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| 1 | Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi显示文摘BACKGROUND:Many Chinese herbs,especially herbal injections,have been shown to have anti-tumor effects in recent years.However,since most reports focus on the clinical effectiveness of these herbs,their mechanisms of action are not well understood.In this study,we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis,SC),and monitored the expression of Bcl-2 and caspase-8.METHODS:Injectable SC was applied to HepG2 cells at different concentrations and the cells were collected 12,24 and 48 hours later.5-fluorouracil was used as a positive control group,and fluorescence-activated cell-sorting cytometry was used to measure the apoptosis rate of HepG2 cells and the expression of Bcl-2 and caspase-8 proteins.RESULTS:SC induced apoptosis in HepG2 cells in a concentration and time-dependent manner,and the expression of caspase-8 was elevated and prolonged.However,it did not significantly influence the expression of Bcl-2.CONCLUSION:Injectable SC may induce apoptosis in HCC cells by regulating the expression of caspase-8. | Department of General Surgery (Lu Y and Zhang BY),Department of Bio-Information (Jia ZX),Affiliated Medical College Hospital,Qingdao University,Qingdao 266003,China Shanghai Jiaotong University School of Medicine,Shanghai 200025,China (Wu WJ) Department of Medicine,Heze Medical College,Heze 274000,China (Lu ZQ) | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 17 |
| 2 | Age of the Shahewan rapakivi granite in the Qinling Orogen, China, and its constraints on the end time of the main erogenic stage of this orogen显示文摘the Qinling Mountains in central China are a joint orogenic zone between the Sino-Korean (or North China) and the Yangtze (or South China) craton blocks, the two major tectonic units of eastern Asia. On the end time of the main orogenic stage in this orogenic | Zhang, ZQ Zhang, GW Tang, SH Lu, XX | 1999 | Chinese Science Bulletin1999，44，21： | 15 |
| 3 | Anachronistic facies in the Lower Triassic of South China and their implications to the ecosystems during the recovery time显示文摘The end-Permian mass extinction not only severely distressed the Paleozoic ecosystems but also dramatically changed the sedimentary systems, resulting in a peculiar Early Triassic ecosystem and submarine environment during the recovery time following the mass extinction. The Lower Triassic is characteristic of the wide occurrence of various distinctive sediments and related sedimentary structures, such as flatpebble conglomerates, vermicular limestone, subtidal wrinkle structures, microbialite, carbonate seafloor fans, thin-bedded limestone and zebra limestone-mudstone. These sediments were common in the Precambrian to Early Ordovician marine settings, and then they occurred only in some extreme and unusual environments with the expansion of metazoan faunas. However, the Early Triassic witnessed an 'anachronistic' reappearance of some distinctive sedimentary records in normal shallow marine settings. The study of these anachronistic facies should be of great importance for the understanding of the unique ecosystem and marine environment through the great Paleozoic-Mesozoic transition. The anachronistic facies characterized by vermicular limestone have been documented in many localities in South China and occur at various horizons of the Lower Triassic. Most types of re- ported distinctive sediments over the world have been observed in the Lower Triassic of South China. This provides an excellent opportunity for understanding the Early Triassic environment and its co- evolution with the biotic recovery. Among the anachronistic facies the vermicular limestone is the most characteristic and common distinctive sediments in the Lower Triassic of South China but has received relatively few investigations. Taking it as a case study, we will detail the variation of vermicular limestone and its stratigraphic distribution in the Three Gorges area, Hubei Province. The investigation on the vermicular limestone and other distinctive sediments from the Lower Triassic of South China further indicates that the appearance of anachronistic facies immediately following the mass extinction and the elimination from normal shallow marine facies with the radiation of Mesozoic marine faunas imply the natural response of the sedimentary systems and ecosystems to the great Paleozoic-Mesozoic transitional events and their induced harsh environments. Therefore, the ups and downs of the anachronistic facies may act as a proxy for the evolution of ecosystems independent of fossil analyses. | XiaoMing Zhao (1) (2) JinNan Tong (1) HuaZhou Yao (2) KeXin Zhang (1) Chen Zq (3) | 2008 | Science China Earth Sciences2008，51，11： | 14 |
| 4 | Discovery of virus pathogen from soft-shelled turtle Trionyx sinesis显示文摘THE soft-shelled turtle Trionyx sinesis, because of its nutritional and medicinal values, | Zhang, QY Li, ZQ Jiang, YL Liang, SC Gui, JF | 1997 | Chinese Science Bulletin1997，42，6： | 3 |
| 5 | Expression of gap junctions and inhibition of cell growth in communication-defected cells after transfection with gap junction gene Cx43 cDNA显示文摘Gap junctions form intercellular channels for direct exchange of metabolites and second messengers between adjacent cells. The existence of a multi-gene family encoding gap junction proteins, i. e. the connexins (Cx), has been recently demonstrated. Despite the overall sequence homologies and a similar predicted structural motif, their functional properties differ in various tissues. Because of coexpression of two or more connexin proteins in one tissue, determination of properties specific for each connexin is complicated. The regulation of expression of gap junctions and their roles in cellular activities remain mostly unelucidative. Controlled manipulation of connexin molecules in Xenopus oocyte expression system has been use- | Zhang, ZQ Lin, ZX Wang, NQ Han, YL | 1997 | Chinese Science Bulletin1997，42，5： | 3 |
| 6 | Chromosomal aberrations andsister-chromatid exchanges of lymphocytes of workers exposed to sulphur dioxide显示文摘 | Meng ZQ Zhang LZ | 1990 | Mutat Res1990，241，： | 2 |
| 7 | Observation of frequenciesof lymphocytes with micronuclei in human peripheral blood cultures from workers in a sulphuric acid factory显示文摘 | Meng ZQ Zhang LZ | 1990 | Environ Mol Mutagen1990，15，： | 2 |
| 8 | Cytogenetic damage induced in human lymphocytes by sodium bisulfite显示文摘 | Meng ZQ Zhang LZ | 1992 | Mutat Res1992，298，： | 2 |
| 9 | Insights into human CD34(+) hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome显示文摘 | Liu F Lu J Fan HH Wang ZQ Cui SJ Zhang GA Chi M Zhang X Yang PY Chen Z Han ZG | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 10 | DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice 显示文摘 | Meng ZQ Qin GH Zhang B | 2004 | Mutagenesis2004，19，6： | 1 |
| 11 | Percutaneous transluminal sptal myocardial ablation for hypertrophic obstructive cardiomyopathy: The Chinese experience in 119 patients from a single center显示文摘 | Li ZQ Cheng TO Zhang WW | 2004 | International Journal of Cardiology2004，93，23： | 1 |
| 12 | Impaired CD200-CD200R- mediated microglia silencing enhances midbrain dopaminergic neuro- degeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK显示文摘 | Wang XJ Zhang S Yan ZQ | 2011 | FreeRadic BiolMed2011，50，9： | 1 |
| 13 | Salvage gemcitabine-vinorelbine chemotherapy in patients with me- tastatic nasopharyngeal carcinoma pretreated with platinum-based chemotherapy 显示文摘 | Chen C Wang FH Wang ZQ An X Luo HY Zhang L et ol | 2012 | Oral Oncol2012，48，11： | 1 |
| 14 | Different roles of two nitric oxide activated pathways in spinal long-term potentiation of C-fiber-evoked field potentials显示文摘 | Zhang XC Zhang YQ Zhao ZQ | | 0，，： | 1 |
| 15 | Interstitial lung diseases after leflunomide use in nephropathy: an analysis of reported cases in Chinese literature显示文摘 | Zhang WX Zhou W Zhang ZQ | 2011 | Nephrol Dial Transplant2011，26，4： | 1 |
| 16 | Cerebral angiogenesis after collagenase-induced intracerebral hemorrhage in rats显示文摘 | Tang T LiuXJ Zhang ZQ | 2007 | Brain Research2007，1175，： | 1 |
| 17 | HSP70 protects intestinal epithelial cells from hypoxia/recxygenstion injury via a mech- anism that involves the mitochondrial pathways显示文摘 | Yuan ZQ Zhang Y Li XL | 2010 | European Journal of Pharmacology2010，643，23： | 1 |
| 18 | Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral therapy 显示文摘 | Schacker T Little S Connick E Gebhard-Mitchell K Zhang ZQ Krieger J Pryor J Havlir D Wong JK Richman D Corey L Haase AT | 2000 | J Infect Dis2000，181，1： | 1 |
| 19 | Acute mesenteric venous thrombosis: a better outcome achieved through improved imaging techniques and a changed policy of clinical management显示文摘 | Zhang J Duan ZQ Song QB | 2004 | Eur J Vasc Endovasc Surg2004，28，3： | 1 |
| 20 | Polymerase chain reaction-based deletion screening of bisufite (sulfur dioxide)-enhanced gpt-mutants in CHO-AS52 cells显示文摘 | Meng ZQ Zhang B | 1999 | Mutation Res1999，425，： | 1 |
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