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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Noncoherent sequential acquisition of PN sequence for DS/SS communications with/without dhannel fading显示文摘 | TANTARTANS S LAN A W VINCENT P J | 1995 | IEEE Trans on COM1995，43，2： | 2 |
| 3 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 4 | Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy显示文摘 | Alan Sugar Christopher J Rapuano William W Culbertson David Huang Gary A Varley Peter J Agapitos Vincent P de Luise Douglas D Koch | 2002 | Ophthalmology2002，，1： | 2 |
| 5 | Preparation and Swelling Properties of Poly ( NIPAM ) Minigel Particles Prepared by Inverse Suspension Polymerization 显示文摘 | Dowding P J Vincent B Williams E | 2000 | J Colloid and Interface Sei2000，221，26： | 1 |
| 6 | The me-chanical design of nacre显示文摘 | Jackson A P Vincent J F V Turner R M | | 0，，： | 1 |
| 7 | Out-of-sample exten- sions for LLE, isomap, MDS, eigenmaps, and spectral clustering显示文摘 | Bengio Y Palement J Vincent P | 2004 | Neural Computation2004，16，10： | 1 |
| 8 | Late Cenozoic tectonics of the Kepingtoge thrust zone : interaction between the Tianshan and the Tarim Basin, northwest China显示文摘 | Allen M B Vincents S J Wheeler P J | 1999 | Tectonics1999，18，： | 1 |
| 9 | Particle size variation over a transverse dunein the Nafud as Sirr,central Saudi Arabia显示文摘 | Vincent P J | 1984 | Journal ofArid Environments1984，7，2： | 1 |
| 10 | Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia显示文摘 | Vincent P C Clark S J | 1999 | Cancer Res1999，59，15： | 1 |
| 11 | Late Cenozoic tectonics of the Kepingtage thrust zone, interaction of the Tien Shan and Tarim Basin, Northwest China 显示文摘 | Allen M B Vincent S J and Wheeler P J | 1999 | Tectonics1999，18，4： | 1 |
| 12 | Transcriptio- nal organization of the avian adenovirus CELO 显示文摘 | Vincent P Arnauld C Picault J | 1998 | J Virol1998，72，11： | 1 |
| 13 | The mechanical design of nacre 显示文摘 | Jackson A P Vincent J F V Turner R M | 1988 | Proc R Soc Lond B1988，234，： | 1 |
| 14 | High efficacy of β-blocker in long-QT syndrome type I显示文摘 | VINCENT G M SCHWARTZ P J DENJOY I | 2009 | Circulation2009，119，： | 1 |
| 15 | Cavitations in noncircular journal bearings显示文摘 | Vincent B Maspeyrot P Frene J | 1997 | Wear1997，207，： | 1 |
| 16 | Progress in Ingorganic Chemistry 显示文摘 | VINCENT L P ANN J S BRAIN R G | 1997 | 45:83 -1761997，45，： | 1 |
| 17 | Out-of-sample extensions for LLE, Isomap, MDS, eigenmaps, and spectral clustering 显示文摘 | Bengio Y Paiement J Vincent P | 2004 | Neural Computation2004，6，21： | 1 |
| 18 | The significance of needle placement site in acupuncture 显示文摘 | Vincent C A Richardson P H Black J J et aI | 1989 | J PsychosomRes1989，33，4： | 1 |
| 19 | Class-Based n-gram Models of Natural Language显示文摘 | PETER F B VINCENT J D P PETER V D JENIFER C L ROBERT L M | 1992 | Computational Linguistics1992，，： | 1 |
| 20 | Production of antibodies in murine mucosal immunization with Toxoplasma gondii excreted/secreted antigens显示文摘 | Hafid J Vincent N Flori P | 2005 | Vet Parasitol2005，128，12： | 1 |
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