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| 1 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 2 | Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas显示文摘 | Yu Hou Huahu Guo then Cao Xianlong Li Boqiang Hu Ping Zhu Xinglong Wu Lu Wen FuchouTang Yanyi Huang Jirun Peng | 2016 | Cell Research2016，26，3： | 48 |
| 3 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 4 | Distribution of heavy metals in sediments of the Pearl River Estuary,Southern China:Implications for sources and historical changes显示文摘The distribution of heavy metals(Pb,Zn,Cd and As) in sediments of the Pearl River Estuary was investigated.The spatial distribution of heavy metals displayed a decreasing pattern from the turbidity maxima to both upstream and downstream of the estuary,which suggested that suspended sediments played an important role in the trace metal distribution in the Pearl River Estuary.In addition,metal concentrations were higher in the west part of the estuary which received most of the pollutants from the Pearl River.In the sediment cores,fluxes of heavy metals were consistent with a predominant anthropogenic input in the period 1970-1990.From the mid-1990s to the 2000s,there was a significant decline in heavy metal pollution.The observed decline has shown the result of pollution control in the Pearl River Delta.However,it is noteworthy that the metal concentrations in the most recent sediment still remained considerably high.Taken together,the enrichment of heavy metals in sediments was largely controlled by anthropogenic pollution. | Feng Ye Xiaoping Huang Dawen Zhang Lei Tian Yanyi Zeng | 2012 | Journal of Environmental Sciences2012，24，4： | 18 |
| 5 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 6 | H3K4me3 epigenomic landscape derived from ChIP-Seq of 1000 mouse early embryonic cells显示文摘 | Jie Shen Dongqing Jiang Yusi Fu Xinglong Wu Hongshan Guo Binxiao Feng Yuhong Pang Aaron M Streets Fuchou Tang Yanyi Huang | 2015 | Cell Research2015，25，1： | 4 |
| 7 | Thermochronology of Mesozoic Sandstone from the Beipiao Basin and Its Implication to Meso-Cenozoic Tectonic Evolution of the Eastern Yan-Liao Orogenic Belt显示文摘Combining the single-grain low-temperature apatite fission track with high-temperature zircon U-Pb dating of sandstone can better reveal the temporal association between the source and depositional site, and identify both the age component of the source terrain and subsequent thermo-tectonic events after deposition. This paper introduces the single- grain zircon U-Pb dating and fission track (FT) dating of sediments from the Beipiao basin in Northeast China. The U-Pb ages of 18 single zircon grains collected from the early Jurassic Beipiao Formation range from 194.3±2.9 to 233.8±4.2 Ma and most of apatite FT ages are about 30-40 Ma, indicating that the eastern part of the Yan-Liao orogenic belt experienced an obvious tectonic seesawing during Meso-Cenozoic time. The eastern part of Liaoning Province (the Liaodong block) uplifted in the early Mesozoic (230-190 Ma) and formed a geological landscape of high mountains, while the western part of the province (the Liaoxi area) subsided relatively and thousand-meter-scale sediments were deposited. During the Cenozoic (30-40 Ma), the Liaoxi area uplifted as a whole, and the Xialiaohe Basin sank intensively. The topographic landscape had a great change: high mountains in the west and east of Liaoning Province and low plains in the central area. | YANYi LINGe XIABin LIZi'an LIZhongcheng | 2005 | Acta Geologica Sinica(English Edition)2005，79，2： | 3 |
| 8 | A Multifunctional Anti-Proton Electrolyte for High-Rate and Super-Stable Aqueous Zn-Vanadium Oxide Battery显示文摘Large volumetric expansion of cathode hosts and sluggish transport kinetics in the cathode–electrolyte interface,as well as dendrite growth and hydrogen evolution at Zn anode side are considered as the system problems that cause the electrochemical failure of aqueous Zn-vanadium oxide battery.In this work,a multifunctional anti-proton electrolyte was proposed to synchronously solve all those issues.Theoretical and experimental studies confirm that PEG 400 additive can regulate the Zn^(2+) solvation structure and inhibit the ionization of free water molecules of the electrolyte.Then,smaller lattice expansion of vanadium oxide hosts and less associated by-product formation can be realized by using such electrolyte.Besides,such electrolyte is also beneficial to guide the uniform Zn deposition and suppress the side reaction of hydrogen evolution.Owing to the integrated synergetic modifica-tion,a high-rate and ultrastable aqueous Zn-V_(2)O_(3)/C battery can be constructed,which can remain a specific capacity of 222.8 m Ah g^(-1)after 6000 cycles at 5 A g^(-1),and 121.8 m Ah g^(-1) even after 18,000 cycles at 20 A g^(-1),respectively.Such“all-in-one”solution based on the electrolyte design provides a new strategy for developing high-performance aqueous Zn-ion battery. | Yangwu Chen Dingtao Ma Kefeng Ouyang Ming Yang Sicheng Shen Yanyi Wang Hongwei Mi Lingna Sun Chuanxin He Peixin Zhang | 2022 | Nano-Micro Letters2022，14，9： | 3 |
| 9 | Immobilization of insulin-like growth factor-1 onto thermosensitive hydrogels to enhance cardiac progenitor cell survival and differentiation under ischemic conditions显示文摘Stem cell therapy is a promising approach to treat myocardial infarction. However, direct delivery of stem cells into hearts experiences poor cell engraftment and differentiation, due to ischemic conditions(low nutrient and oxygen) in the infarct hearts. Development of suitable cell carriers capable of supporting cell survival and differentiation under these harsh conditions is critical for improving the efficacy of current stem cell therapy. In this work, we created a family of novel cell carriers based on thermosensitive hydrogels and insulin-like growth factor 1(IGF-1), and investigated if these cell carriers can improve cell survival and differentiation under ischemic conditions. The thermosensitive hydrogels were synthesized from N-isopropylacryla- mide, acrylic acid, acrylic acid N-hydroxysuccinicimide ester, and 2-hydroxyethyl methacrylate-oligo(hydroxybutyrate). The hydrogel solutions can be readily injected through 26G needles, and can quickly solidify at 37 oC to form highly flexible hydrogels. IGF-1 was immobilized into the hydrogels in order to support long-term cell survival and differentiation. Different amount of IGF-1 was immobilized by using hydrogels with different content of N-hydroxysuccinicimide ester groups. Cardiosphere derived cells were encapsulated in the hydrogels and cultured under ischemic conditions. The results demonstrated that a significant improvement of cell survival and differentiation was achieved after IGF-1 immobilization. These IGF-1 immobilized hydrogels have the potential to improve cell survival and differentiation in infarct hearts. | LI ZhenQing XU YanYi LI HaiChang GUAN JianJun | 2014 | Science China Chemistry2014，57，4： | 3 |
| 10 | Optical frequency divider with division uncertainty at the 10^(-21) level显示文摘Optical clocks with unprecedented accuracy of 10^(-18) promise innovations in many research areas.heir applications rely to a large extent on the ability of precisely converting the frequency from one optical clock to another,or particularly to the frequencies in the iber telecom band for long-distance transmission.his report demonstrates a low-noise,high-precision optical frequency divider,which realizes accurate optical frequency conversion and enables precise measurement of optical frequency ratios.By measuring against the frequency ratio between the fundamental and the second harmonic of a 1064-nm laser instead of a second copy of the same system,we demonstrate that the optical frequency divider has a fractional frequency division instability of 6×10^(-19) at 1 s and a fractional frequency division uncertainty of 1.4×10^(-21).he remarkable numbers can support frequency division of the best optical clocks in the world without frequency-conversion-caused degradation of their performance. | Yuan Yao Yanyi Jiang Hongfu Yu Zhiyi Bi Longsheng Ma | 2016 | National Science Review2016，3，4： | 3 |
| 11 | Progress and trend of narrow-linewidth lasers显示文摘High frequency stability, narrow-linewidth lasers have been long dreamed of since the invention of the laser. They have recently developed dramatically due to the advent of optical clocks. State-of-the-art narrow-linewidth lasers have been constructed by using the Pound-Drever-Hall (PDH) technique to lock the laser frequencies to the resonance of ultra-stable external optical cavities with high finesse. This paper introduces the developments of narrow-linewidth lasers, with a focus on the improvements of length stability of optical reference cavities, including optical cavity designs of vibration insensitivity and low thermal noise. Future trends and alternative methods for narrow-linewidth lasers are also discussed. | CHEN HaiQin JIANG YanYi BI ZhiYi MA LongSheng | 2013 | Science China(Technological Sciences)2013，56，7： | 3 |
| 12 | Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws显示文摘Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression. | Ming Ma Lu Liu Ruirui Shi Jianyun Zhang Xiaotian Li Xuefen Li Jiaying Bai Jianbin Wang Yanyi Huang Tiejun Li | 2021 | International Journal of Oral Science2021，13，2： | 3 |
| 13 | Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3显示文摘Class II HDACs, such as HDAC4, are critical regulators of the immune response in various immune cells;however, its role in innate immunity remains largely unknown.Here, we report that the overexpression of HDAC4 suppresses the production of type I interferons triggered by pattern-recognition receptors (PRRs). HDAC4 repressed the translocation of transcription factor IRF3 to the nucleus, thereby decreasing IRF3-mediated IFN-β expression. In particular, we also determined that HDAC4 can be phosphorylated and simultaneously block the phosphorylation of IRF3 at Ser386 and Ser396 by TBK1 and IKKε, respectively, by interacting with the kinase domain of TBK1 and IKKε. Furthermore, IFN-β may stimulate the expression of HDAC4. Our findings suggest that HDAC4 acts as a regulator of PRR signaling and is a novel mechanism of negative feedback regulation for preventing an overreactive innate immune response. | Qi Yang Jielin Tang Rongjuan Pei XiaoXiao Gao Jing Guo Chonghui Xu Yun Wang QianWang Chunchen Wu Yuan Zhou Xue Hu He Zhao Yanyi Wang Xinwen Chen Jizheng Chen | 2019 | Journal of Molecular Cell Biology2019，11，2： | 2 |
| 14 | Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis显示文摘Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma.However,a predictor of oral leukoplakia prognosis has not yet been identified.We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections.Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia.We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information.The malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)group.Together,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia. | Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 15 | Experimental Study on Hydrogen Leakage and Emission of Fuel Cell Vehicles in Confined Spaces显示文摘Hydrogen safety is one of the most important safety indicators in fuel cell vehicles(FCVs)(unlike in other types of alternative energy vehicles).This indicator in FCVs is directly related to the user’s personal safety in daily vehicle usage.This paper analyzes the safety standards of FCVs in confined spaces.A sealed test chamber and an appropriate test method are devel-oped to evaluate vehicle safety based on specific test requirements.Two FCVs are subjected to static hydrogen leakage and hydrogen emission testing performed in a confined space.The results reveal that the hydrogen concentration in the vicinity of the vehicles approximates 0.0004%which is much lower than 1%while parked for 8 h during the hydrogen leakage test.In the hydrogen emission test under operating conditions,the concentration of the hydrogen gas emitted from the vehicles exceeds 2300 ppm in the vicinity,which requires careful consideration.Based on experiment and analysis,recommendations for the hydrogen safety standards of FCVs in confined spaces are proposed. | Dong Hao Xiaobing Wang Yanyi Zhang Renguang Wang Guang Chen Jun Li | 2020 | Automotive Innovation2020，3，2： | 2 |
| 16 | Optical frequency division显示文摘Frequency can be measured much more precisely than any other physical quantity,and much of precision metrology depends critically on the measurement of frequency and its inverse,timeinterval.Optical electromagnetic waves(or‘light’),oscillating at more than 1014 per second,are at least 1000 times more precise for tim e/length measurement compared to microwave frequencies near 1 GHz.However,electronics do not respond to such rapid optical oscillations.Thus,optical frequencies cannot be measured directly,and must be divided down to the radiofrequency(RF)regime for electronic counting.It has been a historical challenge to realize optical frequency division with arbitrary divisors.In the 1970s;the absolute frequency of a methane-stabilized He-Ne laser was measured by dividing its frequency to the RF region with a frequency chain based on many nonlinear frequency conversions.By measuring the laser frequency,the measurement accuracy of the velocity of light was improved 100 times[1]. | Yuan Yao Yanyi Jiang Longsheng Ma | 2020 | National Science Review2020，7，12： | 2 |
| 17 | An integrated microfluidic device for long-term culture of isolated single mammalian cells显示文摘We developed an integrated microfluidic chip for long-term culture of isolated single cells. This polydimethylsiloxane (PDMS) based device could accurately seed each single cell into different culture chambers, and isolate one chamber from each other with monolithically integrated pneumatic valves. We optimized the culture conditions, including the frequency of medium replacement and the introduction of conditioned medium, to keep the single cells alive for 4 days. We cultured a few hundred cells in a separated chamber on the same chip to continuously supply the conditioned medium into the culture chambers for single cells. This approach greatly facilitated the growth of single cells, and created a suitable microenvironment for observing cells' autonomous process in situ without the interference of other adjacent cells. This single cell colony assay is expandable to higher throughput, fitting the needs in the studies of drug screening and stem cell differentiation. | ZHENG ChunHong CHEN Gui’E PANG YuHong HUANG YanYi | 2012 | Science China Chemistry2012，55，4： | 2 |
| 18 | A flow cytometry-based assay for quantitative analysis of cellular proliferation and cytotoxicity in vitro 显示文摘 | WANG Yanyi ZHANG Xiaoxiang | 2002 | Journal of Immunological Methods2002，268，3： | 1 |
| 19 | Photoelectric behavior of nanocrystalline TiO2 electrode with a novel terpyridyl ruthenium complex显示文摘 | Wang Zhongsheng Huang Chunhui Huang Yanyi | 2002 | Solar Energy Materials & Solar Cells2002，71，2： | 1 |
| 20 | Development of Automatic Fault Tree Synthesis System Using Decision Matrix 显示文摘 | YANG Zongxiao ZHENG Yanyi XUE Jinxue | 2009 | International Journal of Production Economics2009，，121： | 1 |
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