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| 1 | Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment显示文摘Variation of maternal gut microbiota may increase the risk of autism spectrum disorders(ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. Gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother–child pairs of ASD children and 30 matched mother–child pairs of healthy children. Significant differences were observed in the gut microbiome composition between ASD and healthy children in our Chinese cohort. Several unique bacterial biomarkers, such as Alcaligenaceae and Acinetobacter, were identified. Mothers of ASD children had more Proteobacteria, Alphaproteobacteria, Moraxellaceae, and Acinetobacter than mothers of healthy children. There was a clear correlation between gut microbiome profiles of children and their mothers; however, children with ASD still had unique bacterial biomarkers, such as Alcaligenaceae, Enterobacteriaceae, and Clostridium. Candidate biomarkers discovered in this study had remarkable discriminatory power. The identified patterns of mother–child gut microbiome profiles may be important for assessing risks during the early stage and planning of personalized treatment and prevention of ASD via microbiota modulation. | Ning Li Junjie Yang Jiaming Zhang Cheng Liang Ying Wang Bin Chen Changying Zhao Jingwen Wang Guangye Zhang Dongmei Zhao Yi Liu Lehai Zhang Jun Yang Guimei Li Zhongtao Gai Lei Zhang Guoping Zhao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 6 |
| 2 | Preparation of Starch Succinate WITH INTERMEDIATE DS BY AQUEOUS SLURRY REACTION显示文摘The succinylation of cornstarch by slurry reaction has been studied using sodium hydroxide as catalyst. Several reaction parameters afJecting the succinylation were investigated including the concentration of starch in water, the ratio of succinic anhydride to starch, the reaction time and the reaction temperature. The favorable conditions for an intermediate degree of substitution (DS) and reasonably high reaction efficiency (RE) are pH 8.5~9.0, 50% starch by weight to water, succinic anhydride to starch I/I (w/w), reaction time 4h, reaction temperature 30 ℃Under these conditions, the DS of 0.45 and RE of 28% were achieved. The addition of an adequate amount of crosslinking agent imparted starch succinate water absorbency. | ZHU Changying WANG Bin ZHAO Fukai CAO Yurong WANG Linfu XU Jiayi Department of Chemistry, NanKai University, Tianjin, 300071, China | 2001 | Chinese Journal of Reactive Polymers2001，10，2： | 5 |
| 3 | TMEM43-S358L mutation enhances NF-κBTGFp signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy显示文摘Arrhythmogenic right ventricular dysplasia/cardiomyopathy(ARVD/C)is a genetic cardiac muscle disease that accounts for approximately 30%sudden cardiac death in young adults.The Ser358Leu mutation of transmembrane protein 43(TMEM43)was commonly identified in the patients of highly lethal and fully penetrant ARVD subtype,ARVD5.Here,we generated TMEM43 S358L mouse to explore the underlying mechanism.This mouse strain showed the classic patholo.gies of ARVD patients,including structural abnormalities and cardiac fibrofatty.TMEM43 S358L mutation led to hyper-activated nuclear factor kB(NFkB)activation in heart tissues and primary cardiomy.ocyte cells.Importantly,this hyper activation of NF-κB directly drove the expression of pro-fibrotic gene,transforming growth factor beta(TGFβ),and enhanced downstream signal,indicating that TMEM43 S358L mutation up-regulates NF-κB-TGFβ signal cascade during ARVD cardiac fibrosis.Our study partially reveals the regulatory mechanism of ARVD development. | Guoxing Zheng Changying Jiang Yulin Li Dandan Yang Youcai Ma Bing Zhang Xuan Li Pei Zhang Xiaoyu Hu Xueqiang Zhao Jie Du Xin Lin | 2019 | Protein & Cell2019，10，2： | 5 |
| 4 | Prediction of the effective thermal conductivity of packed bed with micro-particles for thermochemical heat storage显示文摘The heat transfer property of the powder bed greatly affects the performance of a thermochemical heat storage system. Therefore, an accurate evaluation of effective thermal conductivity(ETC) is a key for developing thermochemical heat storage systems. This paper focuses on the ETCs of commonly used porous thermochemical materials, such as Mg O/Mg(OH)2and Ca O/Ca(OH)2powders, as well as the corresponding composites with embedded metal foams. Random sphere-like particles packing(RSPP)method is proposed to reconstruct the microstructures of the powder and micro-scale generation method and computed tomography are adopted for the metal foams. Energy transport equations through porous media are solved by the lattice Boltzmann method(LBM) to obtain ETC. Results obtained using RSPP-LBM method agree with experimental data better than other existing methods. For thermochemical heat storage, the variation of ETC during chemical reactions is numerically predicted. Metal foam-embedded thermochemical materials are also studied to evaluate the enhancing effects of the metal foams. Results show that ETC of the powders is dominated by the gas phase, whereas that of the metal foam composites is dominated by the metal phase. | Zhihao Pan Changying Zhao | 2017 | Science Bulletin2017，62，4： | 2 |
| 5 | Design, Synthesis and Biological Activity of Tetrazole-bearing Uric Acid Transporter 1 Inhibitors显示文摘 | CAI Wenqing LIU Wei XIE Yafei WU Jingwei LIU Yuqiang LIU Changying XU Weiren TANG Lida WANG Jianwu ZHAO Guilong | 2017 | Chemical Research in Chinese Universities2017，33，1： | 2 |
| 6 | Extensively Drug-Resistant(XDR)Salmonella Typhi Outbreak by Waterborne Infection——Beijing Municipality,China,January-February 2022显示文摘Summary What is already known about this topic?Typhoid fever remains a major public health problem in developing countries.Waterborne typhoid fever affects an estimated 27 million people worldwide each year.Decades of indiscriminate antibiotic usage has driven the emergence and spread of multidrug-resistant(MDR)and even extensively drug-resistant(XDR)Salmonella Typhi(S.Typhi)strains. | Yu Wang Dan Lu Yingying Jin Huanxin Wang Bing Lyu Xin Zhang Ying Huang Gaolin Shu Baiwei Liu Changying Lin Hao Zhao Mingqiang Zhao Lingyu Shen Zhiyong Gao Daitao Zhang Quanyi Wang Mei Qu Lei Jia | 2022 | China CDC weekly2022，4，12： | 1 |
| 7 | Chromosome-level Genomes Reveal the Genetic Basis of Descending Dysploidy and Sex Determination in Morus Plants显示文摘Multiple plant lineages have independently evolved sex chromosomes and variable karyotypes to maintain their sessile lifestyles through constant biological innovation.Morus notabilis,a dioecious mulberry species,has the fewest chromosomes among Morus spp.,but the genetic basis of sex determination and karyotype evolution in this species has not been identified.In this study,three high-quality genome assemblies were generated for Morus spp.[including dioecious M.notabilis(male and female)and Morus yunnanensis(female)]with genome sizes of 301–329 Mb and were grouped into six pseudochromosomes.Using a combination of genomic approaches,we found that the putative ancestral karyotype of Morus species was close to 14 protochromosomes,and that several chromosome fusion events resulted in descending dysploidy(2n=2x=12).We also characterized a~6.2-Mb sex-determining region on chromosome 3.Four potential male-specific genes,a partially duplicated DNA helicase gene(named MSDH)and three Ty3_Gypsy long terminal repeat retrotransposons(named MSTG1/2/3),were identified in the Y-linked area and considered to be strong candidate genes for sex determination or differentiation.Population genomic analysis showed that Guangdong accessions in China were genetically similar to Japanese accessions of mulberry.In addition,genomic areas containing selective sweeps that distinguish domesticated mulberry from wild populations in terms of flowering and disease resistance were identified.Our study provides an important genetic resource for sex identification research and molecular breeding in mulberry. | Zhongqiang Xia Xuelei Dai Wei Fan Changying Liu Meirong Zhang Peipei Bian Yuping Zhou Liang Li Baozhong Zhu Shuman Liu Zhengang Li Xiling Wang Maode Yu Zhonghuai Xiang Yu Jiang Aichun Zhao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 8 | Manufacture of Cheddar cheese using probiotic Lactobacillus plantarum K25 and its cholesterol-lowering effects in a mice model显示文摘 | Li Zhang Xue Zhang Chunhong Liu Changying Li Shengyu Li Tiezhu Li Da Li Yujuan Zhao Zhennai Yang | 2013 | World Journal of Microbiology and Biotechnology2013，，1： | 1 |
| 9 | Manufacture of Cheddar cheese using probiotic Lactobacillus plantarum K25 and its cholesterol-lowering effects in a mice model显示文摘 | Li Zhang Xue Zhang Chunhong Liu Changying Li Shengyu Li Tiezhu Li Da Li Yujuan Zhao Zhennai Yang | 2013 | World Journal of Microbiology and Biotechnology2013，，1： | 1 |
| 10 | Extreme points and rotundity of Orlicz-Sobolev spaces显示文摘 | Chen Shutao Hu Changying Charles Xuejin Zhao | 2002 | Inter J Math Math Sci2002，32，5： | 1 |
| 11 | Uniform rotundity of Orlicz-Sobolev spaces显示文摘 | Chen Shutao Hu Changying Charles Xuejin Zhao | 2003 | Soochow J Math2003，29，3： | 1 |
| 12 | Special issue: Nanotechnology in energy显示文摘 | Changying ZHAO Zhuomin ZHANG Xing ZHANG | 2018 | Frontiers in Energy2018，12，1： | 1 |
| 13 | Efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection for the treatment of renal anemia in Chinese hemodialysis patients:A randomized,open-label,parallel-group,noninferiority phase III trial显示文摘Background:This study was to explore the clinical efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection(recombinant human erythropoietin injection,rHuEPO)for the treatment of anemia associated with chronic kidney failure in Chinese patients undergoing hemodialysis.Method:This study was a multicenter,randomized,open-label,intergroup parallel control phase III noninferiority trial from April 19,2013 to September 9,2014 at 25 sites.In this study,the members of the darbepoetin alfa group underwent intravenous administration once per week or once every two weeks.The members of the control drug epoetin alfa group underwent intravenous administration two or three times per week.All subjects underwent epoetin alfa administration during the 8-week baseline period.After that,subjects were randomly assigned to the darbepoetin alfa group or epoetin alfa group.The noninferiority in the changes of the average Hb concentrations from the baseline to the end of the evaluation period(noninferiority threshold:-1.0 g/dl)was tested between the two treatments.The time-dependent hemoglobin(Hb)concentration and the maintenance rate of the target Hb concentration(the proportion of subjects with Hb concentrations between 10.0 and 12.0 g/dl)were also evaluated.Iron metabolism,including changes in the serum iron,total iron-binding capacity,ferritin,transferrin saturation,and comparisons of the dose adjustments between the two groups during the treatment period were analyzed further.Adverse events(AEs)were also observed and compared,and the safety was analyzed between the two treatment groups.The conversion rate switching from epoetin alfa to darbepoetin alfa was also discussed.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:Four hundred and sixty-six patients were enrolled in this study,and ultimately 384 cases were analyzed for safety,including 267 cases in the darbepoetin alfa group and 117 cases in the epoetin alfa group.There were 211 cases in the per-protocol set,including 152 cases in the darbepoetin alfa group and 59 cases in the epoetin alfa group.The changes in the average Hb concentrations from the baseline to the end of the evaluation period were-0.07 and-0.15 g/dl in the darbepoetin alfa group and epoetin alfa group respectively.The difference between the two groups was 0.08 g/dl(95%confidence interval[CI]:-0.22 to 0.39),and the lower limit of the 95%CI was-0.22>-1.0 g/dl.The average Hb concentrations of the two groups were 10.88-11.43 g/dl(darbepoetin alfa)and 10.91-11.38 g/dl(epoetin alfa)during the study period of Weeks 0-28,with the maintenance rates of the target Hb concentration ranging within 71%-87%and 78%-95%in the darbepoetin alfa group and epoetin alfa group respectively.During the period of comparison between the two groups,the incidence of AEs in the darbepoetin alfa group was 61.42%,while in the epoetin alfa group it was 56.41%.All of the adverse events and reactions in the study were those commonly associated with hemodialysis.Conclusion:The overall efficacy and safety of darbepoetin alfa for the treatment of Chinese renal anemia patients undergoing hemodialysis are consistent with those of epoetin alfa. | Bicheng Liu Nan Chen Jinghong Zhao Aiping Yin Xiongfei Wu Changying Xing Gengru Jiang Junzhou Fu Mei Wang Rong Wang Jianying Niu Ping Fu Zhaohui Ni Fanfan Hou Jiuyang Zhao Jing Chen Yuqing Chen Wei Shi Jianghua Chen Wenge Li Gang Xu Ling Zhong Wenhu Liu Guohua Ding Yuichiro Kondo Changhe Yue Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，2： | 1 |
| 14 | Thermal property characterization of a low melting-temperature ternary nitrate salt mixture for thermal energy storage systems 显示文摘 | ZHAO Changying WU Zhigen | 2011 | Solar Energy Materials and Solar Cells2011，95，12： | 1 |
| 15 | Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority Phase III trail显示文摘Background:Erythropoietin is a glycoprotein that mainly regulates erythropoiesis.In patients with chronic renal failure with anemia,darbepoetin alfa can stimulate erythropoiesis,correct anemia,and maintain hemoglobin levels.This study was designed to demonstrate the efficacy and safety of darbepoetin alfa injections as being not inferior to epoetin alfa injections(Recombinant Human Erythropoietin injection,rHuEPO)when maintaining hemoglobin(Hb)levels within the target range(10.0-12.0 g/dL)for the treatment of renal anemia.Methods:Ninety-five patients were enrolled in this study from April 15,2013 to April 10,2014 at 25 sites.In this study,patients(n=95)aged 18-70 years were randomized into a once per week intravenous darbepoetin alfa group(n=56)and a twice or three times per week intravenous epoetin alfa group(n=39)for 28 weeks,who had anemia with hemoglobin levels between 6 g/dL and 10 g/dL due to chronic kidney disease(CKD)and were undergoing hemodialysis or hemofiltration with ESA-naive(erythropoiesis stimulating agent-naive).The primary efficacy profile was the mean Hb level(the non-inferiority margin was-1.0 g/dL,week 21-28);the secondary efficacy profiles were the Hb increase rate(week 0-4),the target Hb achievement cumulative rate and time,the change trends of the Hb levels,and the target Hb maintenance ratio.Adverse events(AEs)were observed and compared,and the efficacy and safety were analyzed between the two treatment groups.Additionally,the frequencies of dose adjustments between the darbepoetin alfa and epoetin alfa groups were compared during the treatment period.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:The mean Hb level was 11.3 g/dL in the darbepoetin alfa group and 10.7 g/dL in the epoetin alfa group,respectively;the difference of the lower limits of the 95%confidence intervals(CI)between the two groups was 0.1 g/dL(>-1.0 g/dL),and non-inferiority was proven;the Hb levels started to increase in the first four weeks at a similar increase rate;no obvious differences were observed between the groups in the target Hb achievement cumulative rates,and the Hb levels as well as the target Hb level maintenance rate changed over time.The incidence of AEs was 62.5%in the darbepoetin alfa group and 76.9%in the epoetin alfa group.All the adverse events observed in the study were those commonly associated with hemodialysis.Conclusion:Darbepoetin alfa intravenously once per week can effectively increase Hb levels and maintain the target Hb levels well,which makes it not inferior to epoetin alfa intravenously twice or three times per week.Darbepoetin alfa shows an efficacy and safety comparable to epoetin alfa for the treatment of renal anemia. | Nan Chen Changying Xing Jianying Niu Bicheng Liu Junzhou Fu Jiuyang Zhao Zhaohui Ni Mei Wang Wenhu Liu Jinghong Zhao Ling Zhong Xiongfei Wu Wenge Li Yuqing Chen Wei Shi Jianghua Chen Aiping Yin Ping Fu Rong Wang Gengru Jiang Fanfan Hou Guohua Ding Jing Chen Gang Xu Yuichiro Kondo Yuliang Su Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，1： | 1 |
| 16 | The Temperature Dependence of Effective Thermal Conductivity of Open-Celled Steel Alloy Foams 显示文摘 | ZHAO Changying LU Tianjian Hodson H P Jackson J D | 2004 | Mate- rials Science and Engineering A2004，367，12： | 1 |
| 17 | Analyti- cal Consideration of Thermal Radiation in Cellular Metal Foams With Open Cells 显示文摘 | ZHAO Changying Tassou S A LU Tianjian | 2008 | International Journal of Heat and Mass Transfer2008，51，34： | 1 |
| 18 | Ther- mal Transport in High Porosity Cellular Metal Foams 显示文摘 | ZHAO Changying Kim T LU Tianjian et M | 2004 | Journal of ThermophysicsHeat Transfer2004，18，30： | 1 |
| 19 | Thermal property characterization of a low melting-temperature ternary nitrate salt mixture for thermal energy storage systems 显示文摘 | Zhao Changying Wu Zhigang | 2011 | Solar Energy Materials & Solar Cells2011，95，： | 1 |
| 20 | Thermal analysis on metal-foam filled heat exchangers, part I: metal-foam filled pipes 显示文摘 | LU W ZHAO Changying TASSOU S A | 2006 | International Journal of Heat and Mass Transfer2006，49，1516： | 1 |
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