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| 1 | Local recurrence of a parosteal osteosarcoma 21 years after incomplete resection显示文摘Parosteal osteosarcoma (POS) is the most common form of surface osteosarcoma. Its symptoms are insidious and its duration prior to diagnosis is considerably longer than that of other types of osteosarcoma. We report a case of POS with a growing mass but no evidence of metastasis. This tumor, which was diagnosed as calcified hematoma with benign characteristics, was incompletely resected in our hospital 21 years before the diagnosis of recurrence. The patient underwent a wide en bloc resection in our hospital and was free of symptoms, with no signs of tumor recurrence or metastasis during a 53-month follow-up. | Andrés Combalia Ernesto Muoz-Mahamud Antonio Palacín Jaume Pomés Vicente López | 2011 | Chinese Journal of Cancer2011，30，12： | 5 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | Hepatocyte transplantation program:Lessons learned andfuture strategies显示文摘This review aims to share the lessons we learned over time during the setting of the hepatocyte transplantation(HT) program at the Hepatic Cell Therapy Unit at Hospital La Fe in Valencia. New sources of liver tissue for hepatocyte isolation have been explored. The hepatocyte isolation and cryopreservation procedures have been optimized and quality criteria for assessment of functionality of hepatocyte preparations and suitability for HT have been established. The results indicate that:(1) Only highly viable and functional hepatocytes allow to recover those functions lacking in the native liver;(2) Organs with steatosis(≥ 40%) and from elderly donors are declined since low hepatocyte yields, viability and cell survival after cryopreservation, are obtained;(3) Neonatal hepatocytes are cryopreserved without significant loss of viability or function representing high-quality cells to improve human HT;(4) Cryopreservation has the advantage of providing hepatocytes constantly available and of allowing the quality evaluation and suitability for transplantation; and(5) Our results from 5 adults with acute liver failure and 4 from children with inborn metabolic diseases, indicate that HT could be a veryuseful and safe cell therapy, as long as viable and metabolically functional human hepatocytes are used. | Eugenia Pareja Ibars Miriam Cortes Laia Tolosa Maria JoséGómez-Lechón Slivia López JoséVicente Castell JoséMir | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 4 | The role of multimodality therapy for resectable esophageal cancer显示文摘 | Meneu-Diaz J C Blazquez L A Vicente E | 2000 | Am J Surg2000，179，6： | 2 |
| 5 | Heparin cofactor Ⅱ inhibits arterial thrombosis after endothelial injury 显示文摘 | He L Vicente CP Westrick RJ | 2002 | J Clin Invest2002，109，2： | 2 |
| 6 | Pleiotropic effects of lactate dehydrogenase inactivationin Lactobacillus casei显示文摘 | María J José L G Vicente M Gaspar P | 2005 | Research in Microbiology2005，156，： | 1 |
| 7 | Control of molecular weight distribution in emulsion polymerization using on-line reaction calorimeter 显示文摘 | Vicente M Benamor S Gugliotta L M | 2001 | Indus and Eng Chem Res2001，40，1： | 1 |
| 8 | Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat 显示文摘 | Vicente E Degerone D Bohn L | 2009 | Brain Res2009，1251，： | 1 |
| 9 | Optimized chemical stability and electrochemical performance of LiFePO4 composite materials obtained by ZnO coating显示文摘 | LEON B VICENTE C P T1RADO J L | 2008 | Journal of The Electrochemical Society2008，155，3： | 1 |
| 10 | Effects of Temperature and Salinity on Artificially Reproduced Eggs and Larvae of the Leopard Grouper Mycteroperca rosacea 显示文摘 | Vicente G L Margarita K M Minerva M G | 2004 | Aquaculture2004，234，： | 1 |
| 11 | Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat显示文摘 | Vicente E Degerone D Bohn L | 2009 | Brain Res2009，1251，： | 1 |
| 12 | New insights into the mechanism of aminoglycoside nephrotoxicity: an inte grative point of view 显示文摘 | Lopez-Novoa JM Quiros Y Vicente L | 2011 | Kidney Int2011，79，1： | 1 |
| 13 | Pressurized liquid extraction for the determination of polyphenols in apple显示文摘 | ALONSO-SALCES R M KORTA E BARRANCO A BERRUETA L A GALLO B VICENTE F | 2001 | Journal of Chromatography A2001，933，1： | 1 |
| 14 | Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat 显示文摘 | Vicente E Degerone D Bohn L | 2009 | Brain Res2009，1251，： | 1 |
| 15 | Predictors of the level of patient satisfaction in a university hospital显示文摘 | Castillo L Dougnac A Vicente I | | 0，，06： | 1 |
| 16 | pl 6 (Ink4a) over- expression in cancer: a tumor suppressor gene associated with senes- cence and high - grade tumors 显示文摘 | Romagosa C Simonetti S L6pez - Vicente L | 2011 | Oncoqene2011，30，18： | 1 |
| 17 | Effect of cigarette smoking on serum alpha-tocopherol and the lipid profile in a Portuguese population显示文摘 | LOPES P A SANTOS M C VICENTE L VIEGAS-CRESPO A M | 2004 | Clin Chim Acta2004，348，12： | 1 |
| 18 | Recent advances in the synthesis and catalytic applications of pillared clays 显示文摘 | Gil A Gandia L M and Vicente M A | 2000 | Catal Rev -Sci Eng2000，42，12： | 1 |
| 19 | Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat显示文摘 | Vicente E Degerone D Bohn L | 2009 | Brain Res2009，1251，： | 1 |
| 20 | McMansions: The Extent and Regulation of Super-Sized Houses显示文摘 | Nasar Jack L Jennifer S Evans-Cowley Vicente Mantero | 2007 | Journal of Urban Design2007，12，3： | 1 |
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