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| 1 | Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘 | Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 141 |
| 2 | Osteoarthritis:toward a comprehensive understanding of pathological mechanism显示文摘Osteoarthritis(OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently,there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes. | Di Chen Jie Shen Weiwei Zhao Tingyu Wang Lin Han John L Hamilton Hee-Jeong Im | 2017 | Bone Research2017，5，1： | 121 |
| 3 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 4 | Molecular mechanism about lymphogenous metastasis of hepatocarcinoma cells in mice显示文摘AIM To investigate the correlation between lymphogenous metastasis and matrix metalloproteinases (MMPs) activity and the expression of Fas Iigand of tumor cells in lymph nodes.METHODES Fifty-six inbred 615-mice were equally divided into 2 groups and inoculated with Hca-F and Hca-P cells. Their lymph node metastatic rates were examined.Growth fraction of lymphocytes in host lymph nodes was detected by flow cytometry. The Hca-F and Hca-P cells were cultured with extract of lymph node, liver or spleen.The quantity of MMPs in these supernatants was examined by zymographic analysis. The expression of Fas ligand,PCNA, Bcl-2 protein of Hca-F and Hca-P cells in the mice were examined by immunohistochemistry. The apoptosis signals of macrophages in lymph nodes were observed with in situ DNA fragmentation.RESULTS On the 28th day post-inoculation, the lymph node metastatic rate of Hca-F was 80% (16/20), whereas that of Hca-P was 25% (5/20). The growth fraction of lymphocytes was as follows: in the Hca-F cells, the proliferating peak of lymphocytes appeared on the 14th day post-inoculation and then decreased rapidly, while in HcaP cells, the peak appeared on the 7th day post-inoculation and then kept at a high level. With the extract of lymph node, the quantity of the MMP-9 activity increased (P<0.01) and active MMP-9 and MMP-2 were produced by both Hca-F and Hca-P tumor cells, which did not produce MMPs without the extract of lymph node or with the extracts of the liver and spleen. The expression of Fas Ligand of Hca-F cells was stronger than that of Hca-P cells (P<0.01). The expressions of PCNA and Bcl-2 protein of Hca-F cells in the tumors of inoculated area were the same as that of Hca-P cells. In situ DNA fragmentation showed that the positive signals of macrophages were around HcaF cells.CONCLUSION Secretion of MMPs which was associated with metastatic ability of Hca-F and Hca-P tumor cells depends on the environment of lymph nodes. The increased expression of Fas ligand protein of Hca-F tumor cells with high lymphogenous metastatic potential in lymph nodes may help tumor cells escape from being killed by host lymphocytes. | Li Hou Ying Li Yong-Hua Jia Bo Wang Yi Xin Mao-Ying Ling Shen Lü Department of Pathology,Dalian Medical University,Dalian 116027,Liaoning Province,ChinaDepartment of Biochemistry,Dalian Medical University,Dalian 116027,Liaoning Province,China | 2001 | World Journal of Gastroenterology2001，7，4： | 47 |
| 5 | Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro显示文摘Suxiao Jiuxin 药片(SJP ) 是为在中国的急性冠的症候群的处理的繁体中文药,它包含二个主要部件, tetramethylpyrazine (TMP ) 和龙脑(BOR ) 。因此远然而,在心脏的微型环境上位于 SJP 的有益的效果下面的分子的机制是未知的。心脏的间充质的干细胞(C-MSCs ) 通过 microvesicles (exosomes ) 的版本与 cardiomyocytes (厘米) 交流恢复心脏的动态平衡并且得到修理,部分地通过 epigenetic 规章的机制。在这研究,我们检验了 SJP 处理是否改变了 C-MSC-derived exosomes (SJP-Exos ) 引起 epigenetic 在接受者厘米的色彩的改变。从老鼠心孤立的 C-MSC 是有 SJP (SJP-Exos ) 的 pretreated, TMP (TMP-Exos ) 或 BOR (BOR-Exos ) 。然后, HL-1 房间,一根鼠标 cardiomyocyte 线,从控制与 exosomes 被对待 C-MSCs (Ctrl-Exos ) , SJP-Exos, TMP-Exos 或 BOR-Exos。有 SJP-Exos 的处理显著地增加了 histone 的蛋白质层次 3 离氨酸 27 trimethylation (H3K27me3 ) ,为心脏的 transcriptional 抑制的一个关键 epigenetic 染色质标记,在 HL-1 房间。为了推进,探索 SJP-Exo-mediated H3K27me3 upregulation 的机制,我们在对待 exosome 的 HL-1 房间估计了关键 histone methylases (EZH1, EZH2 和 EED ) 和 demethylases (JMJD3 和 UTX ) 的 mRNA 表示层次。有 SJP-Exo 的处理有选择地在接受者 HL-1 房间压制了 UTX 表示。而且, PCNA,房间复制的一个内长的标记,比在 Ctrl-Exo-treated HL-1 房间在 SJP-Exo-treated HL-1 房间是显著地更高的。这些结果证明 SJP-Exos 增加 cardiomyocyte 增长并且证明 SJP 能调制 C-MSC-derived exosomes 引起 epigenetic 染色质在接受者 cardiomyocytes 改变;因而, SJP-Exos 可能被用来支持 cardiomyocyte 增长。 | Xiao-fen RUAN Yongdun LI Cheng-wei JU Yan SHEN Wei LEI Can CHEN Yang LI Hong YU Yu-tao LIU II-man KIM Xiao-long WANG Neal L WEINTRAUB Yaoliang TANG | 2018 | Acta Pharmacologica Sinica2018，39，4： | 23 |
| 6 | Characterization and Genetic Analysis of a Novel Rice Spotted-leaf Mutant HM47 with Broad-spectrum Resistance to Xanthomonas oryzae pv. oryzae显示文摘A stable inherited rice spotted-leaf mutant HM47 derived from an EMS-induced IR64 mutant bank was identified. The mutant expressed hypersensitive response (HR)-like symptoms throughout its whole life from the first leaf to the flag leaf, without pathogen invasion. Initiation of the lesions was induced by light under natural summer field conditions. Expression of pathogenesis-related genes including PAL, PO-C1, POX22.3 and PBZ1 was enhanced significantly in association with cell death and accumulation of H2O2 at and around the site of lesions in the mutant in contrast to that in the wild-type (WT). Disease reaction to Xanthomonas oryzae pv. oryzae from the Philippines and China showed that HM47 is a broad-spectrum disease-resistant mutant with enhanced resistance to multiple races of bacterial blight pathogens tested. An F2 progeny test showed that bacterial blight resistance to race HB-17 was cosegregated with the expression of lesions. Genetic analysis indicated that the spotted-leaf trait was controlled by a single recessive gene, tentatively named spl HM47 , flanked by two insertion/deletion markers in a region of approximately 74 kb on the long arm of chromosome 4. Ten open reading frames are predicted, and all of them are expressed proteins. Isolation and validation of the putative genes are currently underway. | Bao-Hua Feng Yang Yang Yong-Feng Shi Hai-Chao Shen Hui-Mei Wang Qi-Na Huang Xia Xu Xiang-Guang Lü Jian-Li Wu | 2013 | Journal of Integrative Plant Biology2013，55，5： | 17 |
| 7 | A 2.8 Ma record of environmental evolution and tectoni events inferred from the Cuoe core in the middle of Tibetan Plateau显示文摘Based on a multi-proxy investigation into the deep core of the Cuoe Lake in the middle of Tibetan Plateau, a 2.8 Ma paleoclimatic and paleoenvironmental evolution is recon- structed. The result of magnetic stratum indicates that the lake basin was formed at about 2.8 MaBP, while the multi-proxy analyses of lithology, grain size, magnetic susceptibility and geo- chemical elements reveal that there have been three major environmental evolution stages and at least two intensive uplifts of the Tibetan Plateau in the lake basin area, i.e. during 2.8—2.5 MaBP, the lake basin came into being as a result of the disaggregation of the planation surface and rapid rising of the Tibetan Plateau. During 2.5—0.8 MaBP, with gradual uplift of the Tibetan Plateau, the environment of this area was more effectively controlled by the climatic cycle of the alternative glacial-interglacial stages. After 0.8 MaBP, the middle part of the Plateau accelerated its uplift and entered cryoshere. | SHEN Ji1,Lü Houyuan2,WANG Sumin1,CHEN Shiyue1,YANG Xiangdong1,WU Yanhong1 & ZHU Zhaoyu3 1.Nanjing Institute of Geography and Limnology,Chinese Academy of Sciences,Nanjing 210008,China 2.Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing 100029,China 3.Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,China Correspondence should be addressed to Shen Ji(email: jishen@niglas.ac.cn) | 2004 | Science China Earth Sciences2004，47，11： | 15 |
| 8 | Insoluble β-glucan from the cell wall of Candida albicans induces immune responses of human THP-1 monocytes through Dectin-1显示文摘背景 -glucan 是 Candida albicans 的主要结构部件(C。albicans ) 房间墙。Dectin-1 能作为主要 C 类型 lectin 模式识别受体(PRR ) 认出真菌的 -glucan 并且导致有免疫力的回答,这被表明了。在这研究,我们寻求了澄清是否从 C 的房间墙的不可溶解的 -glucan。albicans (CalG ) 能在人的 THP-1 单核白血球(一根人的尖锐 monocytic 白血病房间线) 导致有免疫力的回答并且在 vitro 与 CalG 被质问决定内在的 mechanisms.Methods 人 THP-1 单核白血球。Dectin-1,像使用费的受体(TLR2 ) , proinflammatory cytokine (TNF-) 和 chemokine (IL-8 ) 的 mRNA 表示是由即时反向的抄写聚合酶链反应(RT-PCR ) 的 assayed。TNF-8 和 IL-8 的分泌物被连接酶的 immunosorbent 试金(ELISA ) 测量。H2O2 版本被 microplate 决定荧光灯试金。西方的弄污被用来分析 THP-1 单核白血球的 IkB- phosphorylation 和 degradation.Results 暴露到导致的 CalG TNF-8.CalG 和 IL-8.CalG 的增加的基因表示和分泌物以一种时间依赖者方式导致了 H2O2 版本。有 zymolyase 的 CalG hydrolyzed 没能导致基因表示和 TNF- , IL-8 和 H2O2 版本的分泌物。CalG 起来调整 Dectin-1 的 mRNA,而 TLR2 的 mRNA 水平没被改变。与 CalG 质问的 THP-1 单核白血球以一种时间依赖者方式导致了 NF-KB 的激活。 Dectin-1 禁止者 laminarin 在 THP-1 单核白血球堵住了TNF-和 H2O2 的 导致CalG 的生产,但是没有如此的效果与抵销抗体和 .Conclusion CalG 可以玩的 LPS 禁止者(多粘菌素 B )的 anti-TLR2 在预告的处理被观察在在通过 Dectin-1 的人的 THP-1 房间的有免疫力的回答的激活的一个角色,不, TLR2.This 工作被资助从中国(号码 30671893 )的国家自然 ScienceFoundation 支持。 | LI Min LIU Ze-hu CHEN Qing ZHOU Wu-qing YU Mei-wen Lü Gui-xia LU Xue-lian SHEN Yong-nian LIU Wei-da WU Shao-xi | 2009 | Chinese Medical Journal2009，，5： | 13 |
| 9 | Diagenetic fluid evolution and water-rock interaction model of carbonate cements in sandstone: An example from the reservoir sandstone of the Fourth Member of the Xujiahe Formation of the Xiaoquan-Fenggu area, Sichuan Province, China显示文摘Carbonate cement is the most abundant cement type in the Fourth Member of the Xujiahe Formation in the Xiaoquan-Fenggu area of the West Sichuan Depression. Here we use a systematic analysis of carbonate cement petrology, mineralogy, carbon and oxygen isotope ratios and enclosure homogenization temperatures to study the precipitation mechanism, pore fluid evolution, and distribution of different types of carbonate cement in reservoir sand in the study area. Crystalline calcite has relatively heavy carbon and oxygen isotope ratios(δ13C = 2.14‰, δ18O = -5.77‰), and was precipitated early. It was precipitated directly from supersaturated alkaline fluid under normal temperature and pressure conditions. At the time of precipitation, the fluid oxygen isotope ratio was very light, mainly showing the characteristics of a mixed meteoric water-seawater fluid(δ18O = -3‰), which shows that the fluid during precipitation was influenced by both meteoric water and seawater. The calcite cement that fills in the secondary pores has relatively lighter carbon and oxygen isotope ratios(δ13C = -2.36‰, δ18O = -15.68‰). This cement was precipitated late, mainly during the Middle and Late Jurassic. An important material source for this carbonate cement was the feldspar corrosion process that involved organic matter. The Ca2+, Fe3+ and Mg2+ ions released by the clay mineral transformation process were also important source materials. Because of water-rock interactions during the burial process, the oxygen isotope ratio of the fluid significantly increased during precipitation, by about 3‰. The dolomite cements in calcarenaceous sandstone that was precipitated during the Middle Jurassic have heavier carbon and oxygen isotope ratios, which are similar to those of carbonate debris in the sandstone(δ13C = 1.93‰, δ18O = -6.11‰), demonstrating that the two are from the same source that had a heavier oxygen isotope ratio(δ18O of about 2.2‰). The differences in fluid oxygen isotope ratios during cement precipitation reflect the influences of different water-rock interaction systems or different water-rock interaction strengths. This is the main reason why the sandstone containing many rigid particles(lithic quartz sandstone) has a relatively negative carbon isotope ratio and why the precipitation fluid in calcarenaceous sandstone has a relatively heavier oxygen isotope ratio. | LIU SiBing HUANG SiJing SHEN ZhongMin Lü ZhengXiang SONG RongCai | 2014 | Science China Earth Sciences2014，57，5： | 13 |
| 10 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 11 | Community Dynamics of Seed Rain in Mixed Evergreen Broad-leaved and Deciduous Forests in a Subtropical Mountain of Central China显示文摘Seed dispersal is a key process within community dynamics.The spatial and temporal variations of seed dispersal andthe interspecific differences are crucial for understanding species coexistence and community dynamics.This might alsohold for the mixed evergreen broadleaved and deciduous forests in the mountains of subtropical China,but until now littleexisting knowledge is available for this question.In 2001,we chose to monitor the seed rain process of our mixed evergreenbroad-leaved and deciduous forest communities in Mount Dalaoling National Forest Park,Yichang,Hubei Province,China.The preliminary analyses show obvious variations in seed rain density,species compositions and timing of seed rain amongfour communities.The average seed rain densities of the four communities are 2.43±5.15,54.13±182.75,10.05±19.30and 24.91±58.86 inds./m^2,respectively;about one tenth the values in other studies in subtropical forests of China.In eachcommunity,the seed production is dominated by a limited number of species,and the contributions from the others aregenerally minor.Fecundity of evergreen broadleaved tree species is weaker than deciduous species.The seed rain of fourcommunities begins earlier than September,and stops before December,peaking from early September to late October.The beginning date,ending date and peak times of seed rain are extensively varied among the species,indicating differenttypes of dispersal strategies.According to the existing data,the timing of seed rain is not determined by the climateconditions in the same period,while the density of seed rain may be affected by the disturbances of weather variations ata finer temporal resolution. | Ze-Hao Shen Yuan-Yuan Tang Nan Lü Jun Zhao Dao-Xing Li Gong-Fang Wang | 2007 | Journal of Integrative Plant Biology2007，49，9： | 9 |
| 12 | VX-765 reduces neuroinflammation after spinal cord injury in mice显示文摘Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord. A mouse model of T9 contusive spinal cord injury was established using an Infinite Horizon Impactor, and VX-765, a selective inhibitor of caspase-1, was administered for 7 successive days after spinal cord injury. The results showed that:(1) VX-765 inhibited spinal cord injury-induced caspase-1 activation and interleukin-1β and interleukin-18 secretion.(2) After spinal cord injury, an increase in M1 cells mainly came from local microglia rather than infiltrating macrophages.(3) Pro-inflammatory Th1 Th17 cells were predominant in the Th subsets. VX-765 suppressed total macrophage infiltration, M1 macrophages/microglia, Th1 and Th1 Th17 subset differentiation, and cytotoxic T cells activation;increased M2 microglia;and promoted Th2 and Treg differentiation.(4) VX-765 reduced the fibrotic area, promoted white matter myelination, alleviated motor neuron injury, and improved functional recovery. These findings suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18. This may be a potential strategy for treating spinal cord injury. This study was approved by the Animal Care Ethics Committee of Bengbu Medical College(approval No. 2017-037) on February 23, 2017. | Jing Chen Yu-Qing Chen Yu-Jiao Shi Shu-Qin Ding Lin Shen Rui Wang Qi-Yi Wang Cheng Zha Hai Ding Jian-Guo Hu He-Zuo Lü | 2021 | Neural Regeneration Research2021，16，9： | 8 |
| 13 | Successful treatment of experimental autoimmune myocarditis by adenovirus-mediated gene transfer of antisense C Ⅱ TA显示文摘 | Cai G Zhang J Liu L Shen Q | 2005 | 第二军医大学学报2005，26，8： | 7 |
| 14 | Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system显示文摘把烟碱的醋胆素受体(nAChRs ) 基于形成功能的 neuronal 的五个子单元的作文,他们被组织进任何一个 heteromeric (包括伪和尾子单元) 或 homomeric (包括的仅仅伪子单元) 受体。nAChRs 被知道是对钙离子可渗透的差别,与有到钙的最高的渗透之一的伪 7 nAChR 子类型。通过 nAChRs 的钙流入,特别地通过伪 -bungarotoxin 敏感的伪 7 包含 nAChRs,是提起细胞质的钙层次的一个很有效的方法。nAChRs 的激活能调停细胞质的钙信号的三种类型:( 1 )通过 nAChRs 指导钙流入,( 2 )通过被 调停nAChR 的去极激活的电压依赖者钙隧道( VDCC )的间接的钙流入,并且( 3 )导致钙的钙版本( CICR )(由开始的二来源被触发)从 endoplasmic 蜂窝胃(嗯)通过 ryanodine 受体和肌醇( 1,4,5 ) -triphosphate 受体( IP3Rs )。下游的发信号事件由 调停nAChR 的钙回答调停了能被组织进即时效果(例如 neurotransmitter 版本,能在 nAChR 激活以后发生在毫秒,短期的效果(例如 nAChR 的恢复,通过细胞的发信号的不敏感性串联),并且长期的效果(例如经由基因表示的 neuroprotection )。另外, nAChR 活动能被细胞质的钙层次调整,建议一种复杂相互的关系。在为 neuronal nAChRs 的成像技术,动物模型,和更多的有势力和子类型选择的 ligands 的进一步的进展将在理解 neuronal 帮助发信号的调停 nAChR 的钙,并且导致改进治疗学的处理的发展。 | Jian-xin SHEN Jerrel L YAKEL | 2009 | Acta Pharmacologica Sinica2009，30，6： | 7 |
| 15 | Investigation of recombinant Schistosoma japonicum paramyosin fragments for immunogenicity and vaccine efficacy in mice显示文摘 | Zhang DM Pan WQ Qian L Duke M Shen LH McManus DP | 2006 | 第二军医大学学报2006，27，6： | 6 |
| 16 | Extractive distillation: Advances in conceptual design, solvent selection,and separation strategies显示文摘Extractive distillation(ED) is one of the most promising approaches for the separation of the azeotropic or closeboiling mixtures in the chemical industry. The purpose of this paper is to provide a broad overview of the recent development of key aspects in the ED process involving conceptual design, solvent selection, and separation strategies. To obtain the minimum entrainer feed flow rate and reflux ratio for the ED process, the conceptual design of azeotropic mixture separation based on a topological analysis via thermodynamic feasibility insights involving residue curve maps, univolatility lines, and unidistribution curves is presented. The method is applicable to arbitrary multicomponent mixtures and allows direct screening of design alternatives. The determination of a suitable solvent is one of the key steps to ensure an effective and economical ED process. Candidate entrainers can be obtained from heuristics or literature studies while computer aided molecular design(CAMD) has superiority in efficiency and reliability. To achieve optimized extractive distillation systems, a brief review of evaluation method for both entrainer design and selection through CAMD is presented. Extractive distillation can be operated either in continuous extractive distillation(CED) or batch extractive distillation(BED), and both modes have been well-studied depending on the advantages in flexibility and low capital costs. To improve the energy efficiency, several configurations and technological alternatives can be used for both CED and BED depending on strategies and main azeotropic feeds. The challenge and chance of the further ED development involving screening the best potential solvents and exploring the energy-intensive separation strategies are discussed aiming at promoting the industrial application of this environmentally friendly separation technique. | Shirui Sun Liping Lü Ao Yang Shun'an Wei Weifeng Shen | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 6 |
| 17 | Identifi cation of a novel male sterile wheat mutant dms conferring dwarf status and multi-pistils显示文摘Plant height and fertility are two important traits of wheat(Triticum aestivum L.), whose mutants are ideal materials for studies on molecular mechanisms of stem and floral organ development. In this study, we identified a dwarf, multi-pistil and male sterile(dms hereafter) wheat mutant from Zhoumai 18. Simple sequence repeat(SSR) marker assay with 181 primer pairs showed that only one locus of GWM148-2B was divergent between Zhoumai 18 and dms. There were three typical phenotypes in the progeny of dms, tall(T; ca. 0.8 m), semi-dwarf(M; ca. 0.6 m) and dwarf(D; under 0.3 m) plants. Morphological investigation indicated that the internode length of M was shortened by about 20–50 mm each; the internode number of D was 2 less than that of T and Zhoumai 18, and its internode length was shorter also. The pollen vigor and hybridization test demonstrated that dms mutant was male sterility. Segregated phenotypes in progeny of M suggested that the multi-pistils and sterility were controlled by one recessive gene locus which was designated as dms temporarily, and the plant height was controlled by a semi-dominant gene locus Dms. Therefore, progeny individuals of the dms had three genotypes, Dms Dms for tall plants, Dmsdms for semi-dwarf plants and dmsdms for dwarf plants. The mutant progenies were individually selected and propagated for more than 6 generations, thus a set of near isogenic lines of T, M and D for dms were developed. This study provides a set germplasms for studies on molecular mechanisms of wheat stem and spike development. | DUAN Zong-biao SHEN Chun-cai LI Qiao-yun Lü Gui-zhen NI Yong-jing YU Dong-yan NIU Ji-shan | 2015 | Journal of Integrative Agriculture2015，14，9： | 6 |
| 18 | Efficacy and advantages of modified Traditional Chinese Medicine treatments based on'kidney reinforcing'for chronic aplastic ane-mia:a randomized controlled clinical trial显示文摘OBJECTIVE:To compare the efficacy of modified treatments based on 'kidney reinforcing' in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),'kidney reinforcing and Qi tonifying'(KQ),and 'kidney reinforcing and blood circulation invigorating'(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery. | Wu Dijiong Shen Yiping Ye Baodong Fang Bingmu Lin Shengyun Chen Zhilu Jiang Huifang Feng Changwei He Lüyuan Gao Yanting Liu Yonglin Liu Yonghua Zhu Jiajia Wu Liqiang Shao Keding Zhou Yuhong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 6 |
| 19 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 20 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
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