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| 1 | Estimation of carbon sinks in chemical weathering in a humid subtropical mountainous basin显示文摘The fluvial geochemistry of the mainstream and tributaries of the Zengjiang River was investigated,and the mass balance approach and deduction methods were used to estimate the uptake of atmospheric CO2 through rock chemical weathering.The results showed that the chemical runoff mainly consisted of HCO3-,Ca2+,Na+,and dissolved Si,and that silicate mineral weathering was significant,but carbonate mineral weathering was a minor source of dissolved loads in the Zengjiang River basin because of the low amount of interlayered carbonate rock strata in the catchment.The ion composition indicated that atmospheric CO2 was the primary erosive agent for rock chemical weathering in the Zengjiang River basin.The CO2 consumption fluxes caused by rock chemical weathering were(3.50-3.81) × 105 mol km-2 a-1,which is just lower than that in tropical and subtropical basalt and carbonate regions,and is much higher than that in temperate and cold-temperate regions,indicating that surficial chemical weathering processes in the humid and hot monsoon current influencing the low-middle latitude zone of the Northern Hemisphere constitutes a significant carbon sink in the global biogeochemical cycle. | TAO Zhen GAO QuanZhou WANG ZhenGang ZHANG ShengHua XIE ChenJi LIN PeiSong RUAN XiaoBing LI ShuHong MAO HaiRuo | 2011 | Chinese Science Bulletin2011，56，35： | 15 |
| 2 | Antitumor effects of an engineered and energized fusion protein consisting of an anti-CD20 scFv fragment and lidamycin显示文摘Antibody-based fusion proteins are the next generation of antibody therapies for cancer and other diseases.CD20 antigen,which is overexpressed on cell membranes in nearly 95% of cases of B-cell Non-Hodgkin's Lymphoma,is an attractive target for the therapy of B-lymphoid malignancies.Lidamycin (LDM) is a potent enediyne-containing antitumor antibiotic that now has entered phase II clinical trials.In this study,we prepared an engineered fusion protein,scFv-LDP,consisting of an anti-CD20 scFv fragment and the apoprotein LDP of LDM using DNA recombination.After purification and refolding,scFv-LDP was found to bind specifically to CD20-positive lymphoma cells using ELISA and indirect immunofluorescent cytochemical staining assays.The energized fusion protein scFv-LDP-AE was obtained using molecular reconstitution of the active chromophore AE of LDM and scFv-LDP.MTT assay revealed potent cytotoxicity of scFv-LDP-AE to CD20-positive Raji and Daudi cells,with IC 50 values of 1.21×10-11 and 6.24×10-11 mol L-1,respectively.An in vivo subcutaneous xenograft model of CD20-positive B cell lymphoma in BALB/c (nu/nu) mice was also utilized.Drugs were given intravenously on day 14 and 21 after tumor transplantation.In terms of maximal tolerated doses,scFv-LDP-AE at 0.3 mg kg-1 suppressed tumor growth by 79.3%,and LDM at 0.05 mg kg-1 by 68.6% (P<0.05).Results suggested scFv-LDP-AE could be a potential candidate for tumor-targeting therapy. | FANG Hong MIAO QingFang ZHANG ShengHua CHENG Xin XIONG DongSheng ZHEN YongSu | 2011 | Science China(Life Sciences)2011，54，3： | 6 |
| 3 | Effect of interaction between different CeO_(2)plane and platinum nanoparticles on catalytic activity of Pt/CeO_(2)in toluene oxidation显示文摘The plane exposure of support vitally affects the catalytic performance of the catalyst.In this work,CeO_(2)nanorods((110)plane exposure),nano-octahedrons((111)plane exposure)and nano-cubes((100)plane exposure)were prepared as the supports of Pt/CeO_(2)samples to investigate the effect of CeO_(2)plane exposure on total toluene oxidation.Characterizations reveal that the(110)plane of CeO_(2)is more helpful to the dispersion of Pt species,followed by(111)face.The improved dispersion of Pt species can enhance the metal-supports interaction,which promotes the electron transfer of CeO_(2)carrier to Pt nanoparticles and the adsorption-activation of O_(2),thereby facilitating the total oxidation of toluene via the Langmuir-Hinshelwood(L-H)mechanism.Therefore,Pt/CeO_(2)-r(nanorods)sample expresses excellent catalytic performance of toluene oxidation.Finally,the procedure of toluene total oxidation was studied by in-situ diffuse reflectance infrared Fourier transform(DRIFT)spectroscopy.We expect that this work can contribute to the development of an effective sample for the decomposition of volatile organic compounds(VOCs). | Shengsheng Chang Yong jia Yiqing Zeng Fuping Qian Lina Guo Shenghua Wu Jinli Lu Yunlong Han | 2022 | Journal of Rare Earths2022，40，11： | 6 |
| 4 | Surface Acidity/Basicity and Catalytic Reactivity of CeO2/7-Al2O3 Catalysts for the Oxidative Dehydrogenation of Ethane with Carbon Dioxide to Ethylene显示文摘Dehydrogenation of ethane to ethylene in CO2 was investigated over CeO2/γ-Al2O3 catalysts at 700℃ in a conventional flow reactor operating at atmospheric pressure. XRD, BET and microcalorimetric adsorption techniques were used to characterize the structure and surface acidity/basicity of the CeO2/γ-Al2O3 catalysts. The results show that the surface acidity decreased while the surface basicity increased after the addition of CeO2 to γ-Al2O3. Accordingly, the activity of the hydrogenation reaction of CO2 increased, which might be responsible for the enhanced conversion in the dehydrogenation of ethane to ethylene. The highest ethane conversion obtained was about 15% for the 25%CeO2/γ-Al2O3. The selectivity to ethylene was high for all the CeO2, γ-Al2O3 and CeO2/γ-Al2O3 catalysts. | Xin Ge, Shenghua Hu, Qing Sun. Jianyi ShenSchool of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China | 2003 | Journal of Natural Gas Chemistry2003，12，2： | 6 |
| 5 | Investigation of tribological performances of MCMB显示文摘Tribological properties of Meso-carbon Microbeads (MCMB) powders as a special addi-tive in pentaerythritol were investigated on an Optimal SRV tribotester at 300℃. The coarsely dis-persed lubricant system demonstrates fine lubricious effectiveness at the operation temperature.The friction coefficient dropped from 0.2 to circa 0.12 in the presence of MCMB in pentaerythritolfor the No.45 carbon steel tribomate. Raman spectroscopy analysis indicated the partial transfor-mation of MCMB into increased ordered structures that contributed to the lowering of friction. | CUI Xiaohao LI Shenghua SONG Huaihe JIN Yuansheng FU Honglan 1. National Tribology Laboratory, Tsinghua University, Beijing 100084, China 2. Institute of Carbon Fibers & Composites, Beijing University of Chemical Technology, Beijing 100029, China 3. Department of Biology, Peking University, Beijing 100871, China | 2001 | Science China Mathematics2001，44，S1： | 6 |
| 6 | Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors显示文摘Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective. | Shenghua Gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian Zhang Peng Zhan Xinyong Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 5 |
| 7 | Verticality Detection Algorithm Based on Local Image Sharpness Criterion显示文摘In the high precision image measurement system,the verticality error between the axis of the shooting system and the measured object can bring error of the measurement result.The high demand of the system’s vertical degree is raised by measure system due to the demands of high precision and disposable full field imaging in the micro-parts imaging measurement.The existing method of optical axis verticality detection cannot meet the demand all.In order to achieve the high-precision adjustment of the system optical axis,the algorithm of detecting verticality based on regional image definition is proposed.First,the objected standard image is divided into fixed area.Then,the object plane is moved from the downside to the upside of the focus plane,meanwhile,recording the definition function values of each standard image region at each step,and fitting out the clearest positions of the regions.Finally,according to the inter-regional relations between the locations and the height difference of the each regional clearest position,the small angle between the optical axis and the measured surface can be calculated.The experiment is based on the given image of lithography template with the scale of 10 μm as move unit,and the results show that this method effective reduced the small angle between the system optical axis and the measured body in high-precision image measuring system,the evaluation accuracy is less than 0.1°,meeting the requirements in high-precision measurement.The proposed method of detecting verticality based on regional image definition can evaluate the verticality error between the axis of the shooting system and the measured object accurately,effectively and conveniently. | ZHANG Jin WANG Zhong YE Shenghua YANG Chun LI Lin | 2012 | Chinese Journal of Mechanical Engineering2012，25，1： | 5 |
| 8 | The Strategy of Application Integration in Implementing PDM显示文摘Combining with real project three levels of application integration in implementing PDM are introduced in this paper. Based on the research on the integration ability between major PDM systems and CAD systems, this paper discusses the strategy of realizing the application integration in three levels. | Feng Shenghua Li Jianming Tong Bingshu (Precision Instrument Department Tsinghua Univ., Beijing. 100084) | 1998 | Computer Aided Drafting,Design and Manufacturing1998，8，2： | 4 |
| 9 | Target detection for low angle radar based on multi-frequency order-statistics显示文摘For radar targets flying at low altitude, multiple pathways produce fade or enhancement relative to the level that would be expected in a free-space environment. In this paper, a new detection method based on a wide-ranging multi-frequency radar for low angle targets is proposed. Sequential transmitting multiple pulses with different frequencies are first applied to decorrelate the coherence of the direct and reflected echoes. After receiving all echoes,the multi-frequency samples are arranged in a sort descending according to the amplitude. Some high amplitude echoes in the same range cell are accumulated to improve the signal-to-noise ratio and the optimal number of high amplitude echoes is analyzed and given by experiments. Finally, simulation results are presented to verify the effectiveness of the method. | Yunhe Cao Shenghua Wang Yu Wang Shenghua Zhou | 2015 | Journal of Systems Engineering and Electronics2015，26，2： | 4 |
| 10 | Molecular Weight Controllable Degradation of Laminaria japonica Polysaccharides and Its Antioxidant Properties显示文摘In this study, molecular weight controllable degradation of algal Laminaria japonica polysaccharides(LPS) was investigated by ultrasound combined with hydrogen peroxide. Three main factors, i.e., ultrasonic power(A), ultrasonic time(B), and H_2O_2 concentration(C) were chosen for optimizing parameters by employing three-factors, three-levels BBD. The influence of degradation on structure change and antioxidant activities was also investigated. A second-order polynomial equation including molecular weight(Y) of Laminaria japonica polysaccharides and each variable parameter, i.e., ultrasonic power(A), ultrasonic time(B), and H_2O_2 concentration(C), was established: Y=20718.67-4273.13A-4000.38B-1438.75C+2333.25AB+1511.00AC+873.00BC+2838.29A^2 + 2490.79B^2+873.04C^2. The equation regression coefficient value(R^2 = 0.969) indicated that this equation was valid. The value of the adjusted determination coefficient(adjusted R^2 = 0.914) also confirmed that the model was highly significant. The results of selected experimental degradation conditions matched with the predicted value. FT-IR spectra revealed that the structures of LPS before and after degradation were not significantly changed. Antioxidant activities of LPS revealed that low Mws possessed stronger inhibitory than the original polysaccharides. The scavenging effects on superoxide radicals was the highest when IC50 of crude LPS was 4.92 mg mL^(-1) and IC50 of Mw 18.576 KDa was 1.02 mg mL^(-1), which was fourfold higher than initial polysaccharide. | ZHA Shenghua ZHAO Qingsheng ZHAO Bing OUYANG Jie MO Jianling CHEN Jinjin CAO Lili ZHANG Hong | 2016 | Journal of Ocean University of China2016，15，4： | 4 |
| 11 | Performance Prediction of Switched Reluctance Motor using Improved Generalized Regression Neural Networks for Design Optimization显示文摘Since practical mathematical model for the design optimization of switched reluctance motor(SRM)is difficult to derive because of the strong nonlinearity,precise prediction of electromagnetic characteristics is of great importance during the optimization procedure.In this paper,an improved generalized regression neural network(GRNN)optimized by fruit fly optimization algorithm(FOA)is proposed for the modeling of SRM that represent the relationship of torque ripple and efficiency with the optimization variables,stator pole arc,rotor pole arc and rotor yoke height.Finite element parametric analysis technology is used to obtain the sample data for GRNN training and verification.Comprehensive comparisons and analysis among back propagation neural network(BPNN),radial basis function neural network(RBFNN),extreme learning machine(ELM)and GRNN is made to test the effectiveness and superiority of FOA-GRNN. | Zhu Zhang Shenghua Rao Xiaoping Zhang | 2018 | CES Transactions on Electrical Machines and Systems2018，2，4： | 4 |
| 12 | Transformation of plant young proembryos by electroporation显示文摘It is first reported that plant young proembryos expressed exogenous reporter genes by electroporation. Young proembryos with 8-32 cells and globular proembryos with 250-400 cells could be isolated by enzymatic maceration combined with microdissection. After electroporation with GUS or GFP genes, the proembryos were cultured for 1 -2 d in KM8p medium. At the field strength of electroporation 500-1 500 V/cm, blue reaction of GUS or green fluorescence of GFP could be observed in the proembryos. The highest transient expression frequency of young proembryos (2.2%) was obtained at the field strength of 750 V/cm, whereas the highest frequency of globular proembryos (5.9%) was obtained at the field strength of 1 250 V/cm. Taking the proportion of transformed cells in the whole cells of proembryos as efficient transformation frequency, the efficient transformation frequency of the young proembryos was 7 times that of the globular proembryos. | Shitao Li Shenghua Wang Hongyuan Yang | 2000 | Chinese Science Bulletin2000，45，13： | 4 |
| 13 | Low‐dimensional material supported single‐atom catalysts for electrochemical CO_(2) reduction显示文摘Converting CO_(2) emissions to valuable carbonaceous chemicals/fuels under mild conditions provides a sustainable way to maintain carbon balance and alleviate the energy shortage.Low‐dimensional material(LDM)supported single‐atom catalysts(SACs)have been attracted significant attention for electrochemical CO_(2) reduction reaction(ECR)in recent years.This is mainly because integrating the single‐atoms and LDMs can inherit the advantages of themselves and the synergy effects between them are potential to enhance the ECR performance.In this review,we summarized the strategies for synthesizing LDM supported SACs for ECR,and different LDM supported SACs for ECR have been briefly introduced.Moreover,some optimization strategies for LDM supported SACs towards CO_(2) electroreduction are highlighted.At the end of this review,the perspectives and challenges of LDM supported SACs for ECR are provided. | Bingqing Wang Shenghua Chen Zedong Zhang Dingsheng Wang | 2022 | SmartMat2022，3，1： | 4 |
| 14 | Responses of bacterial strains isolated from drinking water environments to N-acyI-L-homoserine lactones and their analogs during biofilm formation显示文摘 | Zhuoying WU1 Qing WANG, Feng GUO Shenghua ZHANG Qipei JIANG Xin YU | 2014 | Frontiers of Environmental Science & Engineering2014，8，2： | 3 |
| 15 | Effects of forced aeration on community dynamics of free and attached bacteria in copper sulphide ore bioleaching显示文摘Bacterial community dynamics and copper leaching with applied forced aeration were investigated during low-grade copper sulphide bioleaching to obtain better bioleaching efficiency.Results illustrated that appropriate aeration improved bacterial concentrations and leaching efficiencies.The highest bacterial concentration and Cu^(2+)concentration after 14-d leaching were 7.61×10^(7) cells·mL^(−1) and 704.9 mg·L^(−1),respectively,at aeration duration of 4 h·d^(−1).The attached bacteria played a significant role during bioleaching from 1 to 7 d.However,free bacteria dominated the bioleaching processes from 8 to 14 d.This phenomenon was mainly caused by the formation of passivation layer through Fe3+hydrolysis along with bioleaching,which inhibited the contact between the attached bacteria and ore.Meanwhile,16S rDNA analysis verified the effect of Acidithiobacillus ferrooxidans and Acidithiobacillus thiooxidans on the bioleaching process.The results demonstrate the importance of free and attached bacteria in bioleaching. | Wei Chen Shenghua Yin I.M.S.K.Ilankoon | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，1： | 3 |
| 16 | A Near Infrared Cyanine-Based Fluorescent Probe for Highly Selectively Detecting Glutathione in Living Cells显示文摘包含 thiol 组的氨基酸在把生物氧化作为减小平衡起重要作用。由于 biothiols 的重要细胞的功能,开发有效方法检测 biothiols 在是必要的复杂化生物系统。在这个工作,我们发展了一基于花青荧光灯探查作为一个检测的组利用 thioether,它出现了荧光灯“刺激”向 GSH 和它的反应能被用作 biomarker 决定细胞的 GSH。 | Xiaole Sheng Dan Chen Meijiao Cao Yufeng Zhang Xie Han Xiaoqiang Chen Shenghua Liu Haiyan Chen Jun Yin | 2016 | Chinese Journal of Chemistry2016，34，6： | 3 |
| 17 | The Standards for Drinking Water Quality of China(2022 Edition)Will Take Effect显示文摘Safe drinking water is a valuable public health resource that affects people’s livelihood and is essential for human health,making it an international concern for drinking water quality improvement.The Standards for Drinking Water Quality of China(China SDWQ)is a legal document approved and issued by the Standardization Administration of the People’s Republic of China that serves as a starting point for protecting public health and ensuring the quality of human life.There are three versions of China SDWQ,including the 1985 edition,2006 edition,and 2022 edition.China SDWQ(2022 edition)sets a wide variety of indices covering biological,chemical,physical,and other risk factors in drinking water.Additionally,it establishes management requirements for the entire water supply process,providing a technical basis and criteria for ensuring drinking water safety and a scientific basis for developing drinking water safety policies and proposing targeted public health protection measures. | Jiayi Han Lan Zhang Bixiong Ye Shenghua Gao Xiaoyuan Yao Xiaoming Shi | 2023 | China CDC weekly2023，5，13： | 3 |
| 18 | The metastable constituent effects on size-dependent deformation behavior of nanolaminated micropillars: Cu/FeCoCrNi vs Cu/CuZr显示文摘Metastable high entropy alloys(HEAs) and amorphous metallic glasses(MGs), with the chemical disordered character, are intensively studied due to their excellent performance. Here, we introduce Cu to separately constrain these two metastable materials and comparatively investigate their deformation behaviors and mechanical properties of Cu/HEA Fe Co Cr Ni and Cu/MG Cu Zr nanolaminated micropillars in terms of intrinsic layer thickness h and extrinsic pillar diameter D. The metastable HEA layers, as the hard phase in Cu/HEA micropillars, are stable and dominate the deformation, while transformation(crystallization) occurs in MG which plays a minor role in deformation of Cu/MG micropillars. The h-controlled deformation mode transits from the D-independent homogenous-like deformation at large h to the Ddependent shear banding at small h in both Cu/HEA and Cu/MG micropillars. Although both Cu/HEA and Cu/MG micropillars exhibit a maximum strain hardening capability controlled by h, the former manifests much lower hardening capability compared with the latter. The intrinsic size h and extrinsic size D have a strong coupling effect on the strength of Cu/HEA and Cu/MG micropillars. The strength of strength of Cu/HEA micropillars exhibits the D-dependent transition from 'smaller is stronger' to 'smaller is weaker'with increasing h. By contrast, the strength of Cu/MG micropillars exhibits the transition from bulk-like D-independent behavior at large h to small volume D-dependent behavior(smaller is stronger) at small h. | Yufang Zhao Jinyu Zhang YaQiang Wang Shenghua Wu Xiaoqing Liang Kai Wu Gang Liu Jun Sun | 2021 | Journal of Materials Science & Technology2021，，9： | 3 |
| 19 | A hybrid matching method for geospatial services in a composition-oriented environment显示文摘With the development of Internet and GIS,large volumes of spatial data,powerful computing resources and many spatial data processing functions are published in the form of Web services.Finding suitable geospatial services in the composition-oriented environment is a crucial task.The semantic Web provides a kind of technology to find and compose various service resources automatically through the Web.This paper proposes a hybrid method for the semantic matching of geospatial services.The method includes two parts.Part 1 puts forward a multi-level semantic matching approach,which matches single geospatial service at four levels:classification,input/output,precondition/effect and the quality of service(QoS).This multi-level matching approach makes single service matching quicker and more accurate.Part 2 puts forward a matching algorithm for a geospatial service chain based on the context.The algorithm adopts a trace algorithm,taking account of the effect of the context.It restricts the input/output parameters of the current service by the input/output parameters of service chain,pre-service and sub-service.It matches the atomic service dynamically in a composition-oriented environment,and accurately converts the abstract model of geospatial services into an executable geospatial service chain.A case study of the flood analysis for the Poyang Lake illustrates the effectiveness of our context-based matching method for geospatial services. | LUO An 1,2,WANG YanDong 1,2 & CHEN ShengHua 2 1 State Key Laboratory of Software Engineering,Wuhan University,Wuhan 430072,China 2 State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Wuhan 430079,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 3 |
| 20 | Effect of Lamb Age and in vitro Culture System of Oocytes on JIVET Technology显示文摘[Objectives] This study was conducted to investigate the effects of lamb age and in vitro culture system of oocytes on the results of juvenile in vitro embryo transfer( JIVET). [Methods]Ten Dorper × small-tailed Han lambs aged 5 to 10 weeks were induced to superovulate via i. p. injection of pregnant mare's serum gonadotropin( PMSG). The oocytes were matured in basal maturation solution or modified maturation solution,which was prepared by adding 200 μmol/L cysteine to the basal maturation solution. Then,the oocytes were fertilized in fertilization medium I containing 2% estrus sheep serum( ESS) or fertilization medium II containing 3 mg/ml bull serum albumin( BSA). Finally,the number of oocytes,oocyte maturation rate and cleavage rate of the lambs of different ages were determined. [Results]The average number of oocytes recovered per lamb was( 111. 00 ± 16. 97),( 139. 50 ± 28. 99),( 108. 50 ± 17. 68) and( 42. 00 ± 11. 31) for5-,7-,8-and 10-week-old Dorper × small-tailed Han lambs,respectively. The number of oocytes obtained from 5-,7-and 8-week-old lambs was significantly higher than that from 10-week-old lambs( P < 0. 05),but there was no significant difference among 5-,7-and 8-week-old lambs( P > 0. 05). The maturation rate of oocytes cultured in modified maturation solution was 3. 64% higher than that in basal maturation solution. The cleavage rate of oocytes in fertilization medium I was very significantly higher than that in fertilization medium II( P < 0. 01). [Conclusions] The results of JIVET can be improved by harvesting oocytes from lambs aged 5-8 weeks,adding a certain amount of cysteine into oocyte maturation solution,and a certain amount of ESS into fertilization medium. | Yangyi MAO Huidi LUO Guanwu ZHANG Zhiwu WANG Peng ZHAO Jun LI Hongyu GUO Shenghua ZHOU Huihui GUO Chunyan LI | 2019 | Agricultural Biotechnology2019，8，1： | 3 |
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