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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 3 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 4 | Methionine deficiency and its hydroxy analogue influence chicken intestinal 3-dimensional organoid development显示文摘Methionine and its hydroxy analogue(MHA)have been shown to benefit mouse intestinal regeneration.The intestinal organoid is a good model that directly reflects the impact of certain nutrients or chemicals on intestinal development.Here,we aimed to establish a chicken intestinal organoid culture method first and then use the model to explore the influence of methionine deficiency and MHA on intestinal organoid development.The results showed that 125-mm cell strainer exhibited the highest efficiency for chicken embryo crypt harvesting.We found that transforming growth factor-b inhibitor(A8301)supplementation promoted enterocyte differentiation at the expense of the proliferation of intestinal stem cells(ISC).The mitogen-activated protein kinase p38 inhibitor(SB202190)promoted intestinal organoid formation and enterocyte differentiation but suppressed the differentiation of enteroendocrine cells,goblet cells and Paneth cells.However,the suppression of enteroendocrine cell and Paneth cell differentiation by SB202190 was alleviated at the presence of A8301.The glycogen synthase kinase 3 inhibitor(CHIR99021),valproic acid(VPA)alone and their combination promoted chicken intestinal organoid formation and enterocyte differentiation at the expense of the expression of Paneth cells and goblet cells.Chicken serum significantly improved organoid formation,especially in the presence of A8301,SB202190,CHIR99021,and VPA,but inhibited the differentiation of Paneth cells and enteroendocrine cells.Chicken serum at a concentration of 0.25%meets the requirement of chicken intestinal organoid development,and the beneficial effect of chicken serum on chicken intestinal organoid culture could not be replaced by fetal bovine serum and insulin-like growth factor-1.Moreover,commercial mouse organoid culture medium supplemented with A8301,SB202190,CHIR99021,VPA,and chicken serum promotes chicken organoid budding.Based on the chicken intestinal organoid model,we found that methionine deficiency mimicked by cycloleucine suppressed organoid formation and organoid size,and this effect was reinforced with increased cycloleucine concentrations.Methionine hydroxy analogue promoted regeneration of ISC but decreased cell differentiation compared with the results obtained with L-methionine.In conclusion,our results provide a potentially excellent guideline for chicken intestinal organoid culture and insights into methionine function in crypt development. | Youli Wang Qihang Hou Yuqin Wu Yanwei Xu Yan Liu Jing Chen Lingling Xu Yuming Guo Shuai Gao Jianmin Yuan | 2022 | Animal Nutrition2022，，1： | 4 |
| 5 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 6 | Multi-scale mechanotransduction of the poroelastic signals from osteon to osteocyte in bone tissue显示文摘In order to quantify the poroelastic mechanical signals conduction and evaluate the biomechanical effectiveness of functional units(osteocyte processes,canaliculi and lacuna)in lacunar-canalicular system(LCS),a multiscale poroelastic finite element model was established by using the Comsol Multiphysics software.The poroelastic mechanical signals(pore pressure,fluid velocity,von-Mises stress,strain)were analyzed inside the osteon-osteocyte system.The effects of osteocyte(OCY)’s shape(ellipse and circle),long axis directions(horizontal and vertical)and mechanical properties(Elastic modulus and permeability)on its poroelastic responses were examined.It is found that the OCY processes is the best mechanosensor compared with the OCY body,lacunae and canaliculi.The mechanotransduction ability of the elliptic shaped OCY is stronger than that of circular shaped.The pore pressure and flow velocity around OCYs increase as the elastic modulus and permeability of OCY increase.The established model can be used for studying the mechanism of bone mechanotransduction at the multiscale level. | Xiaogang Wu Chaoxin Li Kuijun Chen Yuqin Sun Weilun Yu Meizhen Zhang Yanqin Wang Yixian Qin Weiyi Chen | 2020 | Acta Mechanica Sinica2020，36，4： | 2 |
| 7 | Animal exercise studies in cardiovascular research:Current knowledge and optimal design--A position paper of the Committee on Cardiac Rehabilitation,Chinese Medical Doctors’Association显示文摘Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However,the underlying mechanisms of the beneficial effects of exercise have yet to be elucidated.Animal exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular protection.However,standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective,high-quality animal studies using exercise to prevent and treat cardiovascular diseases.In our review,we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training,emphasizing the appropriate measurements and analysis in these chronic exercise models.We also provide recommendations for optimal design of animal exercise studies in cardiovascular research,including the choice of exercise models,control of exercise protocols,exercise at different stages of disease,and other considerations,such as age,sex,and genetic background.We hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases. | Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao | 2021 | Journal of Sport and Health Science2021，10，6： | 2 |
| 8 | A review on COVID-19 transmission,epidemiological features,prevention and vaccination显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused hundreds of millions of infections and millions of deaths over past two years.Currently,many countries have still not been able to take the pandemic under control.In this review,we systematically summarized what we have done to mitigate the COVID-19 pandemic,from the perspectives of virus transmission,public health control measures,to the development and vaccination of COVID-19 vaccines.As a virus most likely coming from bats,the SARS-CoV-2 may transmit among people via airborne,faecal-oral,vertical or foodborne routes.Ourmeta-analysis suggested that the R0 of COVID-19 was 2.9(95%CI:2.7–3.1),and the estimates in Africa and Europe could be higher.The median Rt could decrease by 23–96%following the nonpharmacological interventions,including lockdown,isolation,social distance,and face mask,etc.Comprehensive intervention and lockdown were the most effective measures to control the pandemic.According to the pooled R0 in our meta-analysis,there should be at least 93.3%(95%CI:89.9–96.2%)people being vaccinated around the world.Limited amount of vaccines and the inequity issues in vaccine allocation call for more international cooperation to achieve the antiepidemic goals and vaccination fairness. | Yuqin Zhang Gonghua Wu Shirui Chen Xu Ju Wumitijiang Yimaer Wangjian Zhang Shao Lin Yuantao Hao Jing Gu Jinghua Li | 2022 | Medical Review2022，2，1： | 2 |
| 9 | Sulfonic groups functionalized Zr-metal organic framework for highly catalytic transfer hydrogenation of furfural to furfuryl alcohol显示文摘The highly selective catalytic transfer hydrogenation(CTH)of furfural(FF)to furfuryl alcohol(FOL)is a significant route of biomass valorization.Herein,a series microporous Zr-metal organic framework(ZrMOF)functionalized by sulfonic groups are prepared.Based on the comprehensive structural characterizations by means of X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),N2 physisorption,Thermogravimetric(TG)and Fourier transformed infrared spectroscopy(FTIR),we find that sulfonic acid(–SO_(3)H)functional groups are tethered on the UIO-66 without affecting the structure of the framework.Systematic characterizations(NH_(3)-TPD,CO_(2)-TPD,and in-situ FTIR)demonstrate that modifying of sulfonic groups on UIO-66 results in the formation of stronger Lewis acidic-basic and Brnsted acidis sites.The cooperative role of the versatile Lewis acidic-basic and Brnsted acidic sites in 60%mol fraction of sulfonic acid-containing UIO-66(UIO-S_(0.6))retain high surface area and exhibit excellent catalytic performance of 94.7%FOL yield and 16.9 h^(-1).turnover number(TOF)under mild conditions.Kinetic experiments reveal that the activation energy of the CTH of furfural(FF)over UIO-S_(0.6) catalyst is as low as 50.8 k J mol^(-1).Besides,the hydrogen transfer mechanism is investigated through isotope labeling experiments,exhibiting that theβ-H in isopropanol is transferred to the a-C of FF by forming six-membered intermediates on the Lewis acidic-basic and Brnsted acidic sites of the UIO-S_(0.6),which is the rate-determining step in the formation of FOL. | Jingcheng Wu Dong Liang Xiangbo Song Tingsen Liu Tianyi Xu Shuangyin Wang Yuqin Zou | 2022 | Journal of Energy Chemistry2022，31，8： | 2 |
| 10 | Peroxisome proliferator activated receptor-γ ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells显示文摘 | Jiajun Liu Huiling Lu Renwei Huang Dongjun Lin Xiangyuan Wu Qu Lin Xinyao Wu Jing Zheng Xianglin Pan Jun Peng Yuqin Song Maohong Zhang Ming Hou Feng Chen | 2005 | Cancer Chemotherapy and Pharmacology2005，，4： | 1 |
| 11 | Assessment of Serum PRL,MLT,TSH,FSH and LH Concentrations in the Goat (Capra hircus) Exposing to Different Photoperiod Regimes显示文摘In many seasonally breeding species,photoperiod is an important factor involved in reproduction. Capra hircus breeds are normally considered short-day breeders. An experiment was carried out to evaluate whether or not photoperiodic regimens influence circulating hormone levels( prolactin,melatonin,thyrotropin stimulating hormine,luteinizing hormone,follicle stimulating hormone) of Henan huai local goat exposing to different photoperiodic regimens. The results showed that plasma levels of prolactin,melatonin,thyrotropin stimulating hormine,luteinizing hormone and follicle stimulating hormone were higher in the 8 L∶ 16 D photoperiodic regimen than that in the 16 L∶ 8 D photoperiodic regimen. Levels of those hormones decreased on day 7 and day 28 when the 16 L∶ 8 D photoperiodic regimen was used continuously. It was concluded that serum concentrations of the hormones increased in summer when short day( 8 L∶ 16 D) was used and decreased when the goats were transferred from short day for 42 d to long day exposure for 28 d. We suggest that in summer,levels of hormones changing may be due to short day animals. Changing of related hormones is still determined by the mechanism of internal regulation of short day animal's exposure to light changes. Shortening light may also help increase the reproductive activity of goat and thus increase productivity. | Huibin SHI Zhilong TIAN Yuqin WANG Zhibo WU Fang YANG Jianping WANG Mingxing CHU CaiHong WEI | 2018 | Agricultural Biotechnology2018，7，4： | 1 |
| 12 | Spectrophotometric Method for the Direct Determination of Anionic Surfactant Sodium Dodecyl Benzenesulfonate (SDBS) Using a Hydrophobic Near-Infrared (NIR) Cationic Cyanine Dye Without Solvent Extraction显示文摘 | Wu Yuqin Zheng Hong Chen Jinlong | 2004 | Analytical Letters2004，37，4： | 1 |
| 13 | Novel nonaqueous capillary electrophoresis separation and determination of bioactive flavone derivatives in Chinese herbs 显示文摘 | QI Shengda LI Yuqin WU Shuixian | 2005 | J Sep Sci2005，28，16： | 1 |
| 14 | Composition dependence of viscosity for Al_(1-x)Mg_x(0=x=0.10) alloys显示文摘Viscosities of molten Al(1-x)Mgx (0≤x≤0.10) alloys have been measured in the temperature range of 973 K―1173 K by a torsional oscillation cup method. The viscosity dependence on temperature for Al(1-x)Mgx (0≤x≤0.10) melts obeys Arrhenius equation. The viscosity increases with increasing mag-nesium concentration in the investigated system. There is an important relationship between viscosity and its glass-forming ability for metallic melt. | WANG YuQing WU YuQin BIAN XiuFang | 2007 | Chinese Science Bulletin2007，52，11： | 1 |
| 15 | Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling显示文摘 | Xiangzheng Chen Yangping Wu Yangfu Jiang Yan Zhou Yuxi Wang Yuqin Yao Cheng Yi Lantu Gou Jinliang Yang | 2012 | Journal of Molecular Medicine2012，，11： | 1 |
| 16 | Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade显示文摘 | Ma Jianhui Meng Yan Kwiatkowski David J Chen Xinxin Peng Haiyong Sun Qian Zha Xiaojun Wang Fang Wang Ying Jing Yanling Zhang Shu Chen Rongrong Wang Lianmei Wu Erxi Cai Guifang Malinowska-Kolodziej Izabela Liao Qi Liu Yuqin Zhao Yi Sun | 2010 | Journal of Clinical Investigation2010，，1： | 1 |
| 17 | Phase I trial of human umbilical cord-derived mesenchymal stem cells for treatment of severe bronchopulmonary dysplasia显示文摘Severe bronchopulmonary dysplasia(BPD)is a chronic lung disorder that primarily affects premature babies with extremely low birth weight and involves in multiple organ system;no effective pharmacotherapy for this disease exists,and mortality remains high.Based on the evidence from previous preclinical studies and phase I clinical trials,this study aims to test the safety of intravenous application of a single dose of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)in patients with severe BPD.The Mesenchymal Stem cells for Bronchopulmonary Dysplasia Treatment(MSBDT)trial is a single center,open-label,dose-escalation phase I clinical trial.Severe BPD patients were enrolled in Children Hospital of Chongqing Medical University,Chongqing,China.The first six patients were treated with low-dose hUC-MSCs(1×10^(6) cells/kg)and the next seven patients were treated with high-dose hUC-MSCs(5×10^(6) cells/kg).This study is registered with ClinicalTrials.gov,number NCT03558334.No prespecified infusion-associated adverse events,immediate complication,respiratory or cardiovascular compromise were observed during infusion and 24 h after infusion.No significant changes in safety laboratory values were observed.One death event occurred in the low-dose group on study day 10,and one death event occurred in the high-dose group on study day 24,while,after review in detail,the two cases are not believed to be infusion-associated events.In conclusion,intravenous application of a single dose of hUC-MSCs was tolerated in thirteen patients with severe BPD. | Yunqiu Xia Tingyuan Lang Yuqin Niu Xian Wu Ou Zhou Jihong Dai Lei Bao Ke Yang Lin Zou Zhou Fu Gang Geng | 2023 | Genes & Diseases2023，10，2： | 1 |
| 18 | Tribologieal property study of novel water-soluble triazine derivative显示文摘 | HE ZHONGYI WU YUQIN LEI JUANttONG | 2014 | Proc Imeche Part J : Journal of Engineering Tribology2014，228，4： | 1 |
| 19 | A new method for the prediction of network security situations based on recurrent neural network with gated recurrent unit显示文摘Purpose-The purpose of this paper is to solve the shortage of the existing methods for the prediction of network security situations(NSS).Because the conventional methods for the prediction of NSS,such as support vector machine,particle swarm optimization,etc.,lack accuracy,robustness and efficiency,in this study,the authors propose a new method for the prediction of NSS based on recurrent neural network(RNN)with gated recurrent unit.Design/methodology/approach-This method extracts internal and external information features from the original time-series network data for the first time.Then,the extracted features are applied to the deep RNN model for training and validation.After iteration and optimization,the accuracy of predictions of NSS will be obtained by the well-trained model,and the model is robust for the unstable network data.Findings-Experiments on bench marked data set show that the proposed method obtains more accurate and robust prediction results than conventional models.Although the deep RNN models need more time consumption for training,they guarantee the accuracy and robustness of prediction in return for validation.Originality/value-In the prediction of NSS time-series data,the proposed internal and external information features are well described the original data,and the employment of deep RNN model will outperform the state-of-the-arts models. | Wei Feng Yuqin Wu Yexian Fan | 2020 | International Journal of Intelligent Computing and Cybernetics2020，13，1： | 1 |
| 20 | Efficacy and safety of obinutuzumab for the first-line treatment of follicular lymphoma:a subgroup analysis of Chinese patients enrolled in the phase III GALLIUM study显示文摘Backgrounds:GALLIUM is a global phase Ⅲ study that demonstrated significant improvements in progression-free survival(PFS)for obinutuzumab plus chemotherapy(G-chemo)vs.rituximab plus chemotherapy(R-chemo)in previously untreated patients with follicular lymphoma(FL).This study aimed to report the results of a subgroup of patients in China.Methods:Patients were randomized to G-chemo or R-chemo.Responders received maintenance therapy for 2 years or until disease progression.The primary endpoint was investigator(INV)-assessed PFS.Secondary endpoints included the overall response rate(ORR)and complete response rate(CRR)at the end of induction chemotherapy,overall survival(OS),and safety.Results:Overall,58 patients with FL were randomized to the G-chemo(n=25)and R-chemo arms(n=33).The INV-assessed PFS rate at 3 years was 81.8%in the G-chemo arm,vs.70.2%in the R-chemo arm(hazard ratio 0.35;95%confidence interval:0.09-1.34;P=0.1120).The INV-assessed CRRs(without positron emission tomography[PET])in these arms were 24.0%and 21.2%,respectively,whereas the ORRs were 80.0%and 90.9%,respectively.INV-assessed CRR-PET was 52.6%in the G-chemo,vs.60.9%in the R-chemo.Median OS was not reached in either arm.Grade 3 to 5 adverse events were more frequent in the R-chemo arm(97.0%vs.88.0%).Conclusions:The results of this subgroup analysis were consistent with those of the global population,and they suggest that G-chemo has a positive benefit-risk profile in patients from China with FL.Trial registration:ClinicalTrials.gov,No.NCT01332968. | Xiaonan Hong Yuqin Song Yuankai Shi Qingyuan Zhang Wei Guo Gang Wu Junmin Li Jifeng Feng Anastasiia Kinkolykh Andrea Knapp Tongyu Lin | 2022 | Chinese Medical Journal2022，，4： | 1 |
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