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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | Liver inflammatory pseudotumor or parasitic granuloma?显示文摘INTRODUCTION Liver pseudotumor is a very rare benign lesion.Since the first case reported by Pack and Baker in1953,only 40 cases had been reported up to 1996.The diagnostic challenge of hepatic inflammatorypseudotumor is emphasized by the fact that most ofthe reported cases were diagnosed by surgicalprocedures.Pathogenesis and etiology of | Ji XL Shen MS Yin T | 2000 | World Journal of Gastroenterology2000，6，3： | 3 |
| 3 | Cyclosporin A protects Balb/c mice from liver damage induced by superantigen SEB and D-GaIN显示文摘AIM To investigate the pathogenic effect ofSEB and D-GalN on liver and the protection ofcyclosporin A, the relationship between hepaticapoptosis and necrosis and the possiblemechanism of acute hepatic necrosis.METHODS After staphylococcal enterotoxin B(SEB ) mixed with D--galactosamine (D-GaiN )were injected intraperitoneally into Balb/c miceand those previously treated with cyclosporin A,blood samples were collected and livers wereisolated at 2, 6, 12 and 24 h. Patterns othepatocellular death were studiedmorphologically and biochemically, circulatingcytokines (TNF-a, IFN--y ) and mice mortalitywithin 24h was assessed.RESU’LTS The SEB could induce the typicalapoptotic changes of hepatocytes, the D-GaiNcould induce hepatocytes apoptosis anddegeneration at the same time, and the micehaving received the SEB + D-GaiN injectionsdeveloped apoptosis at 2 and 6 h, but after 12 hhepatocytes were characterized by severein jury, whereas all the examinations in thecyclosporin A treated mice were normal.CONCLUSION Hepatic cell apoptosis might berelated to necrosis, and massive hepatocyteapoptosis is likely the initiating step of acutehepatic necrosis in mice. The effects induced bySEB and D--GaiN on hepatocytes might bemediated by T cells, and could be prevented bycyclosporin A. | Yin, T Tong, SQ Xie, YC Lu, DY | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 4 | Targeting EGFR and sonic hedgehog pathways for locally advanced eyelid and periocular carcinomas显示文摘For patients with metastatic or locally advanced eyelid and periocular carcinoma not amenable to surgical excision, targeted therapies have shown efficacy with better tolerability compared to cytotoxic chemotherapy. Overexpression of epithelial growth factor receptor was found in squamous cell carcinomas. Vismodegib targets the mutation in the hedgehog pathway identified in basal cell carcinoma and basal cell nevus syndrome. Targeted therapies provide a novel and potentially effective treatment alternative for patients with eyelid carcinoma not amendable for surgery, including those with metastatic, locally advanced disease, advanced age, and significant comorbidities. High cost, need for long-term treatment, and toxicity are relative limitations. | Vivian T Yin Helen Merritt Bita Esmaeli | 2014 | World Journal of Clinical Cases2014，2，9： | 2 |
| 5 | E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas显示文摘 | Tamura G Yin J Wang S Fleisher AS Zou T Abraham JM Kong D Smolinski KN Wilson KT James SP Silverberg SG Nishizuka S Terashima M Motoyama T Meltzer SJ | | 0，，： | 2 |
| 6 | Stability analysis and design of fuzzy control systems显示文摘 | Yin T K | 1992 | Fuzzy Sets and Systems1992，45，2： | 2 |
| 7 | Photoreductive dehalogenation of halogenated benzene derivatives using ZnS or CdS nanocrystallites as photocatalysts 显示文摘 | YIN H B RWADA Y J KITAMURA T | 2001 | Environ Sci Technol2001，35，： | 1 |
| 8 | Role of probucol in preventing contrast-induced acute kidney injury after coronary interventional procedure显示文摘 | Li G P Yin L Liu T | 2009 | Am J Cardiol2009，103，4： | 1 |
| 9 | A Si- Mo Fused Slurry Coating for Oxidation Protection of Carbon/Carbon Composites 显示文摘 | Fang H T Zhu J C Yin D Z | 2001 | Journal of Materials Sciences Letters2001，20，2： | 1 |
| 10 | Synthesis andproperties of highly sulfonated proton conductingpolyimides from bis(3-sulfopropoxy)benzidine diam-ines显示文摘 | Yin Y Fang J H Watari T | 2004 | Journal of Material Chemistry2004，14，： | 1 |
| 11 | PTD4 - apoptin protein anddacarbazine show a synergistic antitumor effect on B16 - FImelanoma in vitro and in vivo 显示文摘 | Jin J L Gong J Yin T J | 2011 | Eur J Pharmacol2011，654，1： | 1 |
| 12 | Uniform silver nanowires synthesis by reducing AgNO3 with ethylene glycol in the presence of seeds and poly (vinyl pyrrolidone)显示文摘 | Sun Y Yin Y Mayers B T | | 0，，11： | 1 |
| 13 | Downregulation of adiponectin induced by tumor necrosis factor alpha is involved in the aggravation of posttraumatic myocardial ischemia/reperfusion injury显示文摘 | Liu S Yin T Wei X | | 0，，： | 1 |
| 14 | Time-Resolved Electronic Phase Transitions in Manganites 显示文摘 | Ward T Z Zhang X G Yin L F | 2009 | Phys Rev Lett2009，102，： | 1 |
| 15 | Cross-linking of gelatin by chlo- rine dioxide steam显示文摘 | He S Yin T Zhen J | 2015 | Food Hydrocolloids2015，45，1： | 1 |
| 16 | Dynamic reduction-based structural damage detection of transmission tower utilizing ambient vibration data 显示文摘 | Yin T Lam H F Chow H M | 2009 | Engineering Structures2009，31，9： | 1 |
| 17 | Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1-rationale and perspectives 显示文摘 | Yin T Miyata T | 2007 | Thromb Res2007，120，1： | 1 |
| 18 | Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1-Rationate and perspectives 显示文摘 | Yin T Miyata T | 2007 | Thrombosis Research2007，120，1： | 1 |
| 19 | Dynamic reduction-based structural damage detection of transmission tower utilizing ambient vibration data显示文摘 | Yin T Lam H F Chow H M | 2009 | Engineering Structures2009，，31： | 1 |
| 20 | Geologic evolution of the Him alaya Tibetan orogen 显示文摘 | Yin A Harris on T M | 2000 | Earth Planet Sciences2000，81，： | 1 |
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