|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells显示文摘 | Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang | 2017 | Cell Research2017，27，1： | 40 |
| 2 | Research progress on electrical signals in higher plants显示文摘This review introduces the characteristics of electrical signals in higher plants and their corresponding physiological significance, and describes in detail the impact of environmental factors (e.g. light and temperature) on the electrical potential of the plants. Also, we evaluate the measurement techniques used for electrical signals in plants, including intracellular measurement, extracellular measurement, measurement of the ion channel based on the patch-clamp technique and on the non-invasive microelectrode vibrating probe technique. We also give a brief review of the applications of these methods for investigating electrical signals in plants. The ionic mechanism of electrical activity in plants is then discussed in terms of environmental response in higher plants, and this is used to provide a theoretical basis for quantitative description of the electrical signals in plants. A model for interpretation of the electrical signal mechanisms in higher plants is discussed, but further experiments are required for the verification of this model. | Xiaofei Yana, Zhongyi Wang a, Lan Huang a, Cheng Wang b, Ruifeng Hou b, Zhilong Xu b, Xiaojun Qiao b a College of Information and Electrical Engineering, China Agricultural University, Beijing 100083, China b National Engineering Research Center for Information Technology in Agriculture, Beijing 100097, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 13 |
| 3 | Enhanced Detection of Rolling Element Bearing Fault Based on Stochastic Resonance显示文摘Early bearing faults can generate a series of weak impacts. All the influence factors in measurement may degrade the vibration signal. Currently, bearing fault enhanced detection method based on stochastic resonance(SR) is implemented by expensive computation and demands high sampling rate, which requires high quality software and hardware for fault diagnosis. In order to extract bearing characteristic frequencies component, SR normalized scale transform procedures are presented and a circuit module is designed based on parameter-tuning bistable SR. In the simulation test, discrete and analog sinusoidal signals under heavy noise are enhanced by SR normalized scale transform and circuit module respectively. Two bearing fault enhanced detection strategies are proposed. One is realized by pure computation with normalized scale transform for sampled vibration signal, and the other is carried out by designed SR hardware with circuit module for analog vibration signal directly. The first strategy is flexible for discrete signal processing, and the second strategy demands much lower sampling frequency and less computational cost. The application results of the two strategies on bearing inner race fault detection of a test rig show that the local signal to noise ratio of the characteristic components obtained by the proposed methods are enhanced by about 50% compared with the band pass envelope analysis for the bearing with weaker fault. In addition, helicopter transmission bearing fault detection validates the effectiveness of the enhanced detection strategy with hardware. The combination of SR normalized scale transform and circuit module can meet the need of different application fields or conditions, thus providing a practical scheme for enhanced detection of bearing fault. | ZHANG Xiaofei HU Niaoqing CHENG Zhe HU Lei | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 11 |
| 4 | Multi-scale bistable stochastic resonance array: A novel weak signal detection method and application in machine fault diagnosis显示文摘Weak signal detection based on stochastic resonance (SR) can hardly succeed when noise intensity exceeds the optimal value of SR. This paper explores a novel parallel bistable SR array mechanism by decomposed multi-scale noises from input signal. A smoother output with lower noise is obtained from the combination of colored noise SR effect and parallel bistable SR array. The influence of noise intensity and array size on the SR effect and output noise intensity is analyzed through numerical simulation. A signal detection method based on the new SR mechanism and normalized scale transform is proposed for the case of heavy background noise. Simulation is conducted to confirm the effectiveness of parameter tuning and amplitude tuning of normalized scale transform on the proposed SR model. The proposed method has three advantages: the input noise intensity of each unit is reduced by wavelet decomposition; the output noise level decreases due to array ensemble average; the SR effect of each unit is optimized by normalized scale transform for high frequency signal. Experiment on bearing inner and outer race fault diagnosis has verified the effectiveness and advantages of the proposed SR model in comparison with traditional SR method and kurtogram. | ZHANG XiaoFei HU NiaoQing HU Lei CHENG Zhe | 2013 | Science China(Technological Sciences)2013，56，9： | 9 |
| 5 | CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells显示文摘 | Yongping Zhang Xingying Zhang Chen Cheng Wei Mu Xiaojuan Liu Na Li Xiaofei Wei Xiang Liu Changqing Xia Haoyi Wang | 2017 | Frontiers of Medicine2017，11，4： | 9 |
| 6 | Magnetic properties and large magnetocaloric effects of GdPd intermetallic compound显示文摘With the intention to explore excellent magnetocaloric materials, the intermetallic compound GdPd was synthesized by arc melting and heat treatment. The microstructure, magnetic and magnetocaloric properties of the intermetallic compound of GdPd were investigated by X-ray diffraction(XRD), scanning electron microscopy(SEM) and the physical property measurement system(PPMS). A large reversible magnetocaloric effect is observed in GdPd accompanied by a second order magnetic phase transition from paramagnetism to ferromagnetism at ~39 K. The paramagnetic Curie temperature(θp) and the effective magnetic moment(μ_(eff))are determined to be 34.7 K and 8.12 μ_B/Gd,respectively. The maximum entropy change(|△S_M^(Max)|) and the relative cooling power(RCP) under a field change of 5 T are estimated to be 20.14 J/(kg·K) and 433 J/kg, respectively. The giant reversible magnetocaloric effects(both the large△S_M and the high RCP) together with the absence of thermal and field hysteresis make the GdPd compound an attractive candidate for low-temperature magnetic refrigeration. | Jianjun Huo Yusong Du Gang Cheng Xiaofei Wu Lei Ma Jiang Wang Zhengcai Xia Guanghui Rao | 2018 | Journal of Rare Earths2018，36，10： | 8 |
| 7 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 7 |
| 8 | Corrigendum to“Research progress on electrical signals in higher plants”[Progress in Natural Science 19(2009) 531-541]显示文摘The authors would like to inform the readers that in the above mentioned paper,the word'Loosestrife'on p.533, the ninth line of the left-hand column should be replaced by'Desmodium motorium'.In addition,the cited refer- | Xiaofei Yan Zhongyi Wang Lan Huang Cheng Wang Ruifeng Hou Zhilong Xu Xiaojun Qiao | 2009 | Progress in Natural Science:Materials International2009，19，12： | 7 |
| 9 | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization显示文摘NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectively. Although p100 responds to noncanonical NF-κB stimuli for processing, it does not undergo degradation, but rather becomes accumulated, along with canonical NF-κB activation. We show here that the stability of p100 is tightly controlled by a deubiquitinase, Otub1. Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-κB activation but also causes steady-state p100 degradation, leading to aberrant NF-κB activation in the canonical pathway. B-cell-conditional deletion of Otub1 results in B-cell hyperplasia, antibody hyper-production, and lupus-like autoimmunity. Otub1-deficient B cells display aberrantly activated phenotypes and overproduce the cytokine IL-6, contributing to autoimmunity induction. Thus, maintenance of p100 stability by Otub1 serves as an unusual mechanism of NF-κB regulation that prevents autoimmunity. | Yanchuan Li Jin-Young Yang Xiaoping Xie Zuliang Jie Lingyun Zhang Jianhong Shi Daniel Lin Meidi Gu Xiaofei Zhou Haiyan S. Li Stephanie S. Watowich Antrix Jain Sung Yun Jung Jun Qin Xuhong Cheng Shao-Cong Sun | 2019 | Cell Research2019，29，6： | 3 |
| 10 | Rearrangement on surface structures by boride to enhanced cycle stability for LiNi0.80Co0.15Al0.05O2 cathode in lithium ion batteries显示文摘The side reaction between the active material and liquid-electrolyte cause structural damage and particle pulverization is one of the important factors leading to the capacity decay of LiNi0.80Co0.15Al0.05O2(NCA)materials in Li ion batteries(LIBs).Surface modification is an effective strategy for NCA cathodes,which could alleviate the degradation associated with surface processes.Herein,a surface structure rearrangement of NCA cathode secondary particles was reported by in-situ forming a solid electrolyte LiBO2.The LiBO2 is beneficial for alleviating the stress during charge/discharge process,thereby slowing down the rate of cracks formation in the secondary particles,which facilitates the Li+de-intercalation as well as prevents penetration of the liquid-electrolyte into the interior of the particles.As a result,the surface structure rearrangement NCA(RS-NCA)delivers a high discharge capacity of 202.5 m Ah g^-1 at 0.1 C,and exhibits excellent cycle stability with discharge capacity retaining 148 m Ah g^-1 after 200 cycles at 2 C.This surface structure rearrangement approach provides a new viewpoint in designing high-performance high-voltage LIBs. | Shubiao Xia Wenjin Huang Xiang Shen Jiaming Liu Feixiang Cheng Jian-Jun Liu Xiaofei Yang Hong Guo | 2020 | Journal of Energy Chemistry2020，29，6： | 3 |
| 11 | In situ nitrogen removal processes in intertidal wetlands of the Yangtze Estuary显示文摘Estuarine and intertidal wetlands are important sites for nitrogen transformation and elimination.However,the factors controlling nitrogen removal processes remain largely uncertain in the highly dynamic environments.In this study,continuous-flow experiment combined with 15 N isotope pairing technique was used to investigate in situ rates of denitrification and anaerobic ammonium oxidation(anammox)and their coupling with nitrification in intertidal wetlands of the Yangtze Estuary.The measured rates varied from below the detection limit to 152.39μmol N/(m^2·hr)for denitrification and from below the detection limit to 43.06μmol N/(m^2·hr)for anammox.The coupling links of nitrogen removal processes with nitrification were mainly dependent on nitrate,organic carbon,sulfide,dissolved oxygen and ferric iron in the estuarine and intertidal wetlands.Additionally,it was estimated that the actual nitrogen removal processes annually removed approximately 5%of the terrigenous inorganic nitrogen discharged into the Yangtze Estuary.This study gives new insights into nitrogen transformation and fate in the estuarine and intertidal wetlands. | Cheng Liu Lijun Hou Min Liu Yanling Zheng Guoyu Yin Hongpo Dong Xia Liang Xiaofei Li Dengzhou Gao Zongxiao Zhang | 2020 | Journal of Environmental Sciences2020，32，7： | 2 |
| 12 | Analysis of the ore-controlling role of Guojiadian mantle branch structure,Northwest Shandong Peninsula,China显示文摘Metallogenesis in the gold ore-concentrated zone of Northwest Shandong Peninsula is closely related to deep processes.The region in the eastern part of North China entered into the stage of mantle plume evolution during the Yanshanian movement,following the long-time stage of stable platform evolution during Paleozoic time.At that time,the ore-concentrated zone of Northwest Shandong Peninsula just entered into the development-evolution stage of the Laiyang sub-mantle plume and the Guojiadian mantle branch structure in its periphery.The core-mantle-source gold was present in the gas-liquid form,and it migrated through mantle plume→sub-mantle plume→mantle branch structure→favorable tectonic expansion zone to the favorable loci of the mantle branch structure,where gold was deposited as ores,thereafter constituting a series of large-to medium-sized gold deposits distributed around the Guojiadian mantle branch structure.This study also dealt with the Jiaojia fault as the main detachment(fault altered rock) belt on the northwestern margin of the mantle branch structure and also presented a basic cognition about the fact that the Sanshandao fault as the listric fault on the hanging wall of the detachment belt.Furthermore,on this basis,this study also pointed out the orientation for further ore prospecting in this region. | NIU Shuyin Sun Aiqun ZHANG Jianzhen MA Baojun WANG Baode CHEN Chao ZHANG Fuxiang LIU Cheng ZHANG Xiaofei | 2012 | Chinese Journal Of Geochemistry2012，31，4： | 2 |
| 13 | A cohort study of adolescents with depression in China:tracking multidimensional outcomes and early biomarkers for intervention显示文摘Background Depression in adolescents is recognised as a global public health concern,but little is known about the trajectory of its clinical symptoms and pathogenesis.Understanding the nature of adolescents with depression and identifying earlybiomarkers can facilitatepersonalised intervention andreducediseaseburden.Aims To track multidimensional outcomes of adolescents with depression and develop objective biomarkers for diagnosis,as well as response to treatment,prognosis and guidance for early identification and intervention.Methods This is a multidimensional cohort study on the Symptomatic trajectory and Biomarkers of Early Adolescent Depression(sBEAD).We planned to recruit more than 1000 adolescents with depression and 300 healthy controls within 5 years.Multidimensional clinical presentations and objective indicators are collected at baseline,weeks 4,8,12 and 24,and years 1,2,3,4 and 5.Conclusions To the best of our knowledge,this is the first longitudinal cohort study that examines multidimensional clinical manifestations and multilevel objective markers in Chinese adolescents with depression.This study aims at providing early individualised interventions for young,depressed patients to reduce the burden of disease. | Xiaofei Zhang Yanling Zhou Jiaqi Sun Ruilan Yang Jianshan Chen Xiaofang Cheng Zezhi Li Xinlei Chen Chanjuan Yang Xinhong Zhu Liping Cao | 2022 | General Psychiatry2022，35，4： | 2 |
| 14 | Establishment of two-dimensional gel electrophoresis for soybean protein isolate and its application显示文摘To optimize the conditions for the establishment of two-dimensional gel electrophoresis(2-DE)of soybean protein isolate(SPI),we investigated Ampholine mixture,anodic and cathodic electrolytes,loading amount of sample,acrylamide concentration,p H gradient and gel staining method in twodimensional gel electrophoresis to optimize the protein imaging conditions in two-dimensional gel.The results of mixed-level design experiments showed that Ampholine,loading amount and gel staining method had significant effect(P<0.05)on 2-DE of SPI.The optimal conditions were Ampholine mixture(pH 3–10+pH 5–7 or pH 4–6+pH 5–7),loading amount of 2 mg sample and silver staining.Although the acrylamide concentration of the gel,the p H gradient,the anodic and cathodic electrolyte solutions had significant statistical effects on the protein separation degree,the complexity of the protein composition and the visibility of the gel images were more inclined to the 12%gel,the 3–10 pH gradient and the H3PO4/NaOH electrolyte.According to the established conditions,the hydrolyzed products of SPI emulsion were determined by 2-DE,and the dynamic changes of protein in the process of enzymatic hydrolysis were described. | Xinkai Lu Yaoming Cui Junjun Guan Xue Liu Hao Zhu Xuyang Ji Jianzhang Zheng Yunlong Cheng Xiaofei Fu | 2020 | Grain & Oil Science and Technology2020，3，3： | 2 |
| 15 | Fast parallel factor decomposition technique for coherently distributed source localization显示文摘This paper links parallel factor(PARAFAC) analysis to the problem of nominal direction-of-arrival(DOA) estimation for coherently distributed(CD) sources and proposes a fast PARAFACbased algorithm by establishing the trilinear PARAFAC model.Relying on the uniqueness of the low-rank three-way array decomposition and the trilinear alternating least squares regression, the proposed algorithm achieves nominal DOA estimation and outperforms the conventional estimation of signal parameter via rotational technique CD(ESPRIT-CD) and propagator method CD(PM-CD)methods in terms of estimation accuracy. Furthermore, by means of the initialization via the propagator method, this paper accelerates the convergence procedure of the proposed algorithm with no estimation performance degradation. In addition, the proposed algorithm can be directly applied to the multiple-source scenario,where sources have different angular distribution shapes. Numerical simulation results corroborate the effectiveness and superiority of the proposed fast PARAFAC-based algorithm. | CHENG Qianlin ZHANG Xiaofei CAO Renzheng | 2018 | Journal of Systems Engineering and Electronics2018，29，4： | 2 |
| 16 | Design and optimization of an integrated MEMS gas chamber with high transmissivity显示文摘Non-Dispersive InfraRed(NDIR)gas sensor is widely used for gas detection in collieries and the gas chemical industry,etc.The performance of the NDIR gas sensor depends on the volume,optical length and transmittance of the gas chamber.However,the existing gas sensor products have problems of large volume,high cost and incapable of integration,which need to develop towards the miniaturized sensor.This paper first presents the theoretical background of the NDIR gas sensor and the novel structure of a fully integrated infrared gas sensor and its micro-machined gas chamber structure.Then,the light structure and the gas flow of the gas chamber are optimized on Tracepro software and Ansys workbench,respectively,and the technological process for preparing the Micro-Electro-Mechanical System(MEMS)gas chamber is designed.Finally,we produce a gas chamber with a small volume and good transmissivity,which would be the most important part of producing the miniaturized NDIR gas sensor. | Yang Jing Cheng Yuhua Yuan Yupeng Li Xiaofei Zhang Zuwei Xu Ming Wang Dengpan Mu Jiangdong Mei Yong Zhang Yuzhe | 2021 | Digital Communications and Networks2021，7，1： | 2 |
| 17 | Synergism of 1D CdS/2D Modified Ti_(3)C_(2)T_(x) MXene Heterojunctions for Boosted Photocatalytic Hydrogen Production显示文摘Rational design and controllable synthesis of visible-light-responsive photocatalysts that exhibit both good hydrogen-producing efficiency and stability in the water splitting reaction are undoubtedly a challenge. Here we report an integrated CdS nanorod/oxygen-terminated Ti_(3)C_(2)T_(x) MXene nanosheet heterojunction with a high catalytic hydrogen evolution reaction(HER) activity. By incorporating one-dimensional(1D)CdS nanorods onto annealed ultrathin two-dimensional(2D) MXene nanosheets, the mixed-dimensional 1D/2D heterojunction achieved a hydrogen-evolving rate of 8.87 mmol·g^(-1)·h^(-1), much higher than that of bulk CdS and CdS/unmodified MXene hybrid catalysts. The enhanced HER activity and stability of the designed heterojunction catalyst are attributed to the presence of oxygen-containing terminal groups on the surface of thermally treated Ti_(3)C_(2)T_(x) MXene, extended light absorption spectra as well as the precisely constructed intimate Schottky contact, implying an accelerated interfacial charge transfer and efficient, long-term photocatalytic hydrogen production performance. The results demonstrate that oxygen-terminated 2D MXene can be well utilized as a functional platform for the development of novel heterojunction photocatalysts. | Shi Cheng Qianqian Xiong Chengxiao Zhao Xiaofei Yang | 2022 | Chinese Journal of Structural Chemistry2022，41，8： | 2 |
| 18 | Assessment of strong earthquake risk in the Chinese mainland from 2021 to 2030显示文摘The long-term earthquake prediction from 2021 to 2030 is carried out by researching the active tectonic block boundary zones in the Chinese mainland.Based on the strong earthquake recurrence model,the cumulative probability of each target fault in the next 10 years is given by the recurrence period and elapsed time of each fault,which are adopted from relevant studies such as seismological geology,geodesy,and historical earthquake records.Based on the long-term predictions of large earthquakes throughout the world,this paper proposes a comprehensive judgment scheme based on the fault segments with the seismic gap,motion strongly locked,sparse small-moderate earthquakes,and apparent Coulomb stress increase.This paper presents a comprehensive analysis of the relative risk for strong earthquakes that may occur in the coming 10 years on the major faults in the active tectonic block boundary zones in the Chinese mainland.The present loading rate of each fault is first constrained by geodetic observations;the cumulative displacement of each fault is then estimated by the elapsed time since the most recent strong earthquake. | Zhigang Shao Yanqiang Wu Lingyun Ji Faqi Diao Fuqiang Shi Yujiang Li Feng Long Hui Zhang Wuxing Wang Wenxin Wei Peng Wang Xiaoxia Liu Qi Liu Zhengyang Pan Xiaofei Yin Yue Liu Wei Feng Zhenyu Zou Jia Cheng Renqi Lu Yueren Xu Xi Li | 2023 | Earthquake Research Advances2023，3，1： | 2 |
| 19 | Simultaneous passivation of bulk and interface defects through synergistic effect of anion and cation toward efficient and stable planar perovskite solar cells显示文摘Bulk and interface carrier nonradiative recombination losses impede the further improvement of power conversion efficiency(PCE)and stability of perovskite solar cells(PSCs).It is highly necessary to develop multifunctional strategy to minimize surface and interface nonradiative recombination losses.Herein,we report a bulk and interface defect passivation strategy via the synergistic effect of anions and cations,where multifunctional potassium sulphate(K_(2)SO_(4))is incorporated at SnO_(2)/perovskite interface.We find that K^(+)ions in K_(2)SO_(4)diffuse into perovskite layer and suppress the formation of bulk defects in perovskite films,and the SO_(4)^(2-)ions remain located at interface via the strong chemical interaction with SnO_(2)layer and perovskite layer,respectively.Through this synergistic modification strategy,effective defect passivation and improved energy band alignment are achieved simultaneously.These beneficial effects are translated into an efficiency increase from 19.45%to 21.18%with a low voltage deficit of0.53 V mainly as a result of boosted open-circuit voltage(V_(oc))after K_(2)SO_(4)modification.In addition,the K_(2)SO_(4)modification contributes to ameliorated stability.The present work provides a route to minimize bulk and interface nonradiative recombination losses for the simultaneous realization of PCE and stability enhancement by rational anion and cation synergistic engineering. | Cong Zhang Huaxin Wang Haiyun Li Qixin Zhuang Cheng Gong Xiaofei Hu Wensi Cai Shuangyi Zhao Jiangzhao Chen Zhigang Zang | 2021 | Journal of Energy Chemistry2021，30，12： | 2 |
| 20 | In vitro transcribed sgRNA causes cell death by inducing interferon release显示文摘Dear editor The clustered regularly in terspaced short palindromic repeats (CRISPR) and the CRISPR-associated proteins 9 (Cas9) systems are powerful tools for gene editing. Ribonucleoprotein (RNP) complex composed of Cas9 pro? tein and sgRNA binds to specific genomic loci and gen erate DNA double strand breaks. While plasmids expressing Cas9 protein and sgRNA are routinely transfected into various cell lines to perform gene editing (Cong et al., 2013;Mali et al., 2013;Ran et al., 2013), direct delivery of Cas9-sgRNA RNP has shown higher efficiency and lower off-target effects (Kim et al., 2014), especially in human primary cells such as T cells (Hendel et al., 2015;Schumann et al., 2015). SgRNA can be gen erated by either in vitro transcript! on (IVT) or chemical syn thesis. IVT is widely used to gen erate sgRNAs, since it can be easily performed in most labs. | Wei Mu Na Tang Chen Cheng Wen Sun Xiaofei Wei Haoyi Wang | 2019 | Protein & Cell2019，10，6： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员