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| 1 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 2 | Global robust optimal sliding mode control for uncertain affine nonlinear systems显示文摘The problem of robustifying linear quadratic regulators(LQRs) for a class of uncertain affine nonlinear systems is considered.First,the exact linearization technique is used to transform an uncertain nonlinear system into a linear one and an optimal LQR is designed for the corresponding nominal system.Then,based on the integral sliding mode,a design approach to robustifying the optimal regulator is studied.As a result,the system exhibits global robustness to uncertainties and the ideal sliding mode dynamics is the same as that of the optimal LQR for the nominal system.A global robust optimal sliding mode control(GROSMC) is realized.Finally,a numerical simulation is demonstrated to show the effectiveness and superiority of the proposed algorithm compared with the conventional optimal LQR. | Pang Haiping Chen Xia | 2009 | Journal of Systems Engineering and Electronics2009，20，4： | 5 |
| 3 | Influence of filler morphology on percolation threshold of isotropical conductive adhesives (ICA)显示文摘Different aspect ratio silver nano-structured materials including nanocubes,nanorods and nanowires were prepared by micro-waved assisted glycol reduction method.Different characterization methods including SEM and XRD were processed on these nanomaterials.Isotropical conductive adhesives(ICA) were developed by using these Ag nanomaterials as conductive fillers.It was found that the conductivity and thermal conductivity percolation threshold of the ICA depended on the morphologies of the fillers,lower percolation threshold could be obtained by using higher aspect ratio filler.A modified percolation threshold theory was put forward to explain and simulate the experiment results,the simulated results could match the experiment results very well. | TAO Yu YANG ZhenGuo LU XiaoLu TAO GuoLiang XIA YanPing WU HaiPing | 2012 | Science China(Technological Sciences)2012，55，1： | 4 |
| 4 | The First OCCCO Pentadentate Chelates:Osmium Mediated Stepwise Oxidations of Terminal Alkynes by Pyridine N-Oxide显示文摘of main observation and conclusion Oxygen atom transfer reactions between alkynes and heteroarene N-oxides are currently mediated by transition metal,such as gold,ruthenium or rhodium,but they have never been catalyzed by osmium.Herein,we report stepwise oxidations of terminal alkynes mediated by an osmium carbolong complex,using pyridine N-oxide as the oxidant,yielding novel aldehyde-or carboxylic acid-coordinated osmapentalyne derivatives selectively.The mechanism was illustrated by density functional theory calculations,providing a new route for oxygen atom transfer between heteroarene N-oxides and alkynes. | Jianfeng Lin Qiannan Xu Xinlei Lin Yuhui Hua Dafa Chen Yonghong Ruan Hong Zhang Haiping Xia | 2020 | Chinese Journal of Chemistry2020，38，11： | 4 |
| 5 | Metallaaromatics Containing Main-group Heteroatoms显示文摘 | Hongjian Wang Xiaoxi Zhou Haiping Xia | 2018 | Chinese Journal of Chemistry2018，36，2： | 3 |
| 6 | Synthesis and Characterization of Osmium Polycyclic Aromatic Complexes via Nucleophilic Reactions of Osmapentalyne显示文摘 | Qin Zhu Congqing Zhu Zhihong Deng Guomei He Jiangxi Chen Jun Zhu Haiping Xia | 2017 | Chinese Journal of Chemistry2017，35，5： | 3 |
| 7 | Alternation of Metal-Bridged Metallacycle Skeletons:From Ruthena- pentalyne to Ruthenapentalene and Ruthenaindene Derivative显示文摘The reaction of ruthenapentalyne with one equivalent of isocyanide led to the formation of a rare ruthenapentalene complex by nucleophilic addition.When excess isocyanides were used,the metal-bridged ruthenaindene derivatives can be isolated and were formed by one carbon of isocyanide insertion into the ruthenacycle.Complexes 3 represent the first metallaindene derivatives with a second-row transition metal at the bridge-head position.The transformations from ruthenapentalyne via ruthenapentalene to ruthenaindene derivatives are of interest and can be extended to the syntheses of other polycyclic ruthenacycles.These unique metallacycles exhibit considerable stability and broad spectral absorption spanning the visible spectrum,enabling their potential applications in photoelectric materials. | Jinhua Li Huijun Kang Kaiyue Zhuo qingde Zhuo Hong Zhang Yu-Mei Lin Haiping Xia | 2018 | Chinese Journal of Chemistry2018，36，12： | 3 |
| 8 | Photoluminescence properties of Tm^(3+)/Tb^(3+)/Sm^(3+) tri-doped Na_(5)Y_(9)F_(32) single crystal with high thermal stability for white light-emitting diodes显示文摘A novel Tm^(3+)/Tb^(3+)/Sm^(3+)tri-doped Na_(5)Y_(9)F_(32)single crystal was synthesized by a modified Bridgman method for the propose of white light emitting diodes.The fluorescence spectra of various Sm^(3+)ion concentrations and fixed 0.4 mol%Tm^(3+)and 0.5 mol%Tb^(3+)were measured and studied systematically excited by near-ultraviolet light of 355 nm.The Sm3+ion concentration takes apparent effect on the relative intensity of peaks in the visible region and the color coordinate combining from these emission bands.A near pure white light emission with color coordinates(0.3295,0.3057)and color temperature(5657 K)can be obtained when the concentrations of Tm^(3+),Tb^(3+)and Sm^(3+)ions are 0.4 mol%,0.5 mol%and 0.8 mol%,respectively.Furthermore,the practical down-conversion internal quantum yield was measured by integrating spheres at about 14.39%.The tri-doped Na_(5)Y_(9)F_(32)single crystal shows a high thermal stability inferring from the temperature dependent emission in which the integrated emission intensities are reduced only by^3%with the increase of temperature from 280 to 450 K.The present results demonstrate that the Tm^(3+)/Tb^(3+)/Sm^(3+)tri-doped Na_(5)Y_(9)F_(32)single crystal may provide a promising candidate for white light-emitting diodes,luminescent materials and fluorescent display devices. | Yang Qiao Xiong Zhou Jianli Zhang Haiping Xia Hongwei Song Baojiu Chen | 2021 | Journal of Rare Earths2021，39，5： | 3 |
| 9 | Optical spectroscopy and crystal-field strength of Cr^(3+) in various solid matrixes显示文摘Cr^(3+): BeAl_2O_4 水晶, Cr^(3+): LiNbO_3 水晶,和 ZnO-Al_2O_3-SiO_2glass-ceramic 被 Czochralski 技术获得,布里奇曼方法,并且融化分别地处理。上述 Cr^(3+)-incorporatedsolid-state 材料的光吸收和排放系列被记录。为种 high-qualityCr^(3+) 的技术参数: BeAl_2O_4 和 Cr^(3+): LINbO_3 晶体被获得。结果显示 Cr^(3+) 的光吸收和荧光系列在各种各样的矩阵显示出许多差别。Thesharp 线排出物在 Cr^(3+) 被观察: BeAl_2O_4 和 Cr^(3+): LiNbO_3 晶体。为在不同矩阵的 Cr^(3+) 的 Thecrystal 地参数(D_q ) 从他们的相应系列被计算。它被显示那 Cr^(3+): BeAl_2O_4 和 Cr^(3+): LiNbO_3 属于 thehigh 地地点水晶,当时 Cr^(3+): ZnO-Al_2O_3-SiO_2 玻璃并且眼镜陶器属于 theweak 地地点水晶。 | XIA Haiping WANG Jinhao WANG Hongyin ZHANG Jianli ZHANG Yuepin XU Tiefeng | 2006 | Rare Metals2006，25，1： | 2 |
| 10 | Growth and Optical Spectra of Tb^(3+)/Eu^(3+) Co-doped Cubic NaYF_4 Single Crystal for White Light Emitting Diode显示文摘High quality Tb^(3+)/Eu^(3+) co-doped cubic NaYF_4 single crystal in the size of Φ1.0 cm×6.6 cm was grown by a modified Bridgman method using KF as assistant flux for NaF-YF_3 system under the condition of completely closed Pt crucible.A white light emission from the combination of the violet-blue,blue,green,orange,and red lights with chromaticity coordinates of x = 0.3107,y = 0.3274,correlated color temperature of T_c = 6637 K,color rendering index of R_a = 83,and color quality scale of Q_a = 82 could be obtained from 1.51 mol%Tb^(3+) and 1.42 mol%Eu^(3+) co-doped cubic NaYF_4 single crystal when being excited by a 369 nm light.This indicates that Tb^(3+)/Eu^(3+) co-doped cubic NaYF_4 single crystal has a potential application in white light emitting diode excited by ultraviolet light. | Yongzhang Jiang Haiping Xia Jiazhong Zhang Shuo Yang Haochuan Jiang Baojiu Chen | 2015 | Journal of Materials Science & Technology2015，31，12： | 2 |
| 11 | Synthesis and characterization of stable osmafuran starting from HC≡CCH(OH)C≡CH and OsHCl(CO)(PPh_3)_3显示文摘This paper presents a new convenient route to prepare osmafuran starting from readily accessible HC≡C CH(OH)C≡CH and OsHCl(CO)(PPh3)3.Treatment of a solution of OsHCl(CO)(PPh3)3 in dichloromethane with HC≡C CH(OH)C≡CH,followed by the addition of acetic acid,produced osmafuran [Os(CHC(PPh3)CO(CH2CH3))Cl(CO)(PPh3)2]Cl(2).2 has been isolated in good yield and fully characterized.1H and 13C NMR spectra show the characteristic downfield chemical shifts of the ring hydrogen and carbon atoms.NMR and X-ray diffraction data provide strong evidence for the aromatic nature of 2.Probably due to the effect of the phosphonium substituent,2 exhibits remarkable thermal stability,air stability and lower reactivity. | ZHANG Hong,LIN Ran,LUO Ming & XIA HaiPing State Key Laboratory for Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China | 2010 | Science China Chemistry2010，53，9： | 2 |
| 12 | Effects of greenness on preterm birth: A national longitudinal study of 3.7 million singleton births显示文摘Exposure to greenness may lead to a wide range of beneficial health outcomes.However,the effects of greenness on preterm birth(PTB)are inconsistent,and limited studies have focused on the subcategories of PTB.A total of 3,751,672 singleton births from a national birth cohort in China's Mainland were included in this study.Greenness was estimated using the satellitebased Normalized Difference Vegetation Index(NDVI)and Enhanced Vegetation Index with 500-m and 1,000-m buffers around participants’addresses.The subcategories of PTB(20-36 weeks)included extremely PTB(EPTB,20-27 weeks). | Lina Zhang Shuyan Shi Shenpeng Wu Ying Yang Jihong Xu Ya Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Zuoqi Peng Cong Liu Weidong Wang Yixuan Jiang Su Shi Renjie Chen Haidong Kan Yuan He Xia Meng Xu Ma | 2022 | The Innovation2022，3，3： | 2 |
| 13 | White Light Emission Characteristics of Tb3+/Sm3+Co-Doped Glass Ceramics Containing YPO4 Nanocrystals显示文摘The Tb^(3+)/Sm^(3+) single-doped and co-doped glasses and glass ceramics containing YPO_4 nanocrystals have been synthesized by melt quenching method. The structural and luminescent properties of these glass specimens were investigated. Under 375 nm wavelength excitation, the emission spectra combined with blue, green and red bands were observed, which achieved the white light emission. Moreover, the energy transfer between Tb^(3+) and Sm^(3+)ions was validated by decay lifetime measurement and energy level diagram.The color coordinates(x = 0.333, y = 0.333), correlated color temperature(5595 K) and the color rendering index(Ra = 80.5) indicated that the glass ceramics were considered to be good lighting source. Hence,the YPO_(4-) based Tb^(3+)/Sm^(3+) co-doped glass ceramics can act as potential matrix materials for white lightemitting diodes under ultraviolet excitation. | Zhixiong Zhang Yuepin Zhang Cheng Wang Zhigang Feng Weihuan Zhang Haiping Xia | 2017 | Journal of Materials Science & Technology2017，33，5： | 2 |
| 14 | Silicon-phthalocyanine bonding with SiO_2 matrix and its strong optical limiting effects显示文摘Silicon-phthalocyanine (SiPc) is chemically bonded to 3-aminopropltriethoxysilane (NH2(CH2)3Si(OC2H5)3, KH550) by the nucleophilic substituted reaction between the active chlorine of silicon dichlorine phthalocyanine (SiPcCI2) and amino-group of KH550. The reacted product is hybridized with 3-glycidoxypropltrimethoxysilane (CH2OCHCH2O(CH2)3Si(OCH3)3, KH560) with sol-gel processing to form sol-gel inorganic material with good physical-chemical and optical properties. Due to tethering SiPc to the network, the aggregation of SiPc is effectively prevented in sol-gel derived matrix, and the doping concentration of SiPc in the form of monomer in the matrix is greatly enhanced. The cross-linkage of SiPcCI2 and KH550 is estimated and confirmed with FT-IR spectra. The optical limiting effects (OLE) of the gel with different content of SiPc are investigated with a frequency double Q-switched Nd3+:YAG laser of 8 nsec. pulse. | XIA Haiping, PU Bingyin, ZHANG Yuepin, ZHANG Jianli, FANG Jianghua & WANG CunkuanDepartment of Chemistry, Ningbo University, Ningbo 315211, China Correspondence should be addressed to Xia Haiping | 2000 | Chinese Science Bulletin2000，45，23： | 2 |
| 15 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 16 | Distribution and diversity of hepatitis B virus genotypes in Yunnan, China显示文摘 | Binghui Wang Yue Feng Zheng Li Haiping Duan Ting Zhao Amei Zhang Li Liu Zulqarnain Baloch Xueshan Xia | 2014 | Virol2014，，10： | 1 |
| 17 | Growth of LiNbO3 Crystals by the Bridgman Method 显示文摘 | Haiping Xia Jinhao Wang Jianli Zhang | | Journal of Crystal Growth0，，： | 1 |
| 18 | Metallacycle Expansion and Annulation:Access to Tetrazolo-Fused Osmacycles by Reaction of Cyclic Osmium Carbyne with Sodium Azide显示文摘The reaction of a cyclic osmacarbyne complex with sodium azide led to the formation of a ring expansion-annulation product,a unique tetrazole annulated polycyclic metallacycle.The reaction proceeds by insertion of a nitrogen atom into the metal carbon triple bond and the second azide participating in the[2+3]cycloaddition.The successful isolation and characterization of metalla-azirine complex and metallapyridinium derivative strongly validated the mechanism for the formation of the title complex.The work demonstrates a new strategy to enrich the varieties of aza-metallacyclic species. | Hongjian Wang Yu-Mei Lin Siyuan Chen Yonghong Ruan Haiping Xia | 2021 | Chinese Journal of Chemistry2021，39，12： | 1 |
| 19 | 显示文摘 | XIA Haiping ZHU Congshan GAN Fuxi(Shanghai Institute of Optics and Fine Mechanics Academic Sinica P. O. Box 800-211 Shanghai 201800 China) | 1995 | Chinese Journal of Lasers1995，，03： | 1 |
| 20 | Nonexistence and existence results for a class of fourth‐order difference Dirichlet boundary value problems显示文摘 | Xia Liu Yuanbiao Zhang Haiping Shi | 2015 | Math. Meth. Appl. Sci2015，，4： | 1 |
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