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| 1 | 中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果显示文摘目的 评价妇女在妊娠前后服用单纯 40 0 μg叶酸增补剂对胎 /婴儿神经管畸形 (NTDs)的预防效果。方法 1993~ 1995年在中国北方的NTDs高发地区和南方的NTDs低发地区妇女增补叶酸的推广项目中 ,共募集从孕前或孕后任何时间开始服药的妇女 130 142名 ,未服药的妇女 1176 89名 ;设计的服药方法从婚检时开始到孕满 3个月为止 ,每天服用单纯叶酸片 40 0 μg ;最后对妇女的分娩结局进行监测并进行预防效果的对比评价研究。结果 服药组妇女生育的胎婴儿中共发现 10 2例NTDs ,对照组胎婴儿中共发现 173例NTDs。末次月经前募集的未服药妇女在孕 2 0周以后分娩的胎婴中NTDs发生率 ,北方为 4 8‰ (16 / 3 318) ,南方为 1 0‰ (2 8/ 2 82 6 5 ) ,而妊娠前后服药妇女组则分别为1 0‰ (13/ 13 0 12 )和 0 6‰ (34/ 5 86 38)。与末次月经前募集的未服药妇女组相比 ,北方服药妇女NTDs发生率明显降低 ,其中依从性大于 80 %的服药组妇女预防率达 85 % (95 %CI为 6 2 %~ 94% ) ,南方地区服叶酸的预防率为 41% (95 %CI为 3 %~ 6 4% )。结论 妇女在妊娠前后每天服用单纯叶酸 40 0 | 李竹 RobertJ Berry 李松 J David Erickson 王红 Cynthia A Moore 赵平 Joseph Mulinare 洪世欣 Lee-Yang C Wong 呼和牧人 Jacqueline Gindler 郝玲 Adolfo Correa 朱慧萍 Elaine Gunter | 2000 | 中华医学杂志2000，80，7： | 185 |
| 2 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 3 | 新型冠状病毒肺炎及其心血管效应:流行病学研究的系统综述显示文摘少数新型冠状病毒肺炎(新冠肺炎)患者病情严重,其特征是炎症、微血管损伤和凝血障碍,可能导致心肌损伤、静脉血栓栓塞症(venous thromboembolism, VTE)和动脉闭塞事件。有心血管病危险因素或既往有心血管病的个体可能面临更大的风险。目的:评估各种环境(包括社区、疗养院和医院)中,与新冠肺炎疑似或确诊病例相关的既往存在心血管合并症的患病率。研究者还评估了疑似或确诊新冠肺炎患者随后发生心血管并发症和临床事件的性质和发生率。 | Pellicori P Doolub G Wong CM Lee KS Mangion K Ahmad M Berry C Squire I Lambiase PD Lyon A McCon-nachie A Taylor RS Cleland JG 刘青(摘译) 练桂丽(审校) | 2021 | 中华高血压杂志2021，29，5： | 3 |
| 4 | A survey of threshold techniques显示文摘 | SAHOO P K SOLTANI S Wong A K C | 1988 | Computer Vision Graphics Image Processing1988，41，： | 1 |
| 5 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C ZhangJ Hui A B Wong N Lau T K Leung T N | 2004 | Clin Chem2004，50，： | 1 |
| 6 | Three-dimensional analysis of single pile response to lateral soil movements显示文摘 | Pan J L Goh A T C Wong K S | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，，26： | 1 |
| 7 | A vector space model for information retrieval显示文摘 | Sahon G Wong A Yang C S | 1975 | Communications of the ACM1975，，： | 1 |
| 8 | Capecitabine as adjuvant treatment for stage Ⅲ colon cancer显示文摘 | TWELVES C WONG A NOWACKI M P | 2005 | N Engl J Med2005，352，26： | 1 |
| 9 | Speciation of heavy metals during co-composting of sewage sludge with lime显示文摘 | WONG J W C SELVAM A | 2006 | Chemosphere2006，63，6： | 1 |
| 10 | The effect of pH and role Ni^2+ in zinc phosphating of 2024 - Al alloy显示文摘 | AKHTAR A S SUSAC D WONG P C | 2006 | Appl Surf Sci2006，，253： | 1 |
| 11 | A New Method of Gray-level Picture Thresholding Using the Entropy of the Histogram显示文摘 | Sahoo P K Wong A K C | 1985 | Computer Vision Graphics and Image Processing1985，29，2： | 1 |
| 12 | A Vector Space Model for Automatic Indexing显示文摘 | Salton G Wong A Yang C S | 1975 | Communications of the ACM1975，18，11： | 1 |
| 13 | PFS clustering method显示文摘 | Vogel M A Wong A C | 1979 | IEEE PAMI1979，3，： | 1 |
| 14 | Dynamic stress and displacement around cylindrical cavities of arbitrary shapes显示文摘 | Datta S K Wong K C Shah A H | 1984 | ASME Journal of Applied Mechanics1984，51，： | 1 |
| 15 | A vector space model for automatic indexing 显示文摘 | G Salton A Wong C S Yang | 1975 | Communications of the ACM1975，18，11： | 1 |
| 16 | A Survey of Thresholding Technique显示文摘 | Sahoo P K Tanis S Wong A K C | 1988 | Computer Vision Graphics Image Processing1988，41，2： | 1 |
| 17 | Investigation of candidate VRM topologies for future microprocessors显示文摘 | Zhou X Wong P Xu P Lee F C Huang A Q | 2000 | IEEE Transactions on Power Electronics2000，15，6： | 1 |
| 18 | A Vector Space Model for Automatic Indexing显示文摘 | Salton G Wong A Yang C S | 1975 | Communications of ACM1975，18，11： | 1 |
| 19 | Mining fuzzy association rules in databases 显示文摘 | Kuok C Fu A Wong M | 1998 | SIGMOD Record1998，27，1： | 1 |
| 20 | A new method of gay-level picture thresholding using the entropy of the histogram 显示文摘 | Kaput J N Sahoo P K Wong A K C | 1981 | Computer Vision Graphics and Image Processing1981，29，： | 1 |
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