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| 1 | Design of TRIP Steel With High Welding and Galvanizing Performance in Light of Thermodynamics and Kinetics显示文摘A new type of transformation induced plasticity (TRIP) steel with not only high strength and high ductility but also superior welding and galvanizing properties was designed and developed recently. Low carbon and low silicon content were preliminarily selected with the aim of meeting the requirements of superior quality in both welding and galvanizing. Phosphorus was chosen as one of the alloying elements, because it could reduce carbon activity in cementite and increase the stability of austenite. In addition, the possibility of phosphorus segregating at grain boundary was also discussed by thermodynamics as well as kinetics. Phase diagram was estimated at high temperature and the composition of the steel was then selected in the hyperperitectic range to avoid problems, which might occur in sheet steel continuous casting. Phase diagram in the inter-critical temperature was estimated for the steel to obtain the starting temperature of fast cooling. For understanding the minimum rate of fast cooling, pearlite growth kinetics was calculated with self-developed diffusion coefficients of elements in grain boundary. Overaging temperature was determined through the calculation of T0 temperature by both equilibrium and para-equilibrium assumptions, which was different from the current determination, which is only based on an equilibrium estimation. | LI Lin DE COOMAN B C LIU Ren-dong VLEUGELS j ZHANG Mei SHI Wen | 2007 | Journal of Iron and Steel Research(International)2007，14，6： | 13 |
| 2 | 标准辅助化疗基础上增加塞来昔布或安慰剂对Ⅲ期结肠癌患者无复发生存的疗效对比研究:CALGB/SWOG 80702(Alliance)随机对照研究显示文摘背景:既往观察性和随机对照研究已表明阿司匹林和环氧化酶-2(COX-2)抑制剂可降低肠道息肉和肠癌的发生风险。COX-2抑制剂塞来昔布治疗非转移性结肠癌的效果尚未明确。目的:本研究旨在明确FOLFOX辅助化疗基础上增加塞来昔布是否能提高Ⅲ期结肠癌患者的无复发生存率。方法:本研究为在美国、加拿大的654个中心开展的采用2×2析因设计的Ⅲ期临床研究,从2010年6月至2015年11月共纳入2526例Ⅲ期结肠癌患者,随访时间截止为2020年8月10日。以化疗时长和是否接受塞来昔布治疗作为2个随机因素,入组患者被随机分配接受3个月或6个月的FOLFOX辅助化疗(每两周1次)及随机接受联合3年塞来昔布(400 mg QD,n=1263)或安慰剂(n=1261)治疗。主要终点测量指标为3年无复发生存率(DFS),次要终点测量指标包括总生存、不良反应及心血管特异性不良事件。本次仅报道以是否接受塞来昔布治疗的随机分组研究结果。结果:入组患者平均年龄(61±11)岁,1134例(44.9%)为女性,最终2524例被纳入初步分析。患者治疗方案依从性(即接受塞来昔布或安慰剂治疗2.75年以上或持续治疗至复发、死亡或不可接受的不良事件)在塞来昔布组和安慰剂组分别为70.8%和69.9%。经过6年中位随访期,塞来昔布组和安慰剂组各有337例和363例患者出现疾病复发或死亡,3年无复发生率分别为76.3%和73.4%(疾病复发或死亡风险比HR=0.89,95%CI:0.76~1.03,P=0.12)。塞来昔布治疗对DFS的影响不会因辅助化疗时长(3个月或6个月)而存在差异(交互作用P=0.61)。两组5年生存率分别为84.3%和81.6%(死亡风险比HR=0.86,95%CI:0.72~1.04,P=0.13)。任何级别的高血压病发生率在塞来昔布组和安慰剂组分别为14.6%和10.9%,而2级或以上肌酐水平升高的发生率在两组分别为1.7%和0.5%。结论:对于Ⅲ期结肠癌患者,在标准辅助化疗的基础上联合3年塞来昔布治疗与安慰剂比较,对患者无复发生存率的改善不明显。 | 邱萌 MEYERHARDT J A SHI Q FUCHS C S | 2021 | 结直肠肛门外科2021，27，3： | 6 |
| 3 | 塞内加尔病毒特异性重组分析揭示了塞尼卡病毒聚合酶保真性与病毒重组发生的相关性显示文摘塞尼卡病毒(SVA)是一种新出现的感染猪并可导致仔猪死亡的病毒。最近的研究显示,SVA在猪体内可发生重组,表明了重组在SVA进化过程中的重要性。越来越多的研究表明,病毒聚合酶保真性的改变能显著降低病毒的毒力,而且病毒聚合酶也是影响病毒重组的主要因素。因此,通过提高病毒聚合酶的保真性获得重组缺陷病毒株、不但具有重要的理论价值,作为可使减毒株更加安全的技术手段、也具有疫苗开发的应用价值。由于微RNA病毒科的病毒均具有高度的变异性和复杂性,通过提升病毒聚合酶的保真性、结合其它减毒策略,可获得足够安全和有效的减毒活疫苗候选毒株。 | Li C Wang H Shi J | 2019 | 中国预防兽医学报2019，41，5： | 5 |
| 4 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 5 | Detection of streptomycin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by denaturing HPLC analysis and DNA sequencing显示文摘 | Shi R Zhang J Li C | 2007 | Microbes Infect2007，9，1415： | 1 |
| 6 | Speciation of heavy metals in marine sediments from the East China Sea by ICP-MS with sequential extraction显示文摘 | Yuan C G Shi J B He B | 2004 | Environment International2004，30，： | 1 |
| 7 | Preparation and characterization of PbO2 electrodes doped with different rare earth oxides 显示文摘 | Kong J T Shi S Y Kong L C | 2007 | Electrochim Acta2007，53，： | 1 |
| 8 | ATP-induced changes in energy status and membrane integrity of harvested litchi fruit and its relation to pathogen resistance 显示文摘 | YI C QU H X JIANG Y M SHI J DUAN X W JOYCE D C LI Y B | 2008 | Journal of Phytopathology2008，156，： | 1 |
| 9 | Inhibitory effect of CD147/HAb18 mono- clonal antibody on cartilage erosion and synovitis in the SCID mouse model for rheumatoid arthritis显示文摘 | Jia J Wang C Shi Z | 2009 | Rheumatology ( Oxford)2009，48，7： | 1 |
| 10 | Prevalence,treatment,and associated disability of Mental Disorders in four provinces in China during 2001-05:an epidemiological survey显示文摘 | Phillips MR Zhang J Shi C | 2009 | Lancet2009，373，9680： | 1 |
| 11 | C64 H4 : production, i-solation,and structural characterizations of a stable unconventional fulleride显示文摘 | Wang C R Shi Z Q Wan L J | 2006 | J Am Chem Soc2006，128，20： | 1 |
| 12 | Energy efficient clustering al- gorithm for maximizing lifetime of wireless sensor networks 显示文摘 | Xiang M Shi W R Jiang C J | 2010 | In- ternational Journal of Electronicsand Communications2010，64，5： | 1 |
| 13 | Targeted proton delivery in the catalyzed reduction of oxygen to water by bimetallic pacman porphyrins显示文摘 | Chang C J Loh Z-H Shi C | 2004 | Journal of the American Chemical Society2004，126，10： | 1 |
| 14 | Analysis of seed and maternal genetic effects for nutritive quality traits of grain in indica rice显示文摘 | Shi C H Zhu J | 1995 | Chinese J of Genet1995，20，3： | 1 |
| 15 | miR-181b as a key regulator of the oncogenic process and its clinical implications in cancer 显示文摘 | Liu J Shi W Wu C | 2014 | BiomedRep2014，2，1： | 1 |
| 16 | Detection of streptomycin resistance in Mycobacterium tuberculosis clinical isolates from China as deter- mined by denaturing HPLC analysis and DNA sequencing显示文摘 | Shi R Zhang J Li C | 2007 | Mi- crobes Infect2007，9，14： | 1 |
| 17 | Enhancement in early strengths of slag-cement mortars by adjusting basieity of the slag prepared from fly-ash of MSWI显示文摘 | LEE T C WANG W J SHI P Y | 2009 | Cement and Concrete Research2009，39，8： | 1 |
| 18 | Construction of Low- carbon Tourist Attractions Based on Low- carbon Economy显示文摘 | SHI C PENG J J | 2011 | Energy Procedia2011，，5： | 1 |
| 19 | Threedimensional centrifuge modelling of basement excavation effects on an existing tunnel in dry sand 显示文摘 | NG C W W SHI J W HONG Y | 2013 | Canadian Geotechnical Journal2013，50，8： | 1 |
| 20 | Quantum key distribution over 122km standard telecom fiber 显示文摘 | GOBBY C YUAN Z L SHIEDS A J | 2004 | Appl Phys Lett2004，84，19： | 1 |
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