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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | 堪察加地区现今地壳运动与变形特征研究显示文摘利用俄罗斯堪察加地区1995~2005年的 GPS 观洲数据,研究了该区现今地壳水平运动速度场特征.在球坐标系中解算了各应变率分量,分析了应变率场的空间分布特征.并与地震学和地质学研究结果进行了综合对比分析.结果表明.堪察加半岛北部的微板块边界并不明显.堪察加南部测站运动速度大于中部和北部地区.愈靠近东部板块汇聚区,测站速度越大.从东海岸到西海岸,测站水平速度存在明显的梯度衰减特征,水平运动方向与太平洋板块向西北的俯冲方向基本一致.各应变率分量具有东部海岸大于中部和西海岸、从东至西呈梯度衰减的特点.堪察加大部分地区处于 EW 和 NS 向压缩状念.局部存在拉张.面应变率结果显示绝大部分为压缩区;刚性转动结果表明大部分地区表现为顺时针转动,北部地区和南端顺时针旋转性明显.东部有效应变率明显大于西部地区,东西向梯度衰减关系明显.主压应变率明显大于主张应变率.特别是在东海岸地区.主压应变率方向与中等以上地震的主压应力轴在水平方向的投影方向基本一致.地壳变形场在空间分布上的不一致性主要与太平洋板块在堪察加半岛东南侧的俯冲深度、俯冲方位角、俯冲倾角和俯冲带的耦合强度有关. | 孟国杰 申旭辉 Vladimir Smirnov Eugene A Rogozhin 伍吉仓 | 2009 | 地球物理学报2009，52，3： | 12 |
| 3 | Predicting intrinsic disorder in proteins: an overview显示文摘 | Bo He Kejun Wang Yunlong Liu Bin Xue Vladimir N Uversky A Keith Dunker | 2009 | Cell Research2009，19，8： | 11 |
| 4 | Basic characteristics and development of yield criteria for geomaterials显示文摘The yield criteria of geomaterials play a crucial role in studying and designing the strength of materials and structures.The basic characteristics of yield criteria for geomaterials need to be studied under the framework of continuum mechanics.These characteristics include the effects of strength difference(SD) of materials in tension and compression,normal stress,intermediate principal stress,intermediate principal shear stress,hydrostatic stress,twin-shear stresses,and the convexity of yield surface.Most of the proposed yield criteria possess only one or some of these basic characteristics.For example,the Tresca yield criterion considers only single-shear stress effect,and ignores the effect of SD,normal stress,intermediate principal stress,intermediate principal shear stress,hydrostatic stress,and twin-shear stresses.The Mohr-Coulomb yield criterion accounts for the effect of SD,normal stress,single-shear stress and hydrostatic stress,but disregards the effect of intermediate principal stress,intermediate principal shear stress,and twin-shear stresses.The basic characteristics remain to be fully addressed in the development of yield criterion.In this paper,we propose a new yield criterion with three features,that is,newly developed,better than existing criteria and ready for application.It is shown that the proposed criterion performs better than the existing ones and is ready for application.The development of mechanical models for various yield criteria and the applications of the unified strength theory to engineering are also summarized.According to a new tetragonal mechanical model,a tension-cut condition is added to the unified strength theory.The unified strength theory is extended to the tension-tension region. | Maohong Yu Gulyun Xia Vladimir A Kolupaev | 2009 | Journal of Rock Mechanics and Geotechnical Engineering2009，1，1： | 7 |
| 5 | Experimental study on the performance of a rotational supercavitating evaporator for desalination显示文摘Efforts have been made on experimental research of a supercavitation device for desalination,which is named rotational supercavitating evaporator(RSCE).The RSCE is characterised by the simple construction and responsive capacity control,and only requires rough filtration of the source water for scaling-and fouling-free operations.The present study has been conducted for the water flow at temperature of around 22–30°C and atmospheric pressure as the first step for investigation of the performance characteristics of RSCE.The multiply factor extremal experiments conducted with the Box-Wilson’s method have revealed the salinity of the condensate,the temperature of steam inside the supercavity,and dependence of the shape of supercavity on the rate of steam extraction and rotation speed of impeller.The shape of impeller and the expected supercavitating effects it generates have been confirmed by experimental results at the rotation speed of 5430 rpm(round per minute).The design of the steam extraction openings has been approved during the evacuation of steam.The experimental dependencies have been obtained in form of statistically valid regression equations,which can be used for engineering design of RSCE. | LIKHACHEV Dmitriy S LI FengChen KULAGIN Vladimir A | 2014 | Science China(Technological Sciences)2014，57，11： | 6 |
| 6 | Monoclonal immunoscintigraphy for detection of metastasis and recurrence of colorectal cancer显示文摘AIM:To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal cancer.METHODS:Monoclonal immunoscintigraphy was performed in patients operated on for colorectal adenocar-cinoma suspected of local recurrence and metastatic disease.The results were compared with conventional diagnostics.RESULTS:Immunoscintigraphic investigation was done in 53 patients.Tumor recurrence occurred in 38 patients,and was confirmed by other diagnostic modalities in 35.In 15 patients,immunoscintigraphic findings were negative,and confirmed in 14 with other diagnostic methods.Comparative analysis confirmed good correlation of immunoscintigraphic findings and the results of conventional diagnostics and the level of tumor marker carcinoembryonic antigen.Statistical analysis of parameters of radiopharmaceutical groups imacis,indimacis and oncoscint presented homogenous characteristics all of three radiopharmaceuticals.The analysis of immunoscintigraphic target focus was clearly improved using tomography.CONCLUSION:Immunoscintigraphy is highly specific and has a good predictive value in local recurrence of colorectal cancer. | Vera Artiko Ana Koljevic Markovi Dragana obi-aranovi Milorad Petrovi Andrija Anti Mirjana Stojkovi Marinko Zuvela Djordjije aranovi Milica Stojkovi Neboja Radovanovi Danijel Galun Aleksandar Milovanovi Jovica Milovanovi Anica Bobi-Radovanovi Zoran Krivokapic Vladimir Obradovi | 2011 | World Journal of Gastroenterology2011，17，19： | 4 |
| 7 | Numerical study on the characteristics of natural supercavitation by planar symmetric wedge-shaped cavitators for rotational supercavitating evaporator显示文摘With the application of supercavitation effect, a novel device named rotational supercavitating evaporator(RSCE) was recently designed for desalination. In order to improve the blade shape of rotational cavitator in RSCE for performance optimization and then design three-dimensional blades, numerical simulations are conducted on the supercavitating flows(with cavitation number ranging from 0.055 to 0.315) around two-dimensional planar symmetric wedge-shaped cavitators with different wedge angles varied from 10 to 180 degrees. Proper numerical method for simulating supercavitating flows around planar symmetric cavitator is established, and assessment of k-ε-v2 -f turbulence model in simulating cavitating flows is conducted. It shows that the size of computational domain would affect the simulation result. Empirical formulae for supercavity dimensions about cavitation number at different wedge angles are obtained, which are of significant importance in the subsequent design of three-dimensional blade. The characteristics of resistance at different wedge angles are discussed, which, together with the characteristics of supercavity dimensions, play important roles in the optimal design of RSCE. | ZHENG ZhiYing LI FengChen LI Qian KULAGIN Vladimir A | 2015 | Science China(Technological Sciences)2015，58，6： | 3 |
| 8 | Linagliptin alleviates fatty liver disease in diabetic db/db mice显示文摘AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(BKS.Cg-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, P = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independent to changes in the plasma glucose levels. CONCLUSION The DPP4 inhibitor linagliptin alleviates liver steatosis and structural changes in the hepatic microvasculature and lymphatic roots in a model of NAFLD in diabetic db/db mice. | Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova Eugenii L Zavjalov Galina V Koncevaya Vladimir I Konenkov | 2016 | World Journal of Diabetes2016，7，19： | 2 |
| 9 | Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma显示文摘AIM:To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin's hepatic lymphoma.METHODS:The research included patients with a diagnosis of Hodgkin's lymphoma with metastatic focal lesions in the liver and controls.Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal,hepatic and splenic veins were examined.Hepatic perfusion index (HPI) estimated by HRA was calculated.RESULTS:In the majority of patients,hepatomegaly was observed.Lesions were mostly hypoechoic and mixed,solitary or multiple.Some of the patients presented with dilated splenic veins and hepatofugal blood flow.A pulse wave was registered in the centre and at the margins of lymphoma.The average velocity of the pulse wave was higher at the margins (P>0.05).A continuous venous wave was found only at the margins of lymphoma.There was no linear correlation between lymphoma size and velocity of pulse and continuous wave (r=390,P<0.01).HPI was significantly lower in patients with lymphomas than in controls (P<0.05),pointing out increased arterial perfusion in comparison to portal perfusion.CONCLUSION:Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin's hepatic lymphoma and estimation of its intensity.Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions. | Mirjana V Stojkovi Vera M Artiko Irena B Radoman Slavko J Knezevi Snezana M Luki Mirko D Kerkez Nebojsa S Leki Andrija A Anti Marinko M Zuvela Vitomir I Rankovi Milorad N Petrovi Dragana P obi Vladimir B Obradovi | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 10 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 11 | Predictors of microsurgical varicocelectomy efficacy in male infertility treatment:critical assessment and systematization显示文摘In this review,we tried to systematize all the evidence(from PubMed[MEDLINE],Scopus,Cochrane Library,EBSCO,Embase,and Google Scholar)from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment.Regarding the outcomes of varicocele repair,we considered semen improvement and pregnancy and analyzed them separately.Based on the 2011 Oxford CEBM Levels of Evidence,we assigned a score to each trial that studied the role of the predictor.We systematized the studied predictors based on the total points,which were,in turn,calculated based on the number and quality of studies that confirmed or rejected the studied predictor as significant,into three levels of significance:predictors of high,moderate,and low clinical significance.Preoperative total motile sperm count(TMSC)coupled with sperm concentration can be a significant predictor of semen improvement and pregnancy after varicocelectomy.In addition,for semen improvement alone,scrotal Doppler ultrasound(DUS)parameters,sperm DNA fragmentation index(DFI),and bilateral varicocelectomy are reliable predictors of microsurgical varicocelectomy efficacy. | Azizbek B Shomarufov Vladimir A Bozhedomov Nikolay I Sorokin Igor P Matyukhov Abdukodir A Fozilov Shukhrat A Abbosov Armais A Kamalov | 2023 | Asian Journal of Andrology2023，25，1： | 2 |
| 12 | The denaturation of circular enterocin AS-48 by urea and guanidinium hydrochloride显示文摘 | EVA S C VLADIMIR V F G/kLVEZ A | 2002 | Biochimica ET Biophysica Acta2002，1598，： | 1 |
| 13 | Detection of atomic deuterium in the upper atmosphere of mars 显示文摘 | Vladimir A Krasnopolsky Michael J | 1998 | Science1998，280，5369： | 1 |
| 14 | A foliar spray of rnicronu- trient solutions induces local and systemic protection against powdery mildew in cucumber plants显示文摘 | Moshe R Vladimir A Reuven R | 1997 | Iduropean Journal of Plant Pathology1997，103，： | 1 |
| 15 | 显示文摘 | Tatiana S Yury A Vladimir B | 2010 | Journal of Crystal Growth2010，318，： | 1 |
| 16 | Nicotine increases microdialysate brain amino acid concentrations and induces conditioned place preference 显示文摘 | Vladimir A Kashkin Philippe Dw | 2005 | European Neuropsychopharmacology2005，15，6： | 1 |
| 17 | 查看详情显示文摘 | Vladimir A Krasnopol S | | 0，，： | 1 |
| 18 | Distribution of currents in the lightning protective system of a residential building-part Ⅱ:numerical modeling显示文摘 | LI L VLADIMIR A R | 2008 | IEEE Transactions On Power Delivery2008，23，10： | 1 |
| 19 | Extraction of pure components from overlapped signals in gas chromatography-mass spectrometry (GC-MS) 显示文摘 | Vladimir A Likic | 2009 | Bio Data Mining2009，2，： | 1 |
| 20 | Biogeochemical signatures and microbial activity of different cold-seep habitats along the Gulf of Mexico deep slope显示文摘 | Samantha B J Marshal W B Vladimir A S | 2010 | Deep-Sea Research Ⅱ2010，57，： | 1 |
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