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| 1 | Strengthening population medicine to promote public health显示文摘As we enter.2022,we are facedwith the fact that coronavirus disease2019(CovID-19)has been devastating the world formore than 2full years.Since the original outbreak of COVID-19in December2019,the disease has proved to be a major threat to global health and,perhaps more importantly,one that is not likely to be resolved soon.Severe_acute respiratory syndrome coronavirus. | Chen Wang Simiao Chen Guangliang Shan Zhiwei Leng Till Bärnighausen Weizhong Yang | 2022 | Chinese Medical Journal2022，，10： | 3 |
| 2 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 3 | One hundred and eighteen years of the German health insurance system: are there any lessons for middle- and low-income countries?显示文摘 | Till B?rnighausen Rainer Sauerborn | 2002 | Social Science & Medicine2002，，10： | 2 |
| 4 | Fe (0)-supported autotrophic denitrifica- tion 显示文摘 | Till B A Weathers L J | 1998 | Environmental Science & Technology1998，32，5： | 1 |
| 5 | Functionalization of acetylene-terminated monolay-ers on Si (100) surfaces:A click chemistry approach显示文摘 | Simone Ciampi Till B(o)cking Kristopher A Kilian | 2007 | Langmuir2007，23，18： | 1 |
| 6 | Fe(0)-supported autotrophic denitrification显示文摘 | TILL B A WEATHERS L J ALVAREZ P J J | 1998 | Environmental Science and Technology1998，32，： | 1 |
| 7 | Large-scale discovery of induced point mutations with high-throughout,TILL显示文摘 | Till B J Reynolds S EA | 2003 | Genome Research2003，7，： | 1 |
| 8 | Discovery of nucleotide pol-ymorphisms in the Musa gene pool by Ecotilling 显示文摘 | Till B J Jankowicz - Cieslak J Sagi L Huynh OA Utsushi H Swennen R Terauchi R Mba C | 2010 | Theor Appl Genet2010，121，： | 1 |
| 9 | Mismatch cleavage by single- strand specific nuclease 显示文摘 | Till B J Burtner C Comai L | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 10 | Br and Alliance and Cus-tomer-based Br and-equity Effects显示文摘 | Washburn J H Till B D PRILUCK R | 2004 | Psychology and Market-ing2004，21，7： | 1 |
| 11 | Brand Alliance and Customer-Based Brand Equity Effects 显示文摘 | WASHBURN J H TILL B D PRIUCK R | 2004 | Psychology & Marketing2004，21，7： | 1 |
| 12 | Efficient discovery of DNA polymorphisms in natural populations by Eeotilling显示文摘 | Luca Comai Kim Young Till B J | 2004 | The Plant Journal2004，37，： | 1 |
| 13 | Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells显示文摘 | Parekkadan B Tilles AW Yarmush ML | 2008 | Stem Cells2008，26，7： | 1 |
| 14 | Mismatch cleavage by single-strand specific nucleases显示文摘 | TILL B J BURTNER C COMAI L | 2004 | Nucleic Acids Res2004，32，8： | 1 |
| 15 | Single-nucleotide mutations for plant functional genomics 显示文摘 | Henikoff S Till B J Comai L | 2003 | Annu Rev Plant Biol2003，54，： | 1 |
| 16 | Matching Products with Endorsers:Attractiveness versus Expertise显示文摘 | TILL B D BUSLER M | 1998 | Journal of Consumer Marketing1998，5，6： | 1 |
| 17 | Efficient discovery of DNA polymorphisms in natural populations by Ecotilling显示文摘 | COMAI L YOUNG K TILL B J | 2004 | Plant J2004，37，： | 1 |
| 18 | A protocol for TILLING and Ecotilling in plants and animals显示文摘 | Till B J Troy Zerr Luca Comai et a l | 2006 | Nature Protocols2006，5，： | 1 |
| 19 | Mismatch cleavage by single-strand specific nucleases显示文摘 | Till B J Burner C Comai L | 2004 | Nucl Acids Res2004，32，8： | 1 |
| 20 | Largescale discovery of induced point mutations with high-throughput TILLING 显示文摘 | Till B J Reynolds S H Greene E A etal | 2003 | Genome Res2003，13，： | 1 |
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