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| 1 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010,,10: | 3 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014,20,33: | 2 |
| 3 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007,,10: | 2 |
| 4 | Nature of surface bonding on voltammetrically oxidized noble-metals in aqueous-media as probed by real-time surface-enhanced Raman-speetroseopy 显示文摘 | Zhang Y Gao X P Weaver M J | 1993 | Journal of Physical Chemistry1993,97,33: | 1 |
| 5 | Acoustic coupling into the ionosphere from seismic waves of the earthquake at Kurile Islands on August 11, 1969显示文摘 | Weaver P F Yuen P C Prolss G W | 1971 | Nature1971,226,: | 1 |
| 6 | Marketing your community:image analysis of Norfolk 显示文摘 | Chon K Weaver P A Kim C Y | 1991 | The Cornell H R A Quarterly1991,31,4: | 1 |
| 7 | Capsid pro- tein of eastem equine encephalitis virus inhibits host cell gene expression 显示文摘 | AGUILAR P V WEAVER S C BASLER C F | 2007 | J Virol2007,81,8: | 1 |
| 8 | Differential progression of neonatal diethylstilbestrol-induced disruption of the hamster testis and seminal vesicle 显示文摘 | Hendry W J Weaver B P Naccarato T R | 2006 | Reproductive Toxicology2006,21,3: | 1 |
| 9 | Game-theoretic control of small- scale power systems显示文摘 | Weaver W W Krein P T | 2009 | IEEE Transactions on Power Delivery2009,24,3: | 1 |
| 10 | The content of favorable and unfavorable polyunsaturated fatty acids found in commonly eaten fish显示文摘 | Weaver K Ivester P Chilton J | 2008 | J Am Diet Assoc2008,108,7: | 1 |
| 11 | The impact of social media on destinationbranding: Consumer-generated videos versus destination marketer-generatedvideos 显示文摘 | Lim Y Chung Y Weaver P A | 2012 | Journal of Vacation Marketing2012,18,3: | 1 |
| 12 | Being Uncertain:The Rela- tionship Between Entrepreneurial Orientation and Environmental and Enviromental Uncertainty 显示文摘 | Weaver K M P H Dickson B Gibson | 2002 | Journal of Enterprising Culture2002,2,: | 1 |
| 13 | Efficacy Of rofecoxib,celecoxib,and acetaminophen in osteoarthritis of the knee:a randomized trial显示文摘 | Geba Gregory P Weaver Arthur L Plois Adam B | 2002 | The journal of American medical association2002,287,1: | 1 |
| 14 | Requirement of the DEAD-box Protein Dedlp for Messenger RNA Translation显示文摘 | Chuang R Y Weaver P L Liu Z | 1997 | Science1997,275,: | 1 |
| 15 | Current methods for obtaining,logging and splitting marine sediment cores显示文摘 | Weaver P P E Schultheiss P J | | 0,,: | 1 |
| 16 | The effects of benzene exposure on apoptosis in epithelial lung cells: localization by tcrminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) and the irnmunocytochemical localization of apoptosis-related gene products显示文摘 | WEAVER C V LIU S P LU J F | 2007 | Cell Biology and Toxicology2007,23,3: | 1 |
| 17 | Heterogeneous Heck catalysis with palladium-grafted molecular sieves显示文摘 | Mehnert C P Weaver D W Ying J Y | 1998 | Journal of the American Chemical Society1998,120,12: | 1 |
| 18 | Brachytic stem trait,row spacing,and plant population effects on soybean yield显示文摘 | Adams P D Weaver D B | 1998 | Crop Science1998,38,3: | 1 |
| 19 | Expandingthe Effeetor CD4 T-Cell Repertoire:the Thl7 Lineage 显示文摘 | Harrington L E Mangan P R Weaver C T | 2006 | Curr Opin Immunol2006,18,3: | 1 |
| 20 | Marketing your community:Image analysis of norfolk 显示文摘 | Chon K S Weaver P A Kim C Y( 1991 ) | 1991 | The Cornell Hotel and Restaurant Administration Quarterly1991,3137,: | 1 |