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| 1 | The effects of land consolidation on the ecological connectivity based on ecosystem service value: A case study of Da'an land consolidation project in Jilin province显示文摘Land consolidation has a profound impact on landscape patterns and ecological functions at various scales through engineering and biological measures. In recent years, China invests more than 100 billion RMB yuan on land consolidation each year. To understand how land consolidation affects landscape patterns and ecosystems, we investigated the ecosystem service value and the ecological connectivity in a consolidated area of Da'an city from 2008 to 2014 using a revised ecological connectivity index. The results indicated that land consolidation has certain negative influences on the ecosystem services in this area. The total ecosystem service value will decrease by nearly 30% in the late stage of consolidation. This decrease is caused by the loss of ecosystem service of the wetland and grassland, despite a sensible increase of cultivated land. In addition, land consolidation could change the ecological connectivity as well as the land use structure. Up to 85% of the entire area will be in low connectivity in the late stage of consolidation, representing a 6.23% increase in the total coverage compared to pre-consolidation. Finally, the different connectivity landscape and their key areas can be identified by the revised ecological connectivity index effectively. This study is helpful to trace out the relationships between landscape pattern and ecological process, and provides insights for ecological planning and designing of land consolidation in this area. We suggest that more attentions should be paid to improve the quality and ecosystem service value per unit area of the landscape, to establish ecological compensation mechanism of wetland losses, and to create the ecological corridors along the least accumulated impendence surface in the key areas during land consolidation. | WANG Jun YAN Shenchun GUO Yiqiang LI Junran SUN Guoqing | 2015 | Journal of Geographical Sciences2015，25，5： | 26 |
| 2 | HMGB 1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts显示文摘支持发炎的因素(HMGB1 ) 高活动性的组盒子蛋白质 1 在气喘的致病被含有。在这研究,我们使用了长期的气喘的一个鼠科的模型在航线改变上评估 HMGB1 的效果。女 BALB/c 老鼠随机被划分成四个组:控制, ovalbumin (卵) 气喘, OVA+适应于不同地区生活的动物抗体和 OVA+ anti-HMGB1 抗体。Anti-HMGB1 抗体治疗在白天 21 上被开始并且与卵在 intranasal 挑战前每星期被管理三次 6 个星期。在这个鼠标模型, HMGB1 表示显著地被提高。anti-HMGB1 抗体组展出了免疫球蛋白 E (IgE ) 和煽动性的调停人的减少的层次并且与卵组相比减少了煽动性的房间累积,航线 hyperresponsiveness (AHR ) ,粘液合成,光滑的肌肉厚度和肺骨胶原内容。有 HMGB1 的治疗增加了增长,移植,骨胶原分泌物和 α在 MRC-5 房间的光滑的肌肉肌动朊(SMA ) 表示。有 HMGB1/IL-1β 的处理;建筑群显著地增加了转变生长因素的表示和分泌物(TGF-β 1 ) ,矩阵 metalloproteinase (MMP )-9 和脉管的 endothelial 生长因素(VEGF ) 。总的来说,这些结果建议那项堵住的 HMGB1 活动可以颠倒航线由压制航线发炎和 modulating 肺成纤维细胞显型和激活改变。 | Changchun H ou Jinliang Kong Yue Liang Hong Huang Hanchun Wen Xiaowen Zheng Lihong Wu Yiqiang Chen | 2015 | Cellular & Molecular Immunology2015，12，4： | 19 |
| 3 | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination显示文摘 | Yiqiang Cui Yuyu Niu Jiankui Zhou Yongchang Chen Yiwei Cheng Shangang Li Zongyong Ai Chu Chu Hong Wang Bo Zheng Xuejin Chen Jiahao Sha Xuejiang Guo Xingxu Huang Weizhi Ji | 2018 | Cell Research2018，28，3： | 13 |
| 4 | Construction and external validation of a nomogram that predicts lymph node metastasis in early gastric cancer patients using preoperative parameters显示文摘Objective: To create a nomogram to predict the incidence of lymph node metastasis(LNM) in early gastric cancer(EGC) patients and to externally validate the nomogram.Methods: To construct the nomogram,we retrospectively analyzed a primary cohort of 272 EGC patients.Univariate analysis and a binary logistic regression were performed.A nomogram predicting the incidence of LNM in EGC patients was created.The discrimination ability of the nomogram was measured using the concordance index(c-index),and the nomogram was also calibrated.Then,another prospective cohort of 81 patients was analyzed to validate the nomogram.Results: In the primary cohort,LNM was pathologically confirmed in 37(13.6%) patients.In multivariate analysis,the presence of an ulcer,the maximum lesion diameter observed via gastroscopy,the thickness of the lesion observed via endoscopic ultrasonography,and the presence of enlarged lymph nodes on computed tomography(CT) were independent risk factors for LNM.A nomogram was then created based on the regression model with the c-index of 0.905,and the calibration curve of the nomogram fell approximately on the ideal 45-degree line.The cut-off score of the nomogram was 110,and the sensitivity,specificity,positive predictive and negative predictive values of the nomogram in the primary cohort were 81.1%,86.0%,47.6% and 96.7%,respectively,and in the prospective validation cohort were 75.0%,91.0%,60.0% and 95.5%,respectively.The calibration curve of the external validation cohort was almost on the 45-degree line.Conclusions: We developed an effective nomogram predicting the incidence of LNM for EGC patients. | Yinan Zhang Yiqiang Liu Ji Zhang Xiaojiang Wu Xin Ji Tao Fu Ziyu Li Qi Wu Zhaode Bu Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，6： | 12 |
| 5 | Prognostic role of lymph node metastasis in early gastric cancer显示文摘Objective: To clarify the relationship between clinicopathological features and lymph node metastasis and to propose the potential indications of lymph node metastasis for prognosis in early gastric cancer(EGC) patients. Methods: We retrospectively observed 226 EGC patients with lymph node resection, and analyzed the associations between lymph node metastasis and clinicopathological parameters using the chi-square test in univariate analysis and logistic regression analysis in multivariate analysis. Overall survival analysis was determined using the Kaplan-Meier and log-rank test. We conducted multivariate prognosis analysis using the Cox proportional hazards model.Results: Of all the EGC patients, 7.5%(17/226) were histologically shown to have lymph node metastasis. The differentiation, lymphovascular invasion and depth of invasion were independent risk factors for lymph node metastasis in EGC. The 5- and 10-year survival rates were significantly lower in patients with lymph node metastasis than in those without and the patients also had shorter progress-free survival time. Lymph node metastasis and tumor size were independent prognostic factors for EGC. The status of the lymph nodes was a significant factor in predicting recurrence or metastasis after surgery. Conclusions: The undifferentiated carcinoma and lymphovascular and/or submucosal invasion were associated with a higher incidence of lymph node metastasis in EGC patients, whom need to perform subsequent D2 lymphadenectomy or laparoscopic lymph node dissection and more rigorous follow-up or additional chemotherapy/radiation after D2 gastrectomy for poor prognosis and high recurrence/metastasis rate. | Zhixue Zheng Yiqiang Liu Zhaode Bu Lianhai Zhang Ziyu Li Hong Du Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，2： | 12 |
| 6 | Partial discharge characteristics of interturn insulation used for inverter-fed traction motor under bipolar impulses显示文摘Inverter-fed traction motors,which are employed for electric-multiple-units(EMUs),are subjected to Pulse Width Modulated(PWM) impulse voltage.Impulse voltage has fast rise/fall time and high repetition frequency.The failure mechanism of insulation under impulses is different from that of standard 50 Hz sinusoidal condition.Partial discharge(PD) characteristics(discharge number,mean discharge quantity and phase resolved partial discharge(PRPD) pattern) with different frequencies and different rise times of impulse voltage were investigated.The results reveal that discharge number and mean discharge quantity increase,while PRPD pattern moves to the zero of impulse voltage with decrease of rise time.Discharge number and PRPD pattern follow that trend with increase of frequency,the value of mean discharge quantity is similar.Memory effect of the deposited space charges on PD was studied.PRPD pattern moves to the zero of bipolar impulse voltage due to the role of space charges,with increase of frequency and decrease of rise time.It is revealed that available discharge time is prolonged and overvoltage across the cavity increases with augment of frequency,which results in discharge number increasing.Under the condition of shortening the rise time,with the same statistical time lag tL,△V would increase if dV/dt is higher,which results in enhancement of discharge quantity.Discharge number increases with reduction of rise time,because the decreased multiple of td is lower than the increased multiple of dV/dt.Study of PD characteristics and role of space charges is helpful to the exploration of the destructive mechanism of insulating materials under bipolar impulse. | WU GuangNing CAO KaiJiang LUO Yang GAO Bo WANG Peng ZHANG YiQiang XU HuiHui | 2012 | Science China(Technological Sciences)2012，55，8： | 9 |
| 7 | Effect Comparison of different formulation of Dang-Gui-Bu-Xu-Tang on myelosuppression mouse显示文摘Objective:To compare effect of different formulation of Dang-Gui-Bu-Xu-Tang(DCBXT) on myelosuppression mouse.Methods:HPLC was used to measure active ingredients of two DGBXT formulations,Hemopoesic function of bone marrow was measured by hemopoietic progenitor cell culture and peipheral blood count.And hemopoietic factors in bone marrow were tested by ELISA.Results:The content level of astragaloside A in granule formulation was higher than that in decoction and the content ratio of active ingredient was close to 5:1.Two DGBXD formulations could significantly improve amount of peripheral blood cells,and bone marrow cells of bone marrow suppression mice(P<0.05).DGBXD granule formulation significantly increased the colony quantity of all progenitor cell lines and amount of G2/M and S phase cells(P<0.05). It also significantly decreased amount of G0/G1 phase cells in the bone marrow and was more effective(P<0.05).Conclusions:DGBXT decoction and the granule formulation all can improve the hematopoietic function of bone marrow suppression mouse.They can improve quantities of peripheral blood and nucleated bone marrow cells,and yield of the hematopoietic stem/progenitor cells in vitro colony;balance the expression of cytokine(EPO,TPO and GM-GSF) in bone marrow microenvirement.They can also facilitate hematopoietic stem/progenitor cells to enter the cell cycle.And the effect of granule formulation is more satisfactory. | Suchun Yan Yiqiang Xie Bide Zhu Yingguang Han Wei Guo | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 9 |
| 8 | Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys显示文摘 | Yongchang Chen Yiqiang Cui Bin Shen Yuyu Niu Xiaoyang Zhao Lei Wang Jianying Wang Wei Li Qi Zhou Weizhi Ji Jiahao Sha Xingxu Huang | 2015 | Cell Research2015，25，2： | 8 |
| 9 | Shear strength of frozen clay under freezing-thawing cycles using triaxial tests显示文摘Using a new low-temperature dynamic triaxial apparatus, the influence law of freezing-thawing cycles on clay shear strength is studied. In this research, the concept of correction coefficients of freezing-thawing cycles on clay static strength, cohesion and internal friction angles is proposed, and the change patterns, correction curves and regressive formulae of clay static strength, cohesion and internal friction angles under freezing-thawing cycles are given. The test results indicate that with increasing numbers of freezing-thawing cycles, the clay static strength and cohesion decrease exponentially but the internal friction angle increases exponentially. The performance of static strength, cohesion and internal friction angles are different with increasing numbers of freezing-thawing cycles, i.e., the static strength decreases constantly until about 30% of the initial static strength prior to the freezing-thawing cycling and then stays basically stable. After 5-7 freezing-thawing cycles, the cohesion decreases gradually to about 70% of the initial cohesion. The internal friction angle increases about 20% after the first freezing-thawing cycle, then increases gradually close to a stable value which is an increase of about 40% of the internal friction angle. The freezing-thawing process can increase the variation of the density of the soil samples; therefore, strict density discreteness standards of frozen soil sample preparation should be established to ensure the reliability of the test results. | Wang Miao Meng Shangjiu Sun Yiqiang Fu Haiqing | 2018 | Earthquake Engineering and Engineering Vibration2018，17，4： | 8 |
| 10 | Pathogenic effects of biofilm with chronic pseudomonas aeruginosa lung infection in rats显示文摘Objective:To establish an animal model of P.aeruginosa biofilm associated with chronic pulmonary infection and investigate the pathogenic effects of biofilm.Methods:Experiments in vitro,measuring the MICS,MBCS of levofloxacin(LFX),ceftazidime(CAZ)in PAO579 in alginate beads and planktonic PAO579.Rats were challenged with 0.1 ml of PAO579(109CFU/ml)in alginate beads or 0.1 ml of planktonic PAO579(109 CFU/ml),3,7,14 days after challenging,bacteriological,pathological features were observed.Results:The MICS,MBCS of LFX,CAZ in PAO579 in alginate beads were higher than those in planktonic PAO579 in vitro.CFU/lung in alginate beads group was significantly higher than that in planktonic bacteria group(P = 0.002,P = 0.004,P = 0.002,respectively);macroscopic lung pathology and the inflammation in alginate beads group were significantly more severe compared to those in planktonic bacteria group in vivo.Conclusion:P.aeruginosa biofilm protected bacterium from killing of antibiotics and might mediate the host immune damage in the lung tissue and made bacterium evade the host immune defense. | Ping Yan Yiqiang Chen Zhijun Song Hong Wu Jinliang Kong Xuejun Qin | 2008 | Journal of Nanjing Medical University2008，22，1： | 7 |
| 11 | Rotation of the Earth as a Triaxial Rigid Body显示文摘The Earth is taken as a triaxial rigid body, which rotates freely in the Euclidian space. The starting equations are the Euler dynamic equations, with A smaller than B and B smaller than C. The Euler equations are solved, and the numerical results are provided. In the calculations, the following parameters are used: (C-B)/A=0.003 273 53; (B-A)/C=0.000 021 96; (C-A)/B=0.003 295 49, and the mean angular velocity of the Earth's rotation, ω =0.000 072 921 15 rad/s. Calculations show that, besides the self-rotation of the Earth and the free Euler procession of its rotation, there exists the free nutation: the nutation angle, or the angle between the Earth's momentary rotation axis and the mean axis that periodically change with time. The free nutation is investigated. | SHEN Wenbin CHEN Wei WANG Wenjun LIANG Yiqiang | 2007 | Geo-Spatial Information Science2007，10，2： | 6 |
| 12 | Nest predators, nest-site selection and nest success of the Emei Shan Liocichla(Liocichla omeiensis), a vulnerable babbler endemic to southwestern China显示文摘Background: The Emei Shan Liocichla(Liocichla omeiensis) is a globally vulnerable babbler, endemic to southwestern China. We investigated its nest predators, nest-site selection and nest success at the Laojunshan National Nature Reserve in Sichuan, China in order to identify the precise nesting-habitat requirements of the species, and to test whether the nest-site-selection cues, preferred by the Emei Shan Liocichla, are positively associated with nest success.Methods: We used infrared cameras to determine nest predators. We compared the microhabitat attributes between nest and random sites, as well as successful and failed nests. We used Binary Logistic Regression to determine the most important variables affecting nest-site selection of the Emei Shan Liocichla. We used the nest survival analysis in Program MARK to estimate daily nest survival rates(DSR). Nest success was calculated using the Mayfield method.Results: In total 56 nests were found. The DSR for all nests that contained at least one egg was 0.9564 ± 0.0091(95 % CI 0.9346–0.9711)(n = 40), while the total nest success was 27.5 %. We identified four categories of predators in 10 nest predation events, i.e. squirrels(n = 5), snakes(n = 3), raptors(n = 1) and wasps(n = 1). We found that:(1) nest predation was the primary reason for nest failure of the Emei Shan Liocichla,(2) tree cover, bamboo cover, liana abundance and distance to forest edge or gap were the most important variables affecting nest-site selection of this species, and(3) the nest-site-selection variables we measured appeared not to be positively associated with nest success.Conclusions: Our findings suggest that the Emei Shan Liocichla tended to select nest sites near forest edges or gaps with good concealment and that nest-site selection by this species was nonrandom but not necessarily adaptive. Reducing forest-edge development and protecting bamboo stands should be effective for conservation of this species. | Yiqiang Fu Benping Chen Simon D.Dowell Zhengwang Zhang | 2016 | Chinese Birds2016，，3： | 6 |
| 13 | Evaluation of asthma control: a questionnaire-based survey in China显示文摘 | Su Nan Lin Jiangtao Chen Ping Li Jing Wu Changgui Yin Kaisheng Liu Chuntao Chen Yiqiang Zhou Xin Yuan Yadong Huang Xingang | 2014 | Chinese Medical Journal2014，，11： | 5 |
| 14 | The Adaptive LASSO Spline Estimation of Single-Index Model显示文摘In this paper, based on spline approximation, the authors propose a unified variable selection approach for single-index model via adaptive L1 penalty. The calculation methods of the proposed estimators are given on the basis of the known lars algorithm. Under some regular conditions, the authors demonstrate the asymptotic properties of the proposed estimators and the oracle properties of adaptive LASSO(aL ASSO) variable selection. Simulations are used to investigate the performances of the proposed estimator and illustrate that it is effective for simultaneous variable selection as well as estimation of the single-index models. | LU Yiqiang ZHANG Riquan HU Bin | 2016 | Journal of Systems Science & Complexity2016，29，4： | 4 |
| 15 | Use of near-infrared reflectance spectroscopy for the rapid determination of the digestible energy and metabolizable energy content of corn fed to growing pigs显示文摘Background: The ability of near-infrared reflectance spectroscopy(NIRS) to determine the digestible energy(DE)and metabolizable energy(ME) content of corn fed to growing pigs was tested. One hundred and seventeen corn samples, comprising different planting regions and varieties were collected from all over China in a three-year period. The samples were randomly split into a calibration set(n = 88) and a validation set(n = 29). The actual and calculated DE and ME content of the corn samples was determined by digestion-metabolism experiments and the prediction equations of Noblet and Perez(J Anim Sci. 71:3389–98,1993). The samples were then subjected to NIRS scanning and calibrations were performed by the modified partial least square(MPLS) regression method based on77 different spectral pre-treatments. The NIRS equations based on the actually determined and calculated DE and ME were built separately and then validated using validation samples.Results: The NIRS equations obtained from actually determined DE, the coefficient of determination for calibration(RSQ_(cal)), cross-validation(R^2_(CV)), and validation(RSQ_v) were 0.89, 0.87 and 0.86, and these values for determined ME were 0.87, 0.86 and 0.86. For the NIRS equations built from calculated DE, the RSQ_(cal), R^2_(CV), and RSQvvalues were 0.88, 0.85 and 0.84, and these values for calculated ME were 0.86, 0.84 and 0.82. Except for the equation based on calculated ME(RPD_v= 2.38, < 2.50), the other three equations built from actually determined energy and calculated DE produced good prediction performance(RPD_vranging from 2.53 to 2.69, > 2.50) when applied to validation samples.Conclusion: These results indicate that NIRS can be used as a quantitative method for the rapid determination of the available energy in corn fed to growing pigs, and the NIRS equations based on the actually determined energy produced better predictive performance than those built from calculated energy values. | Juntao Li Quanfeng Li Defa Li Yiqiang Chen Xiaoxiao Wang Wenjun Yang Liying Zhang | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 4 |
| 16 | Solvent engineering towards scalable fabrication of high-quality perovskite films for efficient solar modules显示文摘Over the last decade,remarkable progress has been made in metal halide perovskite solar cells(PSCs),which have been a focus of emerging photovoltaic techniques and show great potential for commercialization.However,the upscaling of small-area PSCs to large-area solar modules to meet the demands of practical applications remains a significant challenge.The scalable production of high-quality perovskite films by a simple,reproducible process is crucial for resolving this issue.Furthermore,the crystallization behavior in the solution-processed fabrication of perovskite films can be strongly influenced by the physicochemical properties of the precursor inks,which are significantly affected by the employed solvents and their interactions with the solutes.Thus,a comprehensive understanding of solvent engineering for fabricating perovskite films over large areas is urgently required.In this paper,we first analyze the role of solvents in the solution-processed fabrication of large-area perovskite films based on the classical crystal nucleation and growth mechanism.Recent efforts in solvent engineering to improve the quality of perovskite films for solar modules are discussed.Finally,the basic principles and future challenges of solvent system design for scalable fabrication of high-quality perovskite films for efficient solar modules are proposed. | Zhaoyi Jiang Binkai Wang Wenjun Zhang Zhichun Yang Mengjie Li Fumeng Ren Tahir Imran Zhenxing Sun Shasha Zhang Yiqiang Zhang Zhiguo Zhao Zonghao Liu Wei Chen | 2023 | Journal of Energy Chemistry2023，，5： | 4 |
| 17 | Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant显示文摘A moderate inflammatory response at the early stages of fracture healing is necessary for callus formation.Over-active and continuous inflammation,however,impairs fracture healing and leads to excessive tissue damage.Adequate fracture healing could be promoted through suppression of local over-active immune cells in the fracture site.In the present study,we achieved an enriched concentration of PD-L1 from exosomes(Exos)of a genetically engineered Human Umbilical Vein Endothelial Cell(HUVECs),and demonstrated that exosomes overexpressing PD-L1 specifically bind to PD-1 on the T cell surface,suppressing the activation of T cells.Furthermore,exosomal PD-L1 induced Mesenchymal Stem Cells(MSCs)towards osteogenic differentiation when pre-cultured with T cells.Moreover,embedding of Exos into an injectable hydrogel allowed Exos delivery to the surrounding microenvironment in a time-released manner.Additionally,exosomal PD-L1,embedded in a hydrogel,markedly promoted callus formation and fracture healing in a murine model at the early over-active inflammation phase.Importantly,our results suggested that activation of T cells in the peripheral lymphatic tissues was inhibited after local administration of PD-L1-enriched Exos to the fracture sites,while T cells in distant immune organs such as the spleen were not affected.In summary,this study provides the first example of using PD-L1-enriched Exos for bone fracture repair,and highlights the potential of Hydrogel@Exos systems for bone fracture therapy through immune inhibitory effects. | Ze Lin Yuan Xiong Weilin Meng Yiqiang Hu Lili Chen Lang Chen Hang Xue Adriana CPanayi Wu Zhou Yun Sun Faqi Cao Guodong Liu Liangcong Hu Chenchen Yan Xudong Xie Chuanchuan Lin Kaiyong Cai Qian Feng Bobin Mi Guohui Liu | 2022 | Bioactive Materials2022，7，7： | 4 |
| 18 | Community structure and carbon and nitrogen storage of sagebrush desert under grazing exclusion in Northwest China显示文摘Overgrazing is regarded as one of the key factors of vegetation and soil degradation in the arid and semi-arid regions of Northwest China.Grazing exclusion(GE)is one of the most common pathways used to restore degraded grasslands and to improve their ecosystem services.Nevertheless,there are still significant controversies concerning GE’s effects on grassland diversity as well as carbon(C)and nitrogen(N)storage.It remains poorly understood in the arid desert regions,whilst being essential for the sustainable use of grassland resources.To assess the effects of GE on community characteristics and C and N storage of desert plant community in the arid desert regions,we investigated the community structure and plant biomass,as well as C and N storage of plants and soil(0-100 cm depth)in short-term GE(three years)plots and adjacent long-term freely grazing(FG)plots in the areas of sagebrush desert in Northwest China,which are important both for spring-autumn seasonal pasture and for ecological conservation.Our findings indicated that GE was beneficial to the average height,coverage and aboveground biomass(including stems,leaves and inflorescences,and litter)of desert plant community,to the species richness and importance values of subshrubs and perennial herbs,and to the biomass C and N storage of aboveground parts(P<0.05).However,GE was not beneficial to the importance values of annual herbs,root/shoot ratio and total N concentration in the 0-5 and 5-10 cm soil layers(P<0.05).Additionally,the plant density,belowground biomass,and soil organic C concentration and C storage in the 0-100 cm soil layer could not be significantly changed by short-term GE(three years).The results suggest that,although GE was not beneficial for C sequestration in the sagebrush desert ecosystem,it is an effective strategy for improving productivity,diversity,and C and N storage of plants.As a result,GE can be used to rehabilitate degraded grasslands in the arid desert regions of Northwest China. | DONG Yiqiang SUN Zongjiu AN Shazhou JIANG Shasha WEI Peng | 2020 | Journal of Arid Land2020，12，2： | 3 |
| 19 | Association between HER2 status and response to neoadjuvant anthracycline followed by paclitaxel plus carboplatin chemotherapy without trastuzumab in breast cancer显示文摘Background:We recently showed HER2-positive breast cancers are less likely to respond to neoadjuvant anthracycline chemotherapy.Here,we investigated whether HER2-positive breast cancers responded to sequential neoadjuvant anthracycline followed by paclitaxel plus carboplatin regimen in the absence of trastuzumab.Methods:Women(n=372) with operable primary breast cancer initially received two cycles of neoadjuvant anthracyclines,the clinical tumor response was assessed,then patients were received four cycles of paclitaxel plus carboplatin regimen.All the patients did not received trastuzumab treatment in the neoadjuvant setting.HER2 status was determined by immunohistochemistry and/or by fluorescence in situ hybridization in corebiopsy breast cancer tissue obtained before the neoadjuvant chemotherapy.Results:Eighteen percent(67/372) of patients achieved a pathologic complete response(p CR) in their breast.HER2-positive tumors had a significant higher p CR rate than HER2-negative tumors(33.0% versus 13.5%,P<0.001) in this cohort of 372 patients,and positive HER2 status remained an independent favorable predictor of p CR in a multivariate analysis [odds ratio(OR),2.26;95% confidence interval(CI),1.18 to 4.36,P=0.015].Furthermore,patients who responded to initial anthracycline regimens were more likely to respond to paclitaxel plus carboplatin than patients who did not(p CR,27.2% versus 14.6%,P=0.005).Patients with HER2-positive tumors exhibited a significant higher p CR rate than did patients with HER2-negative tumors in both anthracycline response group(40.5% versus 20.0%,P=0.025) and anthracycline non-response group(28.3% versus 11.3%,P=0.002).Conclusions:Under the circumstance of no trastuzumab treatment,women with HER2-positive cancers derive a large benefit from paclitaxel-carboplatin-based neoadjuvant chemotherapy. | Lu Yao Juan Zhang Yiqiang Liu Tao Ouyang Jinfeng Li Tianfeng Wang Zhaoqing Fan Tie Fan Benyao Lin Yuntao Xie | 2015 | Chinese Journal of Cancer Research2015，27，6： | 3 |
| 20 | Effects of marine sediment on the response of a submerged floating tunnel due to p- wave incidence显示文摘Submerged floating tunnel (SFT) is a novel type traffic structure for crossing long strait and deep lakes. To investigate the dynamic pressure acting on an SFT under compression (P) wave incidence, a theoretical analysis model considering marine sediment effect has been proposed. Based on displacement potential functions, the reflection and refraction coefficients of P wave in different media are derived. Numerical examples are employed to illustrate the effects of the thickness of sediment layer, the incident P wave angle, the tether stiffness and spacing, and the permeability of the sediment on the dynamic pressure loading on the SFT. The results show that dynamic pressure is related to the saturation of sediment and affected by the thickness of sediment. The partially saturated sediment will amplify the dynamic pressure loading on the SFT, and the resonance frequency increases a little with the fully saturated sediment. Besides, increasing the tether stiffness and decreasing in the tether spacing will lead to a dynamic pressure falling. Deepening the SFT position and reducing the permeability of the sediment are effective measures to reduce dynamic pressure acting on the SFT. | Heng Lin Yiqiang Xiang Zhengyang Chen Ying Yang | 2019 | Acta Mechanica Sinica2019，35，4： | 3 |
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