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| 1 | Mitophagy links oxidative stress conditions and neurodegenerative diseases显示文摘Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress conditions and central neurodegenerative diseases. Proper regulation of mitophagy is crucial for maintaining homeostasis; conversely, inadequate removal of mitochondria through mitophagy leads to the generation of oxidative species, including reactive oxygen species and reactive nitrogen species, resulting in various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. These diseases are most prevalent in older adults whose bodies fail to maintain proper mitophagic functions to combat oxidative species. As mitophagy is essential for normal body function, by targeting mitophagic pathways we can improve these disease conditions. The search for effective remedies to treat these disease conditions is an ongoing process, which is why more studies are needed. Additionally, more relevant studies could help establish therapeutic conditions, which are currently in high demand. In this review, we discuss how mitophagy plays a significant role in homeostasis and how its dysregulation causes neurodegeneration. We also discuss how combating oxidative species and targeting mitophagy can help treat these neurodegenerative diseases. | Ulfuara Shefa Na Young Jeong In Ok Song Hyung-Joo Chung Dokyoung Kim Junyang Jung Youngbuhm Huh | 2019 | Neural Regeneration Research2019，14，5： | 21 |
| 2 | Early expressions of hypoxia-inducible factor 1alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous neural stem cells after focal cerebral ischemia显示文摘Endogenous neural stem cells become 'activated' after neuronal injury, but the activation sequence and fate of endogenous neural stem cells in focal cerebral ischemia model are little known. We evaluated the relationships between neural stem cells and hypoxia-inducible factor-1α and vascular endothelial growth factor expression in a photothromobotic rat stroke model using immunohistochemistry and western blot analysis. We also evaluated the chronological changes of neural stem cells by 5-bromo-2′-deoxyuridine(BrdU) incorporation. Hypoxia-inducible factor-1α expression was initially increased from 1 hour after ischemic injury, followed by vascular endothelial growth factor expression. Hypoxia-inducible factor-1α immunoreactivity was detected in the ipsilateral cortical neurons of the infarct core and peri-infarct area. Vascular endothelial growth factor immunoreactivity was detected in bilateral cortex, but ipsilateral cortex staining intensity and numbers were greater than the contralateral cortex. Vascular endothelial growth factor immunoreactive cells were easily found along the peri-infarct area 12 hours after focal cerebral ischemia. The expression of nestin increased throughout the microvasculature in the ischemic core and the peri-infarct area in all experimental rats after 24 hours of ischemic injury. Nestin immunoreactivity increased in the subventricular zone during 12 hours to 3 days, and prominently increased in the ipsilateral cortex between 3–7 days. Nestin-labeled cells showed dual differentiation with microvessels near the infarct core and reactive astrocytes in the peri-infarct area. BrdU-labeled cells were increased gradually from day 1 in the ipsilateral subventricular zone and cortex, and numerous BrdU-labeled cells were observed in the peri-infarct area and non-lesioned cortex at 3 days. BrdU-labeled cells rather than neurons, were mainly co-labeled with nestin and GFAP. Early expressions of hypoxia-inducible factor-1α and vascular endothelial growth factor after ischemia made up the microenvironment to increase the neuronal plasticity of activated endogenous neural stem cells. Moreover, neural precursor cells after large-scale cortical injury could be recruited from the cortex nearby infarct core and subventricular zone. | Seung Song Jong-Tae Park Joo Young Na Man-Seok Park Jeong-Kil Lee Min-Cheol Lee Hyung-Seok Kim | 2014 | Neural Regeneration Research2014，9，9： | 17 |
| 3 | The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition显示文摘Background: Understanding the composition of the microbial community and its functional capacity during weaning is important for pig production as bacteria play important roles in the pig's health and growth performance. However,limited information is available regarding the composition and function of the gut microbiome of piglets in early-life.Therefore, we performed 16 S rRNA gene and whole metagenome shotgun sequencing of DNA from fecal samples from healthy piglets during weaning to measure microbiome shifts, and to identify the potential contribution of the early-life microbiota in shaping piglet health with a focus on microbial stress responses, carbohydrate and amino acid metabolism.Results: The analysis of 16 S rR NA genes and whole metagenome shotgun sequencing revealed significant compositional and functional differences between the fecal microbiome in nursing and weaned piglets. The fecal microbiome of the nursing piglets showed higher relative abundance of bacteria in the genus Bacteroides with abundant gene families related to the utilization of lactose and galactose. Prevotel a and Lactobacil us were enriched in weaned piglets with an enrichment for the gene families associated with carbohydrate and amino acid metabolism. In addition, an analysis of the functional capacity of the fecal microbiome showed higher abundances of genes associated with heat shock and oxidative stress in the metagenome of weaned piglets compared to nursing piglets.Conclusions: Overal, our data show that microbial shifts and changes in functional capacities of the piglet fecal microbiome resulted in potential reductions in the effects of stress, including dietary changes that occur during weaning.These results provide us with new insights into the piglet gut microbiome that contributes to the growth of the animal. | Robin B.Guevarra Sang Hyun Hong Jin Ho Cho Bo-Ra Kim Jiwon Shin Jun Hyung Lee Bit Na Kang Young Hwa Kim Suphot Wattanaphansak Richard E.Isaacson Minho Song Hyeun Bum Kim | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 16 |
| 4 | Reinfection rate and endoscopic changes after successful eradication of Helicobacter pylori显示文摘AIM:To determine the long-term outcomes regarding reinfection with Helicobacter pylori(H.pylori)and endoscopic changes after successful H.pylori eradication. METHODS:From June 1994 to January 2007,186 patients(M:F=98:88;mean age 50.0±11.4 years), in whom H.pylori had been successfully eradicated, were enrolled.The mean duration of follow up was 41.2±24.0 mo. RESULTS:H.pylori reinfection occurred in 58 patients (31.2%).The average annual reinfection rate was 9.1% per patient year.No recurrence of peptic ulcer was detected at the follow up endoscopy.There were no significant differences between the H.pylori eradication regimens for the reinfection rate and no significant differences in endoscopic findings between the H.pylorirecurred group and the H.pylori-cured group.CONCLUSION:The reinfection rate in Korea is 9.1% which represents a decreasing trend.There was no relationship between H.pylori infection status and changes in endoscopic findings.There was also no recurrence or aggravation of ulcers. | Kum Hei Ryu Sun Young Yi Youn Ju Na Su Jung Baik Su Jin Yoon Hae-Sun Jung Hyun Joo Song | 2010 | World Journal of Gastroenterology2010，16，2： | 14 |
| 5 | Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases显示文摘Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where reactive oxygen species are the main source of oxidative stress. When the normal redox balance is disturbed, deoxyribonucleic acid, lipid, and protein molecules are oxidized under pathological conditions, like diabetes mellitus that leads to diabetic peripheral neuropathy. In diabetes mellitus-induced diabetic peripheral neuropathy, due to hyperglycemia, pancreatic beta cell(β cell) shows resistance to insulin secretion. As a consequence, glucose metabolism is disturbed in neuronal cells which are distracted from providing proper cell signaling pathway. Not only diabetic peripheral neuropathy but also other central damages occur in brain neuropathy. Neurological studies regarding type 1 diabetes mellitus patients with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis have shown changes in the central nervous system because high blood glucose levels(HbA1 c) appeared with poor cognitive function. Oxidative stress plays a role in inhibiting insulin signaling that is necessary for brain function. Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine β synthase, cystathionine γ lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide. This review is to explore the pathogenesis of diabetes mellitus-induced diabetic peripheral neuropathy and other neurological comorbid disorders under the oxidative stress condition and the anti-oxidative effects of hydrogen sulfide. | Rubaiya Tabassum Na Young Jeong Junyang Jung | 2020 | Neural Regeneration Research2020，15，2： | 9 |
| 6 | Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma显示文摘AIM:To select appropriate patients before surgical resection for hepatocellular carcinoma(HCC),especially those with advanced tumors.METHODS:From January 2000 to December 2012,we retrospectively analyzed the medical records of 298 patients who had undergone surgical resections for HCC with curative intent at our hospital.We evaluated preoperative prognostic factors associated with histologic grade of tumor,recurrence and survival,especially the findings of pre-operative imaging studies such as positron emission tomography-computed tomography(PETCT)and magnetic resonance imaging(MRI).And then,we established a scoring system to predict recurrence and survival after surgery dividing the patients into two groups based on a tumor size of 5 cm.RESULTS:Of the 298 patients,129(43.3%)developed recurrence during the follow-up period.The 5 year disease free survival and overall survival were 47.0%and58.7%respectively.In multivariate analysis,a serum alpha-fetoprotein(AFP)level of>100 ng/m L and a standardized uptake value(SUV)of PET-CT of>3.5 were predictive factors for histologic grade of tumor,recurrence,and survival.Tumor size of>5 cm and a relative enhancement ratio(RER)calculated from preoperative MRI were also significantly associated with prognosis in univariate analysis.We established a scoring system to predict prognosis using AFP,SUV,and RER.In those with tumors of>5 cm,it showed predicted both recurrence(P=0.005)and survival(P=0.001).CONCLUSION:The AFP,tumor size,SUV and RER are useful for prognosis preoperatively.An accurate prediction of prognosis is possible using our scoring system in large size tumors. | Jae Hyun Han Dong Goo Kim Gun Hyung Na Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You | 2014 | World Journal of Gastroenterology2014，20，45： | 8 |
| 7 | Discrepancies between primary physician practice and treatment guidelines for Helicobacterpylori infection in Korea显示文摘瞄准:在 Helicobacter pylori 的诊断和治疗评估主要照顾医生的态度(H。pylori ) 感染。方法:在汉城大城市的区域的主要照顾医生从 1 月回答了自我管理的问询表到 2003 年 3 月。结果:108 位医生对问询表作出回应。为严峻的 H 的最经常的原因。pylori 感染是胃的并且十二指肠溃疡(93.5% 和 88.9% ,分别地) 。为有 H 的病人。pylori 积极消化不良, 28.7% 医生总是试着根除蠕虫并且 34.4% 有选择地对待。主要照顾医生的一个大比例(28.7%) 对待 H。一个病人的请求基础上的 pylori。仅仅, 9.3% 主要照顾医生总是进行了在对待 H 以后测试的后续。pylori 感染。什么时候 H。pylori 没被第一治疗清除, 40.7% 医生再使用一样的政体, 16.7% 改变了到另一三倍的政体并且 25% 到四倍的政体。结论:指南的发行几乎独自没在实践上有很少影响,这很好被记录了。在在连续医药教育形式的主要照顾医生和胃的肠学之间的通讯被要求。 | Byeong Gwan Kim Ji Won Kim Ji Bong Jeong Young Jin Jung Kook Lae Lee Young Soo Park Jin Huk Hwang Jin Uk Kim Na Young Kim Dong Ho Lee Hyun Chae Jung In Sung Song | 2006 | World Journal of Gastroenterology2006，12，1： | 8 |
| 8 | Inflammatory markers as selection criteria of hepatocellular carcinoma in living-donor liver transplantation显示文摘AIM:To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma(HCC)patients in living-donor liver transplantation(LDLT).METHODS:From October 2000 to November 2011,224 patients who underwent living donor liver transplantation for HCC at our institution were enrolled in this study.We analyzed disease-free survival(DFS)and overall survival(OS)after LT in patients with HCC and designed a new score model using pretransplant neutrophil-lymphocyte ratio(NLR)and C-reactive protein(CRP).RESULTS:The DFS and OS in patients with an NLR level≥6.0 or CRP level≥1.0 were significantly worse than those of patients with an NLR level<6.0 or CRP level<1.0(P=0.049,P=0.003 for NLR and P=0.010,P<0.001 for CRP,respectively).Using a new score model using the pretransplant NLR and CRP,we can differentiate HCC patients beyond the Milan criteria with agood prognosis from those with a poor prognosis.CONCLUSION:Combined with the Milan criteria,new score model using NLR and CRP represent new selection criteria for LDLT candidates with HCC,especially beyond the Milan criteria. | Gun Hyung Na Dong Goo Kim Jae hyun Han Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You | 2014 | World Journal of Gastroenterology2014，20，21： | 6 |
| 9 | Clinical analysis of patients with hepatocellular carcinoma recurrence after living-donor liver transplantation显示文摘AIM: To evaluated patterns and outcomes of hepatocellular carcinoma(HCC) recurrence after living donor liver transplantation(LDLT).METHODS: From 2001 to 2014, 293 patients underwent LDLT for HCC at our transplant center. We retrospectively reviewed 54(18.4%) patients with HCC recurrence after LDLT. We evaluated patterns and outcomes of HCC recurrence after LDLT, with particular attention to the Milan criteria at transplantation, treatments for HCC-recurrent patients, and factors related to survival after HCC recurrence. Furthermore, we evaluated the efficacy of combination treatment of sorafenib and an mT OR inhibitor.RESULTS: The 1-, 2-, and 3-year overall survival rates after HCC recurrence were 41.1%, 20.5%, and 15.4%, respectively. The median time interval between LDLT and HCC recurrence was 6.5 mo. Although recurrence rates according to the Milan criteria at LDLT were significantly different, HCC recurrence patterns and survival rates after HCC recurrence were not significantly different between the two groups. Time to recurrence < 12 mo(P = 0.048), multiple recurrences at HCC recurrence(P = 0.038), and palliative treatment for recurrent tumors(P = 0.003) were significant independent prognostic factors for poor survival after HCC recurrence in a multivariate analysis. The combination treatment of sorafenib and sirolimus showedsurvival benefits in the palliative treatment group(P = 0.005).CONCLUSION: Curative treatment for recurrent HCC after LDLT is the most important factor in survival rates after HCC recurrence and combination treatments of sorafenib and an m TOR inhibitor could have survival benefits in patients with HCC recurrence after LT in the palliative treatment group. | Gun Hyung Na Tae Ho Hong Young Kyoung You Dong Goo Kim | 2016 | World Journal of Gastroenterology2016，22，25： | 5 |
| 10 | Endocrine Regulation of Energy Metabolism by the Skeleton显示文摘 | Na Kyung Lee Hideaki Sowa Eiichi Hinoi Mathieu Ferron Jong Deok Ahn Cyrille Confavreux Romain Dacquin Patrick J. Mee Marc D. McKee Dae Young Jung Zhiyou Zhang Jason K. Kim Franck Mauvais-Jarvis Patricia Ducy Gerard Karsenty | 2007 | Cell2007，，3： | 5 |
| 11 | A highly sensitive chemical gas detecting transistor based on highly crystalline CVD-grown MoSe2 films显示文摘有原子厚度的分层的半导体由于他们的高级搬运人活动性,大 surface-to-volume 比率,和对他们的包围环境的快速的电的回答在高效的电子设备作为活跃元素正在变得日益重要。这里,我们报导高度敏感的 chemical-vapor-deposition-grown 的第一实现多层的 MoSe 2 地效果晶体管(联邦货物税) 在一没有 2 气体传感器。这个传感器展出了超离频敏感(S = ca。1,907 为在 300 ppm 的没有 2) ,即时反应,并且快速的开关切换。我们的 MoSe 2 气体传感器的高敏感在 2 气体专心于在离开状态政体在洞电流导致重要增加的 MoSe 2, 的 NO 劝诱的原子价乐队附近处于差距状态被归因于变化。设备建模和量运输模拟表明没有 2 集中的差距状态的变化是在 MoSe 2 的关键机制基于联邦货物税没有 2 气体传感器。这全面研究,它探讨材料生长,设备制造,描述,和设备模拟,不是仅仅为高效的化学传感器显示 MoSe 2 联邦货物税的用途,而且建立怎么出现理解化学的一个基础在分层的半导体设备影响搬运人运输。 | Jongyeol Baek Demin Yin Na Liu Inturu Omkaram Chulseung Jung Healin Im Seongin Hong Seung Min Kim Young Ki Hong Jaehyun Hur Youngki Yoon Sunkook Kim | 2017 | Nano Research2017，10，6： | 4 |
| 12 | Janus‐faced role of SIRT1 in tumorigenesis显示文摘 | Na‐Young Song Young‐Joon Surh | 2012 | Annals of the New York Academy of Sciences2012，，1： | 3 |
| 13 | Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases显示文摘Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related diseases is oxidative stress.In recent years,the importance of H2S has become clear,although its antioxidant function has not yet been fully explored.The enzymes cystathionineβ-synthase,cystathionineγ-lya-se,and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S.Previously,H2S was considered a neuromodulator,given its role in long-term hippocampal potentiation,but it is now also recognized as an antioxidant in age-related neurodegeneration.Due to aerobic metabolism,the central nervous system is vulnerable to oxidative stress in brain aging,resulting in age-associated degenerative diseases.H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes,including superoxide dismutase,catalase,and glutathione peroxidase,which protect against the effects of aging by regulating apoptosis-related genes,including p53,Bax,and Bcl-2.This review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and Down syndrome. | Rubaiya Tabassum Na Young Jeong Junyang Jung | 2020 | Neural Regeneration Research2020，15，4： | 3 |
| 14 | Hydrogen sulfide controls peripheral nerve degeneration and regeneration:a novel therapeutic strategy for peripheral demyelinating disorders or nerve degenerative diseases显示文摘After peripheral nerve injury,the process of Wallerian degeneration is initiated in the distal stump of injured nerves.Wallerian degeneration in peripheral nerves involves axonal degeneration and degradation of the myelin sheath in Schwann cells.This provides the necessary conditions for axonal regeneration and remyelination.After nerve injury,macrophages are also recruited to the distal nerve stump and,together with Schwann cells,play a role in the clearance | Junyang Jung Na Young Jeong | 2014 | Neural Regeneration Research2014，9，24： | 3 |
| 15 | High-performance colorful semitransparent perovskite solar cells with phase-compensated microcavities显示文摘 | Kyu-Tae Lee Ji-Yun Jang Na Young Ha Soonil Lee Hui Joon Park | 2018 | Nano Research2018，11，5： | 3 |
| 16 | Effect of tellurium on the microstructure and mechanical properties of Fe-14Cr oxide-dispersion-strengthened steels produced by additive manufacturing显示文摘Conventionally,Te has primarily been used to improve the machinability of steel and its alloys.In this work,Te was used to refine the grains of an oxide-dispersion-strengthened(ODS)steel produced by additive manufacturing(AM)with fixed processing parameters.Addition of Te to the raw powder produced an ODS steel with a fine-grained microstructure,in contrast to the ODS steel manufactured without Te.Moreover,the addition of Te resulted in superior yield strength and ultimate tensile strength,which was attributed to the combined effects of grain refinement and the finer nanoparticles(NPs)composed of Terich composite NPs and Cr-rich NPs.For the first time,the AM technique was used to obtain grain and nanoparticle sizes of~3.4μm and 6 nm,respectively,from the Te-added ODS steel. | Barton Mensah Arkhurst Jee Hwan Bae Min Young Na Hye Jung Chang Hyun Gil Kim Il Hyun Kim Ho Jin Ryu Jeoung Han Kim | 2021 | Journal of Materials Science & Technology2021，，36： | 3 |
| 17 | Clinical significance of MET gene amplification in metastatic or locally advanced gastric cancer treated with first-line fluoropyrimidine and platinum combination chemotherapy显示文摘Objective: To investigate the clinical significance of MET gene amplification in patients with gastric cancer in the palliative setting.Methods: MET amplification was assessed using fluorescence in situ hybridization(FISH) in 50 patients and quantitative polymerase chain reaction(qPCR) in 326 patients;259 patients treated with first-line fluoropyrimidine and platinum were included for survival analysis.Results: The results of FISH and qPCR indicated that the c-MET/CEP7 ratio was correlated with gene copy number. The optimal cutoff value for the copy number using qPCR to detect MET gene amplification with FISH was 5(κ=0.778, P<0.001). Twenty-one out of 326 patients(6.4%) were identified as MET amplification with a copy number of >5 detected by qPCR. MET-amplified gastric cancer was associated with an Eastern Cooperative Oncology Group(ECOG) performance status(PS) score of ≥2(33.3% vs. 10.5% P=0.007), peritoneal metastasis(76.2% vs. 46.2%, P=0.008), and elevated bilirubin levels(28.6% vs. 7.3%, P=0.006). The median overall survival(OS) and progression-free survival(PFS) were 11.9 and 5.6 months, respectively. MET-amplified gastric cancer was not associated with survival outcomes [hazard ratio(HR)=0.68, 95% confidence interval(95% CI): 0.35-1.32,P=0.254 for PFS;HR=0.68, 95% CI: 0.35-1.32, P=0.251 for OS].Conclusions: qPCR can be used to detect MET gene amplification. MET amplification was not a predictor of poor prognosis in patients with metastatic or unresectable gastric cancer. | Seyoung Seo Min-Hee Ryu Baek-Yeol Ryoo Yangsoon Park Young Soo Park Young-Soon Na Chae-Won Lee Ju-Kyung Lee Yoon-Koo Kang | 2019 | Chinese Journal of Cancer Research2019，31，4： | 3 |
| 18 | Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced pluripotent stem cells显示文摘The combination of disease-specific human induced pluripotent stem cells(iPSC)and directed cell differentiation offers an ideal platform for modeling and studying many inherited human diseases.Wilson’s disease(WD)is a monogenic disorder of toxic copper accumulation caused by pathologic mutations of the ATP7B gene.WD affects multiple organs with primary manifestations in the liver and central nervous system(CNS).In order to better investigate the cellular pathogenesis of WD and to develop novel therapies against various WD syndromes,we sought to establish a comprehensive platform to differentiate WD patient iPSC into both hepatic and neural lineages.Here we report the generation of patient iPSC bearing a Caucasian population hotspot mutation of ATP7B.Combining with directed cell differentiation strategies,we successfully differentiated WD iPSC into hepatocyte-like cells,neural stem cells and neurons.Gene expression analysis and cDNA sequencing confirmed the expression of the mutant ATP7B gene in all differentiated cells.Hence we established a platform for studying both hepatic and neural abnormalities of WD,which may provide a new tool for tissue-specific disease modeling and drug screening in the future. | Fei Yi Jing Qu Mo Li Keiichiro Suzuki Na Young Kim Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2012 | Protein & Cell2012，3，11： | 3 |
| 19 | 尼可地尔在经皮冠状动脉介入治疗不稳定心绞痛时对心肌的保护作用显示文摘心肌损伤通常在经皮冠状动脉介入治疗(PCI)过程中出现,并且损伤可以通过对心肌酶的测试使之容易被监控。众所周知,尼可地尔是三磷酸腺苷ATP-敏感的K+通道的开启器,通过减小作用电位从而具有抗心律失常效应和保护心脏作用。比如,通过松弛血管平滑肌以减少微冠状动脉血流阻力。研究尼可地尔的心肌保护作用,IONA研究(尼可地尔对心绞痛的作用)即大规模对稳定型心绞痛进行的研究表明,尼可地尔口服给药能够减少冠心病致死率和非致命型心肌梗塞或胸痛意外住院治疗。目前已经对数个不稳定心绞痛(UAP)或急性心肌梗塞病人进行了尼可地尔心脏保护效应的研究评估,但还没有进行大规模研究。此研究的目的在于通过对经尼可地尔注射并PCI治疗12~48h后的不稳定心绞痛患者的心肌酶进行评估来预期考察尼可地尔的心脏保护作用。 | Ju Han Kim Myung Ho Jeong Kyung Ho Yun Kye Hun Kim Dong Koo Kang Seo Na Hong Sang Yup Lim Sang Hyun Lee Yun Sang Lee Young Joon Hong Hyung Wook Park Weon Kim Young Keun Ahn Jeong Gwang Cho Jong Chun Park Jung Chaee Kang 田玉敬 | 2017 | 首都食品与医药2017，24，18： | 3 |
| 20 | Performance of Weibull function as a diameter distribution model for Pinus thunbergii stands in the eastern coast of South Korea显示文摘This study was carried out to determine the performance of percentile-based Weibull diameter distribution model for Pinus thunbergii stands thriving along the eastern coast of South Korea.The parameter recovery technique was used to estimate the three parameters of the Weibull model.The analysis demonstrated satisfactory results based on the following test statistics for the principal percentile models:fit index(FI) range from 0.501(minimum diameter) to 0.932(50th diameter percentiles) and root mean square error(RMSE) range from 0.112(quadratic mean diameter) to 3.572(minimum diameter).The developed model was further evaluated by determining the mean bias(ē) in trees per ha(TPH) for each diameter class,and the results showed highest over-prediction in the 20 cm,andunder-prediction in the 16 cm and 24 cm diameter classes.The goodness of fit tested by KolmogorovSmirnov(KS) test showed no significant differences(p>0.05) between the observed and predicted diameter distributions for almost all plots.Using site index and aboveground biomass(AGB) models developed for P.thunbergii in South Korea,a model to predict the AGB per ha for each diameter class and subsequently the total AGB of the stand was created.An application guide was also created,which will serve as a decision-support tool for forest managers in quantifying the future total AGB in P.thunbergii stands located in the eastern coast of South Korea and,subsequently,the quantification of potential carbon stocks aside from being a vital input in designing efficient management and protection strategies for these stands. | ABINO Azyleah Canizares KIM Sung Yong LUMBRES Roscinto Ian Canicosa JANG Mi Na YOUN Ho doong PARK Ki Hyung LEE Young Jin | 2016 | Journal of Mountain Science2016，13，5： | 2 |
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