|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?显示文摘AIM: To analyze outcomes in patients who underwent liver transplantation(LT) for hepatocellular carcinoma(HCC) and received autologous intraoperative blood salvage(IBS). METHODS: Consecutive HCC patients who underwent LT were studied retrospectively and analyzed according to the use of IBS or not. Demographic and surgical data were collected from a departmental prospective maintained database. Statistical analyses were performed using the Fisher's exact test and the Wilcoxon rank sum test to examine covariate differences between patients who underwent IBS and those who did not. Univariate and multivariate Cox regression models were developed to evaluate recurrence and death,and survival probabilities were estimated using the Kaplan-Meier method and compared by the log-rank test.RESULTS: Between 2002 and 2012,158 consecutive patients who underwent LT in the same medical center and by the same surgical team were identified. Among these patients,122(77.2%) were in the IBS group and 36(22.8%) in the non-IBS group. The overall survival(OS) and recurrence free survival(RFS) at 5 years were 59.7% and 83.3%,respectively. No differences in OS(P=0.51) or RFS(P=0.953) were detected between the IBS and non-IBS groups. On multivariate analysis for OS,degree of tumor differentiation remained as the only independent predictor. Regarding patients who received IBS,no differences were detected in OS or RFS(P=0.055 and P=0.512,respectively) according to the volume infused,even when outcomes at 90 d or longer were analyzed separately(P=0.518 for both outcomes).CONCLUSION: No differences in RFS or OS were detected according to IBS use. Trials addressing this question are justified and should be designed to detect small differences in long-term outcomes. | Raphael LC Araujo Carlos Andrés Pantanali Luciana Haddad Joel Avancini Rocha Filho Luiz Augusto Carneiro D’Albuquerque Wellington Andraus | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 14 |
| 2 | Lumbar pedicle cortical bone trajectory screw显示文摘 | Song Tengfei Wellington K Hsu Ye Tianwen | 2014 | Chinese Medical Journal2014，，21： | 11 |
| 3 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 4 | Venetoclax联合低剂量阿糖胞苷治疗不耐受强化化疗的初治急性髓系白血病患者:一项Ⅲ期随机、安慰剂对照试验中中国队列结果显示文摘目的:探讨Venetoclax联合低剂量阿糖胞苷(LDAC)在不能耐受强化诱导化疗的中国急性髓系白血病(AML)患者中的疗效及安全性。方法:一项Ⅲ期随机、双盲安慰剂对照试验(VIALE-C)中中国队列的结果。在本项国际临床试验中,入组了不适合接受强化化疗、新诊断为AML的18岁或以上的成人患者。在全球范围内,患者(211例)按2∶1的比例随机分配接受Venetoclax+LDAC或安慰剂+LDAC(28 d为1个周期),在第1~10天接受LDAC。主要研究终点为总生存(OS);次要研究终点包括缓解率、无事件生存期及不良事件(AE)。结果:入组15例中国患者(Venetoclax组9例;安慰剂组6例)。中位年龄为72(61~86)岁。与安慰剂组相比,Venetoclax组的死亡风险下降38%(HR=0.62,95%CI 0.12~3.07)。对延长6个月随访进行的计划外分析显示,Venetoclax组的中位OS时间为9.0个月,安慰剂组为4.1个月。完全缓解(CR)率与血细胞计数未完全恢复的CR(CRi)率分别为33%(3/9)和0(0/6)。最常见的非血液学AE(Venetoclax组与安慰剂组)为低钾血症(5/9和4/6)、呕吐(4/9和3/6)、便秘(2/9和4/6)和低白蛋白血症(1/9和4/6)。结论:Venetoclax联合LDAC在中国患者中表现出有意义的疗效和可管理的安全性特征,这与在全球VIALE-C人群中的观察结果一致,使其成为不适合接受强化化疗的新诊断AML患者的一个重要治疗选择。 | 胡豫 金洁 张钰 胡建达 李军民 魏旭东 高素君 Zha Jiuhong Jiang Qi Wu Jun Wellington Mendes Andrew H.Wei 王建祥 | 2021 | 中华血液学杂志2021，42，4： | 7 |
| 5 | 婴儿主导早产儿喂养方式显示文摘近年来,婴儿主导喂养方式(infant driven feeding,IDF)被广泛应用,但其临床获益研究较少,本研究以早产儿为观察对象,分析IDF是否较传统的医生主导喂养方式(practitioner driven feeding,PDF)有优势。IDF是按照较客观的评分表实施喂养,通过反映早产儿觉醒度及活动能力的"准备程度评分"决定是否经口喂养; | 周颖 冯琪 Wellington A Perlman JM | 2016 | 中国新生儿科杂志2016，31，6： | 5 |
| 6 | Strengthen the Environmental Sense of Local Community with PRA and MIGIS显示文摘It was widely recognized that rural development especially rural development in the poor areas is closely related with environment issue. It is also common bias that farmers in the poor areas lack of environmental awareness, and their production activities directly cause the environment degradation. The study has shown that with appropriate outside facilitation. a poor rural community can not only analyze its environmental problem, but can also make feasible planning to recover the problem. | CAI Kui, MA Huan-cheng, John McDinnon, Jack McConchie, Jean McKinnon (Yunnan Institute of Geography, Kunming 650092, China, Southwest Forestry College,Kunming 650092, China, 3. School of Earth Science, Wellington-Victoria University,Wellington, New Zeal | 2000 | Journal of Geographical Sciences2000，10，2： | 5 |
| 7 | Factors associated with risk of malaria infection among pregnant women in Lagos, Nigeria显示文摘Background:Pregnant women living in an area of stable malaria transmission such as Lagos,Nigeria,have been identified as being at an increased risk of the effects of malaria infection.In this area,most of the infections are asymptomatic which means they are overlooked and untreated much to the detriment of the mother and her foetus.The reality of scaled-up malaria interventions with long-lasting insecticide treated nets,vector control,artemisinin combination therapy(ACT)and intermittent preventive treatment of malaria pregnancy(IPTp)using sulphadoxine pyrimethamine(SP)is that it is also essential to determine the risk factors at play in these kinds of circumstances.This study was aimed at identifying the factors associated with risk of malaria infection in pregnant women in Lagos,Southwest Nigeria.Methods:Demographic information and malaria prevention practices of the pregnant women studied were captured using structured questionnaire.Microscopy was used to establish malaria infection,species identification and parasite density.Relative risk and multivariate logistic regression analysis were used to compare factors associated with malaria in pregnant women.Results:Malaria microscopy details,demographic information and malaria prevention practices of the pregnant women were obtained using a structured questionnaire.The prevalence of malaria using peripheral blood from 1,084 pregnant women that participated in the study was 7.7%.Plasmodium falciparum(P.falciparum)was seen in 95.2%of the cases as either mixed infection with P.malariae(3.6%)or as a mono infection(91.6%).Malaria preventive practices associated with a significant reduction(P<0.05)in the malaria infection was the use of insecticide sprays(RR=0.36,95 C.I.0.24-0.54),and the combined use of insecticide spray and insecticide-treated nets(ITN)(RR=6.53,95%C.I.0.92-46.33).Sleeping under ITN alone(RR=1.07,95%C.I.0.55-2.09)was not associated with significant reduction in malaria infection among the study participants with malaria parasitaemia.Young maternal age(<20years)(RR=2.86,95%C.I.1.48-5.50),but not primigravidity(RR=1.36,95%C.I.0.90-2.05),was associated with an increased risk of malaria infection during pregnancy.After a multivariate logistic regression,young maternal age(OR=2.61,95%C.I.1.13-6.03)and the use of insecticide spray(OR=0.38,95%C.I.0.24-0.63)were associated with an increase and a reduction in malaria infection,respectively.Conclusion:Malaria prevalence was low among the pregnant women studied.Young maternal age and non-usage of insecticidal spray were the main factors associated with an increased risk of malaria infection among pregnant women in Lagos,Nigeria. | Chimere O Agomo Wellington A Oyibo | 2013 | Infectious Diseases of Poverty2013，2，1： | 4 |
| 8 | Enhancement of diversity,stand structure and regeneration of woody species through area exclosure:the case of a mopane woodland in northern Botswana显示文摘Introduction:An area exclosure is the practice of land management that involves the exclusion of livestock and humans from openly accessing an area that is characterized by severe degradation.Area exclosures have been employed as cheap and convenient means of rehabilitating degraded forests/woodlands.A study was carried out to(i)assess the species richness,diversity and evenness;(ii)determine the densities,frequencies,dominance and importance value index;and(iii)assess the population structure and regeneration status of woody species inside and outside the fence(area exclosure)of Okavango Research Institute(ORI)located in Maun,northern Botswana.Results:Thirty-five woody species were recorded inside(32 spp.)and outside(24 spp.)the ORI compound,and the population structure and regeneration status of the woody species were better inside than outside the ORI compound.The exclosure had seven times higher mean density of woody species than outside ORI,and an exceptional regeneration of seedlings was observed inside than outside the ORI compound,suggesting the process of recovery of the degraded woodland.The frequencies of more than half of the woody species also showed increment inside than outside the exclosure.The results suggest that the exclosed area is still in an initial recovery stage since it had been an open grazing area prior to the establishment of the exclosure.Most of the woody species encountered outside ORI showed hampered recruitment and regeneration,owing to different anthropogenic impacts and overgrazing by animals.Conclusions:Despite the relatively short period(10 years)of exclosure establishment,results from the present study have further provided empirical evidences on the actual crucial roles played by area exclosures to increase woody species richness,diversity,evenness,density,frequency,dominance and important value index as well as enhance the population structure and regeneration of the woody species in northern Botswana.Future research is recommended focusing on comparative studies on herbaceous species richness,diversity and density,horizontal and vertical distribution of soil seed banks,species richness of soil microorganisms,plant and soil biomass,plant and soil carbon pools(above and below ground)as well as soil contents and properties inside and outside the ORI compound. | Demel Teketay Keotshephile Kashe Joseph Madome Monica Kabelo John Neelo Mmusi Mmusi Wellington Masamba | 2018 | Ecological Processes2018，7，1： | 4 |
| 9 | The pleiotropic vasoprotective functions of high density lipoproteins(HDL)显示文摘The pleiotropic functions of circulating high density lipoprotein(HDL) on peripheral vascular health are well established. HDL plays a pivotal role in reverse cholesterol transport and is also known to suppress inflammation,endothelial activation and apoptosis in peripheral vessels. Although not expressed in the central nervous system, HDL has nevertheless emerged as a potential resilience factor for dementia in multiple epidemiological studies. Animal model data specifically support a role for HDL in attenuating the accumulation of P-amyloid within cerebral vessels concomitant with reduced neuroinflammation and improved cognitive performance. As the vascular contributions to dementia are increasingly appreciated, this review seeks to summarize recent literature focused on the vasoprotective properties of HDL that may extend to cerebral vessels, discuss potential roles of HDL in dementia relative to brainderived lipoproteins, identify gaps in current knowledge, and highlight new opportunities for research and discovery. | Guilaine Boyce Emily Button Sonja Soo Cheryl Wellington | 2018 | The Journal of Biomedical Research2018，32，3： | 3 |
| 10 | 气候变暖与企业竞争力显示文摘无论你是身处传统的“浓烟滚滚”的重工业,还是在像投资银行这样的“洁净”行业里工作,你所在的公司都会日益感受到气候变化的影响。即便是那些对全球变暖的危险心存怀疑的人也认识到,有太多的人都在担忧这一问题,就凭这一点,其影响范围之广也不容小觑。 | 乔纳森·拉希(Jonathan Lash) 弗雷德·韦林顿(Fred Wellington) 陈媛熙(翻译) | 2009 | 商业评论2009，，9： | 2 |
| 11 | 波士顿Ⅰ型人工角膜移植治疗眼部严重陈旧化学伤和热烧伤12例分析显示文摘目的探讨人工角膜移植术治疗眼部严重陈旧性化学伤和热烧伤的临床疗效。方法对2010年7月~2013年7月12例(12眼)陈旧性眼部烧伤病(酸烧伤、碱烧伤和热烧伤各4例)进行了波士顿Ⅰ型人工角膜移植术。手术方法包括无晶体眼人工角膜植入术和人工晶体眼人工角膜植入术。术后随访时间1~3年,平均2.2年。结果最后一次随访,所有病例人工角膜均与植床愈合良好,无渗漏和脱离。最佳矫正视力4例0.25;1例0.4;4例0.6;2例0.8;1例1.0。正视(不接受镜片)2例;远视(+1.0~+3.5 D)3例;近视(-1.0~-3.5 D)7例。视野30~110度,平均85度。术后并发症包括人工角膜后膜(镜后膜)6例,后发性白内障2例,均经过钇铝石榴石(YAG)激光膜切开术治愈;玻璃体出血5例,经药物治疗治愈;眼压升高4例,3眼停用激素性眼液后恢复正常,另1眼依赖药物控制。结论波士顿Ⅰ型人工角膜移植术是治疗眼部陈旧性化学伤和热烧伤的有效治疗方法。 | 高明宏 陈颖欣 徐旭 于静 禹海 周润海 杜春光 姚颖 王颖 Michael Wellington Belin 王明武 | 2013 | 创伤与急危重病医学2013，1，1： | 2 |
| 12 | Valganciclovir:a review of its use in the management of CMV infection and disease in immunocompro-mised patients显示文摘 | Cvetkovic RS Wellington K | 2005 | Drugs2005，65，6： | 1 |
| 13 | ABC1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation显示文摘 | Wellington CL Walker EK Suarez A Kwok A Bissada N Singaraja R | 2002 | Lab invest2002，82，3： | 1 |
| 14 | Fragrance material review on alpha-amylcinnamyl alcohol显示文摘 | Bhatia SP Wellington GA Cocchiara J | 2007 | Food Chem Toxicol2007，45，： | 1 |
| 15 | Environmental influences on skeletal banding in eastern Pacific (Panama) corals显示文摘 | Gerard M. Wellington Peter W. Glynn | 1983 | Coral Reefs1983，，4： | 1 |
| 16 | Functional responses of riparian vegetation to stream flow diversion in the eastern Sierra Nevada显示文摘 | Smith D Wellington B Nachlinger L | 1991 | Ecological Applications1991，1，： | 1 |
| 17 | Quality of life is- sues for patients following traumatic brachial plexus injury-part 2 research project 显示文摘 | Beverley Wellington MSc BSc ( Hons ) | 2010 | Int J Orth Trau Nut2010，14，2： | 1 |
| 18 | Noninvasive positive pressnre ventilation for trentment of respiratory failure due to sever acute exacerbations of asthma显示文摘 | Ram FS Wellington S Rowe B | 2005 | Cuehrane Data base Syst Rev2005，20，： | 1 |
| 19 | Valdcoxib显示文摘 | Ormrod D Wellington K Wagstaff AJ | 2002 | Drugs2002，62，14： | 1 |
| 20 | Lueinactant: in neonatal respiratory distress syndrome 显示文摘 | Moen MD Perry CM Wellington K | 2005 | Treat Respir Med2005，4，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员