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| 1 | Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China显示文摘 | Cao Hailong Qu Rui Zhang Zhihua Kong Xinyue Wang Shan Jiang Kui Wang Bangmao | 2014 | Chinese Medical Journal2014，，7： | 29 |
| 2 | Long-Term Effect of No-Tillage on Soil Organic Carbon Fractions in a Continuous Maize Cropping System of Northeast China显示文摘Increasing evidence has shown that conservation tillage is an effective agricultural practice to increase carbon (C) sequestration in soils. In order to understand the mechanisms underlying the responses of soil organic carbon (SOC) to tillage regimes, physical fractionation techniques were employed to evaluate the effect of long-term no-tillage (NT) on soil aggregation and SOC fractions. Results showed that NT increased the concentration of total SOC by 18.1% compared with conventional tillage (CT) under a long-term maize (Zea mays L.) cropping system in Northeast China. The proportion of soil large macroaggregates (> 2000 μm) was higher in NT than that in CT, while small macroaggregates (250-2000 μm) showed an opposite trend. Therefore, the total proportion of macroaggregates (> 2000 and 250-2000 μm) was not affected by tillage management. However, C concentrations of macroaggregates on a whole soil basis were higher under NT relative to CT, indicating that both the amount of aggregation and aggregate turnover affected C stabilization. Carbon concentrations of intra-aggregate particulate organic matter associated with microaggregates (iPOM m) and microaggregates occluded within macroaggregates (iPOM mM) in NT were 1.6 and 1.8 times greater than those in CT, respectively. Carbon proportions of iPOM m and iPOM mM in the total SOC increased from 5.4% and 6.3% in CT to 7.2% and 9.7% in NT, respectively. Furthermore, the difference in the microaggregate protected C (i.e., iPOM m and iPOM mM) between NT and CT could explain 45.4% of the difference in the whole SOC. The above results indicate that NT stimulates C accumulation within microaggregates which then are further acted upon in the soil to form macroaggregates. The shift of SOC within microaggregates is beneficial for long-term C sequestration in soil. We also corroborate that the microaggregate protected C is useful as a pool for assessing the impact of tillage management on SOC storage. | HUANG Shan SUN Yan-Ni RUI Wen-Yi LIU Wu-Ren ZHANG Wei-Jian | 2010 | Pedosphere2010，20，3： | 26 |
| 3 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 4 | Survival of transplanted neurotrophin-3 expressing human neural stem cells and motor function in a rat model of spinal cord injury显示文摘<正>BACKGROUND:Many methods have been attempted to repair nerves following spinal cord injury, including peripheral nerve transplantation,Schwann cell transplantation,olfactory ensheathing cell transplantation,and embryonic neural tissue transplantation.However,there is a need for improved outcomes. OBJECTIVE:To investigate the repair feasibility for rat spinal cord injury using human neural stem cells(hNSCs) genetically modified by lentivirus to express neurotrophin-3. DESIGN,TIME AND SETTING:In vitro cell biological experiment and in vivo randomized,controlled, genetic engineering experiment were performed at the Third Military Medical University of Chinese PLA and First People's Hospital of Yibin,China from March 2006 to December 2007. MATERIALS:A total of 64 adult,female,Wistar rats were used for the in vivo study.Of them,48 rats were used to establish models of spinal cord hemisection,and were subsequently equally and randomly assigned to model,genetically modified hNSC,and normal hNSC groups.The remaining 16 rats served as normal controls. METHODS:hNSCs were in vitro genetically modified by lentivirus to secrete both green fluorescence protein and neurotrophin-3.Neurotrophin-3 expression was measured by Western blot. Genetically modified hNSC or normal hNSC suspension(5×10~5) was injected into the rat spinal cord following T_(10) spinal cord hemisection.A total of 5μL Dulbecco's-modified Eagle's medium was infused into the rat spinal cord in the model group.Transgene expression and survival of transplanted hNSCs were determined by immunohistochemistry.Motor function was evaluated using the Basso,Beattie,and Bresnahan(BBB) scale. MAIN OUTCOME MEASURES:The following parameters were measured:expression of neurotrophin-3 produced by genetically modified hNSCs,transgene expression and survival of hNSCs in rats,motor function in rats. RESULTS:hNSCs were successfully genetically modified by lentivirus to stably express neurotrophin-3.The transplanted hNSCs primarily gathered at,or around,the injection site two weeks following transplantation,and gradually migrated towards the surrounding tissue. Transplanted hNSCs were observed 7.0-8.0 mm away from the injection site.In addition,hNSCs were observed 10 weeks after transplantation.At week 4,BBB locomotor scores were significantly greater in the genetically modified hNSC and normal hNSC groups,compared with the model group (P<0.05),and scores were significantly greater in the genetically modified hNSC group compared with the normal hNSC group(P<0.05). CONCLUSION:hNSCs were genetically modified with lentivirus to stably secrete neurotrophin-3. hNSCs improved motor function recovery in rats following spinal cord injury. | Peiqiang Cai Guangyun Sun Peishu Cai Martin Oudega Rui Xiao Xuewen Wang Wei Li Yunbing Shu Cheng Cai Haihao Yang Xuebing Shan Wuhua Luo | 2009 | Neural Regeneration Research2009，4，7： | 18 |
| 5 | Correlation of 4-month infant feeding modes with their growth and iron status in Beijing显示文摘背景:婴儿的生长和开发很长时间是在儿科的一个重要话题。婴儿们必须提供包含所有必要营养素的食物。母乳被相信为正常营养是最理想的天赋和最便宜的食物。但是与在在发达国家的代用品食物的发展的进步,公式牛奶能为婴儿生长满足要求,这被认为。在早幼年期期间,作为健康的最敏感的索引,生长因此是在评估母乳喂养的足够的一个批评部件,喂混合并且喂的公式。铁地位是婴儿健康的另一个重要索引。铁营养缺乏性贫血在世界范围的婴儿仍然是最流行的营养的缺乏索引。这研究是在 4 个月在北京比较婴儿在三个不同的喂模式上(用母乳喂,喂混合并且喂的公式) 在物理变化和铁地位。结果可以在喂模式选择向新母亲提供支持,它将也对在喂模式教育的中国营养协会有用。方法:这是队研究。1001 个正常北京婴儿定期被跟随 12 个月。体重和水平长度被测量。血红素,红血房间计数,红细胞平均容量,吝啬的血球的血红素和浆液铁在 4 个月被分析。结果:在开始的 4 个月内的用母乳喂百分比是 47.9% 。喂的模式不是显著地与母亲的交货年龄,教育,劳动小径也不婴儿性别(P>0.05 ) 有关。婴儿男孩和从 0 ~ 4 个月只以母奶抚育的女孩在 0-6 月有最高的重量。在 4 个月的以母奶抚育的婴儿男孩的贫血症率最高。结论:用母乳喂应该被给更多的强调。新母亲如果可能,母乳喂养他们的婴儿是强制的。社会环境应该也为用母乳喂保证要求。而且,血红素,红细胞平均容量和浆液铁的正常价值,它是原来过去常判定孩子的铁营养缺乏性贫血,可能别为评估婴儿最佳。可能有需要为婴儿开发血红素,红细胞平均容量和浆液铁的性特定的截止层次。 | GONG Yu-hua JI Cheng-ye ZHENG Xiu-xia SHAN Jin-ping HOU Rui | 2008 | Chinese Medical Journal2008，，5： | 15 |
| 6 | Single and competitive adsorption affinity of heavy metals toward peanut shell-derived biochar and its mechanisms in aqueous systems显示文摘Converting peanut shells into biochar by pyrolysis was considered an environmentally friendly and efficient method for agricultural solid waste disposal.The properties of peanut shell-derived biochar(PBC)under different temperature and its adsorption capacity of heavy metals were investigated.It was found that PBC400 exhibited the highest cumulative capability for heavy metals elimination in single solute because of its high specific surface area and rich functional groups.Furthermore,the competitive adsorption revealed that PBC had a substantial difference in adsorption affinity from diverse heavy metal ions,sorption capacity decreased as Pb2+>Cu2+>Cd2+>Ni2+>Zn2+,which was lower than in a single solute.The adsorption process using selected biochar was optimized with respect to p H,reaction time,adsorbent dose,and initial concentration of heavy metals.The kinetic data was well fitted with PSO model,and the Langmuir model was adopted for adsorption equilibrium data in both cases of single solutes and mixed solutes for all heavy metals,which indicated that the removal course was primarily explained by monolayer adsorption,and chemical adsorption occupied an important role.Therefore,peanut shells derived biochar could be a potential and green adsorbent for wastewater treatment. | Rui Shan Yueyue Shi Jing Gu YazhuoWang Haoran Yuan | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 14 |
| 7 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 8 | Role of gut microbiota via the gut-liver-brain axis in digestive diseases显示文摘The gut-brain axis is a bidirectional information interaction system between the central nervous system(CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut-liver-brain axis. | Jian-Hong Ding Zhe Jin Xiao-Xu Yang Jun Lou Wei-Xi Shan Yan-Xia Hu Qian Du Qiu-Shi Liao Rui Xie Jing-Yu Xu | 2020 | World Journal of Gastroenterology2020，26，40： | 13 |
| 9 | Mathematic Model and Analytic Solution for a Cylinder Subject to Exponential Function显示文摘Hollow cylinders are widely used in spacecraft,rockets,weapons,metallurgy,materials,and mechanical manufacturing industries,and so on,hydraulic bulging roll cylinder and hydraulic press work all belong to hollow cylinders. However,up till now,the solution of the cylinder subjected to the pressures in the three-dimensional space is still at the stage of the analytical solution to the normal pressure or the approximate solution to the variable pressure by numerical method. The analytical solution to the variable pressure of the cylinder has not yet made any breakthrough in theory and can not meet accurate theoretical analysis and calculation requirements of the cylindrical in Engineering. In view of their importance,the precision calculation and theoretical analysis are required to investigate on engineering. A stress function which meets both the biharmonic equations and boundary conditions is constructed in the three-dimensional space. Furthermore,the analytic solution of a hollow cylinder subjected to exponential function distributed variable pressure on its inner and outer surfaces is deduced. By controlling the pressure subject to exponential function distributed variable pressure in the hydraulic bulging roller without any rolling load,using a static tester to record the strain supported hydraulic bulging roll,and comparing with the theoretical calculation,the experimental test result has a higher degree of agreement with the theoretical calculation. Simultaneously,the famous Lamè solution can be deduced when given the unlimited length of cylinder along the axis. The analytic solution paves the way for the mathematic building and solution of hollow cylinder with randomly uneven pressure. | LIU Wen SHAN Rui | 2009 | Chinese Journal of Mechanical Engineering2009，22，4： | 13 |
| 10 | Micro RNAs in colorectal cancer:Role in metastasis and clinical perspectives显示文摘Colorectal cancer(CRC)is the third most common malignancy and the third leading cause of cancer related deaths in the United States.Almost 90%of the patients diagnosed with CRC die due to metastases.Micro RNAs(mi RNAs)are evolutionarily conserved molecules that modulate the expression of their target genes post-transcriptionally,and they may participate in various physiological and pathological processes including CRC metastasis by influencing various factors in the human body.Recently,the role mi RNAs play throughout the CRC metastatic cascade has gain attention.Many studies have been published to link them with CRC metastasis.In this review,we will briefly discuss metastatic steps in the light of mi RNAs,along with their target genes.We will discuss how the aberration in the expression of mi RNAs leads to the formation of CRC by effecting the regulation of their target genes.As mi RNAs are being exploited for diagnosis,prognosis,and monitoring of cancer and other diseases,their high tissue specificity and critical role in oncogenesis make them new biomarkers for the diagnosis and classification of cancer as well as for predicting patients’outcome.Mi RNA signatures have been identified for many human tumors including CRC,and mi RNA-based therapies to treat cancer have been emphasized lately.These will also be discussed in this review. | Shan Muhammad Kavanjit Kaur Rui Huang Qian Zhang Paviter Kaur Hamza Obaid Yazdani Muhammad Umar Bilal Jiang Zheng Liu Zheng Xi-Shan Wang | 2014 | World Journal of Gastroenterology2014，20，45： | 13 |
| 11 | Are humic substances soil microbial residues or unique synthesized compounds?A perspective on their distinctiveness显示文摘Humic substances(HS),which are defined as a series of highly acidic,relatively high-molecular-weight,and yellow to black colored substances formed during the decay and transformation of plant and microbial remains,ubiquitously occur in nature.Humic substances represent the largest stable organic carbon pool in terrestrial environments and are the central characteristic of the soil.However,the validity of the HS concept and the justification of their extraction procedure have been recently debated.Here,we argue that the traditional humic paradigm is still relevant.Humic substances are distinctive and complex because the extracted HS formed during the humification are chemically distinct from their precursors and are heterogeneous among soils.By reviewing the concept,formation pathways,and stabilization of HS,we propose that the key question facing soil scientists is whether HS are soil microbial residues or unique synthesized compounds.Without revealing the distinctiveness of HS,it is impossible to address this question,as the structure,composition,and reactivity of HS are still poorly known owing to the heterogeneity and geographical variability of HS and the limits of the currently available analytical techniques.In our view,the distinctiveness of HS is fundamental to the soil,and thus further studies should be focused on revealing the distinctiveness of HS and explaining why HS hold this distinctiveness. | Sen DOU Jun SHAN Xiangyun SONG Rui CAO Meng WU Chenglin LI Song GUAN | 2020 | Pedosphere2020，30，2： | 12 |
| 12 | Inhibition of tumor necrosis factor-α reduces alveolar septal cell apoptosis in passive smoking rats显示文摘背景最近的研究表明了肺房间 apoptosis 在 .Tumor 坏死因素 alpha (TNF-)是的导致香烟的长期的妨碍的肺的疾病( COPD )的致病起一个重要作用涉及 COPD.This 学习的最重要的 cytokines 之一瞄准了调查它的禁止者的 jnfluence , recombinant 人坏死 factor-alpha 受体: IgG Fc 熔化蛋白质( rhTNFR : Fc )在在被动吸烟 rats.Methods 的牙槽的氏族的房间 apoptosis 上, 48 | ZHANG Cheng CAI Shan CHEN Ping CHEN Jian-bo wu Jie WU Shang-jie ZHOU Rui | 2008 | Chinese Medical Journal2008，，7： | 12 |
| 13 | Sequencing of p53 mutation in established human hepatocellular carcinoma cell line of HHC4 and HHC15 in nude mice显示文摘INTRODUCTIONAlthoughtheetiopathologyofhumanhepatocelularcarcinoma(hHCC)isstilunknown,alotofevidencestronglysuggestedthatinfec... | YANG Shan Min, ZHOU Hong, CHEN Rui Chuan, WANG Yu Fang, CHEN Fu, ZHANG Chang Gong, ZHEN Yun, YAN Jiang Hua and SU Jin Hua | 1998 | World Journal of Gastroenterology1998，4，6： | 11 |
| 14 | Effect of Timing of Tracheotomy on Clinical Outcomes: an Update Meta-analysis Including 11 Trials显示文摘Objective To estimate the relative effect of early vs.late tracheotomy on clinical end-points in unselected intensive care unit(ICU)patients undergoing mechanical ventilation.Methods We searched electronic databases(up to February 27,2013)for both randomized control trials and observational studies satisfying the predefined inclusion criteria.Results We retrieved 11 reports of studies including a total of 13 705 patients.Early tracheotomy was associated with significant reductions in mortality[33.3%vs.36.3%;relative risk(RR);0.92;95%confidence interval(CI):0.88,0.97;I2:29%],length of ICU stay(mean difference:6.55 days;95%CI:8.19,4.90;I2:98%)and duration of mechanical ventilation(mean difference:6.53 days;95%CI:11.43,1.63;I2:100%).However,as compared with late tracheotomy,early tracheotomy did not reduce the incidence of hospital pneumonia(21.9%vs.21.0%,RR:0.85;95%CI:0.68,1.06;I2:67%).Conclusions Early tracheotomy can reduce length of ICU stay,duration of mechanical ventilation and mortality but has no influence on hospital pneumonia when compared with late tracheotomy.Once the decision has been made about tracheotomy,clinical physicians should not hesitate to perform the procedure. | Liang Shan Rui Zhang Lian-di Li | 2013 | Chinese Medical Sciences Journal2013，28，3： | 10 |
| 15 | The Effect of PCDH15 Gene Variations on the Risk of Noise-induced Hearing Loss in a Chinese Population显示文摘导致噪音的听觉损失(NIHL ) 是在环境、基因的因素之间的相互作用引起的复杂疾病。这研究调查了在 protocadherin 的基因可变性是否联系了 15 (PCDH15 ) 在一张中国人口位于增加的危险性下面到 NIHL 的发展。结果证明与 rs11004085 的 TT 遗传型相比, CT/CC 遗传型与 NIHL 的增加的风险被联系[调整机会比率(或)= 2.64;95% 信心间隔(CI ) :1.14-6.11, P = 0.024 ] 。另外,在 rs11004085 和 rs978842 之间的重要相互作用基因变化和噪音暴露在高级暴露组被观察(P < 0.05 ) 。而且,当与噪音暴露的高水平结合了时,风险 haplotype TAGCC 被观察(P < 0.05 ) 。因此,我们的学习证实在 PCDH15 的基因变化在人修改危险性到 NIHL 开发。 | XU Xiang Rong WANG Jing Jing YANG Qiu Yue JIAO Jie HE Li Hua YU Shan Fa GU Gui Zhen CHEN Guo Shun ZHOU Wen Hui WU Hui LI Yan Hong ZHANG Huan Ling ZHANG Zeng Rui JIN Xian Ning | 2017 | Biomedical and Environmental Sciences2017，30，2： | 9 |
| 16 | Decreased and dysfunctional circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease显示文摘 | GAN Ye CAO Jun CHEN Yan HE Zhi-hui LUO Hong CAI Shan XIANG Xu-dong ZHOU Rui CHEN Ping YANG Yue | 2013 | Chinese Medical Journal2013，，17： | 8 |
| 17 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 18 | Involvements of chloride ion in decolorization of Acid Orange 7 by activated peroxydisulfate or peroxymonosulfate oxidation显示文摘The effects of chloride anion (Cl-) (up to 1.0 mol/L) on the decolorization of a model compound,azo dye Acid Orange 7 (AO7),by sulfate radical (SO4-) based-peroxydisulfate (PS) or peroxymonosulfate (PMS) oxidation under various activated conditions (UV 254 nm /PS,Thermal (70°C/PS,UV 254 nm /PMS,Co 2+ /PMS) were investigated.Methanol and NH4 + were used as quenching reagents to determine the contributions of active chlorine species (dichloride radical (Cl2-.) and hypochlorous acid (HClO)).The results indicated that the effects of Cl- on the reaction mechanism were different under various activated conditions.For UV/PS and Thermal/PS,the inhibition tendency became more clear as the Cl- concentration increased,probably due to the reaction between Cl- and SO4-.and the generation of Cl2-.or HClO.For UV/PMS,Cl- did not exhibit inhibition when the concentration was below 0.1 mol/L.As Cl- concentration reached to 1.0 mol/L,the decolorization rate of AO7 was,however,accelerated,possibly because PMS directly reacts with Cl- to form HClO.For Co2+ /PMS,Cl- exhibited a significant inhibiting effect even at low concentration ( 0.01 mol/L).When Cl- concentration exceeded 0.1 mol/L,the activation of PMS by Co 2+ was almost completely inhibited.Under this condition,HClO maybe played a major role in decolorization of AO7.The results implicated that chloride ion is an important factor in SO4-.-based degradation of organic contamination in chloride-containing water. | Ping Wang Shiying Yang Liang Shan Rui Niu Xueting Shao | 2011 | Journal of Environmental Sciences2011，23，11： | 7 |
| 19 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 20 | Estimation of the Aerosol Radiative Effect over the Tibetan Plateau Based on the Latest CALIPSO Product显示文摘Based on the CALIPSO(Cloud–Aerosol Lidar and Infrared Pathfinder Satellite Observation) Version 4.10 products released on 8 November 2016, the Level 2(L2) aerosol product over the Tibetan Plateau(TP) is evaluated and the aerosol radiative effect is also estimated in this study. As there are still some missing aerosol data points in the daytime CALIPSO Version 4.10 L2 product, this study re-calculated the aerosol extinction coefficient to explore the aerosol radiative effect over the TP based on the CALIPSO Level 1(L1) and CloudSat 2 B-CLDCLASS-LIDAR products. The energy budget estimation obtained by using the AODs(aerosol optical depths) from calculated aerosol extinction coefficient as an input to a radiative transfer model shows better agreement with the Earth's Radiant Energy System(CERES) and CloudSat 2 B-FLXHR-LIDAR observations than that with the input of AODs from aerosol extinction coefficient from CALIPSO Version 4.10 L2 product. The radiative effect and heating rate of aerosols over the TP are further simulated by using the calculated aerosol extinction coefficient. The dust aerosols may heat the atmosphere by retaining the energy in the layer. The instantaneous heating rate can be as high as 5.5 K day^(–1) depending on the density of the dust layers. Overall, the dust aerosols significantly affect the radiative energy budget and thermodynamic structure of the air over the TP, mainly by altering the shortwave radiation budget. The significant influence of dust aerosols over the TP on the radiation budget may have important implications for investigating the atmospheric circulation and future regional and global climate. | Rui JIA Yuzhi LIU Shan HUA Qingzhe ZHU Tianbin SHAO | 2018 | Journal of Meteorological Research2018，32，5： | 7 |
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