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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Effect of feeding organic acids on selected intestinal content measurements at varying times postweaning in pigs显示文摘 | Risley C R Kornegay E T Lindemann M D Wood C M Eigel W N | 1992 | Journal of Animal Science1992，70，： | 1 |
| 3 | Activa- tion of EphB2 and its ligands promotes vascular smooth muscle cell proliferation 显示文摘 | WOODS T C BLYSTONE C R YOO J | 2002 | J Biol Chem2002，277，3： | 1 |
| 4 | Endotoxin-induced lung injury in mice : structural, functional, and biochemical responses显示文摘 | Rojas M Woods C R Mora A L | 2005 | Am J Physiol Lung Cell Mol Physiol2005，288，： | 1 |
| 5 | Electron microscopy of ion beam thinned porous anodic films formed on aluminum显示文摘 | THOMPSON G E FUNEAUX R C WOOD G C | 1978 | Corros Sci1978，18，： | 1 |
| 6 | Bilateral sprea- ding cerebral hypoperfusion during spontanesous mi- graine headache显示文摘 | Woods R P Iacoboni M Mazziotta J C | 1994 | N Engl J Med1994，331，25： | 1 |
| 7 | Preoperative columella lengthening in bilateral cleft lip and palate 显示文摘 | Grayson BH Cutting C Wood R | 1993 | Plast Recon- str Surg1993，92，7： | 1 |
| 8 | A transgenic zebrafish model of targeted oocyte ablation and de novo oogenesis显示文摘 | WHITE Y A R WOODS D C WOOD A W | 2011 | Dev Dynam2011，240，8： | 1 |
| 9 | The limits of resolution of Zero-phase wavelets显示文摘 | Kalweit R S Wood L C | 1982 | Geophysics1982，47，7： | 1 |
| 10 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 11 | An Automated Method to Calibrate Industrial Robots Using a Virtual Closed Kinematic Chain显示文摘 | Gatla C S Lumia R Wood J Starr G | 2007 | IEEE transactions on robotics and automation2007，11，23： | 1 |
| 12 | Effects of age of acquisi- tion, and repetition priming on object naming 显示文摘 | Barry C Johnston R A Wood R F | 2006 | Visual Cognition2006，13，7： | 1 |
| 13 | An adjuvant autologous therapeutic vaccine ( HSPPC-96 ; vitespen ) versus observation a- lone for patients at high risk of recurrence aher nephreetomy for re- nal cell carcinoma: a multicentre, open-lahel, randomised phase Ill trial 显示文摘 | Wood C Srivastava P Bukowski R et at | 2008 | Lancet2008，372，9633： | 1 |
| 14 | Application of APEX for forestry显示文摘 | Saleh A Williams J R Wood J C | 2004 | Transactions of the ASAE2004，47，3： | 1 |
| 15 | Critical behavior and synchronization of discrete stochastic phase-coupled oscillators显示文摘 | Wood K Broeck C V Kawai R | 2006 | Phys RevE2006，74，03： | 1 |
| 16 | Gold enhanced spectroelectrochemical investigation of 2-mercaptobenzothiazole, isopropyl xanthate and butylethoxycarbonylthiourea adsorption on minerals显示文摘 | HOPE G A BUCKLEY F M MUNCE C G WOODS R | 2007 | Minerals Engineering2007，20，10： | 1 |
| 17 | The effect of fat thickness and sex on pigmeat quality with special reference to problems associated with over-leanness:laboratory and trained taste panel results显示文摘 | Wood J D Jones R C D Francombe M A | 1986 | Animal Production1986，43，： | 1 |
| 18 | Growth hormone receptor and serum binding protein : purification, cloning and expression 显示文摘 | Leung D W Spencer S A Cachianes G Hammonds R G Collins C Henzel W J Bamant R Waters M J Wood W I | 1987 | Nature1987，330，： | 1 |
| 19 | The development of advanced cellulosic fibres显示文摘 | | 1995 | International Journal of Biological Macromolecules1995，17，6： | 1 |
| 20 | Consumer loyalty in the restaurant industry: A preliminary exploration of the issues 显示文摘 | Clark M A Wood R C | 1998 | International Journal of Contemporary Hospitality Management1998，10，4： | 1 |
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