has been shown that the sonochemical yield produced by the bifrequency irradiation appears to be much more than the sum of the yields produced separately by the two irradiations. The bifrequency irradiation, therefore, can be expected to exert a great influence on the development of sonohemical | ZHU Changping, FENG Ruo & ZHAO Yiyun Department of Physics. Jingzhou Normal College, Jingzhou 434100, China State Key Laboratory of Modern Acoustics, Nanjing University, Nanjing 210093, China Chemistry Department of Yunnan University, Kunming 650091, Ch | 2000 | Chinese Science Bulletin2000，45，2： | 7 |
| 4 | Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells显示文摘 | Zhang,W Ge,W Li,CH You,SG Liao,LM Han,Q Deng,WM Zhao,RCH | 2005 | 中国生物学文摘2005，19，3： | 3 |
| 5 | 非洲血统男性的肌肉衰减与新发高血压的关系显示文摘骨骼肌中异位脂肪组织浸润增加与胰岛素抵抗和糖尿病相关。该研究评估骨骼肌脂肪组织的变化能否预测非洲血统男性随后的高血压发展。在Tobago健康研究中,使用计算机断层扫描测定非洲血统男性(年龄40-91岁)的小腿肌肉间脂肪组织和骨骼肌衰减情况,进行前瞻性纵向研究。高血压定义为收缩压≥140和(或)舒张压≥90mmHg(1mmHg=0.133kPa),或接受降压药物治疗。 | 刘莉 叶鹏 Zhao Q Zmuda JM Kuipers AL Bunker CH Patrick AL Youk AO Miljkovic I | 2017 | 中华高血压杂志2017，25，3： | 2 |
| 6 | A CONVENIENT AND EFFICIENT SYNTHESIS OF BIS-IMIDAZOLES显示文摘ACONVENIENTANDEFFICIENTSYNTHESISOFBIS-IMIDAZOLES￥ChengHeZHOU;ShengJinGUO;RuGangXIE,HuaMingZHAO(DepartmentofChemistry.Facultyo... | Zhou, CH Guo, SJ Xie, RG Zhao, HM | 1996 | Chinese Chemical Letters1996，7，4： | 2 |
| 7 | Hedgehog signaling is essential for maintenance of cancer stem cells in myeloid leukaemia显示文摘 | ZHAO C CHEN A JAMIESON CH | 2009 | Nature2009，458，7239： | 1 |
| 8 | Carveya Minocycline and TNF-alpha knockout attenuates neuroinflammation and prevents blood-brain barrier( BBB ) leakage following MPTP treatment 显示文摘 | Zhao CH Ling ZD Desai BS | 2006 | Experimental Neurology2006，198，2： | 1 |
| 9 | Research on improving the measuring accuracy of laser autocollimator used over long distance显示文摘 | ZHAO M R LIN Y CH ZHANG P | 2002 | SPIE2002，4927，： | 1 |
| 10 | Superparamagnetic highmagnetization microspheres with an Fe3O4@SiO2 core and perpendicularly aligned mesoporous SiO2 shell for removal of microcystins显示文摘 | Deng YH Qi DW Deng CH Zhang XM Zhao DY | 2008 | J Am Chem Soc2008，130，： | 1 |
| 11 | Molecular modeling, design, synthesis, and biological evaluation of novel 3', 4'-dicamphanoyl-( + ) -cis-khellactone (DCK) analogs as potent anti-HIV agents 显示文摘 | Xie L Zhao CH Zhou T | 2005 | Bioorg Med Chem2005，13，： | 1 |
| 12 | The role of brain natriuretic peptide and serum triiodothyronine in the diagnosis and prognosis of chronic heart failure 显示文摘 | Du JB Da CH Zhao Y ct al | 2012 | Acta Cardiol2012，67，3： | 1 |
| 13 | Analysis for load limitation of square-shaped silicon diaphragms显示文摘 | ZHAO LL XU CH SHEN G G | | 0，，50： | 1 |
| 14 | Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chroni cally-infected HBeAg positive chinese patients显示文摘 | Yan CH Zhao CY Ding H | 2012 | Antivi ral Res2012，96，2： | 1 |
| 15 | Artificial Spinning and Characterization of Silk Fiber from Bombyx mori Silk Fibroin HexafluoroacetoneHydrate显示文摘 | Masuda H Zhao CH | 2002 | Macromolecules2002，35，： | 1 |
| 16 | A novel sol-gel material prepared by a surface imprinting technique for the selective solid-phase extraction of bisphenol A 显示文摘 | JIANG X M TIAN W Zhao CH | 2007 | Talanta2007，72，1： | 1 |
| 17 | Vitamin D analog EB1089induces apoptosis in a subpopulation of SGC-7901 gastric cancer cells through a mitochondrial-dependent apoptotic pathway显示文摘 | Wang W Zhao CH Zhang N | 2013 | Nutr Cancer2013，65，7： | 1 |
| 18 | , Assessment of Radionuclide Level in Topsoil Samples for Partial Areas of Tibet显示文摘 | L Zhao Xu CH Tuo F | 2012 | Radiation Protec- tion Dosimetry2012，148，3： | 1 |
| 19 | Effectofsynthesized GYY4137,aslowlyreleasinghydrogensulfidedonor,oncellviabilityanddistributionofhydrogensulfideinmice显示文摘 | Yu F Zhao J Tang CH | 2010 | J Peking Uni(Heal Sci)2010，42，5： | 1 |
| 20 | Self - pinning : Dominant coercivity mechanism in exchange - coupled permanent/com- posite magnets 显示文摘 | Zhao G P Wang X L Yang Ch | 2007 | J Appl Phvs2007，101，09： | 1 |
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