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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | The development and evolution of an improved genetic algorithm based on migration on artificial selection 显示文摘 | Pott J C Terri D G Surya B Y | 1994 | IEEE Transcation on SAC1994，，： | 1 |
| 4 | Safety and Efficacy of PanaxGinseng during Pregnancy and Lactation显示文摘 | Seel D Dugoua J Baniel Terri B | 2008 | Can J Clin Pharmacol2008，15，： | 1 |
| 5 | Postoperative irradiation of minor salivary gland malignancies of the head and neck显示文摘 | Le Q T Birdwell S Terris D J | 1999 | Radiother Oncol1999，52，2： | 1 |
| 6 | The efficacy of spinosad againstthe western flower thrips, Frankliniella occidentalis, and its impact on associated biological control agents on greenhouse cucumbers in southern Ontario显示文摘 | Terri J Cynthia S D Ron H | 2005 | Pest Management Science2005，61，： | 1 |
| 7 | Farside Bus Stops are Better显示文摘 | TERRY D S THOMAS G J | 1971 | Traffic Engineering1971，41，3： | 1 |
| 8 | Employee adjustment to an organizational merger:Stress,coping and intergroup differences显示文摘 | Callan V J Sartori G | 1996 | StressMedicine1996，，2： | 1 |
| 9 | Functional indices {or sciatic, peroneal, and posterior tibial nerve lesions in the mouse 显示文摘 | Inserra M M Bloch D A Terris D J | 1998 | Microsurgery1998，18，2： | 1 |
| 10 | Interaction Effects inthe Theory of Planned Behavior:The Interplay of Self-Identityand Past Behavior显示文摘 | Smith J R Terry D J Manstead A S R | 2007 | Journal of Applied Social Psychology2007，37，11： | 1 |
| 11 | Social identity and self-categoriza- tion processes in organizational contex-ts 显示文摘 | Hogg M A Terry D J | 2000 | Academy of Management Review2000，25，： | 1 |
| 12 | The spread of the western flower thrips Frankliniella occidentalis (Pergande)显示文摘 | KRIK W D J TERRY L I | 2003 | Agricultural and Forest Entomology2003，5，： | 1 |
| 13 | The Development and Evolution of an Unproved Genetic Algorithm Based on Migration and Artificial Selection显示文摘 | POTTS J C TERRI D G SURYA B Y | 1994 | IEEE Transactions on SMC1994，24，1： | 1 |
| 14 | Social identity and self-categorization processes in organizational contexts显示文摘 | Hogg M A and Terry D J | 2000 | Academy of Management Review2000，25，1： | 1 |
| 15 | Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer risk显示文摘 | SHEN J GAMMON M D TERRY M B | 2005 | Cancer Epidemiol Biornarkers Prey2005，14，2： | 1 |
| 16 | MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk显示文摘 | SHEN J TERRY M B GAMMON M D | 2005 | Carcinogenesis2005，26，12： | 1 |
| 17 | Safer Sex Behavior: The Role of Attitudes, Norms, and Control Factors 显示文摘 | White K M Terry D J Hogg M A | 1994 | Journal of Applied Social Psychology1994，24，24： | 1 |
| 18 | Plasmid-encoded Tet B tetracycline resistance in Haemophilus parasuis 显示文摘 | Lancashire J F Terry T D Blackall P J | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 19 | Characterization of postoperative edema following laser-assisted uvulopalatopharyngoplasty using MRI and polysomnography:implications for the outpatient of obstructive sleep apnea syndrome显示文摘 | Terris D J Clerk A A Norbash A M | 1996 | Laryngescope1996，106，： | 1 |
| 20 | Near-field optical data storage using a solid immersion lens 显示文摘 | Terris B D Mamin H J Ruger D | 1994 | Appl Phys Lett1994，65，4： | 1 |
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