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| 1 | History and possible mechanisms of prehistoric human migration to the Tibetan Plateau显示文摘Prehistoric human history on the Tibetan Plateau is a hotly debated topic. Archaeological research on the plateau during the past few decades has enormously improved our understanding of the topic and makes it possible for us to consider the processes and mechanisms of prehistoric human migration to the region. By reviewing the published archaeological research on the Tibetan Plateau, we propose that the first people on the plateau initially spread into the He-Huang region from the Chinese Loess Plateau, and then moved to the low elevation Northeastern Tibetan Plateau and perhaps subsequently to the entire plateau. This process consisted of four stages.(1) During the climatic amelioration of the Last Deglacial period(15–11.6 ka BP), Upper Paleolithic hunter-gatherers with a developed microlithic technology first spread into the Northeastern Tibetan Plateau.(2) In the early-mid Holocene(11.6–6 ka BP), Epipaleolithic microlithic hunter-gatherers were widely distributed on the northeastern plateau and spread southwards to the interior plateau, possibly with millet agriculture developed in the neighboring low elevation regions.(3) In the mid-late Holocene(6–4 ka BP), Neolithic millet farmers spread into low elevation river valleys in the northeastern and southeastern plateau areas.(4) In the late Holocene(4–2.3 ka BP), Bronze Age barley and wheat farmers further settled on the high elevation regions of the Tibetan Plateau, especially after 3.6 ka BP. Finally, we suggest that all of the reported Paleolithic sites earlier than the LGM on the Tibetan Plateau need further examination. | ZHANG DongJu DONG GuangHui WANG Hui REN XiaoYan HA PiPu'u QIANG MingRui CHEN FaHui | 2016 | Science China Earth Sciences2016，59，9： | 20 |
| 2 | Relationships between use of statins and arterial stiffness in normotensive and hypertensive patients with coronary artery disease显示文摘 | WANG Zhi-guang CHEN Bing-wei L(U) Na-qiang CHENG Yan-mei DANG Ai-min | 2013 | Chinese Medical Journal2013，，16： | 10 |
| 3 | The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation显示文摘Among various immunoregulatory molecules,the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy.Antibodies targeting two B7 family co-inhibitory receptors,CTLA-4 and PD-1,have elicited long-term clinical outcomes in previously refractory cancer types and are considered a breakthrough in cancer therapy.Despite the success,the relatively low response rate(20–30%)warrants efforts to identify and overcome additional immune-suppressive pathways.Among the expanding list of T cell inhibitory regulators,V domain immunoglobulin suppressor of T cell activation(VISTA)is a unique B7 family checkpoint that regulates a broad spectrum of immune responses.Here,we summarize recent advances that highlight the structure,expression,and multi-faceted immunomodulatory mechanisms of VISTA in the context of autoimmunity,inflammation,and anti-tumor immunity. | Wenwen Xu TạMinh Hiếu Subramaniam Malarkannan Li Wang | 2018 | Cellular & Molecular Immunology2018，15，5： | 8 |
| 4 | The association between the genetic polymorphisms of LMP2/LMP7 and the outcomes of HCV infection among drug users显示文摘Objective:To investigate a possible association of LMP2/LMP7 genes with chronic hepatitis C virus(HCV) infection,and to assess whether LMP2/LMP7 genes could influence the outcomes of HCV infection among drug users.Methods:Genomic DNAs of 362 anti-HCV sero-positive drug users and 225 control drug users were extracted from the peripheral blood leukocytes.The sero-positive patients were divided into those who had persistent infection and those who had spontaneously cleared the infection.Polymorphisms of LMP genes were determined by PCR combined with restriction fragment length polymorphism(RFLP).Results:The distribution of LMP2 genotypes among the control,persistent infection and spontaneous clearance groups were not different.However,the LMP7 codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in control group(OR=1.75,95%CI=1.06~2.90;OR=3.16,95%CI=1.23-8.12;OR=1.94,95%CI=1.21-3.12,respectively).Similarly,the frequencies of the codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in the spontaneous clearance group(OR=1.64,95%CI=1.04-2.57;OR=2.40,95%CI=1.09-5.28;OR=1.76,95%CI=1.152.69,respectively).Stratified analysis indicated that combined genotype Gln/Lys+Lys/Lys of the LMP7 gene was related to an increasing susceptibility to HCV infection(OR=1.91,95%CI=1.02-3.55;OR=2.19,95%CI=1.243.89;OR=1.91,95%CI=1.05-3.48,OR=2.86,95%CI=1.41-5.78,respectively)and the risk of persistent HCV infection(OR=1.94,95%CI=1.12-3.34;OR=2.02,95%CI=1.21-3.38;OR=1.78,95%CI=1.12-2.85,OR=2.23,95%CI=1.09-4.58,respectively)among>30-year-old,males,the injection drug user(IDU)subjects and/or the shorter duration drug users(≤5 y).Conclusion:These results suggest that polymorphism of the LMP7 gene may have an influence on the outcomes of HCV infection,and is one of the factors accounting for the genetic susceptibility to HCV infection among drug users. | Qian Cui Yongxiang Zhang Jing Su Chao Shi Na Lei Keqin Ding Jun Li Rongbin Yu L u Wang Ning Wang | 2010 | The Journal of Biomedical Research2010，24，5： | 6 |
| 5 | A preliminary study on correlations of triple-phase multi-slice CT scan with histological differentiation and intratumoral microvascular/lymphatic invasion in gastric cancer显示文摘许多研究显示出的背景那癌症房间区别和 microvascular 侵略在癌症起一个原则作用前进和转移,和象估计区别和外科的 resectibility 和癌症的预后的 CT, MRI 和美国那样的非侵略的成像技术现在是很重要的。这研究试图与组织学的区别和现在的学习包括了的进步胃的 cancer.Methods 的 intratumor microvascular/lymphatic 侵略探索三倍阶段的多片 CT 扫描的关联有胃的癌症的 64 个病人,所有谁在外科前经历了 routinal 和上面的腹部的双阶段的对比改进多片 CT 考试。手术后的标本被用于组织学的区别,容器由 CD34 识别了的 intratumoral microvascular/lyrnphatic 的癌症房间侵略和 D2-40 表示的决心。在在胃的癌症和组织学的区别以及 intraturnoral microvascular/lymphatic 侵略的三倍阶段的多片 CT 扫描的对比改进比率(CER ) 之间的关联被比较,在那里的 analyzed.Results 是在在胃的癌症和肿瘤的三倍阶段的 CT 扫描的 CER 之间的重要关联组织学的区别(P0.05 ) 。没有侵略,在有 intratumoral microvascular 侵略的胃的癌症的动脉的阶段的 CER 比那显著地高(0.61 楶祴椬灭汵楳楶祴愠摮椠慮瑴湥楴湯愠摮瀠瑵 ? 牧慥? 畢摲湥漠 ? 档汩牤湥琠敨獭汥敶 ? 桴楥? 慦業楬獥愠摮琠敨猠' 覕媮聸维樲鏍剾 D 慥敳漠慲? 祳瑳浥洠瑥票灬敨楮慤整 ? 剏协 ??? 獩愠漠据 ? 慤汩 ? 潣瑮潲汬摥爭汥慥敳映牯畭慬楴湯搠癥汥灯摥琠? 癯牥潣敭猠浯 ? 景琠敨氠浩瑩瑡潩獮愠獳' 覒 X 整 ? 楷桴椠浭摥慩整爭汥慥敳洠瑥票灬敨楮慤整 ? 剉??? 瑉栠獡戠敥 ? 慭歲瑥摥椠 ? 桃湩 ? 楳据 ??? 戠瑵猠楴汬氠捡獫搠瑡 ?... | YIN Xin-dao HUANG Wen-bin L(U) Cheng-yu ZHANG Lin WANG Li-wei XIE Guang-hui | 2011 | Chinese Medical Journal2011，，3： | 6 |
| 6 | Isolation and culture of hepatic stellate cells from mouse liver显示文摘肝的星形的房间(HSC ) 是在肝以内的主要细胞外的生产矩阵的房间并且有众多的 vitalfunctions。为 HSC 的隔离和文化的一个柔韧的协议是重要的因为房间 functionsand 的进一步的调查在肝疾病联系了机制。鼠标肝的卷比老鼠肝的小得多,哪个对更困难的 makesit 比老鼠 HSC 孤立鼠标 HSC (mHSCs ) 。目前,孤立 mHSCs 仍然是挑战 becausethere 不是有效、柔韧的方法孤立并且文化这些房间。在现在的学习, C57BL/6J 老鼠是有包含 liposome 的 dichloromethylene diphosphate (CL2MDP ) 的 intravenouslyinjected 有选择地从 theliver 消除 Kupffer 房间。老鼠肝然后在 situ 被酒,并且 mHSCs 与一种优化密度坡度 centrifugation 技术被孤立。在磷酸盐缓冲区答案(PBS )-liposome 组, mHSCs 的收益是(1. | Wenj u Chang Mengxuan Yang Lujun Song Kuntang Shen Hongshan Wang Xiaodong Gao Min Li Weixin Niu Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 6 |
| 7 | Cryo-EM structure of human heptameric Pannexin 1 channel显示文摘Dear Editor,Cellular communication is crucial during basic development and in the maintenance of homeostasis in adult organisms,and such communication involves the connexin and pannexin(PANX)families of large-pore channels.The PANX family was identified in 20001 and consists of PANX1,PANX2,and PANX3.2 Among the three subtypes,the most studied is PANX1 because of its potential effects on multiple physiological and pathological functions,3 including microbial infection,cancer progression,ischemia,and neurological disorders.Very recently,we also identified mutations in PANX1 causing familial female infertility characterized by oocyte death.4 PANX1 is a major ATP release and nucleotide permeation channel,which is N-glycosylated and forms three species,GLYO,GLY1,and GLY2.5 Cleavage of the C-terminus by Caspase 3/7 activates the channel and causes the release of ATP and UTP,which functions as a 'find-me'signal during apoptosis. | Ronggui Qu Lili Dong Jilin Zhang Xuekui Y u Lei Wang Shujia Zhu | 2020 | Cell Research2020，30，5： | 4 |
| 8 | Improved hybrid position/force controller design of a flexible robot manipulator using a sliding observer显示文摘An improved hybrid position/force controller design of a flexible robot manipulator is presented using a sliding observer. The friction between the end effector and the environment is considered and compensated. For systematic reasons the controller is designed taking into consideration the rigid link subsystems and the flexible joints. The proposed control system satisfies the stability of the two subsystems and copes with the uncertainty of robot dynamics. A sliding observer is designed to estimate the time derivative of the torque applied as input to the rigid part of the robot. For the stability of the observer, it is assumed that the uncertainty of the observed system is bounded. A MRAC algorithm is used for the estimation of the friction forces at the contact point between the end effector and the environment. Finally simulation and experimental results are given, to demonstrate the effectiveness of the proposed controller. | Farooq M Wang Daobo Dar N. U | 2009 | Journal of Systems Engineering and Electronics2009，20，1： | 4 |
| 9 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 10 | Increased circulating level of interleukin-6 and CD8+T cell exhaustion are associated with progression of COVID-19显示文摘Background: Coronavirus disease 2019(COVID-19)is pandemic.It is critical to identify COVID-19 patients who are most likely to develop a severe disease.This study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease progression.Methods:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from December 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,2020.Differences in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of COVID-19.Results: The mean incubation was 8.67(95%confidence interval,6.78–10.56)days.Mean duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)days.Compared to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(<190/µl)of CD8+T cells,and neutrophil/lymphocyte ratio.Thirteen patients deteriorated during hospitalization.Cox regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of COVID-19.During hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumonia-free patients.CD8+lymphocyte count in pneumonia patients did not recover when discharged.Conclusions: Older age and higher levels of C-reactive protein,procalcitionin,interleukin-6,and lactate might predict COVID-19 progression.T lymphocyte,especially CD8+cell-mediated immunity is critical in recovery of COVID-19.This study may help in predicting disease progression and designing immunotherapy for COVID-19. | Peng-Hui Yang Yi-Bo Ding Zhe Xu Rui Pu Ping U Jin Yan Ji-Luo Liu Fan-Ping Meng Lei Huang Lei Shi Tian-Jun Jiang En-Qiang Qin Min Zhao Da-Wei Zhang Peng Zhao Ling-Xiang Yu Zhao-Hai Wang Zhi-Xian Hong Zhao-Hui Xiao Qing Xi De-Xi Zhao Peng Yu Cai-Zhong Zhu Zhu Chen Shao-Geng Zhang Jun-Sheng Ji Fu-Sheng Wang Guang-Wen Cao | 2020 | Infectious Diseases of Poverty2020，9，6： | 3 |
| 11 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 12 | Pampas grass-inspired FeOOH nanobelts as high performance anodes for sodium ion batteries显示文摘High-performance materials are the key to developing new alternative energy-storage systems[1-4].Sodium ion batteries(SIBs)are regarded as the promising large-scale electric energy storage owing to the high abundance and low cost of sodium resources[1,5-9].However,the sluggish kinetics of Na^(+)caused by the large-sized Na^(+)(1.02A)result in the lower energy density and unsatisfactory electrochemical properties[10-14]. | Lianyi Shao Shige Wang Fangdan W u Xiaoyan Shi Zhipeng Sun Yuxin Tang | 2021 | Journal of Energy Chemistry2021，30，3： | 2 |
| 13 | Pseudomonas sp.TK35-L enhances tobacco root development and growth by inducing HRGPnt3 expression in plant lateral root formation显示文摘Rhizosphere colonization is a key requirement for the application of plant growth-promoting rhizobacteria(PGPR)as a bioferilizer.Signaling molecules are often exchanged between PGPR and plants,and genes in plants may respond to the action of PGPR.Here,the luciferase luxAB gene was electrotransformed into Pseudomonas sp.strain TK35,a PGPR with an afinity for tobacco,and the labelled TK35(TK35-L)was used to monitor colonization dynamics in the tobacco rhizosphere and evaluate the effects of colonization on tobacco growth and root development.The transcript levels of the hydroxyproline rich glycoprotein HRGPnt3 gene,a lateral root induction indicator,in tobacco roots were examined by qPCR.The results showed that TK35-L could survive for long periods in the tobacco rhizosphere and colonize new spaces in the tobacco rhizosphere following tobacco root extension,exhibiting significant increases in root development,seedling growth and potassium accumulation in tobacco plants.The upregulation of HRGPnt3 transcription in the inoculated tobacco suggested that TK35-L can promote tobacco root development by upregulating the transcript levels of the HRGPnt3 gene,which promotes tobacco seedling growth.These findings lay a foundation for future studies on the molecular mechanism underlying the plant growth-promoting activities of PGPR.Futhermore,this work provided an ideal potential strain for biofertilizer production. | CAO Yuan-yuan NI Hai-ting LI Ting LAY Khien-duc LIU Dai-song U Kang-miao TANG Xin-yun WANG Xiao-bo QIU Li-juan | 2020 | Journal of Integrative Agriculture2020，19，10： | 2 |
| 14 | Effect of La on Partial Oxidation of Ethanol to Hydrogen over Ni/Fe Catalysts显示文摘The partial oxidation of ethanol to hydrogen was investigated over Ni/Fe/La catalysts prepared by the co precipitation method. The effects of introduction of La promoter and the reaction temperature on the catalytic performance were studied. It was found that the introduction of La into Ni/Fe catalysts is helpful to increase the selectivity to hydrogen and the stability of the catalysts. The results of XRD and XPS characterization show that the structure of the catalyst was changed during the reaction. The existence of LaFeO 3 species is possibly the main reason of the increase of the catalyst stability. | WANG Wei ping, WANG Zhi fei, DING Yan and LU¨ Gong xuan ** State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China | 2003 | Chemical Research in Chinese Universities2003，19，2： | 2 |
| 15 | Persistent organic pollutants in environment of the Pearl River Delta, China: an overview显示文摘 | Jiamo Fu Bixian Mai Guoying Sheng Gan Zhang Xinming Wang Ping’an Peng Xianming Xiao Rong Ran Fanzhong Cheng Xianzhi Peng Zhishi Wang U Wa Tang | 2003 | Chemosphere2003，，9： | 2 |
| 16 | Persistent organic pollutants in environment of the Pearl River Delta, China: an overview显示文摘 | Jiamo Fu Bixian Mai Guoying Sheng Gan Zhang Xinming Wang Ping’an Peng Xianming Xiao Rong Ran Fanzhong Cheng Xianzhi Peng Zhishi Wang U Wa Tang | 2003 | Chemosphere2003，，9： | 2 |
| 17 | Transgenic plants of tall Fescue obtained by direct gene transfer to protoplasts显示文摘 | Wang Z Y Binding H Posselt U K | 1992 | Biology Technology1992，10，： | 1 |
| 18 | Mechanical and viscoelastic properties of semi-interpenetrating,polymer networks of poly(vinyl chloride)/thermosetting resin blends显示文摘 | Pittman C U Xu X M Wang L | 2000 | Polym Eng Sci2000，40，： | 1 |
| 19 | High mobility group 1 protein (HMG-1)stimulates proinflammatory cytokine synthesis in human monocytes显示文摘 | Andersson U Wang H Palmblad K | 2000 | J Exp Med2000，192，4： | 1 |
| 20 | Effect of metallothionein on tolerance of nitroglycerin in rats 显示文摘 | Shakya U Chen Y H Wang X H | 2000 | Acta Pharmacol Sinica2000，21，1： | 1 |
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