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| 1 | An efficient range-free localization algorithm for wireless sensor networks显示文摘Node positioning is a fundamental problem in applications of wireless sensor networks (WSNs). In this paper, a new range-free algorithm, called spring swarm localization algorithm (SSLA), is proposed for positioning WSNs. To determine the locations of sensor nodes, the proposed algorithm uses network topology information and a small fraction of sensor nodes which know their locations. Numerical simulations show that high positioning accuracy can be obtained by using the algorithm. Some examples are given to illustrate the effectiveness of the algorithm. | HE QinBin CHEN FangYue CAI ShuiMing HAO JunJun LIU ZengRong | 2011 | Science China(Technological Sciences)2011，54，5： | 13 |
| 2 | Genome-wide characterization and analysis of b HLH transcription factors in Panax ginseng显示文摘Ginseng(Panax ginseng C.A. Meyer) is one of the best-selling herbal medicines, with ginsenosides as its main pharmacologically active constituents. Although extensive chemical and pharmaceutical studies of these compounds have been performed, genome-wide studies of the basic helix-loop-helix(b HLH) transcription factors of ginseng are still limited. The b HLH transcription factor family is one of the largest transcription factor families found in eukaryotic organisms, and these proteins are involved in a myriad of regulatory processes. In our study, 169 bHLH transcription factor genes were identified in the genome of P. ginseng, and phylogenetic analysis indicated that these PGb HLHs could be classified into 24 subfamilies. A total of 21 RNA-seq data sets, including two sequencing libraries for jasmonate(JA)-responsive and 19 reported libraries for organ-specific expression analyses were constructed. Through a combination of gene-specific expression patterns and chemical contents,6 PGbHLH genes from 4 subfamilies were revealed to be potentially involved in the regulation of ginsenoside biosynthesis. These 6 PGbHLHs, which had distinct target genes, were further divided into two groups depending on the absence of MYC-N structure. Our results would provide a foundation for understanding the molecular basis and regulatory mechanisms of bHLH transcription factor action in P.ginseng. | Yang Chu Shuiming Xiao He Su Baosheng Liao Jingjing Zhang Jiang Xu Shilin Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 13 |
| 3 | Global Pharmacopoeia Genome Database is an integrated and mineable genomic database for traditional medicines derived from eight international pharmacopoeias显示文摘Genomic data have demonstrated considerable traction in accelerating contemporary studies in traditional medicine. However,the lack of a uniform format and dispersed storage limits the full potential of herb genomic data. In this study, we developed a Global Pharmacopoeia Genome Database(GPGD). The database contains 34,346 records for 903 herb species from eight global pharmacopoeias(Brazilian, Egyptian, European, Indian, Japanese, Korean, the Pharmacopoeia of the People’s Republic of China, and U.S. Pharmacopoeia’s Herbal Medicines Compendium). In particular, the GPGD contains 21,872 DNA barcodes from 867 species, 2,203 organelle genomes from 674 species, 55 whole genomes from 49 species, 534 genomic sequencing datasets from 366 species, and 9,682 transcriptome datasets from 350 species. Among the organelle genomes, 534 genomes from 366 species were newly generated in this study. Whole genomes, organelle genomes, genomic fragments, transcriptomes, and DNA barcodes were uniformly formatted and arranged by species. The GPGD is publicly accessible at http://gffzzf938e9d610ce4c4ahvqoxq9cw5kcf6wcf.ffgz.tsg.suse.edu.cn and serves as an essential resource for species identification, decomposition of biosynthetic pathways, and molecular-assisted breeding analysis. Thus, the database is an invaluable resource for future studies on herbal medicine safety, drug discovery, and the protection and rational use of herbal resources. | Baosheng Liao Haoyu Hu Shuiming Xiao Guanru Zhou Wei Sun Yang Chu Xiangxiao Meng Jianhe Wei Han Zhang Jiang Xu Shilin Chen | 2022 | Science China(Life Sciences)2022，65，4： | 11 |
| 4 | Requirement of ultra-high voltage GIS arrester to voltage gradient of metal-oxide varistor显示文摘The surge arrester with excellent protection characteristics would decrease the overvoltage level ap- plied on the power apparatus to reduce their insulation levels and manufacturing bottleneck. The arrester for the 1000-kV ultra-high voltage ac power transmission system is designed as tank-type structure. The field-circuit combination numerical method combining the three-dimensional finite element method with circuit is proposed to analyze the potential distribution of GIS arrester. By comparing several design schemes, the most effective method to improve the potential distribution along the varistor column is to increase the voltage gradient of the ZnO varistor. Synthesizing several influential factors, the suitable voltage gradient of ZnO varistor should be controlled to 435 V/mm, and the resulted nonuniform degree of the potential distribution along the varistor column inside the GIS arrester would be controlled smaller than 10%. The result in this paper provides the fundamental technical index for the study of the high voltage gradient ZnO varistors. | HE JinLiang HU Jun MENG BoWen ZHANG Bo ZHU Bin CHEN ShuiMing ZENG Rong | 2009 | Science China(Technological Sciences)2009，52，2： | 10 |
| 5 | A Comparative Analysis of the Chloroplast Genomes of Four Salvia Medicinal Plants显示文摘Herbgenomics is an emerging field of traditional Chinese medicine(TCM)research and development.By combining TCM research with genomics,herbgenomics can help to establish the scientific validity of TCM and bring it into wider usage within the field of medicine.Salvia Linn.(S.Linn.)is a large genus of Labiatae that includes important medicinal plants.In this herbgenomics study,the complete chloroplast(cp)genomes of two Salvia spp.—namely,S.przewalskii and S.bulleyana,which are used as a surrogate for S.miltiorrhiza—were sequenced and compared with those of two other reported Salvia spp.—namely,S.miltiorrhiza and S.japonica.The genome organization,gene number,type,and repeat sequences were compared.The annotation results showed that both Salvia plants contain 114 unique genes,including 80 protein-coding,30 transfer RNA(tRNA),and four ribosomal RNA(rRNA)genes.Repeat sequence analysis revealed 21 forward and 22 palindromic sequences in both Salvia cp genomes,and 17 and 21 tandem repeats in S.przewalskii and S.bulleyana,respectively.A synteny comparison of the Salvia spp.cp genomes showed a high degree of sequence similarity in the coding regions and a relatively high divergence of the intergenic spacers.Pairwise alignment and single-nucleotide polymorphism(SNP)analyses found some candidate fragments to identify Salvia spp.,such as the intergenic region of the trnV–ndhC,trnQ–rps16,atpI–atpH,psbA–ycf3,ycf1,rpoC2,ndhF,matK,rpoB,rpoA,and accD genes.All of the results—including the repeat sequences and SNP sites,the inverted repeat(IR)region border,and the phylogenetic analysis—showed that S.przewalskii and S.bulleyana are extremely similar from a genetic standpoint.The cp genome sequences of the two Salvia spp.reported here will pave the way for breeding,species identification,phylogenetic evolution,and cp genetic engineering studies of Salvia medicinal plants. | Conglian Liang Lei Wang Juan Lei Baozhong Duan Weisi Ma Shuiming Xiao Haijun Qi Zhen Wang Yaoqi Liu Xiaofeng Shen Shuai Guo Haoyu Hu Jiang Xu Shilin Chen | 2019 | Engineering2019，5，5： | 5 |
| 6 | Electrical parameter statistic analysis and parallel coordination of ZnO varis tors in low-voltage protection devices显示文摘 | He Jinliang Chen Shuiming Zeng Rong | 2005 | IEEE Transactions on Power Delivery2005，20，1： | 1 |
| 7 | C-X3-C motif chemokine ligand 1/receptor 1 regulates the M1 polarization and chemotaxis of macrophages after hypoxia/reoxygenation injury显示文摘Background:Macrophages play an important role in renal ischemia reperfusion injury,but the functional changes of macrophages under hypoxia/reoxygenation and the related mechanism are unclear and need to be further clarified.Methods:The effects of hypoxia/reoxygenation on functional characteristics of RAW264.7 macrophages were analyzed through the protein expression detection of pro-inflammatory factors TNF-αand CD80,anti-inflammatory factors ARG-1 and CD206.The functional implications of C-X3-C motif chemokine receptor 1(CX3CR1)down-regulation in hypoxic macrophages were explored using small interfering RNA technology.Significance was assessed by the parametrict-test or nonparametric Mann-Whitney test for two group comparisons,and a one-way ANOVA or the Kruskal-Wallis test for multiple group comparisons.Results:Hypoxia/reoxygenation significantly increased the protein expression of M1-related pro-inflammatory factors TNF-α,CD80 and chemokine C-X3-C motif chemokine ligand 1(CX3CL1)/CX3CR1 and inhibited the protein expression of M2-related anti-inflammatory factors ARG-1 and CD206 in a time-dependent manner in RAW264.7 cells.However,the silencing of CX3CR1 in RAW264.7 cells using specific CX3CR1-siRNA,significantly attenuated the increase in protein expression of TNF-α(P<0.05)and CD80(P<0.01)and the inhibition of ARG-1(P<0.01)and CD206(P<0.01)induced by hypoxia/reoxygenation.In addition,we also found that hypoxia/reoxygenation could significantly enhance the migration(2.2-fold,P<0.01)and adhesion capacity(1.5-fold,P<0.01)of RAW264.7 macrophages compared with the control group,and CX3CR1-siRNA had an inhibitory role(40%and 20%reduction,respectively).For elucidating the mechanism,we showed that the phosphorylation levels of ERK(P<0.01)and the p65 subunit of NF-κB(P<0.01)of the RAW264.7 cells in the hypoxic/reoxygenation group were significantly increased,which could be attenuated by down-regulation of CX3CR1 expression(P<0.01,both).ERK inhibitors also significantly blocked the effects of hypoxic/reoxygenation on the protein expression of M1-related pro-inflammatory factors TNF-α,CD80 and M2-related anti-inflammatory factors ARG-1 and CD206.Moreover,we found that conditioned medium from polarized M1 macrophages induced by hypoxia/reoxygenation,notably increased the degree of apoptosis of hypoxia/reoxygenation-induced TCMK-1 cells,and promoted the protein expression of pro-apoptotic proteins bax(P<0.01)and cleaved-caspase 3(P<0.01)and inhibited the expression of anti-apoptotic protein bcl-2(P<0.01),but silencing CX3CR1 in macrophages had a protective role.Finally,we also found that the secretion of soluble CX3CL1 in RAW264.7 macrophages under hypoxia/reoxygenation was significantly increased.Conclusions:The findings suggest that hypoxia/reoxygenation could promote M1 polarization,cell migration,and adhesion of macrophages,and that polarized macrophages induce further apoptosis of hypoxic renal tubular epithelial cells by regulating of CX3CL1/CX3CR1 signaling pathway. | Shuiming Guo Lei Dong Junhua Li Yuetao Chen Ying Yao Rui Zeng Nelli Shushakova Hermann Haller Gang Xu Song Rong | 2021 | Chronic Diseases and Translational Medicine2021，7，4： | 1 |
| 8 | Electrical parameter statistic analysis and parallel coordination of ZnO varistors in low-voltage protection devices显示文摘 | Jinliang He Shuiming Chen Rong Zeng | 2005 | IEEE Transactions on Power Delivery2005，20，1： | 1 |
| 9 | Bioremediation of highly contaminated oilfield soil: Bioaugmentation for enhancing aromatic compounds removal显示文摘 | Jun QIAO Chengdong ZHANG Shuiming LUO Wei CHEN | 2014 | Frontiers of Environmental Science & Engineering2014，8，2： | 1 |
| 10 | Discussion on measures against lightning breakage of covered conductors on distribution lines显示文摘 | He Jinliang Gu Shanqiang Chen Shuiming | 2008 | IEEE Transactions on Power Delivery2008，23，2： | 1 |
| 11 | Thermal char- acteristics of high voltage whole-solid-insulated polymeric ZnO surge arrester显示文摘 | Jinliang He Rong Zeng Shuiming Chen | 2003 | IEEE Transactions on Power Delivery2003，18，4： | 1 |
| 12 | Evalua- tion of Transmit Antenna Position in Reverberation Gham- ber显示文摘 | Yuan Zhiyong He Jinliang Chen Shuiming | 2007 | IEEE Transactions on Electromagnetic Compati- bility2007，49，1： | 1 |
| 13 | Potential distribution analysis of suspended-type metal-oxide surge arresters显示文摘 | He Jinliang Zeng Rong Chen Shuiming | 2003 | IEEE Trans on Power Delivery2003，18，4： | 1 |
| 14 | Potential distribution analysis of suspended-type metal-oxide surge arresters显示文摘 | He Jinliang Zeng Rong Chen Shuiming | 2003 | IEEE Transactions on Power Delivery2003，18，4： | 1 |
| 15 | Interannual Variability of the North Pacific Subtropical Countercurrent and Its Associated Mesoscale Eddy Field显示文摘 | Qiu Bo Chen Shuiming | 2010 | Journal of Physical Oceanography2010，，1： | 1 |
| 16 | Laboratory investigation of impulse characteristics of transmission tower grounding devices 显示文摘 | He Jinliang Zeng Rong Chen Shuiming | 2003 | IEEE Transactions on Power Delivery2003，18，3： | 1 |
| 17 | Influence of grain size on distribution of temperature and thermal stress in ZnO varistor ceramics显示文摘 | Qingheng Chen Jinliang He Kexiong Tan Shuiming Chen Minyu Yan Jianxin Tang | 2002 | Science in China Series E: Technolgical Science2002，，4： | 1 |
| 18 | Potential distribution analysis of suspended-type metaloxide surge attesters显示文摘 | He Jinliang Zeng Rong Chen Shuiming | 2003 | IEEE Trans on Power Delivery2003，18，4： | 1 |
| 19 | Experimental and Numerical Evaluation of Surge Current Distribution in Building during a Direct Lightning Stroke显示文摘 | DU Yaping CHEN Shuiming BURNETT J | 2001 | HKIE Transaction2001，8，1： | 1 |
| 20 | Influence of flavone extract from cultivated saussurea on learning and memory in a mouse model of Alzheimer's disease A comparison with estradiol benzoate显示文摘The present study established a mouse model of Alzheimer's disease,and investigated the effects of treatment with flavone extract from artificially cultivated saussurea.A positive control group was treated with estradiol benzoate,and learning and memory ability were examined in the 8-arm radial maze.The learning and recognition ability of mice with Alzheimer's disease treated with flavone extract was significantly improved and the number of hippocampal neurons was significantly increased in the flavone-treated and positive control groups compared with the model group.The results indicate that flavone extract from artificially cultivated saussurea can improve learning and memory deficits in mice with Alzheimer's disease,exerting effects similar to those of estradiol benzoate. | Weiqiang Chen Shuiming Gong Yan Li Ming Li Zemin Yang Lirong Zhanf | 2011 | Neural Regeneration Research2011，6，30： | 1 |
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