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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 恶性弥漫型腱鞘滑膜巨细胞肿瘤显示文摘 | Li C F Wang J W Huang W W 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，4： | 12 |
| 3 | Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid显示文摘 | Shi Y Hou L Tang F Jiang W Wang P Ding M Deng H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 4 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 5 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 6 | Uncharged Thioflavin-T Derivatives Bind to Amyloid-beta Protein With High Affinity and Readily Enter the Brain显示文摘 | Klunk W E Wang Y Huang G F | 2001 | Life Sci2001，69，13： | 2 |
| 7 | Development of 123I-Labelled Agents for Amyloid Imaging显示文摘 | Wang Y Klunk W E Huang G F | 2003 | J Labelled Cpd Radiopharm2003，46，1： | 2 |
| 8 | Synthesis and Evaluation of a Radioiodinated Benzothiazole Derivative as a Radiologand for in vivo Quantitation of Beta-amyloid Deposits in Aging and Alzheimer's Disease显示文摘 | Wang Y Klunk W E Huang G F | 2001 | J Labelled Cpd Radiopharm2001，，： | 2 |
| 9 | Quantitative Analysis of SulfonamideResidues in Natural Animal Casings by HPLC显示文摘 | Sun H W Ai L F Wang F C | 2007 | Chromatographia2007，66，： | 1 |
| 10 | Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats 显示文摘 | Yang X F Wang N P Lu W H | 2003 | Acta Pharmacol Sin2003，24，10： | 1 |
| 11 | Determination of wood density in standing white spruce using Pilodyn tester显示文摘 | MICKO M M WANG E I C TAYLOR F W | 1982 | The Forestry Chronicle1982，58，4： | 1 |
| 12 | Robust H2/H∞ control with missing measurements and time delays显示文摘 | YANG F W WANG Z D HO D W | 2007 | IEEE Transactions on Automatic Control2007，52，9： | 1 |
| 13 | Vaccination of advanced hepatocellular carcinoma patients with tumor lysate- pulsed dendritic cells : a clinical trial显示文摘 | Lee W C Wang H C Hung C F | 2005 | J Immunother2005，28，5： | 1 |
| 14 | Synthesis and microstructure of gallium phosphide nanowires 显示文摘 | Zheng Y F Wang N | 2001 | J Vac Sci Tech B2001，19，4： | 1 |
| 15 | The effect of excess Zn on mineral nutrition and antioxidative response in rapeseed seedlings显示文摘 | WANG CH ZHANG S H WANG P F HOU J ZHANG W J LI W LIN ZH P | 2009 | Chemosphere2009，75，： | 1 |
| 16 | Growth process of β-FeSi2 epitaxial film on Si(Ⅲ) by molecular beam epitaxy显示文摘 | Ji S Y Wang J F Lim J W | 2006 | Applied Surface Science2006，253，2： | 1 |
| 17 | Crystal growth and morphology of the nano-sized hydroxyapatite powders synthesized from CaHPO4-2H2O and CaCO3 by hydrolysis method显示文摘 | Shih W J Chen Y F Wang M C | 2004 | Journal of Crystal Growth2004，270，12： | 1 |
| 18 | Effects of homogenization treatment on recrystallization behavior and dispersoid distribution in an Al-Zn-Mg-Sc-Zr alloy显示文摘 | WU L M WANG W H HSU Y F | 2008 | Journal of Alloys and Compounds2008，456，12： | 1 |
| 19 | Non - invasive ablation of high intensity focused ultrasound for the treatment of patients with primary bone malignancy 显示文摘 | Wu F Wang Z B Chen W Z | 2005 | J of Bone and Joint Sur2005，，： | 1 |
| 20 | Real-time stereographie rendering and display of medical images with programmable GPUs 显示文摘 | WANG X H GOOD W F | 2008 | Computerized Medical Imaging and Graphics2008，32，2： | 1 |
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