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    题名 作者 年代 出处 被引量
1激光剥蚀信号在线平滑和去汞装置:原位微区铅同位素准确分析利器显示文摘激光原位微区分析可在微观尺度上完成样品的元素定量分析或同位素组成测定,为研究成岩、成矿物质来源和追踪地壳与地幔演化历史提供了独特的观察视野。但是,激光剥蚀等离子体质谱的一些缺陷阻碍了地质样品的高精度、高空间分辨率分析,比如:剥蚀池的位置效应、低剥蚀速率下信号波动影响、激光剥蚀脉动式信号导致的光谱螺纹效应、高频激光剥蚀造成的元素分馏效应等。为此,一些学者设计了不同规格和样式的激光剥蚀信号平滑装置来克服这些问题。但是,这些信号平滑装置普遍还存在气体吹扫时间过长和降低激光剥蚀信号灵敏度等问题。因此,研制新型的信号平滑装置对改善LA—ICP—MS的数据质量具有重要的意义。Hu Z Zhang W Liu Y Gao S Li M Zong K Chen H Hu S 刘勇胜 2015矿物岩石地球化学通报2015,34,4:114
22019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W 2020中华高血压杂志2020,28,3:516
3Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells显示文摘Ma Y Xu Y Xiao Z Yang W Zhang C Song E Du Y Li L 2006中国生物学文摘2006,20,5:58
4Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo显示文摘Lin Y Luo E Chen X Liu L Qiao J Yan Z Li Z Tang W Zheng X Tian W 2006中国生物学文摘2006,20,5:31
5Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease显示文摘Tang B Xiong H Sun P Zhang Y Wang D Hu Z Zhu Z Ma H Pan Q Xia JH Xia K Zhang Z 2006中国生物学文摘2006,20,8:30
6新型冠状病毒公认受体血管紧张素转换酶2的单细胞RNA表达情况显示文摘研究发现,2019新型冠状病毒与严重急性呼吸综合征-冠状病毒(severe acute respiratory syndromecoronavirus,SARS-CoV)存在相同的受体———血管紧张素转换酶2(angiotensin converting enzyme 2,ACE2)。在此,研究者基于公共数据库和最新的单细胞转录组测序技术,分析了ACE2RNA在正常人肺中的表达谱。结果表明,ACE2的表达集中在一小部分Ⅱ型肺泡上皮细胞中。刘青(译) 叶鹏(审校) Zhao Y Zhao Z Wang Y Zhou Y Ma Y Zuo W 2020中华高血压杂志2020,28,3:24
7血管周围脂肪组织中的Bmal1通过血管紧张素原转录调控管理静息期血压显示文摘血管周围脂肪组织(perivascular adipose tissue,PVAT)围绕血管,构成了在生理条件下保持血管张力所需的脉管系统的独特的功能整体层。然而,关于PVAT与血压调节之间的关系的资料很少,包括其对昼夜血压变化的潜在作用。Chang L Xiong W Zhao X Fan Y Guo Y Garcia-Barrio M Zhang J Jiang Z Lin JD Chen YE 刘青 叶鹏 2018中华高血压杂志2018,26,2:23
8慢性阻塞性肺疾病加重期间肠道和肺部微生物的动态变化显示文摘肠道-肺微生态系统紊乱和调节障碍在慢性阻塞性肺疾病(COPD)恶化过程中发挥关键性作用然而,COPD急性加重期肠道-肺菌群的动态变化及其在疾病病因学中的潜在作用仍知之甚少。研究者为了解慢性阻塞性肺疾病急性加重期(AECOPD)肠道和肺部微生物的动态变化,在15例AECOPD患者急性发作第1、7天和第4天纵向收集90份标本(痰液和粪便标本各45份)。Sun Z Zhu QL Shen Y 曾雪涛(编译) 2020中华医学杂志2020,100,40:23
9Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome显示文摘Ma,X Fan,L Meng,Y Hou,Z Mao,YDL Wang,W Ding,W Liu,JY 2007南京医科大学学报(自然科学版)2007,27,11:20
10Yes相关蛋白通过肿瘤坏死因子受体相关因子6控制内皮活化和血管炎症显示文摘继发于异常的内皮激活的微血管炎症和内皮功能障碍在败血症和器官衰竭的病理生理学中起关键作用。抑制内皮细胞过度活化的内在信号传导机制尚未完全明了。该研究旨在确定Yes相关蛋白(Yes-associated protein,YAP)(Hippo通路的主要转录共激活剂)在调节内皮活化和血管炎症的强度和程度中的中心作用。刘青 叶鹏 Lv Y Kim K Sheng Y Cho J Qain Z Zhao YY Hu G Pan D Malik AB 2018中华高血压杂志2018,26,8:20
11Multilineage differentiation of adipose-derived stromal cells from GFP transgenic mice显示文摘Lin Y Chen X Yan Z Liu L Tang W Zheng X Li Z Qiao J Li S Tian W 2006中国生物学文摘2006,20,5:16
12A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease.显示文摘Huang J Liu H Gu W Yan Z Xu Z Yang Y Zhu X Li Y 2006中国生物学文摘2006,20,9:16
13Novel redox potential-based screening strategy for rapid isolation of Klebsiella pneumoniae mutants with enhanced 1,3-propanediol- producing capability显示文摘Du, CY Zhang, YP Li, Y Cao, Z 2007中国生物学文摘2007,21,10:15
14Antifungal activities and action mechanisms of compounds from Tribulus terrestris L.显示文摘Zhang JD Xu Z Cao YB Chen HS Yan L An MM Gao PH Wang Y Jia XM Jiang YY 2006第二军医大学学报2006,27,5:14
15Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease显示文摘Feng Z Qin C Chang Y Zhang JT 2006中国生物学文摘2006,20,10:13
16聚桂醇联合曲安奈德病灶内注射治疗婴幼儿血管瘤的安全性评估显示文摘Chai Y,Zhou Z,Song J,et al.Safety of intralesional injection of lauromacrogol combined with triamcinolone for infantile hemangiomas.J Dermatol,2019 Jul.近年来,聚桂醇注射疗法和病灶内注射曲安奈德治疗婴儿血管瘤(IH)的疗效已得到充分证实,但严重或罕见的不良反应也随之增加。本研究的目的是研究病灶内聚桂醇与曲安奈德联合注射治疗IH的安全性,并研究其对婴儿生长发育的影响。赵泽亮 Chai Y Zhou Z Song J 2019中国口腔颌面外科杂志2019,17,5:13
17Ex vivo expansion of hematopoietic stem cells derived from umbilical cord blood in rotating wall vessel显示文摘Liu Y Liu T Fan X Ma X Cui Z 2006中国生物学文摘2006,20,5:11
18曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。 曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x 2016中国肿瘤生物治疗杂志2016,23,1:10
19Necessity and indications of invasive treatment for Budd-Chiari syndrome显示文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure should be performed if the patient's situation worsens in the course of regular follow-up.Department of General Surgery (Fu Y,Sun YL,Ma XX,Xu PQ,Feng LS,Tang Z and Luo CH),Institute of Hepatic Vascular Disease (Sun YL),Department of Radiological Intervention (Guan S and Wang ZW),First Affiliated Hospital,Zhengzhou University School of Medicine,Zhengzhou 450052,China 2011Hepatobiliary & Pancreatic Diseases International2011,10,3:10
20Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y 2006中国生物学文摘2006,20,10:10
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