|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intrahepatic cholestasis of pregnancy显示文摘Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes. The etiology of ICP is complex and not fully understood, but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. Equally unclear are the mechanisms by which the fetal complications occur. This article reviews the epidemiology, clinical features, diagnosis, etiology and management of ICP. | Victoria Geenes Catherine Williamson | 2009 | World Journal of Gastroenterology2009，15，17： | 55 |
| 2 | 中国农村老年人最低社会养老金制度的必要性、可行性和可能的社会效益显示文摘为了改变目前占中国人口70%的农民基本没有老年社会保障的现状,根据其他发展中国家的经验,本文提出了建立一个覆盖全国农村的最低社会养老金制度的构想。该构想不要求受益人付费,开始时养老金额要低,并考虑到地区之间收入水平的差别。这一构想的实施将加快农村脱贫的进程,提高农村老年人的生活水平,缩小城乡差距,有利于新农村建设,并促进社会的安定与和谐。 | 申策 John Williamson | 2006 | 中国农村经济2006，，8： | 25 |
| 3 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 4 | Variability of cell proliferation in the proximal and distal colon of normal rats and rats with dimethylhydrazine induced carcinogenesis显示文摘AIM:To investigate the patterns of cell proliferation in proximal and distal colons in normal rats and rats with1,2-dimethylhydrazine(DMH)induced carcinogenesis using the thymidine analogue bromodeoxyuridine.METHODS:Colonic crypt cell proliferation was immunohistochemically detected using the anti-bromodeoxyuridine Bu20a monoclonal antibody.RESULTS:Marked regional differences were found in both groups.Total labelling index(LI)and proliferative zone size in both normal(8.65±0.34vs7.2±0.45,27.74±1.07vs16.75±1.45)andDMH groups(13.13±0.46vs11.55±0.45,39.60±1.32vs35.52±1.58)were significantly higher in distal than in proximal colon(P<0.05).although the number of cells per proxmal crypt was greater(31.45±0.20vs34.45±0.39,42.68±0.53vs49.09±0.65,P<0.001).Crypt length,total LT and proliferative zone size all increased in both proximal and distal regions of DMH rats compared to normal controls(P<0.0001).In DMH-treated rat colon a shift of labelled cells to higher crypt cell positions was demonstrated distally whist a bi-directional shift was evident proximally(P<0.05).CONCLUSION:Our results show that changes in cell proliferation patterns,as assessed by bromodeoxyuridine uptake,can act as a reliable intermediate marker of colonic cancer formation.Observed differences between proliferation patterns in distal and proximal colon may be associated with the higher incidence of tumors in t he distal colon. | Kate E Williamson Brian J Rowlands | 2002 | World Journal of Gastroenterology2002，8，5： | 12 |
| 5 | The determinants and implications of corporate cash holdings显示文摘 | Tim Opler Lee Pinkowitz René Stulz Rohan Williamson | 1999 | Journal of Financial Economics1999，，1： | 11 |
| 6 | Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases显示文摘Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to cholestasis.Described in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not known.To date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected patients.We report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated cases.Presentation includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis studies.In HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral therapy.Lymphoma was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other cases.In HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes. | Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 7 | Visual outcome after removal of silicone oil in patients undergoing retinectomy for complex retinal detachment显示文摘AIM:To evaluate the functional outcome after removal of silicone oil(ROSO)in patients undergoing retinectomy for complex retinal detachment.·METHODS:We performed a retrospective case note review of patients who underwent ROSO after retinectomy for complex retinal detachment.Patients with less than 6mo follow up and recurrent retinal detachment following ROSO were excluded.·RESULTS:Thirty-six patients were included.The mean best corrected visual acuity(BCVA)pre-ROSO was1.13 log MAR(SD 0.5).The mean BCVA 3mo following ROSO was 1.16 log MAR(SD 0.53),6mo following ROSO1.13(SD 0.63),and 12mo following ROSO 1.18(SD 0.69).At 12mo after ROSO,the BCVA improved in 38.9%of patients,remained unchanged in 25%,and deteriorated in 36.1%,although there was no statistical significant difference in BCVA after ROSO at 3,6 and 12mo(P=0.93).The size of retinectomy ranged from 15°to 270°(SD 53)and did not influence the visual outcome(P=0.11).·CONCLUSION:There was no statistically significant difference in BCVA between pre-and post-ROSO following retinectomy for complex retinal detachment.There was no statistical difference in visual outcome related to the size of the retinectomy. | Roger Wong Marco De Luca Manoharan Shunmugam Tom Williamson Alistair Laidlaw Valeria Vaccaro | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 7 |
| 8 | 利用Bac-to-Bac系统表达棉蚜的乙酰胆碱酯酶显示文摘Bac-to-Bac昆虫杆状病毒表达系统是一种高效真核表达系统。采用重组DNA技术构建棉蚜乙酰胆碱酯酶1(AChE1)表达质粒,应用该系统在昆虫Sf9细胞系中成功表达了棉蚜的AChE1。表达的AChE以可溶性形式释放于细胞培养液中,对其自然底物类似物ATCh1的Km值为(144.5±28.6)μm;对抗蚜威、唑蚜威、氧化乐果和灭赐松等4种杀虫剂的敏感性指数(Ki值)分别为513、l883、5和23(mM·min)^-1,与文献报道的测定结果基本一致。昆虫细胞被重组病毒感染后第2-3天所得产物的活性最高;该产物在-20℃保存90d后活性没有明显下降,4℃保存60d后下降40%,室温(22℃)保存7d后即下降70%。 | 董双林 韩召军 Martin S WILLIAMSON | 2006 | Zoological Research2006，27，1： | 6 |
| 9 | Interactions between Axillary Branches of Arabidopsis显示文摘顶端的优势的研究在豌豆和豆子,射击系统在被整修回到叶子极大地得益于二分支的试金仅仅二活跃 cotyledonary 腋的分支。在这些二分支的射击,证据的大身体证明一个活跃地成长的分支能禁止其它的生长,推动禁止的信号的性质上的研究,它仍然糟糕被理解。这里,我们在 Arabidopsis 描述二分支的试金的建立,用跑的茎上的连续分支。就象在豌豆和豆子的古典研究,这些连续分支能禁止对方的生长。上面的分支能不仅禁止更低的分支,而且更低的分支能禁止上面的分支,说明禁止的信号的双向行动。用异种,当抑制清楚地越过stem from 被播送时,我们证明抑制部分依赖于 MAX 小径和那对禁止的分支活跃,二个分支的脉管的连接是弱的,并且 MAX 小径能够在茎单方地行动。 | Veronica Ongaro Katherine Bainbridge Lisa Williamson Ottoline Leyser | 2008 | Molecular Plant2008，1，2： | 6 |
| 10 | 奶牛乳房炎显示文摘1乳房炎的感染过程
乳腺发炎称为乳房炎。它是一种复杂的疾病,最常见的原因是由于病原细菌通过奶牛乳头管侵入乳房造成的。乳腺由四个独立腺体组成,彼此之间仅通过血管相连。细菌通过奶牛的乳头管进入乳房,乳头管由角蛋白所保护着。不幸的是,原奶为大量细菌的生长提供了优越环境。细菌一进入奶牛乳房就会大量繁殖,生成毒素与酶,刺激脆弱的乳房组织,使奶牛的乳腺发炎。为了抵抗入侵的病菌,奶牛免疫系统产生的体细胞(白细胞)向乳腺聚集。乳房炎的严重程度主要取决于造成感染的病菌类型.以及奶牛本曙对病菌的抵抗能力。 | 曹夙娟 John Williamson | 2007 | 中国奶牛2007，，9： | 6 |
| 11 | Bioassays for allelopathy: Measuring treatment responses with independent controls显示文摘 | G. Bruce Williamson Donald Richardson | 1988 | Journal of Chemical Ecology1988，，1： | 5 |
| 12 | 东亚三国的公共养老金制度改革:名义账户制的应用前景评析显示文摘在人口老龄化形势下,东亚国家的老年人口赡养率迅速攀升。如何改革公共养老金制度,建立与人口、经济社会形势相适应的养老保障体系,是摆在这些国家面前的一个难题。本文将比较中国、韩国和新加坡的公共养老制度,探讨名义账户制(NDC)在三国的应用前景。通过分析名义账户制化解各国现实问题的潜在能力,作者认为中国适用名义账户制的可行性最强,新加坡较低,而韩国介于二者之间。 | John B. Williamson 申策 房连泉 | 2011 | 社会保障研究2011，，5： | 5 |
| 13 | Bioassays for allelopathy: Measuring treatment responses with independent controls显示文摘 | G. Bruce Williamson Donald Richardson | 1988 | Journal of Chemical Ecology1988，，1： | 5 |
| 14 | Utility of tissue microarrays for profiling prognostic biomarkers in clinically localized prostate cancer: the expression of BCL-2, E-cadherin, Ki-67 and p53 as predictors of biochemical failure after radical prostatectomy with nested control for clinical and pathological risk factors显示文摘痊愈不能与经历激进的治疗的临床上局部性的前列腺癌症为所有人被保证。如果他们能改进秘密变形疾病的预言,分子的标记将是无价的。这研究被执行在激进的前列腺切除术标本调查 BCL-2, Ki-67, p53 和 E-cadherin 的表示。我们寻求了估计他们的能力在一个特定的治疗学的背景预言早生物化学的恶化。包括 41 案例对的 82 个病人为病理学的舞台,格利森等级和外科手术前的前列腺特定的抗原(PSA ) 被匹配集中。在每对的一个病人有生物化学的复发(在 2 年外科以内定义为 PSA 0.2 ng mL-1 ) 并且其它没有疾病生物化学地留下了(至少 3 年在外科以后定义同样无法发现的 PSA ) 。Immunohistochemical 分析被执行在四上估计标记表示复制从每个激进的前列腺切除术标本与良性、恶意的织物构造的织物 microarrays。Ki-67, p53 和 BCL-2,然而并非 E-cadherin,显著地在前列腺腺癌的 upregulated 与良性的前列腺织物相比(P < 0.01 ) 。然而,当比较与没有生物化学的复发的病人一起开发了早生物化学的恶化的病人时,在任何标记的表示的重要差别都没被观察。这研究证明 p53, BCL-2 和 Ki-67 的那表情与良性的前列腺织物相比是在临床上局部性的前列腺癌症的 upregulated,没有在 E-cadherin 表示的改变。Biomarker upregulation 没在激进的前列腺切除术以后为生物化学的复发有预示的价值,甚至在考虑病理学的舞台,整个瘤格利森等级和外科手术前的浆液 PSA 水平以后。 | Joseph Nariculam Alex Freeman Simon Bott Phillipa Munson Noriko Cable Nicola Brookman-Amissah Magali Williamson Roger S. Kirby John Masters Mark Feneley | 2009 | Asian Journal of Andrology2009，11，1： | 5 |
| 15 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 16 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 17 | Differential response of tomato genotypes to Xanthomonas-specific pathogen-associated molecular patterns and correlation with bacterial spot (Xanthomonas perforans) resistance显示文摘Plants depend on innate immune responses to retard the initial spread of pathogens entering through stomata,hydathodes or injuries.These responses are triggered by conserved patterns in pathogen-encoded molecules known as pathogen-associated molecular patterns(PAMPs).Production of reactive oxygen species(ROS)is one of the first responses,and the resulting‘oxidative burst’is considered to be a first line of defense.In this study,we conducted association analyses between ROS production and bacterial spot(BS;Xanthomonas spp.)resistance in 63 genotypes of tomato(Solanum lycopersicum L.).A luminol-based assay was performed on leaf tissues that had been treated with a flagellin 22(flg22),flagellin 28 and a Xanthomonas-specific flg22(flg22-Xac)peptide,to measure PAMP-induced ROS production in each genotype.These genotypes were also assessed for BS disease response by inoculation with Xanthomonas perforans,race T4.Although there was no consistent relationship between peptides used and host response to the BS,there was a significant negative correlation(r=−0.25,P<0.05)between foliar disease severity and ROS production,when flg22-Xac was used.This response could potentially be used to identify the Xanthomonas-specific PRR allele in tomato,and eventually PAMP-triggered immunity loci could be mapped in a segregating population.This has potential significance in tomato improvement. | Krishna Bhattarai Frank J Louws John D Williamson Dilip R Panthee | 2016 | Horticulture Research2016，3，1： | 3 |
| 18 | Arsenic and cadmium removal from water by a calcium-modified and starch-stabilized ferromanganese binary oxide显示文摘A new calcium-modified and starch-stabilized ferromanganese binary oxide (Ca-SFMBO)sorbent was fabricated with different Ca concentrations for the adsorption of arsenic (As)and cadmium (Cd) in water.The maximum As(Ⅲ) and Cd(Ⅱ) adsorption capacities of 1%CaSFMBO were 156.25 mg/g and 107.53 mg/g respectively in single-adsorption systems.The adsorption of As and Cd by the Ca-SFMBO sorbent was pH-dependent at values from 1 to 7,with an optimal adsorption pH of 6.In the dual-adsorbate system,the presence of Cd(Ⅱ) at low concentrations enhanced As(Ⅲ) adsorption by 33.3%,while the adsorption of As(Ⅲ) was inhibited with the increase of Cd(Ⅱ) concentration.Moreover,the addition of As(Ⅲ) increased the adsorption capacity for Cd(Ⅱ) up to two-fold.Through analysis by X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared spectroscopy (FTIR),it was inferred that the mechanism for the co-adsorption of Cd(Ⅱ) and As(Ⅲ) included both competitive and synergistic effects,which resulted from the formation of ternary complexes.The results indicate that the Ca-SFMBO material developed here could be used for the simultaneous removal of As(Ⅲ) and Cd(Ⅱ) from contaminated water. | Huxing Chen Fangnan Xu Zhengzheng Chen Ouyuan Jiang Williamson Gustave Xianjin Tang | 2020 | Journal of Environmental Sciences2020，32，10： | 3 |
| 19 | A brief review of recent results in vortex-induced vibrations显示文摘 | C.H.K. Williamson R. Govardhan | 2007 | Journal of Wind Engineering & Industrial Aerodynamics2007，，6： | 2 |
| 20 | Culture, openness, and finance显示文摘 | René M. Stulz Rohan Williamson | 2003 | Journal of Financial Economics2003，，3： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员