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| 1 | Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines显示文摘AIM To observe the effect of acupuncture and moxibustion on the expression of IL 1β and IL 6 mRNA in ulcerative colitis rats. METHODS The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000*!r/*!min . The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (no Freund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n =8), electro acupuncture group (EA, n =8), herbs partition moxibustion group (HPM 8), normal control group (NC, n =8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc ) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT PCR technique was used to study the expression of IL 1β and IL 6 mRNA. RESULTS IL 1β and IL 6 mRNAs were not detected in the spleen and colonic mucosa of the NC rats, whereas they were significantly expressed in that of the MC rats. IL 1β and IL 6 mRNAs were markedly lower in the EA and HPM rats than that in MC rats. There was no significant difference between the levels of IL 1β and IL 6 mRNAs in the EA and HPM rats. The expressions of IL 1β and IL 6 mRNAs were nearly the same in the spleen and colon of all groups. CONCLUSION Acupuncture and moxibustion greatly inhibited the expression of IL 1β and IL 6 mRNA in the experimental ulcerative colitis rats. | Wu HG Zhou LB Pan YY Huang C Chen HP Shi Z Hua XG | 1999 | World Journal of Gastroenterology1999，5，6： | 45 |
| 2 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 3 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 4 | A novel XPF-357A 〉 C polymorphism predicts risk and recurrence of bladder cancer(摘要)显示文摘 | Wang, M Yuan, L Wu, D Zhang, Z Yin, C Fu, G Wei, Q | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 5 |
| 5 | The Novel Mechanical Property of Tongue of a Woodpecker显示文摘Biomaterials such as bone,teeth,nacre and silk are known to have superior mechanical properties due to their specificnanocomposite structures.Here we report that the woodpecker’s tongue exhibits a novel strength and flexibility due to its specialcomposite micro/nanostructure.The tongue consists of a flexible cartilage-and-bone skeleton covered with a thin layer tissue ofhigh strength and elasticity.At the interface between the cartilage-and-bone skeleton and the tissue layer,there is a hierarchicalfiber-typed connection.It is this special design of the tongue that makes the woodpeckers efficient in catching the insects insidetrees.The special micro/nanostructures of the woodpecker’s tongue show us a potential method to enhance the interfacialconnection between soft and hard material layers for bio-inspired composite system designs. | P Zhou X Q Kong C W Wu Z Chen | 2009 | Journal of Bionic Engineering2009，6，3： | 3 |
| 6 | A simple method for predicting the spontaneous combustion potential of sulfide ores at ambient 显示文摘 | WU C LI Z | 2005 | Transaction of Mining and Metallurgy Institute2005，112，2： | 1 |
| 7 | Persistent organic pollutants in water and surface sedimentsof Taihu Lake, China and risk assessment 显示文摘 | Wang H Wang C X Wu W Z | 2003 | Chemosphere2003，50，： | 1 |
| 8 | Monte carlo simulation of particle-cracking damage evolution in metal matrix composites 显示文摘 | Liu H T Sun L Z Wu H C | 2005 | Journal of Engineering Materials and Technology2005，，127： | 1 |
| 9 | Partial Cross Sections and Photoelectron Angular Distributions in the Region of 4s→5p and 5s→6p Resonances in Krypton and Xenon显示文摘 | Wu J Z Caldwell C D | 1991 | Phys Rev1991，44，： | 1 |
| 10 | A survey and comparison of Petri net based deadlock prevention policies for flexible manufacturing systems显示文摘 | LI Z W ZHOU M C WU N Q | 2008 | IEEE Trans on Syst Man Cybern C Appl Reviews2008，38，2： | 1 |
| 11 | Synthesis, characterization and controlled drug release of thermosensitive IPNPNIPAAm hydrogels 显示文摘 | Zhang X Z Wu D Q Chu C C | 2004 | Biomaterials2004，25，： | 1 |
| 12 | A cold-induciblecoactivator of nuclear receptor linked to adaptive thermogenesis显示文摘 | Puigserver P Wu Z Park C W | 1998 | Cell1998，92，： | 1 |
| 13 | The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals显示文摘 | Jia Z S Tang M C Wu J M | 1999 | Food Chemistry1999，64，4： | 1 |
| 14 | Biomass pyrolysis in an argon/hydrogen plasma reactor 显示文摘 | Zhao Z Huang H Wu C | 2001 | Environmental Science and Technology2001，，24： | 1 |
| 15 | In situ measuring and evaluating the thermal resistance of building construction 显示文摘 | Peng C Wu Z | 2008 | Energy and Buildings2008，40，11： | 1 |
| 16 | Convergence error estimate in solving free boundary diffusion problem by radial basis functions method显示文摘 | Wu Z Hon Y C | 2003 | Engineering Analysis with Boundary Elements2003，27，： | 1 |
| 17 | Effect of enamel coating on oxidation and hot corrosion resistance of Ti-24Al-14Nb-3V显示文摘 | GUAN C H TANG Z L WANG F H WU W T | 2000 | Chinese J Mater Res2000，14，： | 1 |
| 18 | Effect of temperature on the hybrid supercapacitor based on NiO and activated carbon with alkaline polymer gel electrolyte显示文摘 | Yuan C Z Zhang X G Wu Q F | 2006 | Solid State Ionics2006，177，1314： | 1 |
| 19 | Assessing the soil quality of long-term reclaimed wastewater irrigated cropland 显示文摘 | Wang Z Chang A C Wu L S | 2003 | Geoderma2003，114，34： | 1 |
| 20 | Towards reliable matching of images containing repetitive patterns 显示文摘 | Fan 13 Wu F C Hu Z Y | 2011 | Pattern Recognition Letters2011，32，14： | 1 |
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