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| 1 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 2 | Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease显示文摘 | Tang B Xiong H Sun P Zhang Y Wang D Hu Z Zhu Z Ma H Pan Q Xia JH Xia K Zhang Z | 2006 | 中国生物学文摘2006，20，8： | 30 |
| 3 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 4 | Experimental investigation on breaching of embankments显示文摘Breaching of embankments has recently drawn more and more attention due to its importance in the development of early warning systems for embankment failures,in the evacuation plans of people at risk,in the design method of embankments based on a risk-approach,etc. The erosion process observed during embankment breaching tests in the laboratory and the analysis of the results are described in this paper. Five embankments,one constructed with pure sand,four with different sand-silt-clay mixtures were tested. The height of the embankments was 75 cm and the width at the crest was 60 cm. Examination of the data from these tests indicated that headcut erosion played an important role in the process of breach growth in the embankments made of cohesive soil mixtures. Flow shear erosion,fluidization of the headcut slope surface,undermining of the headcut due to impinging jet scour and discrete soil mechanical slope mass failure from the headcut were all observed during these tests. For the embankment constructed with pure sand,the breach erosion process was dominated by shear erosion,which led to a gradual and relatively uniform retreat of the downstream slope. The cohesive proportion in the sand-silt-clay mixtures strongly slowed down the erosion process. | ZHU YongHui VISSER P J VRIJLING J K WANG GuangQian | 2011 | Science China(Technological Sciences)2011，54，1： | 17 |
| 5 | Dietary factors and smoking as risk factors for PD in a rural population in China: a nested case-control study显示文摘 | Ma L Zhang L Gao XH Chen W Wu YP Wang Y Li XF Como P Kieburtz K Qiao YL | 2006 | 中国生物学文摘2006，20，8： | 13 |
| 6 | Quantitative Evaluation of Pain with Pain Index Extractecl from Electroencephalogram显示文摘 | Jian-Xiong An Yong Wang Doris K Cope John P Williams | 2017 | Chinese Medical Journal2017，，16： | 13 |
| 7 | 基于1mm精度路面三维图像的裂缝种子自动识别算法显示文摘为了准确地检测路面裂缝,给路面养护管理、路面性能评价与预测、路面结构和材料设计提供参考,基于1mm·像素-1的路面三维图像对裂缝自动识别进行研究。首先,将源图像划分为8像素×8像素的子块以降低图像维度;其次,根据深度验证和对称性检测将8像素×8像素的图像子块识别为裂缝子块(即裂缝种子)或非裂缝子块;然后,根据深度和方向相似性连接裂缝片段;最后,设计去噪算法消除孤立噪声,获得裂缝图像。结果表明:所提出的算法具有较高的准确率(均值92.75%)、召回率(均值58.93%)和运行速度(平均2~3s·张-1),以71.15%的F值优于Otsu分割,Canny边缘检测和另一种子识别算法。 | 彭博 WANG K C P 陈成 蒋阳升 | 2014 | 中国公路学报2014，27，12： | 9 |
| 8 | ^(99m)Tc-labeled HAb18 McAb Fab fragment for radioimmunoimaging in nude mice bearing human hepatocellular carcinoma显示文摘99mTclabeledHAb18McAbFabfragmentforradioimmunoimaginginnudemicebearinghumanhepatocelularcarcinomaQIUKai1,2,WANGBoChen1,CHE... | Qiu K Wang BC Chen ZN Fang P Liu CG Wan WX Liu YF | 1998 | World Journal of Gastroenterology1998，4，2： | 8 |
| 9 | Thunderclap Headache Caused by an Inadvertent Epidural Puncture During Oxygen-ozone Therapy for Patient with Cervical Disc Herniation显示文摘To the Editor: A 54-year-old woman with no significant history of a headache or hypertension underwent epidural oxygen-ozone injection at a concentration of 30 μg/ml (3 ml) for cervical disc herniation at cervical vertebra (C6-C7) level.Throughout the procedure, the routine monitorings of blood pressure, heart rate, and blood oxygen saturation were performed.One minute following the end of the injection, the patient developed a high-intensity headache mimicking symptoms of a ruptured cerebral aneurysm. | Hui Liu Yong Wang Jian-Xiong An John P Williams Doris K Cope | 2016 | Chinese Medical Journal2016，，4： | 7 |
| 10 | 低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系显示文摘低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。 | Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L Fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) | 2020 | 中华高血压杂志2020，28，7： | 7 |
| 11 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 12 | 基于双层连通性检测的路面裂缝图像去噪算法显示文摘为了消除路面裂缝图像中的孤立噪声并保护裂缝边缘的细致特征,本文基于像素和裂缝子块两个层级的连通性检测设计了去噪算法,主要包括3个部分:(1)像素连通性检测,剔除连通性差的像素;(2)孤岛噪声消除算法,删除相对孤立的目标区域;(3)8×8裂缝子块去噪算法。然后,提出了算法流程并探讨参数的选择。最后,应用Visual Studio 2008和Open CV编程对本文算法、常用的中值滤波去噪法、长线段和黑色像素比例法进行性能测试,结果表明,本文算法可有效消除孤立噪声并保持边缘连续性,具有更高的准确率(85.06%)和召回率(85.80%),综合性能指标F1值比后两者分别高0.74%~19.19%和0.20%~12.06%。 | 彭博 罗楠欣 蒋阳升 陈成 K C P WANG | 2015 | 公路交通科技2015，32，11： | 3 |
| 13 | 糖尿病患者累积收缩压负荷与心血管病风险的关系显示文摘该研究旨在评估2型糖尿病患者累积收缩压负荷与心血管事件风险的关系。方法:对百普乐和达美康缓释片对糖尿病和血管疾病的对照评估试验的观察性研究(action in diabetes and vascular disease preterax and diamicron MR controlled evaluation post trial observational study, ADVANCE-ON)中的2型糖尿病患者进行事后分析。 | Wang N Harris K Hamet P Harrap S Mancia G Poulter N Williams B Zoungas S Woodward M Chalmers J Rodgers A 刘青(译) 郑武洪(审校) | 2022 | 中华高血压杂志2022，30，12： | 2 |
| 14 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 15 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 16 | Sliding mode control for uncertain nonlinear systems with multiple inputs containing sector nonlinearities and deadzones 显示文摘 | Hsu K C Wang W Y Lin P Z | 2004 | IEEE Trans on Systems Man and Cybernetics-Part B: Cybernetics2004，34，1： | 1 |
| 17 | Computation of static shapes and voltages for micromachineddeformable mirrors with nonlinear electrostatic actuators 显示文摘 | Wang P K C Hadaegh F Y | 1996 | Journal of Microelectromechanical System1996，5，3： | 1 |
| 18 | A conformationally sensitive GHR antibody : impact on GH signaling and GHR proteolysis显示文摘 | Jiang J Wang X He K Li X Chen C M Sayeski P P Waters M J Frank S J | 2004 | Mol Endocrinol2004，18，12： | 1 |
| 19 | Detailed measurements of local heat transfer coefficient and adiabatic wall temperature beneath an array of impingement jets 显示文摘 | Van Treuren K Wang Z Ireland P et aI | 1995 | Journal of Turbomachinery1995，116，2： | 1 |
| 20 | Investigation of a ponding rrrigation system to recycle agricultural wastewater 显示文摘 | Chen P H Chen L K Wang J T | 2000 | Enviroment International2000，，26： | 1 |
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