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| 1 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 2 | Juvenile polyposis syndrome显示文摘Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer.The cumulative life-time risk of colorectal cancer is 39% and the relative risk is 34.Juvenile polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive changes.Clinically,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis.In about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is found.Both genes play a role in the BMP/TGF-beta signalling pathway.It has been suggested that cancer in juvenile polyposis may develop through the socalled 'landscaper mechanism' where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive carcinoma.Recognition of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk individuals.Each clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis syndrome.In addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of cancer.This review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome. | Lodewijk AA Brosens Danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 5 | Factors relevant in bacterial pyrroloquinoline quinone production显示文摘 | van Kleef M A G Duine J A | 1989 | Applied and Environmental Microbiology1989，55，5： | 2 |
| 6 | 二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。 | Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) | 2010 | 英国医学杂志中文版2010，13，5： | 2 |
| 7 | Experimental investigation of size effect in concrete and sandstone under uniaxial tension显示文摘 | Van M R A Van J G M | 2000 | Engineering Fracture Mechanics2000，65，： | 2 |
| 8 | The dissolution of Na2O-MgO-CaO-SiO2 glass in aqueous HF solutions 显示文摘 | SPIERINGS G A C M van DIJK J | 1987 | J Mater Sci1987，22，： | 2 |
| 9 | Mycorrhizal fungal diversity determines plant biodiversity,ecosystem variability and productivity显示文摘 | van der Heijden M G A Klironomos J N Ursic M | 1998 | Nature1998，396，： | 2 |
| 10 | ZSM-5 zeolite with enhanced acidic properties显示文摘 | Le Van Mao R Le T S Fairbain M Muntasar A Xiao S Denes G | | 0，，： | 2 |
| 11 | Interaction between cisplatin and gemcitabine in vitro and in vivo 显示文摘 | Peters G J Bergman A M Ruiz van Haperen V W | 1995 | Semin Oncol1995，22，411： | 1 |
| 12 | A new technique of reversibly adsorbed phosphate显示文摘 | Fokkink L G J Van Reimsdijk W H | 1987 | Soil Sci Soc Am J1987，51，： | 1 |
| 13 | New synthetic approaches to ammonia-borane and its deuterated derivatives显示文摘 | HU M G PAASSCHEN J M VAN GEANANGEL R A | 1977 | J Inorg Nucl Chem1977，39，12： | 1 |
| 14 | Nucleation and propagation of dislocations in nanocrystalline fcc metals显示文摘 | VAN S H DERLET P M FROSETH A G | 2006 | Acta Materialia2006，54，： | 1 |
| 15 | Stimulation by extracellular ATP and UTP of the stress-activated protein kinase cascade in rat renal mesangial cells显示文摘 | Huwiler A van Rossum G Wartmann M | 1997 | Br i Pharmacol1997，120，： | 1 |
| 16 | Human antibodies as next generation therapeutics显示文摘 | van Dijk M A van de Winkel J G J | 2001 | Curr Opin Chem Biol2001，5，4： | 1 |
| 17 | Use of the upflow sludge blanket (USB) reactor concept for biological wastewater treatment显示文摘 | LETTINGA G van VEISEN A F M HOBMA S M | 1980 | Biotech Bioengrg1980，22，： | 1 |
| 18 | Heuristic to control integrated multi-product multimachine production-inventory systems with job shop routings and stochastic arrival,set-up and processing times显示文摘 | Van Nyen P L M Bertrand J W M Van Ooijen H P G Vandaele N J A | 2005 | OR Spectrum2005，27，23： | 1 |
| 19 | Review of discrete particle modeling of fluidized beds 显示文摘 | DEEN N G van SINT ANNALAND M van der HOEF M A | 2007 | Chemical Engineering Science2007，62，1820： | 1 |
| 20 | Quenching of giant hysteresis effects in La1 - zYzHx switchable mirrors 显示文摘 | van Gogh A T M Nagengast D G Kooij E S | 2000 | Physical Review Letters2000，85，10： | 1 |
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