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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | The microwave processability of semicrystalline polymers显示文摘 | M Chen J W Hellgeth E J Siochi T C Ward J E Mcgrath | 1993 | Polymer Engineering and Science1993，33，17： | 2 |
| 3 | Cancer statistics,2008显示文摘 | Jemal A Siegel R Ward E | | 0，，02： | 2 |
| 4 | Cancer statistics,2009显示文摘 | Jemal A Siegel R Ward E | 2009 | CA:A Cancer Journal for Clinicians2009，，04： | 2 |
| 5 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 6 | Cancer statistics, 2007 显示文摘 | Jemal A Siegel R Ward E | 2007 | CA Cancer J Clin2007，57，1： | 1 |
| 7 | Cancer statistics, 2007 显示文摘 | Jemal A Siegel R Ward E | 2007 | CA Cancer J Clin2007，57，1： | 1 |
| 8 | Cancer statistics, 2006 显示文摘 | Jemal A Siegel R Ward E | 2006 | CA Cancer J Clin2006，56，2： | 1 |
| 9 | Cancer statistics, 2007 显示文摘 | Jemal A Siegel R Ward E | 2007 | CA Cancer J Clin2007，57，1： | 1 |
| 10 | Cancer statistics, 2007 显示文摘 | Jemal A Siegel R Ward E | 2007 | CA Cancer J Clin2007，57，1： | 1 |
| 11 | Failure of spectra polyethylene fiber-reinforced composites under ballistic impact loading显示文摘 | Lee B L Song J W Ward J E | 1994 | Journal of Composite Materials1994，28，13： | 1 |
| 12 | Cancer statistics,2009显示文摘 | Jemal A Siegel R Ward E | 2009 | CA Cancer J Clin2009，59，4： | 1 |
| 13 | CA Cancer statistics显示文摘 | Jemal A Siegel R Ward E | 2009 | Cancer J Clinp2009，59，4： | 1 |
| 14 | A novel plasminogen activator from Streptococcus uberis显示文摘 | Rosey E L Lincoln R A Ward P N | 1999 | FEMS Microbiol Lett1999，178，： | 1 |
| 15 | Multifunctional roles of lactoferrin:a critical overview显示文摘 | Ward PP Paz E Conneely OM | 2005 | Cell Mol Life Sci2005，62，22： | 1 |
| 16 | Mammary gland mophogenesis is enhanced by exposure to flaxseed or its major lignan during suckling in rats显示文摘 | TAN K P CHEN J WARD W E | 2004 | Exp Biol Med2004，229，： | 1 |
| 17 | Cancer statistics,2007显示文摘 | Jemal A Siegel R Ward E | 2007 | CA Cancer J Clin2007，57，1： | 1 |
| 18 | Cancer statistics显示文摘 | Jemal A Murray T Ward E | 2005 | CA Cancer J Clin2005，55，1： | 1 |
| 19 | Patient Participation in Decision Making 显示文摘 | Guadagnoli E Ward P | 1998 | SocSciMed1998，47，3： | 1 |
| 20 | Plasmid DNA encoding replicating Foot-and-mouth disease virus genomes induces antiviral immune response in swine显示文摘 | Ward G Rieder E Mason P W | 1997 | J Virol1997，71，： | 1 |
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