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| 1 | Scour and silting evolution and its influencing factors in Inner Mongolian Reach of the Yellow River显示文摘有河的平衡的河被床变丑调整描绘。在剖面图的侵蚀免职区域反映这个特征,它是研究河的一个底搜索并且由时间系列分析的免职进化。与在这篇论文建议的一个侵蚀免职区域指示物方法,在 Bygl 和 Shhk 车站的侵蚀免职区域数量的时间系列从 1976 ~ 2006 与 31 年的系列持续时间被获得。在它的趋势和变化的分析以后,关于进化的三个不同趋势通过快速的收缩从伪平衡阶段一般来说被观察到最后的新伪平衡。一旦大洪水发生在一些支流,侵蚀免职区域系列的趋势将变化,这也被发现一旦大洪水发生在一些支流,并且它的曾经更大的影响由于有在上游的水库的结束的洪水的减少。几乎所有转弯的点与超沉积洪水发生在一些支流的时间是重合的。与清楚的变化的时间系列自从 1990 年代末,内部蒙古的活动范围在一个新平衡阶段。这能在二个方面被结束。1。从在河收缩的支流结果的大洪水和沉积交通的缺席,并且重获隧道在内部蒙古的活动范围的带流动的能力大洪水高山峰分泌物并且过长的间隔被需要破坏新平衡。2。因为它能在数量表明生气的节的实时变丑,侵蚀免职区域指示物的建议方法具有到隧道搜索免职进化分析的大帮助。 | QIN Yi ZHANG Xiaofang WANG Fenglong YAN Heng HAN Haijun | 2011 | Journal of Geographical Sciences2011，21，6： | 14 |
| 2 | Comparative pharmacokinetics of six major compounds in normal and insomnia rats after oral administration of Ziziphi Spinosae Semen aqueous extract显示文摘Ziziphi Spinosae Semen(ZSS),a traditional Chinese medicine,is used in clinics for the treatment of insomnia in China and other Asian countries.Herein,we described for the first time a comparative pharmacokinetics study of the six major compounds of ZSS in normal control(NC)and para-chlorophenylalanine(PCPA)-induced insomnia model(IM)rats that were orally administered the aqueous extract of ZSS.An ultra-high-performance liquid chromatography coupled with quadrupole orbitrap mass(UHPLC-Q-Orbitrap-MS)method was developed and validated for the simultaneous determination of coclaurine,magnoflorine,spinosin,6000-feruloylspinosin,jujuboside A(JuA),and jujuboside B(JuB)in ZSS in rat plasma.The established approach was successfully applied to a comparative pharmacokinetic study.The systemic exposures of spinosin and 6000-feruloylspinosin were decreased in the IM group compared to the NC group,while plasma clearance(CL)was significantly increased.The Tmax values of JuA and JuB in IM rats were significantly lower than those in NC rats.The T1/2 of JuA in the IM group was significantly accelerated.The pharmacokinetic parameters of coclaurine and magnoflorine were not evidently affected between the two groups.These results indicate that the pathological state of insomnia altered the plasma pharmacokinetics of spinosin,6000-feruloylspinosin,JuA,and JuB in the ZSS aqueous extract,providing an experimental basis for the role of ZSS in insomnia treatment.The comparative pharmacokinetics-based UHPLC-Q-Orbitrap-MS using full-scan mode can therefore provide a reliable and suitable means for the screening of potentially effective substances applied as quality markers of ZSS. | Chenhui Du Yan Yan Chenxi Shen Xiaofang Cui Xiangping Pei Xuemei Qin | 2020 | Journal of Pharmaceutical Analysis2020，10，4： | 14 |
| 3 | Structural insight into substrate specificity of human intestinal maltase-glucoamylase显示文摘Human maltase-glucoamylase(MGAM)hydrolyzes linear alpha-1,4-linked oligosaccharide substrates,playing a crucial role in the production of glucose in the human lumen and acting as an efficient drug target for type 2 diabetes and obesity.The amino-and carboxyl-terminal portions of MGAM(MGAM-N and MGAM-C)carry out the same catalytic reaction but have different substrate specificities.In this study,we report crystal structures of MGAM-C alone at a resolution of 3.1Å,and in complex with its inhibitor acarbose at a resolution of 2.9Å.Structural studies,combined with biochemical analysis,revealed that a segment of 21 amino acids in the active site of MGAM-C forms additional sugar subsites(+2 and+3 subsites),accounting for the preference for longer substrates of MAGM-C compared with that of MGAM-N.Moreover,we discovered that a single mutation of Trp1251 to tyrosine in MGAM-C imparts a novel catalytic ability to digest branched alpha-1,6-linked oligosaccharides.These results provide important information for understanding the substrate specificity of alphaglucosidases during the process of terminal starch digestion,and for designing more efficient drugs to control type 2 diabetes or obesity. | Limei Ren Xiaohong Qin Xiaofang Cao LeleWang Fang Bai Gang Bai Yuequan Shen | 2011 | Protein & Cell2011，2，10： | 9 |
| 4 | Gluconeogenesis during starvation and refeeding phase is affected by previous dietary carbohydrates levels and a glucose stimuli during early life in Siberian sturgeon(Acipenser baerii)显示文摘Gluconeogenesis responses was assessed during a short starvation period and subsequent refeeding in Siberian sturgeon(Acipenser baerii) previously fed different dietary carbohydrates levels and experienced to a glucose stimuli during early life. The sturgeon larvae were previously fed either a high glucose diet(G) or a low glucose diet(F) from the first feeding to yolk absorption(8 to 12 d post-hatching [dph]). Each group of fish was sub-divided into 2 treatments at 13 dph and was fed either a high-carbohydrate diet(H) or a low carbohydrate diet(L) until 20 wk. In the current study, the fish in 4 groups(GL, FL, GH and FH) were experienced to starvation for 21 d following by re-feeding of their corresponding diets for 21 d.Fish were sampled at postprandial 6 and 24 h before starvation(P6 h and P24 h), starvation 7,14 and 21 d(S7, S14 and S21) and 1, 7,14 and 21 d during refeeding(R1, R7, R14 and R21). Plasma samples during refeeding were taken at P6 h at each time point. Glycaemia levels, liver and muscle glycogen contents,activities and mRNA levels of hepatic gluconeogenic enzymes were examined. We found that both dietary carbohydrate levels and early glucose stimuli significantly affected the metabolic responses to starvation and refeeding in Siberian sturgeon(P < 0.05). During prolonged starvation, Siberian sturgeon firstly mobilized the liver glycogen and then improved gluconeogenesis when the dietary carbohydrates were abundant, whereas preserved the liver glycogen stores at a stable level and more effectively promoted gluconeogenesis when the dietary carbohydrates are absent to maintain glucose homoeostasis.During refeeding, as most teleostean, Siberian sturgeon failed controlling the activities and mRNA levels of phosphoenolpyruvate carboxykinase cytosolic forms(PEPCK-C), fructose-1,6-bisphosphatase(FBPase),but particularly controlled phosphoenolpyruvate carboxykinase mitochondrial forms(PEPCK-M) activities and mRNA expression of glucose-6-phosphatase(G6 Pase, except in GL group). Siberian sturgeon has a full compensatory ability on growth, but this ability would be obstructed by early glucose stimuli when refeeding the low carbohydrate diet after S21. | Xiaofang Liang Jia Wang Guan Gong Min Xue Yingchao Dong Xiufeng Wu Xin Wang Chunshan Chen Xufang Liang Yuchang Qin | 2017 | Animal Nutrition2017，，3： | 8 |
| 5 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 6 | Solid Acid Used as Highly Efficient Catalyst for Esterification of Free Fatty Acids with Alcohols显示文摘Anovel solid acid catalyst, which was prepared from sodium alginate (SA) and metal chlorides and characterized with XRD and FT-IR spectrometry, was used for the preparation of biodiesel via esterification reaction. The study results showed that the aluminum-alginate complex prepared in a cheap and easy way exhibited high catalytic activity, and a 92.6% conversion of methyl oleate was obtained in the presence of 4m% of catalyst dosage upon refluxing for 3h of methanol and acid mixed in a molar ratio of 10:1. It should be noted that the catalyst can be applied to the esterification reaction of fatty acids with various carbon chain length on methanol or different short chain alcohols, indicating that the catalyst is suitable for the preparation of biodiesel from waste oils with a high acid value. | Zhang Qiuyun Li Hu Qin Wenting Liu Xiaofang Zhang Yuping Xue Wei Yang Song | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 6 |
| 7 | A new single-cell protein from Clostridium autoethanogenum as a functional protein for largemouth bass(Micropterus salmoides)显示文摘Clostridium autoethanogenum protein(CAP)is a new single-cell protein source originating from inactivated bacteria.An in vitro digestion experiment and an 8-wk growth experiment were conducted to evaluate the molecular weight distribution of the CAP hydrolysate,and the effects of dietary CAP levels on the growth performance,plasma parameters,hepatic and intestinal health,and the diversity of gutadherent microbiota of largemouth bass(Micropterus salmoides).The fish(initial body weight of 47.99±0.01 g)were fed diets where CAP gradually replaced 0%(CAP0),12.5%(CAP12.5),25%(CAP25),37.5%(CAP37.5)and 50%(CAP50)of low-temperature steam dried anchovy fish meal(LTFM)in the diet.Results showed that the content of peptides below 1,000 Da in the CAP hydrolysate(0.56 mg/mL)was higher than that of the LTFM hydrolysate(0.48 mg/mL).Dietary CAP inclusion had no negative effect on growth performance,while whole-body lipid content significantly reduced in the CAP25 and CAP50 groups(P<0.05).The plasma alanine aminotransferase activities and triglyceride concentrations in the CAP inclusion groups were significantly lower than those in the CAP0 group(P<0.05).The plasma aspartate aminotransferase activity was significantly reduced in the CAP37.5 group(P<0.05).The richness and diversity of the gut-adhesive microbiota and the proportion of Clostridium sensu stricto 12 in the CAP50 group were significantly higher than those in the CAP0 group(P<0.05).Dietary CAP inclusion inhibited inflammatory responses by down-regulating the mRNA levels of interleukin 1b(IL1b),IL10 and transforming growth factor b1(P<0.05)in the liver.The mRNA levels of acetyl-CoA carboxylase 1 were significantly down-regulated in the CAP12.5,CAP25 and CAP37.5 groups(P<0.05),while that of fatty acid synthase was significantly down-regulated in the CAP50 group(P<0.05).These results demonstrate that dietary CAP inclusion could improve the hepatic and intestinal health of largemouth bass,and can be helpful to further develop CAP as a functional feed ingredient. | Shifeng Ma Xiaofang Liang Pei Chen Jie Wang Xu Gu Yuchang Qin Christophe Blecker Min Xue | 2022 | Animal Nutrition2022，，3： | 6 |
| 8 | Design, synthesis and in vitro evaluation of phenylbenzamidine derivatives as SSRIs显示文摘A series of phenylbenzamidine analogs were synthesized and tested for their biological activities of inhibiting the reuptake of 5- HT. All of them were new compounds, and their structures were confirmed by 1HNMR, MS and XRD. | Jing Yang Xiaofang Wang Hui Wen Fang Qin Guang Zhong Yang | 2007 | Chinese Chemical Letters2007，18，7： | 4 |
| 9 | Phase Boundary Mapping in ZrNiSn Half-Heusler for Enhanced Thermoelectric Performance显示文摘The solubility range of interstitial Ni in the ZrNi1+xSn half-Heusler phase is a controversial issue,but it has an impact on the thermoelectric properties.In this study,two isothermal section phase diagrams of the Zr-Ni-Sn ternary system at 973K and 1173 K were experimentally constructed based on the binary phase diagrams of Zr-Ni,Zr-Sn,and Ni-Sn.The thermodynamic equilibrium phases were obtained after a long time of heating treatment on the raw alloys prepared by levitation melting.Solubilities of x<0:07 at 973 K and x<0:13 at 1173 K were clearly indicated.An intermediate-Heusler phase with a partly filled Ni void was observed,which is believed to be beneficial to the lowered lattice thermal conductivity.The highest ZT value~0:71 at 973 K was obtained for ZrNi_(1.11)Sn_(1.04).The phase boundary mapping provides an important instruction for the further optimization of ZrNiSn-based materials and other systems. | Xiaofang Li Pengbo Yang Yumei Wang Zongwei Zhang Dandan Qin Wenhua Xue Chen Chen Yifang Huang Xiaodong Xie Xinyu Wang Mujin Yang Cuiping Wang Feng Cao Jiehe Sui Xingjun Liu Qian Zhang | 2020 | Research2020，，1： | 2 |
| 10 | Optimization of the T3-induced Xenopus metamorphosis assay for detecting thyroid hormone signaling disruption of chemicals显示文摘T3-induced Xenopus metamorphosis is an ideal model for detecting thyroid hormone(TH)signaling disruption of chemicals. To optimize the T3-induced Xenopus assay and improve its sensitivity and reproducibility, we intend to develop quantitatively morphological endpoints and choose appropriate concentrations and exposure durations for T3 induction.Xenopus laevis at stage 52 were exposed to series of concentrations of T3(0.31–2.5 nmol/L)for 6 days. By comparing morphological changes induced by T3, we propose head area,mouth width, unilateral brain width/brain length, and hindlimb length/snout-vent length as quantitative parameters for characterizing T3-induced morphological changes, with body weight as a parameter for indicating integrated changes. By analyzing time-response curves, we found that following 4-day exposure, T3-induced grossly morphological changes displayed linear concentration–response curves, with moderate morphological changes resulting from 1.25 nmol/L T3 exposure. When using grossly morphological endpoints to detect TH signaling disruption, we propose 4 days as exposure duration of T3, with concentrations close to 1.25 nmol/L as induction concentrations. However, it is appropriate to examine morphological and molecular changes of the intestine on day 2 due to their early response to T3. The quantitative endpoints and T3 induction concentrations and durations we determined would improve the sensitivity and the reproducibility of the T3-induced Xenopus metamorphosis assay. | Xiaofang Yao Xiaoying Chen Yinfeng Zhang Yuanyuan Li Yao Wang Zongming Zheng Zhanfen Qin Qingdong Zhang | 2017 | Journal of Environmental Sciences2017，29，2： | 2 |
| 11 | Simultaneous suppression of multidrug resistance and antiapoptotic cellular defense induces apoptosis in chemoresistant human acute myeloid leukemia cells显示文摘 | Xiaofang Wang Chun Wang You-wen Qin Shi-ke Yan Yan-rong Gao | 2006 | Leukemia Research2006，，7： | 1 |
| 12 | Harmful effect of ER β on BCRP ‐mediated drug resistance and cell proliferation in ER α/ PR ‐negative breast cancer显示文摘 | Weiwei Li Ming Jia Xiaomin Qin Jing Hu Xiaofang Zhang Gengyin Zhou | 2013 | FEBS J2013，，23： | 1 |
| 13 | Robust hydrogel sensors for unsupervised learning enabled sign-to-verbal translation显示文摘Highly stretchable and robust strain sensors are rapidly emerging as promising candidates for a diverse of wearable electronics.The main challenge for the practical application of wearable electronics is the energy consumption and device aging.Energy consumption mainly depends on the conductivity of the sensor,and it is a key factor in determining device aging.Here,we design a liq-uid metal(LM)-embedded hydrogel as a sensing material to overcome the bar-rier of energy consumption and device aging of wearable electronics.The sensing material simultaneously exhibits high conductivity(up to 22 S m�1),low elastic modulus(23 kPa),and ultrahigh stretchability(1500%)with excel-lent robustness(consistent performance against 12000 mechanical cycling).A motion monitoring system is composed of intrinsically soft LM-embedded hydrogel as sensing material,a microcontroller,signal-processing circuits,Bluetooth transceiver,and self-organizing map developed software for the visu-alization of multi-dimensional data.This system integrating multiple functions including signal conditioning,processing,and wireless transmission achieves monitor hand gesture as well as sign-to-verbal translation.This approach provides an ideal strategy for deaf-mute communicating with normal people and broadens the application of wearable electronics. | Hude Ma Haiyang Qin Xiao Xiao Na Liu Shaolei Wang Junye Li Sophia Shen Shuqi Dai Mengmeng Sun Peiyi Li Xiaofang Pan Mingjun Huang Baoyang Lu Jun Chen Lidong Wu | 2023 | InfoMat2023，5，7： | 1 |
| 14 | The role of N--methy--D--aspartate receptor subunit NR2B in the spinal cord in cancer pain显示文摘 | Juan Zhang ZhengLiong Ma JunHua Wang XiaoFang Zhou XiaoPing Gu YanQing Jin XiaoPing Xia Qin Gao FengMei Mei | 2009 | 麻醉与监护论坛2009，16，3： | 1 |
| 15 | Development and evaluation of a thermostatic nucleic acid testing device based on magnesium pyrophosphate precipitation for detecting Enterocytozoon hepatopenaei显示文摘Enterocytozoon hepatopenaei(EHP)infection has seriously affected prawn culture globally.The symptoms of the infection are not apparent,and traditional detection methods are time consuming and low in accuracy.We developed a new onsite rapid testing device(size 18.8×16.7×6.6 cm^(3))for EHP based on magnesium pyrophosphate precipitation and facilitated by loop mediated isothermal amplification(LAMP).The design and fabrication of the device enables efficient light absorbance.The device has a highly sensitive detector,high-precision thermal controller,and humanized touch screen.The temperature control precision of the device is 0.2-0.3℃ at 60℃,63℃,and 65℃.The coefficients of variation values(CVV)of the luminous power in one channel at light on and off were found to be 0.0097 and 0.0014,respectively,within 1 h.The CVV of the background,luminous power,and values of eight PCR tubes filled with pure water were all less than 5%.In the EHP experiment,eight samples(including seven positive and one negative)confirmed the effectiveness of the device,and four positive and four negative samples verified whether cross-contamination exists.Among them,the rise time of the curve was about 15 min.These results assert that the developed device exhibits enhanced stability and uniformity and has excellent performance with high sensitivity,good specificity,and low testing time.Moreover,the optimal and minimum absorbance range was 555-655 nm for monitoring the production of LAMP. | Zhu Chen Kaixuan Zhao Ziyu He Xiaofang Luo Zuodong Qin Yimin Tan Xiangming Zheng Zuozhong Wu Yan Deng Hui Chen Yuan Guo Song Li | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 16 | Malnutrition associated factors on children under 5 years old in Lhaviyani Atoll,Maldives显示文摘In this report,we aimed to analyze the prevalence of undernutrition and associated factors among children under 5 years of age in Lhaviyani Atoll,Maldives.A total of 800 children(under 5 years old) and their mothers were selected for this study.Data was collected by using a pretested questionnaire and anthropometric measurements were taken from the hospital record book.Chi-square tests and multivariate logistic regression were used to find the association between nutritional status and determinants.The distribution of height for age and weight for age in surveyed children in Maldives was skewed to the left compared with the WHO standard.The prevalence of undernutrition based on underweight(10.75%),stunting(13.5%),and wasting(9.60%) was estimated to be 23.85% among children.Child age,gender and mother’s education were significantly associated with undernutrition(P<0.05).Our survey highlighted that better nutritional interventions are needed to improve child health in this region. | Mariyam Asra Xiaofang Lin Ijaz Ul Haq Asfia Banu Pasha Yingying Shao Rui Qin Manli Hu Ye Ding Zhixu Wang | 2020 | The Journal of Biomedical Research2020，34，4： | 0 |
| 17 | Investigating the Immunogenic Cell Death‑Dependent Subtypes and Prognostic Signature of Triple‑Negative Breast Cancer显示文摘Recently,immunotherapy has emerged as a promising and efective method for treating triple-negative breast cancer(TNBC).However,challenges still persist.Immunogenic cell death(ICD)is considered a prospective treatment and potential combinational treatment strategy as it induces an anti-tumor immune response by presenting the antigenic epitopes of dead cells.Nevertheless,the ICD process in TNBC and its impact on disease progression and the response to immunotherapy are not well understood.In this study,we observed dysregulation of the ICD process and verifed the altered expression of prognostic ICD genes in TNBC through quantitative real-time polymerase chain reaction(qRT-PCR)analysis.To investigate the potential role of the ICD process in TNBC progression,we determined the ICD-dependent subtypes,and two were identifed.Analysis of their distinct tumor immune microenvironment(TIME)and cancer hallmark features revealed that Cluster 1 and 2 corresponded to the immune“cold”and“hot”phenotypes,respectively.In addition,we constructed the prognostic signature ICD score of TNBC patients and demonstrated its clinical independence and generalizability.The ICD score could also serve as a potential biomarker for immune checkpoint blockade and may aid in the identifcation of targeted efective agents for individualized clinical strategies. | Youyang Shi Yuanyuan Wu Feifei Li Kexin Jiang Xiaofang Fang Yu Wang Xiaoyun Song Rui Wang Lixin Chen Jinzhou Zheng Chunyu Wu Yuenong Qin Xiaofei Liu Sheng Liu | 2024 | Phenomics2024，4，1： | 0 |
| 18 | A Dynamic Reputation–based Consensus Mechanism for Blockchain显示文摘In recent years,Blockchain is gaining prominence as a hot topic in academic research.However,the consensus mechanism of blockchain has been criticized in terms of energy consumption and performance.Although Proof-of-Authority(PoA)consensus mechanism,as a lightweight consensus mechanism,is more efficient than traditional Proof-of-Work(PoW)and Proof-of-Stake(PoS),it suffers from the problem of centralization.To this end,on account of analyzing the shortcomings of existing consensus mechanisms,this paper proposes a dynamic reputation-based consensus mechanism for blockchain.This scheme allows nodes with reputation value higher than a threshold apply to become a monitoring node,which can monitor the behavior of validators in case that validators with excessive power cause harm to the blockchain network.At the same time,the reputation evaluation algorithm is also introduced to select nodes with high reputation to become validators in the network,thus increasing the cost of malicious behavior.In each consensus cycle,validators and monitoring nodes are dynamically updated according to the reputation value.Through security analysis,it is demonstrated that the scheme can resist the attacks of malicious nodes in the blockchain network.By simulation experiments and analysis of the scheme,the result verifies that the mechanism can effectively improve the fault tolerance of the consensus mechanism,reduce the time of consensus to guarantee the security of the system. | Xiaofang Qiu Zhi Qin Wunan Wan Jinquan Zhang Jinliang Guo Shibin Zhang Jinyue Xia | 2022 | Computers, Materials & Continua2022，，11： | 0 |
| 19 | A Scalable Double-Chain Storage Module for Blockchain显示文摘With the growing maturity of blockchain technology,its peer-topeer model and fully duplicated data storage pattern enable blockchain to act as a distributed ledger in untrustworthy environments.Blockchain storage has also become a research hotspot in industry,finance,and academia due to its security,and its unique data storage management model is gradually becoming a key technology to play its value in various fields’applications.However,with the increasing amount of data written into the blockchain,the blockchain system faces many problems in its actual implementation of the application,such as high storage space occupation,low data flexibility and availability,low retrieval efficiency,poor scalability,etc.To improve the above problems,this paper combines off-chain storage technology and deduplication technology to optimize the blockchain storage model.Firstly,this paper adopts the double-chain model to reduce the data storage of the major chain system,which stores a small amount of primary data and supervises the vice chain through an Application Programming Interface(API).The vice chain stores a large number of copies of data as well as non-transactional data.Our model divides the vice chain storage system into two layers,including a storage layer and a processing layer.In the processing layer,deduplication technology is applied to reduce the redundancy of vice chain data.Our doublechain storage model with high scalability enhances data flexibility,is more suitable as a distributed storage system,and performs well in data retrieval. | Hui Han Wunan Wan Jinquan Zhang Zhi Qin Xiaofang Qiu Shibin Zhang Jinyue Xia | 2022 | Computers, Materials & Continua2022，，11： | 0 |
| 20 | 小分子化合物诱导人胃上皮细胞直接转化为内胚层多潜能祖细胞显示文摘内胚层干/祖细胞是肝脏、胰腺、小肠等内脏器官的共同起源,在再生医学的基础研究和临床应用中具有广阔的应用前景。因此,寻找一种安全高效的获取内胚层干/祖细胞的方式将具有极其重要的意义。 | 王韫芳 Jinhua Qin Shuyong Wang Wencheng Zhang Jialei Duan Jing Zhang Xin Wang Fang Yan Mingyang Chang Xiaofang Liu Bo Feng Jiang Liu 裴雪涛 | 2017 | 科学新闻2017，19，4： | 0 |
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