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| 1 | Aging:A mitochondrial DNA perspective,critical analysis and an update显示文摘The mitochondrial theory of aging, a mainstream theory of aging which once included accumulation of mitochondrial DNA(mt DNA) damage by reactive oxygen species(ROS) as its cornerstone, has been increasingly losing ground and is undergoing extensive revision due to its inability to explain a growing body of emerging data. Concurrently, the notion of the central role for mtDNA in the aging process is being met with increased skepticism. Our progress in understanding the processes of mtDNA maintenance, repair, damage, and degradation in response to damage has largely refuted the view of mt DNA as being particularly susceptible to ROS-mediated mutagenesis due to its lack of 'protective' histones and reduced complement of available DNA repair pathways. Recent research on mitochondrial ROS production has led to the appreciation that mitochondria, even in vitro, produce much less ROS than previously thought, automatically leading to a decreased expectation of physiologically achievable levels of mtDNA damage. New evidence suggests that both experimentally induced oxidative stress and radiation therapy result in very low levels of mtDNA mutagenesis. Recent advances provide evidence against the existence of the 'vicious' cycle of mtDNA damage and ROS production. Meta-studies reveal no longevity benefit of increased antioxidant defenses. Simultaneously, exciting new observations from both comparative biology and experimental systems indicate that increased ROS production and oxidative damage to cellular macromolecules, including mtDNA, can be associated with extended longevity. A novel paradigm suggests that increased ROS production in aging may be the result of adaptive signaling rather than a detrimental byproduct of normal respiration that drives aging. Here, we review issues pertaining to the role of mtDNA in aging. | Inna N Shokolenko Glenn L Wilson Mikhail F Alexeyev | 2014 | World Journal of Experimental Medicine2014，4，4： | 6 |
| 2 | Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry(Fragaria×ananassa)显示文摘A biparental cross of octoploid strawberry segregating for resistance to Verticillium dahliae,the causative agent of Verticillium wilt,was screened under field conditions for three seasons.Average wilt scores were significantly associated with multiple QTL,which were mostly significant across all years.Markers significantly associated with the traits were used to screen material with known wilt resistance and susceptibility phenotypes.A clear and statistically significant relationship was observed between resistant,tolerant and susceptible material and the total number of markers present in the different resistance classes.In field situations resistance QTL appear to behave in an additive manner.These markers are abundant in the cultivated strawberry germplasm indicating that,despite the large number of markers,clear genetic gain is possible through marker-assisted breeding. | L Antanaviciute NŠurbanovski N Harrison K J McLeary D W Simpson F Wilson D J Sargent R J Harrison | 2015 | Horticulture Research2015，2，1： | 5 |
| 3 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 4 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 5 | Pivot hysteresis model for reinforced concrete members 显示文摘 | Dowell R K Seibel F Wilson E L | 1998 | ACI Structural Journal1998，95，5： | 1 |
| 6 | BetaⅢ-tubulin induces pa- elitaxel resistance in association with reduced effects on microtu- bule dynamic instability 显示文摘 | Kamath K Wilson L Cabral F | 2005 | J Biol Chem2005，208，12： | 1 |
| 7 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 8 | Adding human health risk analysis tools to geographic informa- tion systems 显示文摘 | HELLWEGER F L WILSON L H NARANJO E M | 2002 | Transactions in GIS2002，6，4： | 1 |
| 9 | Active optics 1 :a sys- tem for optimizing the optical quality and reducing the costs of large telescopes显示文摘 | Wilson R N Franza F Noethe L | 1987 | Journal of Modern Optics (S0950 - 0340)1987，34，4： | 1 |
| 10 | Secondary recrystallization in copper显示文摘 | Kronberg M L Wilson F H | 1949 | Trans Am Inst Min Engrs1949，185，： | 1 |
| 11 | class Ⅲ-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability显示文摘 | Kamath K Wilson L Cabral F | 2005 | J Biol Chem2005，280，12： | 1 |
| 12 | Chemically mediated ovipo- sitional behaviors of the European corn borer, Ostrinia nubilalis ( Lepi- doptera:Pyralidae) 显示文摘 | BINDER B F ROBBINS J C WILSON R L | 1995 | Journal of chemical ecology1995，21，9： | 1 |
| 13 | Comparisonof basic visual servoing methods 显示文摘 | Janabi-Sharifi F Deng L F Wilson W J | 2011 | IEEE/ASMETransactions on Mechatronics2011，16，5： | 1 |
| 14 | Pivot hysteresis model for reinforced concrete members显示文摘 | Dowell R K Seible F Wilson E L | 1998 | ACI Structural Journal1998，95，5： | 1 |
| 15 | Active optics 4: set - up and performance of the optics of the ESO new tech- nology telescope (NTT) in the observatory显示文摘 | Wilson R N Franza F Noethe L | 1991 | Journal of Modern Optics(S0950 - 0340)1991，38，2： | 1 |
| 16 | Secondary recrystallization in copper显示文摘 | KRONBERG M L WILSON F H | 1949 | Trans AIME1949，185，1： | 1 |
| 17 | CYP2E1 inhibition enhances mallory body formation显示文摘 | Bardag-Gorce F Wilson L Nan L | | 0，，03： | 1 |
| 18 | Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study显示文摘 | Ronenn Roubenoff Helen Parise Hélène A Payette Leslie W Abad Ralph D’Agostino Paul F Jacques Peter W.F Wilson Charles A Dinarello Tamara B Harris | 2003 | The American Journal of Medicine2003，，6： | 1 |
| 19 | Determination of the binding of hexanal to soy glycinin and betaconglycinin in an aqueous model system using a headspace technique显示文摘 | O'KEEFE S F WILSON L A RESURRECCION A P | 1991 | Journal of Agricultural and Food Chemistry1991，39，6： | 1 |
| 20 | Beta Ⅲ-tubulin induces paclitaxel resistance in association with reduceed effects on mi- erotubule dynamic instability 显示文摘 | Kamath K Wilson L Cabral F | 2005 | Biol Chem2005，208，12： | 1 |
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