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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 4 | Knowledge, perception and practices about malaria, climate change, livelihoods and food security among rural communities of central Tanzania显示文摘Background:Understanding the interactions between malaria and agriculture in Tanzania is of particular significance when considering that they are the major sources of illness and livelihoods.The objective of this study was to determine knowledge,perceptions and practices as regards to malaria,climate change,livelihoods and food insecurity in a rural farming community in central Tanzania.Methods:Using a cross-sectional design,heads of households were interviewed on their knowledge and perceptions on malaria transmission,symptoms and prevention and knowledge and practices as regards to climate change and food security.Results:A total of 399 individuals(mean age=39.8±15.5 years)were interviewed.Most(62.41%)of them had attained primary school education and majority(91.23%)were involved in crop farming activities.Nearly all(94.7%)knew that malaria is acquired through a mosquito bite.Three quarters(73%)reported that most people get sick from malaria during the rainy season.About 50%of the respondents felt that malaria had decreased during the last 10 years.The household coverage of insecticide treated mosquito nets(ITN)was high(95.5%).Ninety-six percent reported to have slept under a mosquito net the previous night.Only one in four understood the official Kiswahili term(Mabadiliko ya Tabia Nchi)for climate change.However,there was a general understanding that the rain patterns have changed in the past 10 years.Sixty-two percent believed that the temperature has increased during the same period.Three quarters of the respondents reported that they had no sufficient production from their own farms to guarantee food security in their household for the year.Three quarters(73.0%)reported to having food shortages in the past five years.About half said they most often experienced severe food shortage during the rainy season.Conclusion:Farming communities in Kilosa District have little knowledge on climate change and its impact on malaria burden.Food insecurity is common and community-based strategies to mitigate this need to be established.The findings call for an integrated control of malaria and food insecurity interventions. | Benjamin K Mayala Carolyn A Fahey Dorothy Wei Maria M Zinga Venera M Bwana Tabitha Mlacha Susan F Rumisha Grades Stanley Elizabeth H Shayo Leonard EG Mboera | 2015 | Infectious Diseases of Poverty2015，4，1： | 2 |
| 5 | An Empirical Analysis of Energy Efficiency in China's Iron and Steel Sector 显示文摘 | Wei Y M Liao H Fan Y | 2007 | Energy Policy2007，32，12： | 1 |
| 6 | Effect of base strength and basicity on catalytic behavior of solid bases for synthesis of dimethyl carbonate from propylene carbonate and methanol显示文摘 | WEI T WANG M H WEI W SUN Y H ZHONG B | 2003 | Fuel Processing Technology2003，83，13： | 1 |
| 7 | Efficient Agrobactetium tumefaciens-mediated transformation of soybeans using an embryonic tip regeneration system显示文摘 | Liu H K Yang C Wei Z M | 2004 | Planta2004，219，： | 1 |
| 8 | Characterization of high-molecular weight glutenin subunit genes from Elytrigia elongate显示文摘 | Wang J R Yan Z H Wei Y M | 2006 | Plant Breeding2006，125，： | 1 |
| 9 | A riccati equation approach to the design of linear robust controllers显示文摘 | Ni M L Wei H X | 1995 | Automatica1995，29，6： | 1 |
| 10 | Effects of clear plastic film mulch on yield of spring wheat显示文摘 | Li F M Guo A H Wei H | 1999 | Field Crops Research1999，63，： | 1 |
| 11 | CO2-expanded solvents:Unique and versatile media for performing homogeneous catalytic oxidations显示文摘 | WEI M MUSIE G T BUSCH D H SUBRAMANIAM B | 2002 | J Am Chem Soc2002，124，11： | 1 |
| 12 | Modified quadratic congruencr code for fiber Bragg-grating-based spectral-amplitude-coding optical CDMA systems显示文摘 | ZOU Wei Shalaby H H M Ghafouri-Shiraz H | 2001 | IEEE J Lightwave Technol2001，19，9： | 1 |
| 13 | ATF5 increases cisplatin-induced apoptosis through up-regulation of Cyc- lin D3 transcription in HeLa cells 显示文摘 | WEI Y Y JIANG J H SUN M Y | 2006 | Biochem Biophys Res Commun2006，339，2： | 1 |
| 14 | A novel magnetic-electric-quadrupole tandem mass spec- trometer of ultra-high abundance sensitivity 显示文摘 | WEI G Y ZHAI L H LI Z M | 2013 | Int J Mass Spectrom2013，，343344： | 1 |
| 15 | Empirical comparison of fast partitio- ning-based clustering algorithms for large data sets 显示文摘 | WEI C P LEE Y H HSU C M | 2003 | Expert Sys- tems with Applications2003，24，4： | 1 |
| 16 | Synthesis of a novel hybrid synergistic flame retardant and its application in PP/IFR 显示文摘 | Qian Y’Wei P Jiang P K Zhao X M Yu H Z | 2011 | Polymer Degradation and Stability2011，96，6： | 1 |
| 17 | Identification and cloning of a key insecticide-metabolizing glutathione S-transferase(MdGST-6A)from a hyper insecticide-resistant strain of the housefly Musca domestica显示文摘 | Wei S H Clark A G Syvanen M | 2001 | Insect Biochem Mol Biol2001，31，12： | 1 |
| 18 | Microbial diversity and abundance in a representative small - production coal mine of central China显示文摘 | Wei M Yu Z Zhang H | 2013 | E- her Fuel2013，27，7： | 1 |
| 19 | Sensitive measurement of optical nonlinearities using a single beam 显示文摘 | SHEIK-BAHAE M SAID A A WEI T H | 1990 | Journal of Quantum Electronic1990，26，4： | 1 |
| 20 | Efficient Agrobacterium tumefaciens-mediated transformation of soybeans using an embryonic tip regeneration system 显示文摘 | Liu H K Yang C Wei Z M | 2004 | Planta2004，219，6： | 1 |
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