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| 1 | Rapid nongenomic inhibitory effects of glucocorticoids on phagocytosis and superoxide anion production by macrophages显示文摘 | Long F Wang YX Liu L Zhou J Cui RY Jiang CL | 2005 | 第二军医大学学报2005，26，10： | 14 |
| 2 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 3 | A novel therapeutic approach to 6-OHDA-induced Parkinson's disease in rats via supplementation of PTD-conjugated tyrosine hydroxylase显示文摘 | Wu SP Fu AL Wang YX Yu LP Jia PY Li Q Jin GZ Sun MJ | 2006 | 中国生物学文摘2006，20，10： | 9 |
| 4 | Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats显示文摘Diethylnitrosamine (DENA) is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in humans than the usual model of tumor implantations. The aim of the present study was to evaluate MRI liver examination in Sprague-Dawley(SD) rats as a routine method to detect hepatocellular carcinoma (HCC) nodules induced by DENA and to follow up their growth. METHODS:Hepatic carcinogenesis was induced in 80 male SD rats using oral DENA solution. All animals were imaged for liver tumor detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) using correspondence scan parameters and a radio-frequency knee coil. Macroscopic examinations were performed along the axial MRI sections to evaluate magnetic resonance imaging (MRI) findings, and histopathological assessment was also performed. RESULTS:No false negative results were obtained on MR images. Hepatic tumors in 72 rats were confirmed macro-scopically and 68 rats were detected by MRI till the 20th week. The smallest and the largest nodules detected by MRI were 2 mm and 37 mm in diameter respectively. The agreement rate of MRI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodules. CONCLUSIONS:The hepatic tumor induced by DENA provides a more representative range of tumors for imaging diagnosis and interventional treatment. MRI is the best approach for scrutinizing pathological changes of rat livers in the period of observation. | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Li X, Zhou XP and Guan YS) Department of Radiology, Ruijin Hospieal. Shanghai Second Medical University, Shanghai 200025 , China. Current address:Astra Zeneca R & D Alderley, Macclesfield SK 10 4 TG U. K. (Wang YX) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 5 | Two closely linked rice U14 boxC/D snoRNAs | Jiang, G Xu, F Jin, YX Wang, DB | 2002 | Progress in Natural Science:Materials International2002，12，1： | 2 |
| 6 | Comparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injury显示文摘 | Wang, YX Cheung, PT Shen, GX Bhatia, I Wu, EX Qiu, DQ Khong, PL | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 7 | Rb-Sr isotope dating of silicalite from the Dajiangping massive sulfide ore deposit,Guangdong Province显示文摘THE Dajiangping pyrite ore deposit located in the Yunfu County of Guangdong Province is asuper-large pyrite ore deposit. Its age has not been defined so far because of the absence of fos-sil. This note is to use Rb-Sr isotope dating of silicalite to constrain the age of the ore depositand place special emphasis on its geological significance. | Wang, HI Li, HY Wang, YX Wang, HH | 1997 | Chinese Science Bulletin1997，42，23： | 2 |
| 8 | Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity显示文摘 | Lee CH Tiep S | 2003 | Cell2003，113，1： | 1 |
| 9 | Role of PKC in the novel synergistic action of urotensin Ⅱ and angiotensin Ⅱ and in urotensin Ⅱ-induced vasoconstriction显示文摘 | Ding YJ Zhu YZ Shi Y Yao T Zhu YC | 2007 | Am J Physiol Heart Circ Physiol2007，292，1： | 1 |
| 10 | Expression of CXCR4 and CXCLl2(SDF-1)in human prostate cancem(PCa)in vivo显示文摘 | Sun YX Wang J Shelburne CE el al | 2003 | J Cell Biochem2003，89，3： | 1 |
| 11 | Mesenchymal stem celltherapy for diabetes through paracrine mechanisms显示文摘 | Xu YX Chen L Wang R | 2008 | Med Hypotheses2008，71，3： | 1 |
| 12 | Pressor effect of N^G-nitro-L-arginine in pentobarbital-anesthetized rats 显示文摘 | Wang YX Pang CC | 1990 | Life Sci Adv1990，9，6： | 1 |
| 13 | Inhibition of Rho-kinase by fasudil attenuated angiotensin Ⅱ-induced cardiac hypertrophy in apolipoprotein E deficient mice显示文摘 | Wang YX da Cunba V Martin-McNulty B | 2005 | Eur J Pharmacol2005，512，23： | 1 |
| 14 | Study on the determination of neurotransmitters using poly(neutral red) coated carbon fiber microelectrodes显示文摘 | SUN YX YE BX WANG Y | 1998 | Microchemical Journal1998，58，： | 1 |
| 15 | Prevalence of cataract surgery and postoperative visual outcome in Greater Beijing: the Bei- jing Eye Study显示文摘 | Liu B Xu L Wang YX | 2009 | Ophthalmology2009，116，： | 1 |
| 16 | MicroRNA-148b is fre- quently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation显示文摘 | Song YX Yue ZY Wang ZN | 2011 | Mol Cancer2011，10，1： | 1 |
| 17 | Biomeehanieal and histomorphometric characterizations of osseointegration during mini-screw healing in rabbit tibiae 显示文摘 | Wu J Bai YX Wang BK | 2009 | Angle Orthod2009，79，3： | 1 |
| 18 | Carbon coated superpara- magnetic iron oxide nanoparticles for sentinel lymph nodes mapping 显示文摘 | Wang YX Wang DW Zhu XM | 2012 | Quant Imaging Med Surg2012，2，1： | 1 |
| 19 | CSMDI exhibits antitumor activity in A375 melanoma cells through activation of the Smad pathway显示文摘 | TANG MR WANG YX GUO S | 2012 | Apoptosis2012，17，9： | 1 |
| 20 | Dobutamine therapy is associated with worse clinical outcomes compared with nesiritide therapy for acute decompen- sated heart failure:a systematic review and meta-analysis显示文摘 | Wang XC Zhu DM Shan YX | 2015 | Am J Cardio- vasc Drugs2015，15，6： | 1 |
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