|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | 2003—2015年中国恶性肿瘤生存率变化:基于17个以人群为基础的肿瘤登记处数据的汇总分析显示文摘中国2003—2015年恶性肿瘤生存率远低于发达国家,且存在很大的地域差异性,以人群为基础的肿瘤生存率数据对了解我国肿瘤防治效果至关重要,因此本研究着重分析2003-2015年间中国恶性肿瘤患者的生存情况及变化趋势。本研究从中国国家癌症中心肿瘤登记中心抽取17个肿瘤登记点的肿瘤登记资料,包括2003—2013年间所有诊断为原发性浸润性恶性肿瘤患者(年龄为0~99岁),及其截至2015年12月31日的生存状态随访数据,分析了2003—2015年间所有恶性肿瘤及26个不同癌种的5年相对生存率,并按不同性别、年龄和地域分布进行描述和分析。 | Zeng H Chen W Zheng R 谢双华(编译) | 2019 | 中华预防医学杂志2019，53，12： | 3 |
| 3 | A new class of folding oligomers: crescent oligoamides显示文摘 | Zhu J Parra R D Zeng H | 2000 | J Am Chem Soc2000，122，： | 1 |
| 4 | Geographic distribution and epidemiology of lung cancer during 2011 in Zhejiang province of China显示文摘 | Chen W Zheng R Zeng H | 2014 | Asian Pac J Cancer Prey2014，15，13： | 1 |
| 5 | A semi torsional spring analogy model for updating unstructured meshes in 3D moving domains显示文摘 | Zeng D H Ethier C R | 2005 | Finite Elements in Analysis and Design2005，41，1112： | 1 |
| 6 | A novel density-tunable nanoeomposites of CdTe quantum dots linked to dendrimer-tethered multiwall carbon nanotubes显示文摘 | Zeng Y L Tang C R Wang H W Jiang J H Tian M N Shen G L Yu R Q | 2008 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2008，70，5： | 1 |
| 7 | Influence of load frequency and ageing heat treatment on fatigue crack propagation rate of as-extruded AZ61 alloy 显示文摘 | ZENG R C KE W HAN E H | 2009 | International Journal of Fatigue2009，31，： | 1 |
| 8 | Food Chemistry显示文摘 | Zeng H J Yang R Wang Q W Li J J Qu L B | 2011 | 127:8422011，127，： | 1 |
| 9 | Annual rpnrt on status of cancer in China, 2011 显示文摘 | Chen W Zheng R Zeng H | 2015 | Chin I Cancer Res2015，27，1： | 1 |
| 10 | Microglial activation in human diabetic retinopathy显示文摘 | ZENG H Y GREEN W R TSO M O | 2008 | Arch Ophthalmol2008，126，2： | 1 |
| 11 | The reduction property of activated carbon fibers显示文摘 | Fu R W Zeng H M Lu Y | 1993 | Carbon1993，31，7： | 1 |
| 12 | Identification of associations between SSR markers and fiber traits in an exotic germplasm derived from multiple crosses among Gossypium tetraploid species显示文摘 | Zeng L H Meredith W R Jr Gutiérrez O A | 2009 | Theor Appl Genet2009，119，： | 1 |
| 13 | Ca M kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo显示文摘 | Passier R Zeng H Frey N | 2000 | J Clin Invest2000，105，10： | 1 |
| 14 | Cancer survival in China, 2003 2005 : A population-based study显示文摘 | Zeng H Zheng R Guo Y | 2014 | Int J Cancer2014，136，8： | 1 |
| 15 | Multiple interval map- ping for quantitative trait loci 显示文摘 | Kao C H Zeng Z B Teasdale R D | 1999 | Genetics1999，152，3： | 1 |
| 16 | Control of grain size, shape and quality by OsSPL16 in rice显示文摘 | Wang S K Wu K Yua Q B Liu X Y Liu Z B Lin X Y Zeng R Z Zhu H T Dong G J Qian Q Zhang G Q Fu X D | 2012 | Nature Genetics2012，44，8： | 1 |
| 17 | Application of an antibacterial dressing spray in the prevention of post-operative infection in oral cancer patients:a phase 1 clinical trial显示文摘 | ZENG Y Z DENG R Z YEUNG H S | 2008 | Afr J Biotechnol2008，7，21： | 1 |
| 18 | Synthesis and characteris- tics of fullerene polysiloxane stationary phase for capillary gas chromatography显示文摘 | Fang P F Zeng Z R Fan J H | 2000 | Journal of Chromatography A2000，867，12： | 1 |
| 19 | Distribution of potentially hazardous trace elements in coals from Shanxi Province,China显示文摘 | Zhang J Y Zheng C G Ren D Y Chou C L Zeng R S Wang Z P Zhao F H Ge Y T | 2004 | Fuel2004，83，： | 1 |
| 20 | Physiological and biochen,ical mechanism of allelopathy of secalonic acid F on higher plant显示文摘 | ZENG R S LUO S M SHI Y H | 2001 | Ag-ronomy Journal2001，93，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员